Base de dados : MEDLINE
Pesquisa : E03.091 [Categoria DeCS]
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[PMID]:29273526
[Au] Autor:Stueber T; Meyer S; Jangra A; Hage A; Eberhardt M; Leffler A
[Ad] Endereço:Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
[Ti] Título:Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity.
[So] Source:Life Sci;194:67-74, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: The anandamide reuptake inhibitor N-arachidonoylaminophenol (AM404) and the reactive substance N-acetyl-p-benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen-induced analgesia by acting at TRPV1 expressed in the peripheral or central nervous system. While NAPQI slowly sensitizes and activates TRPV1 by interacting with distinct intracellular cysteine residues, detailed properties of AM404 as an agonist of TRPV1 have not yet been reported on. We explored the effects of AM404 on recombinant human TRPV1 and in rodent dorsal root ganglion (DRG) neurons. MATERIALS AND METHODS: HEK 293 cells expressing different isoforms of recombinant TRPV1 and rodent DRG neurons were employed for patch clamp and calcium imaging experiments. Cytotoxicity was assessed by propidium iodide and Annexin V staining on TRPV1-HEK 293 cells and with trypan blue staining on DRG neurons. KEY FINDINGS: AM404 activates hTRPV1 at concentrations >1µM and in a concentration-dependent manner. AM404 also potentiates TRPV1-mediated currents evoked by heat and anandamide. Moreover, AM404-evoked currents are potentiated by NAPQI. While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1. In DRG neurons, AM404-evoked calcium influx as well as cell death is mediated by TRPV1. SIGNIFICANCE: AM404 gates TRPV1 by interacting with the vanilloid-binding site, and TRPV1 is the main receptor for AM404 in DRG neurons. While direct activation of TRPV1 requires high concentrations of AM404, it is possible that synergistic effects of AM404 with further TRPV1-agonists may occur at clinically relevant concentrations.
[Mh] Termos MeSH primário: Acetaminofen/farmacologia
Analgésicos não Entorpecentes/farmacologia
Ácidos Araquidônicos/farmacologia
Gânglios Espinais/efeitos dos fármacos
Canais de Cátion TRPV/metabolismo
[Mh] Termos MeSH secundário: Acetaminofen/metabolismo
Analgesia
Analgésicos não Entorpecentes/metabolismo
Animais
Ácidos Araquidônicos/metabolismo
Benzoquinonas/metabolismo
Capsaicina/farmacologia
Gânglios Espinais/citologia
Células HEK293
Seres Humanos
Iminas/metabolismo
Camundongos Endogâmicos C57BL
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Coelhos
Ratos Sprague-Dawley
Fármacos do Sistema Sensorial/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Arachidonic Acids); 0 (Benzoquinones); 0 (Imines); 0 (Sensory System Agents); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); 362O9ITL9D (Acetaminophen); G6S9BN13TI (N-acetyl-4-benzoquinoneimine); S07O44R1ZM (Capsaicin); XVJ94H0U21 (N-(4-hydroxyphenyl)arachidonylamide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  2 / 13779 MEDLINE  
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[PMID]:28450772
[Au] Autor:Nazir N; Jain S
[Ad] Endereço:Department of Anesthesiology, School of Medical Sciences & Research, Sharda University, Greater Noida.
[Ti] Título:A Randomized Controlled Trial Study on the Effect of Adding Dexmedetomidine to Bupivacaine in Supraclavicular Block Using Ultrasound Guidance.
[So] Source:Ethiop J Health Sci;26(6):561-566, 2016 Nov.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The benefits of regional anesthetic techniques are well established. Use of additives to local anesthetics can prolong these benefits. The aim of this study was to find out the effect of adding dexmedetomidine to bupivacaine for supraclavicular block. METHODS: In this randomized, double-blind study, 70 ASA I & II patients of either sex undergoing elective surgeries on the upper limb were given supraclavicular block under ultrasound guidance. Group C (n=35) received 38 mL 0.25% bupivacaine + 2mL normal saline and group D received 38 mL 0.25% bupivacaine + 1 µg/kg dexmedetomidine (2mL). Patients were observed for, onset of motor and sensory block, duration of motor and sensory block, duration of analgesia, sedation score, hemodynamic changes and any adverse events. RESULTS: In group D, the onset was faster (P< 0.001), durations of sensory and motor block duration of and analgesia were prolonged as compared to group C (P < 0.0001).There was a significant drop in heart rate (HR) from the baseline in group D (P < 0.05) at 30, 60, 90 and 120 min. However, none of the patients dropped HR below 50/min. Mean Arterial Pressure (MAP) remained unaffected. The patients in group D were more effectively sedated than those in group C (P < 0.05). No adverse event was reported in either group. CONCLUSION: Dexmedetomidine as adjuvant to bupivacaine in supraclavicular block resulted in faster action, prolonged motor and sensory block, prolonged analgesia with hemodynamic stability and adequate sedation.
[Mh] Termos MeSH primário: Analgésicos não Entorpecentes/uso terapêutico
Anestésicos Locais/uso terapêutico
Bloqueio do Plexo Braquial/métodos
Bupivacaína/uso terapêutico
Dexmedetomidina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Analgesia/métodos
Analgésicos não Entorpecentes/administração & dosagem
Anestésicos Locais/administração & dosagem
Bupivacaína/administração & dosagem
Dexmedetomidina/administração & dosagem
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Hemodinâmica
Seres Humanos
Masculino
Meia-Idade
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Anesthetics, Local); 67VB76HONO (Dexmedetomidine); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29252481
[Au] Autor:Cannesson M; Rice MJ
[Ti] Título:Insight Into Our Technologies: A New Series of Manuscripts in Anesthesia & Analgesia.
[So] Source:Anesth Analg;126(1):25-26, 2018 01.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgesia/tendências
Anestesia/tendências
Invenções/tendências
Publicações Periódicas como Assunto/tendências
[Mh] Termos MeSH secundário: Analgesia/instrumentação
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002392


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[PMID]:28470432
[Au] Autor:Ding Y; Yao P; Hong T; Han Z; Zhao B; Chen W
[Ad] Endereço:Department of Pain Management, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
[Ti] Título:The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain.
[So] Source:J Headache Pain;18(1):51, 2017 Dec.
[Is] ISSN:1129-2377
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperbaric oxygen treatment of neuropathic pain in rats. METHODS: Rats were randomly grouped for establishment of chronic constriction injury (CCI) models. Intrathecal catheters were inserted and 2.5ATA HBO therapy was administered from day 1 post-surgery for 60 minutes daily, continuously for 5 days; menstruum NS, DMSO, NO synthase(NOS) nonspecific inhibitor (L-NAME), soluble guanylyl cyclase(sGC) inhibitor (ODQ) and protein kinase G(PKG) inhibitor (KT5823) were administered intrathecally 30 minutes prior to HBO therapy. Pain-related behaviors in rats were observed at specific time points. Western blot and real-time RT-PCR were used to observe the expressions of PKG1 mRNA and protein in the spinal dorsal horn. RESULTS: Compared with the CCI group, HBO could significantly relieve mechanical and thermal hyperalgesia in rats. After intrathecal administration of L-NAME, ODQ and KT5823, effects of HBO on relieving hyperalgesia in rats were reversed (P < 0.05 vs. HBO), and expression of PKG1 mRNA and protein decreased in the spinal dorsal horn of the animals (P < 0.05 vs. HBO). CONCLUSIONS: Early HBO therapy could significantly improve symptoms of hyperalgesia of neuropathic pain in rats, possibly via activation of the NO-cGMP-PKG signaling transduction pathway.
[Mh] Termos MeSH primário: Proteínas Quinases Dependentes de GMP Cíclico/metabolismo
GMP Cíclico/metabolismo
Oxigenação Hiperbárica/métodos
Neuralgia/metabolismo
Óxido Nítrico Sintase/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Analgesia/métodos
Animais
Masculino
Neuralgia/terapia
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Transdução de Sinais/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.13.39 (Nitric Oxide Synthase); EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinases); H2D2X058MU (Cyclic GMP)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s10194-017-0760-z


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[PMID]:28455601
[Au] Autor:Saeki N; Sugimoto Y; Mori Y; Kato T; Miyoshi H; Nakamura R; Koga T
[Ad] Endereço:Department of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Hiroshima, Hiroshima, 734-8551, Japan. nsaeki@hiroshima-u.ac.jp.
[Ti] Título:Paravertebral block catheter breakage by electrocautery during thoracic surgery.
[So] Source:J Anesth;31(3):463-466, 2017 Jun.
[Is] ISSN:1438-8359
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Advantages of thoracic paravertebral analgesia (TPA) include placement of the catheter closer to the surgical field; however, the catheter can become damaged during the operation. We experienced a case of intraoperative TPA catheter breakage that prompted us to perform an experiment to investigate possible causes. A 50-year-old male underwent a thoracoscopic lower lobectomy under general anesthesia with TPA via an intercostal approach. Following surgery, it was discovered that the catheter had become occluded, as well as cut and fused, so we reopened the incision and removed the residual catheter. From that experience, we performed an experiment to examine electrocautery-induced damage in normal (Portex™, Smith's Medical), radiopaque (Perifix SoftTip™, BBraun), and reinforced (Perifix FX™, BBraun) epidural catheters (n = 8 each). Chicken meat was penetrated by each catheter and then cut by electrocautery. In the normal group, breakage occurred in 8 and occlusion in 6 of the catheters, and in the radiopaque group breakage occurred in 8 and occlusion in 7. In contrast, breakage occurred in only 3 and occlusion in none in the reinforced group, with the 5 without breakage remaining connected only by the spring coil. Furthermore, in 7 of the reinforced catheters, electric arc-induced thermal damage was observed at the tip of the catheter. A TPA catheter for thoracic surgery should be inserted via the median approach, or it should be inserted after surgery to avoid catheter damage during surgery.
[Mh] Termos MeSH primário: Cateteres/efeitos adversos
Eletrocoagulação/efeitos adversos
Bloqueio Nervoso/métodos
Procedimentos Cirúrgicos Torácicos/métodos
[Mh] Termos MeSH secundário: Analgesia/métodos
Anestesia Epidural/métodos
Anestesia Geral/métodos
Cateterismo/efeitos adversos
Eletrocoagulação/métodos
Seres Humanos
Masculino
Meia-Idade
Manejo da Dor
Vértebras Torácicas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s00540-017-2361-z


  6 / 13779 MEDLINE  
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[PMID]:29145981
[Au] Autor:Sayeed Z; Abaab L; El-Othmani M; Pallekonda V; Mihalko W; Saleh KJ
[Ad] Endereço:Department of Orthopaedics, Detroit Medical Center, 4201 St Antoine Street, Detroit, MI 48201, USA.
[Ti] Título:Total Hip Arthroplasty in the Outpatient Setting: What You Need to Know (Part 2).
[So] Source:Orthop Clin North Am;49(1):27-33, 2018 Jan.
[Is] ISSN:1558-1373
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intra- and postoperative phases of outpatient total hip arthroplasty (THA) vary by institution and surgeon. An understanding of an evidence-based approach to enhancing the intra- and postoperative phases of the care continuum is warranted to offer high-value care to outpatient candidates. This article will discuss methods for implementing successful outpatient THA protocols. Specifically it reviews information regarding anesthesia and analgesia modalities, intraoperative considerations, and postoperative rehabilitation amenable to outpatient THA.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios
Artroplastia de Quadril
[Mh] Termos MeSH secundário: Analgesia
Anestesia
Seres Humanos
Seleção de Pacientes
Assistência Perioperatória
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171118
[St] Status:MEDLINE


  7 / 13779 MEDLINE  
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[PMID]:27770844
[Au] Autor:Zeidan F
[Ad] Endereço:Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC.
[Ti] Título:No, Mindfulness Meditation-Based Analgesia Is Not Mediated by Endogenous Opioids.
[So] Source:Am J Med;129(11):e297, 2016 11.
[Is] ISSN:1555-7162
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Meditação
Atenção Plena
[Mh] Termos MeSH secundário: Analgesia
Analgésicos Opioides
Seres Humanos
Manejo da Dor
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27771314
[Au] Autor:Budiansky AS; Margarson MP; Eipe N
[Ad] Endereço:Univerity of Ottawa, Ottawa, ON, Canada.
[Ti] Título:Acute pain management in morbid obesity - an evidence based clinical update.
[So] Source:Surg Obes Relat Dis;13(3):523-532, 2017 Mar.
[Is] ISSN:1878-7533
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasing numbers of patients with morbid obesity are presenting for surgery and their acute pain management requires an evidence-based clinical update. The objective of this study was to complete a literature review for acute pain management in morbid obesity and provide an evidence-based clinical update with recommendations. Using standardized search terms, in March 2015, we completed a literature search to determine evidence for different acute pain pharmacological modalities in morbid obesity. For each modality the highest level of evidence was ascertained and recommendations for each pharmacological modality are presented. Though overall evidence is limited to few well conducted clinical trials, mostly related to weight loss surgery, multimodal analgesia with step-wise, severity-based, opioid-sparing approach appears to improve acute pain management in morbid obesity. The perioperative use of non-opioid adjuvants appears to offer further improvements in patient safety and outcomes. Further research into standardization of pain assessments and implementation of acute pain management protocols is required.
[Mh] Termos MeSH primário: Dor Aguda/prevenção & controle
Analgésicos/uso terapêutico
Cirurgia Bariátrica/efeitos adversos
Obesidade Mórbida/cirurgia
[Mh] Termos MeSH secundário: Analgesia/métodos
Quimioterapia Adjuvante
Terapia Combinada
Seres Humanos
Manejo da Dor/métodos
Dor Pós-Operatória/prevenção & controle
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29049211
[Au] Autor:Zhou F; Du Y; Huang W; Shan J; Xu G
[Ad] Endereço:Department of Orthopedics, Dongyang People's Hospital, Wenzhou Medical University, Dongyang, Zhejiang, China.
[Ti] Título:The efficacy and safety of early initiation of preoperative analgesia with celecoxib in patients underwent arthroscopic knee surgery: A randomized, controlled study.
[So] Source:Medicine (Baltimore);96(42):e8234, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the efficacy and safety of celecoxib 24 hours preoperative, 1 hour preoperative, and 4 hours postoperative administration in patients with arthroscopic knee surgery (AKS).In all, 206 patients who underwent AKS were consecutively recruited and randomized into 3 groups: (1) early preoperative analgesia group (EPEA), celecoxib 400 mg 24 hours preoperative administration; (2) preoperative analgesia group (PEA), celecoxib 400 mg 1 hour preoperative administration; (3) postoperative analgesia group (POA), celecoxib 400 mg 4 hours postoperative administration. Pain visual analog scale (VAS) scores (at rest and at 90 flexion) and patient global assessment (PGA) score were evaluated before and after operation, and also pethidine consumption and adverse events (AEs).The pain-rest VAS score, percentage of patients with moderate-severe pain at rest, and PGA score in the EPEA and PEA groups were decreased compared with POA group at 8 and 12 hours postoperation. Besides, pain-flexion to 90 VAS score in EPEA and PEA groups were also reduced compared with POA group at 8 hours postsurgery. Interestingly, the percentage of patients with moderate-severe pain at 90 flexion at 8 hours postsurgery in PEA group was fewer compared with POA group, whereas at 4 hours postoperation it was reduced in EPEA group compared with PEA and POA groups. As to consumption of pethidine, it was numerically decreased in EPEA and PEA groups compared with POA group. No difference between each 2 groups was found in AEs.Celecoxib was effective and safe as pre-emptive analgesia in AKS, and 1 hour administration before operation might be an optimal choice.
[Mh] Termos MeSH primário: Analgesia/métodos
Artroscopia/efeitos adversos
Celecoxib/administração & dosagem
Inibidores de Ciclo-Oxigenase 2/administração & dosagem
Manejo da Dor/métodos
Dor Pós-Operatória/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Artroscopia/métodos
Método Duplo-Cego
Esquema de Medicação
Feminino
Seres Humanos
Articulação do Joelho/cirurgia
Masculino
Medição da Dor
Dor Pós-Operatória/etiologia
Período Pré-Operatório
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cyclooxygenase 2 Inhibitors); JCX84Q7J1L (Celecoxib)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008234


  10 / 13779 MEDLINE  
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[PMID]:28957364
[Au] Autor:Mukhopadhyay A; Tai BC; Remani D; Phua J; Cove ME; Kowitlawakul Y
[Ad] Endereço:Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Health System, Singapore, Singapore.
[Ti] Título:Age related inverse dose relation of sedatives and analgesics in the intensive care unit.
[So] Source:PLoS One;12(9):e0185212, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sedative and analgesic practices in intensive care units (ICUs) are frequently based on anesthesia regimes but do not take account of the important patient related factors. Pharmacologic properties of sedatives and analgesics change when used as continuous infusions in ICU compared to bolus or short-term infusions during anesthesia. In a prospective observational cohort study, we investigated the association between patient related factors and sedatives/analgesics doses in patients on mechanical ventilation (MV) and their association with cessation of sedation/analgesia. We included patients expected to receive MV for at least 24 hours and excluded those with difficulty in assessing the depth of sedation. We collected data for the first 72 hours or until extubation, whichever occurred first. Multivariate analysis of variance, multivariate regression as well as logistic regression were used. The final cohort (N = 576) was predominantly male (64%) with mean (SD) age 61.7 (15.6) years, weight 63.4 (18.2) Kg, Acute Physiology and Chronic Health Evaluation II score 28.2 (8) and 30% hospital mortality. Increasing age was associated with reduced propofol and fentanyl doses requirements, adjusted to the weight (p<0.001). Factors associated with higher propofol and fentanyl doses were vasopressor use (Relative mean difference (RMD) propofol 1.56 (95% confidence interval (CI) 1.28-1.90); fentanyl 1.48 (1.25-1.76) and central venous line placement (CVL, RMD propofol 1.64 (1.15-2.33); fentanyl 1.41 (1.03-1.91). Male gender was also associated with higher propofol dose (RMD 1.27 (1.06-1.49). Sedation cessation was less likely to occur in restrained patients (Odds Ratio, OR 0.48 (CI 0.30-0.78) or those receiving higher sedative/analgesic doses (OR propofol 0.98 (CI 0.97-0.99); fentanyl 0.99 (CI 0.98-0.997), independent of depth of sedation. In conclusion, increasing age is associated with the use of lower doses of sedative/analgesic in ICU, whereas CVL and vasopressor use were associated with higher doses.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Hipnóticos e Sedativos/farmacologia
Unidades de Terapia Intensiva
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Analgesia
Demografia
Relação Dose-Resposta a Droga
Feminino
Fentanila/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Propofol/administração & dosagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Hypnotics and Sedatives); UF599785JZ (Fentanyl); YI7VU623SF (Propofol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185212



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