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[PMID]:29444393
[Au] Autor:Hallet C; Venneman I; Hans G; Bonhomme V
[Ti] Título:Two different techniques of facial mask induction of anesthesia in children provide identical intubation conditions despite different anesthetic depth.
[So] Source:Acta Anaesthesiol Belg;67(2):81-85, 2016.
[Is] ISSN:0001-5164
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sevoflurane induction in chil- dren is performed using different techniques. Constricted, centered, and symmetrical pupils (CCSP) are classically the endpoint to be achieved before laryngoscopy is performed. OBJECTIVES: We investigated whether two different inhalation induction techniques with the same clinical end- point provided similar intubating conditions and comparable depth of anesthesia as assessed by the Bispectral Index (BIS). METHODS: Following IRB approval, and informed parental consent, 20 children were recruited. They were sched- uled for general anesthesia with tracheal intubation, and randomly assigned to Group 1, where the practitioner used 6% inspired sevoflurane in 50% 02/N20, and no manually assisted ventilation, or Group 2, where inspired sevoflurane was 8% in 50% 02/N20, and ventilation was manually supported upon loss of consciousness. BIS values were blinded. Laryngoscopy was performed after CCSP. Intubation conditions scoring was based on jaw relaxation (mobile = 1, partially mobile = 2, fixed = 3), position of vocal cords (open = 1, half-closed = 2, closed = 3), and cough (no cough = 1, 1 or 2 coughing efforts = 2, persistent coughing = 3). A total score > 3 corresponded to non-optimal conditions. RESULTS: Upon CCSP, BIS values were significantly lower in Group 1 [mean (SD) : 30 (8) - 48 (18), p <0.001], despite significantly higher end-tidal sevoflurane concentration in Group 2 [mean (SD) : 5.0 (0.7) - 6.2 (0.5) ; p <0.001]. Time to CCSP was slightly shorter in Group 2. Intubation conditions were always optimal except for one patient of Group 1. DISCUSSION: Both induction techniques achieve good intubating conditions. Possible explanations for the between-group BIS difference include variable appreciation of the CCSP endpoint, different induction lengths or sevoflurane equilibration times, or sevoflurane-induced increase in electroencephalogram power. A better indicator of the best time to intubate is needed to avoid too deep anesthesia in children.
[Mh] Termos MeSH primário: Anestesia por Inalação/métodos
Intubação Intratraqueal/métodos
Máscaras
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Monitores de Consciência
Método Duplo-Cego
Eletroencefalografia
Seres Humanos
Éteres Metílicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Methyl Ethers); 38LVP0K73A (sevoflurane)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE


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[PMID]:29189357
[Au] Autor:Gropper MA; Shafer SL
[Ti] Título:Dr Ted Eger Obituary.
[So] Source:Anesth Analg;125(6):1829-1830, 2017 12.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anestesia por Inalação/história
Anestesiologistas/história
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Eger T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002592


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[PMID]:28745667
[Au] Autor:Novikov AY; Kovalev VA; Vinichuk NV; Chernyh YA; Golub IE; Sorokina LV
[Ad] Endereço:Primorye regional clinical hospital #1, Vladivostok, Russia.
[Ti] Título:[Prevention and correction of cognitive dysfunction after general anesthesia].
[Ti] Título:Profilaktika i korrektsiia kognitivnykh narushenii posle obshchei anestezii..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):28-31, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution). Patients underwent thyroidectomy with general inhalation anesthesia using desflurane. Cognitive testing was performed one day before operation and 6, 24 and 48 h after. Waking time after stopping desflurane administration and time prior tracheal extubation were recorded. RESULTS AND CONCLUSION: The use of cytoflavin promoted the early post anesthesia adaptation and more rapid recovery of initial cognitive status of the patients.
[Mh] Termos MeSH primário: Período de Recuperação da Anestesia
Anestesia por Inalação/efeitos adversos
Anestésicos Inalatórios/efeitos adversos
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/prevenção & controle
Mononucleotídeo de Flavina/uso terapêutico
Inosina Difosfato/uso terapêutico
Niacinamida/uso terapêutico
Succinatos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Anestésicos Inalatórios/administração & dosagem
Combinação de Medicamentos
Feminino
Seres Humanos
Cuidados Intraoperatórios
Isoflurano/administração & dosagem
Isoflurano/efeitos adversos
Isoflurano/análogos & derivados
Meia-Idade
Doenças da Glândula Tireoide/cirurgia
Tireoidectomia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Drug Combinations); 0 (Succinates); 0 (cytoflavin); 25X51I8RD4 (Niacinamide); 7N464URE7E (Flavin Mononucleotide); 86-04-4 (Inosine Diphosphate); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176128-31


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[PMID]:29110428
[Au] Autor:Gill H
[Ad] Endereço:Bristol Royal Hospital for Children, Bristol, UK.
[Ti] Título:Xenon-augmented pediatric anesthesia: A small step closer?
[So] Source:Paediatr Anaesth;27(12):1174-1175, 2017 12.
[Is] ISSN:1460-9592
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Anestesia por Inalação
Xenônio
[Mh] Termos MeSH secundário: Anestesia
Anestésicos Inalatórios
Criança
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 3H3U766W84 (Xenon)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE
[do] DOI:10.1111/pan.13265


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[PMID]:29049165
[Au] Autor:Yu H; Wu D
[Ad] Endereço:Department of Anesthesiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Effects of different methods of general anesthesia on intraoperative awareness in surgical patients.
[So] Source:Medicine (Baltimore);96(42):e6428, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of the study was to investigate the effects of total intravenous anesthesia (TIVA) and combined of intravenous and inhaled anesthesia (CIIA) on intraoperative awareness in surgical patients.A total of 678 patients were recruited in the CIIA group, while TIVA group included 566 patients. The clinical characteristics and the occurrence of intraoperative awareness were compared between the groups. Mini-Mental State Examination, Generalized Anxiety Disorder 7, and Patient Health Questionnaire 9 tests were performed to estimate cognitive and psychological functions of the patients. In addition, logistic regression analysis was applied to identify the risk factors for intraoperative awareness in surgical patients.In CIIA group, 3 patients (0.44%) were confirmed with intraoperative awareness, while 11 patients (1.94%) in TIVA group underwent intraoperative awareness. The occurrence rate of intraoperative awareness was significantly higher in VITA group than that in the CIIA group (P = .029). Awareness classification demonstrated that intraoperative awareness mainly included auditory, tactile, and pain perceptions. Moreover, 4 patients showed distress after operation. Patients with intraoperative awareness exhibited poor performance in cognitive and psychological tests (P < .001 for all). Logistic regression analysis demonstrated that CIIA (odds ratio [OR] = 0.198, 95% confidence interval [CI] = 0.047-0.827), age (OR = 0.951, 95% CI = 0.908-0.997), midazolam application (OR = 0.158, 95% CI = 0.034-0.736), awareness history (OR = 10.131, 95% CI = 2.206-45.517), and duration of surgery (OR = 1.016, 95% CI = 1.001-1.032) were significantly associated with intraoperative awareness.Intraoperative awareness can significantly influence the cognitive and psychological functions of surgical patients. CIIA and midazolam application may lower the risk of intraoperative awareness.
[Mh] Termos MeSH primário: Anestesia Geral/efeitos adversos
Anestesia Geral/psicologia
Consciência no Peroperatório/psicologia
Complicações Pós-Operatórias/psicologia
Estresse Psicológico/psicologia
[Mh] Termos MeSH secundário: Adulto
Anestesia Geral/métodos
Anestesia por Inalação/efeitos adversos
Anestesia por Inalação/psicologia
Anestesia Intravenosa/efeitos adversos
Anestesia Intravenosa/psicologia
Anestésicos Inalatórios/administração & dosagem
Anestésicos Inalatórios/efeitos adversos
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Éteres Metílicos/administração & dosagem
Éteres Metílicos/efeitos adversos
Meia-Idade
Duração da Cirurgia
Complicações Pós-Operatórias/induzido quimicamente
Período Pós-Operatório
Propofol/administração & dosagem
Propofol/efeitos adversos
Estresse Psicológico/induzido quimicamente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Methyl Ethers); 38LVP0K73A (sevoflurane); YI7VU623SF (Propofol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006428


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[PMID]:28858134
[Au] Autor:Kim EH; Song IK; Lee JH; Kim HS; Kim HC; Yoon SH; Jang YE; Kim JT
[Ad] Endereço:aDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Jongno-gu bDepartment of Anaesthesiology and Pain Medicine, Asan Medical Center, Ulsan College of Medicine, Songpa-GU, Seoul cDepartment of Anesthesiology and Pain Medicine, Keimyung University Dongsan Medical Center, Jung-gu, Daegu, Republic of Korea.
[Ti] Título:Desflurane versus sevoflurane in pediatric anesthesia with a laryngeal mask airway: A randomized controlled trial.
[So] Source:Medicine (Baltimore);96(35):e7977, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Desflurane with a laryngeal mask airway may have advantages during ambulatory anesthesia. However, desflurane-induced airway irritability makes the use of desflurane challenging, especially in children. This study compared desflurane with sevoflurane maintenance anesthesia in terms of respiratory events and the emergence characteristics in children with a laryngeal mask airway. METHODS: This randomized controlled trial evaluated 200 children undergoing strabismus surgery allocated to desflurane or sevoflurane groups. After inducing anesthesia with sevoflurane and thiopental sodium 5 mg kg, the anesthetic agent was changed to desflurane in the desflurane group, whereas sevoflurane was continued in the sevoflurane group. Respiratory events, emergence time, recovery time, and emergence agitation were compared between the groups. RESULTS: The overall respiratory events did not differ between the groups. However, the incidence of mild desaturation (90% ≤ SpO2 < 97%) was significantly higher in the desflurane group (7%) than in the sevoflurane group (0%) (P = .007). Emergence was significantly faster in the desflurane group (6.6 ±â€Š3.9 vs 8.0 ±â€Š2.2 min, P = .003). The recovery time and emergence agitation in the postanesthesia care unit were comparable between groups. Laryngospasm developed in 5 children (1 in the sevoflurane group and 4 in the desflurane group, P = .365); of these, 4 patients were younger than 3 years. CONCLUSION: Desflurane maintenance anesthesia in children with a laryngeal mask airway shows a similar rate of overall respiratory events compared with sevoflurane anesthesia. However, anesthesiologists should be cautious of using desflurane in younger children concerning desaturation events during emergence.
[Mh] Termos MeSH primário: Anestesia por Inalação/métodos
Anestésicos Inalatórios/administração & dosagem
Isoflurano/análogos & derivados
Máscaras Laríngeas
Éteres Metílicos/administração & dosagem
[Mh] Termos MeSH secundário: Anestesia por Inalação/efeitos adversos
Anestesia por Inalação/instrumentação
Anestésicos Inalatórios/efeitos adversos
Criança
Pré-Escolar
Método Duplo-Cego
Feminino
Seres Humanos
Isoflurano/administração & dosagem
Isoflurano/efeitos adversos
Masculino
Éteres Metílicos/efeitos adversos
Transtornos Respiratórios/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Methyl Ethers); 38LVP0K73A (sevoflurane); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007977


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[PMID]:28640124
[Au] Autor:Choi YJ; Min SH; Park JJ; Cho JE; Yoon SZ; Yoon SM
[Ad] Endereço:aDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do bTnTn Hospital cDepartment of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Korea.
[Ti] Título:Comparison of the temperature and humidity in the anesthetic breathing circuit among different anesthetic workstations: Updated guidelines for reporting parallel group randomized trials.
[So] Source:Medicine (Baltimore);96(25):e7239, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: For patients undergoing general anesthesia, adequate warming and humidification of the inspired gases is very important. The aim of this study was to evaluate the differences in the heat and moisture content of the inspired gases with low-flow anesthesia using 4 different anesthesia machines. METHODS: The patients were divided into 11 groups according to the anesthesia machine used (Ohmeda, Excel; Avance; Dräger, Cato; and Primus) and the fresh gas flow (FGF) rate (0.5, 1, and 4 L/min). The temperature and absolute humidity of the inspired gas in the inspiratory limbs were measured at 5, 10, 15, 30, 45, 60, 75, 90, 105, and 120 minutes in 9 patients scheduled for total thyroidectomy or cervical spine operation in each group. RESULTS: The anesthesia machines of Excel, Avance, Cato, and Primus did not show statistically significant changes in the inspired gas temperatures over time within each group with various FGFs. They, however, showed statistically significant changes in the absolute humidity of the inspired gas over time within each group with low FGF anesthesia (P < .05). The anesthesia machines of Cato and Primus showed statistically significant changes in the absolute humidity of the inspired gas over time within each group with an FGF of 4 L/min (P < .05). However, even with low-flow anesthesia, the temperatures and absolute humidities of the inspired gas for all anesthesia machines were lower than the recommended values. CONCLUSION: There were statistical differences in the provision of humidity among different anesthesia workstations. The Cato and Primus workstations were superior to Excel and Avance. However, even these were unsatisfactory in humans. Therefore, additional devices that provide inspired gases with adequate heat and humidity are needed for those undergoing general anesthetic procedures.
[Mh] Termos MeSH primário: Anestesia por Inalação/instrumentação
Umidade
Temperatura Ambiente
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Vértebras Cervicais/cirurgia
Seres Humanos
Meia-Idade
Procedimentos Ortopédicos
Guias de Prática Clínica como Assunto
Tireoidectomia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007239


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[PMID]:28626913
[Au] Autor:Wallden J; Halliday TA; Hultin M
[Ad] Endereço:Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
[Ti] Título:Reply to: Sorbello et al., PONV in bariatric surgery: time for opioid-free anaesthesia.
[So] Source:Acta Anaesthesiol Scand;61(7):858, 2017 08.
[Is] ISSN:1399-6576
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides
Náusea e Vômito Pós-Operatório
[Mh] Termos MeSH secundário: Anestesia por Inalação
Antieméticos
Cirurgia Bariátrica
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Antiemetics)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1111/aas.12923


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[PMID]:28617851
[Au] Autor:Hohlbaum K; Bert B; Dietze S; Palme R; Fink H; Thöne-Reineke C
[Ad] Endereço:Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
[Ti] Título:Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice-Assessing the degree of distress.
[So] Source:PLoS One;12(6):e0179588, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administration of isoflurane, the most commonly used inhalation anesthetic, on the well-being of adult C57BL/6JRj mice, in comparison to single administrations and to untreated animals, when applied six times for 45 min at an interval of 3-4 days. For the animals anesthetized, excitations, phases of anesthesia, and vital parameters were monitored. Well-being after anesthesia was assessed using a behavioral test battery including luxury behavior like burrowing and nest building behavior, the Mouse Grimace Scale (MGS), the free exploratory paradigm for anxiety-related behavior, home cage activity and the rotarod test for activity, as well as food intake and body weight. Additionally, hair corticosterone and fecal corticosterone metabolites were measured. Our results show that nest building behavior, home cage activity, body weight, and corticosterone concentrations were not influenced by anesthesia, whereas changes in burrowing behavior, the MGS, food intake, and the free exploratory behavior indicated that the well-being of the mice was more affected by repeated than single isoflurane anesthesia. This effect depended on the sex of the animals, with female mice being more susceptible than male mice. However, repeated isoflurane anesthesia caused only short-term mild distress and impairment of well-being, mainly in the immediate postanesthetic period. Well-being stabilized at 8 days after the last anesthesia, at the latest. Therefore, we conclude that when using our anesthesia protocol, the severity of both single and repeated isoflurane anesthesia in C57BL/6JRj mice can be classified as mild. However, within the mild severity category, repeated isoflurane anesthesia ranks higher than single isoflurane anesthesia. Additionally, our results imply that male and female mice can differently perceive the severity of a procedure.
[Mh] Termos MeSH primário: Anestesia por Inalação/efeitos adversos
Corticosterona/metabolismo
Ingestão de Alimentos/efeitos dos fármacos
Isoflurano/efeitos adversos
Comportamento de Nidação/efeitos dos fármacos
Caracteres Sexuais
Estresse Psicológico
[Mh] Termos MeSH secundário: Animais
Feminino
Isoflurano/farmacologia
Masculino
Camundongos
Estresse Psicológico/induzido quimicamente
Estresse Psicológico/metabolismo
Estresse Psicológico/fisiopatologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CYS9AKD70P (Isoflurane); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179588


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[PMID]:28444141
[Au] Autor:Bar-Klein G; Lublinsky S; Kamintsky L; Noyman I; Veksler R; Dalipaj H; Senatorov VV; Swissa E; Rosenbach D; Elazary N; Milikovsky DZ; Milk N; Kassirer M; Rosman Y; Serlin Y; Eisenkraft A; Chassidim Y; Parmet Y; Kaufer D; Friedman A
[Ad] Endereço:Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, Zlowotski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
[Ti] Título:Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis.
[So] Source:Brain;140(6):1692-1705, 2017 Jun 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A biomarker that will enable the identification of patients at high-risk for developing post-injury epilepsy is critically required. Microvascular pathology and related blood-brain barrier dysfunction and neuroinflammation were shown to be associated with epileptogenesis after injury. Here we used prospective, longitudinal magnetic resonance imaging to quantitatively follow blood-brain barrier pathology in rats following status epilepticus, late electrocorticography to identify epileptic animals and post-mortem immunohistochemistry to confirm blood-brain barrier dysfunction and neuroinflammation. Finally, to test the pharmacodynamic relevance of the proposed biomarker, two anti-epileptogenic interventions were used; isoflurane anaesthesia and losartan. Our results show that early blood-brain barrier pathology in the piriform network is a sensitive and specific predictor (area under the curve of 0.96, P < 0.0001) for epilepsy, while diffused pathology is associated with a lower risk. Early treatments with either isoflurane anaesthesia or losartan prevented early microvascular damage and late epilepsy. We suggest quantitative assessment of blood-brain barrier pathology as a clinically relevant predictive, diagnostic and pharmaco!dynamics biomarker for acquired epilepsy.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/farmacologia
Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia
Barreira Hematoencefálica/diagnóstico por imagem
Barreira Hematoencefálica/fisiopatologia
Isoflurano/farmacologia
Losartan/farmacologia
Imagem por Ressonância Magnética/métodos
Estado Epiléptico/diagnóstico por imagem
Estado Epiléptico/fisiopatologia
[Mh] Termos MeSH secundário: Anestesia por Inalação
Anestésicos Inalatórios/administração & dosagem
Bloqueadores do Receptor Tipo 1 de Angiotensina II/administração & dosagem
Animais
Biomarcadores
Barreira Hematoencefálica/efeitos dos fármacos
Modelos Animais de Doenças
Eletrocorticografia
Isoflurano/administração & dosagem
Losartan/administração & dosagem
Masculino
Estudos Prospectivos
Ratos
Ratos Sprague-Dawley
Estado Epiléptico/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Angiotensin II Type 1 Receptor Blockers); 0 (Biomarkers); CYS9AKD70P (Isoflurane); JMS50MPO89 (Losartan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx073



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