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[PMID]:25928515
[Au] Autor:Caliskan B; Mutlu N
[Ad] Endereço:Department of Urology, Kocaeli State Hospital, Turkey.
[Ti] Título:Intrarectal ice application prior to transrectal prostate biopsy: a prospective randomised trial accessing pain and collateral effects.
[So] Source:Int Braz J Urol;41(1):101-8; discussion 109, 2015 Jan-Feb.
[Is] ISSN:1677-6119
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To analyze the efficacy of intrarectal ice application as an anesthetic method prior to transrectal ultrasound (TRUS) guided prostate biopsy. MATERIALS AND METHODS: A total of 120 consecutive men were included into the study prospectively. Patients were equally randomized as group 1 and 2 with 60 patients each. Ice was applied as an anesthetic method 5 minutes before procedure to the patients in group 1. Patients in group 2 were applied 10 mL of 2% lidocaine gel 10 minutes before procedure. Twelve core biopsy procedure was performed for all patients. The pain level was evaluated using a visual analogue scale (VAS). RESULTS: Median pain score was 3.5 (1-8) in group 1 and 5 (1-8) in group 2. There is significantly difference between groups regarding the mean sense of pain level during the procedure. (p=0.007) There was also no difference in complications between two groups about presence and duration of macroscopic hematuria and rectal bleeding. CONCLUSIONS: Intrarectal ice application prior to TRUS prostate biopsy has an effect on reducing pain. Development of new techniques about cold effect or ice can make this method more useful and decrease complication rates.
[Mh] Termos MeSH primário: Analgesia/métodos
Anestesia Retal/métodos
Anestésicos Locais/uso terapêutico
Crioanestesia/métodos
Gelo
Biópsia Guiada por Imagem/efeitos adversos
Biópsia Guiada por Imagem/métodos
Lidocaína/uso terapêutico
[Mh] Termos MeSH secundário: Administração Retal
Adulto
Idoso
Idoso de 80 Anos ou mais
Seres Humanos
Complicações Intraoperatórias/prevenção & controle
Masculino
Meia-Idade
Dor/prevenção & controle
Medição da Dor
Estudos Prospectivos
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Ice); 98PI200987 (Lidocaine)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:160513
[Lr] Data última revisão:
160513
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150501
[St] Status:MEDLINE


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[PMID]:17394704
[Au] Autor:Padmanabhan J; Rohatgi A; Niaz A; Chojnowska E; Baig K; Woods WG
[Ad] Endereço:Department of Surgery, Worthing Hospital, West Sussex, UK. padlu@hotmail.com
[Ti] Título:Does rectus sheath infusion of bupivacaine reduce postoperative opioid requirement?
[So] Source:Ann R Coll Surg Engl;89(3):229-32, 2007 Apr.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The aim of this work was to assess the effect of intermittent bupivacaine infusion into rectus sheath space on postoperative opioid requirement, postoperative pain score and peak expiratory flow rate. PATIENTS AND METHODS: A prospective, randomised study involving patients undergoing midline laparotomy. Patients were randomised to receive either intermittent infusion of bupivacaine 0.25% or normal saline via catheters placed in the rectus sheath for 48 h after operation. All patients received intravenous morphine infusion on demand with a patient-controlled analgesic device (PCAD). RESULTS: Forty ASA I-III patients were studied. Nineteen were randomised to receive bupivacaine and 21 patients received normal saline. Patient characteristics and surgical variables were comparable in the two groups. The mean wound lengths were similar. There was no statistically significant difference in postoperative opioid requirement, postoperative pain score and peak expiratory flow rate between the two groups. CONCLUSIONS: Intermittent bupivacaine infusion into the rectus sheath space after midline laparotomy does not reduce postoperative opioid requirement nor does it affect postoperative pain score or peak expiratory flow rate.
[Mh] Termos MeSH primário: Analgésicos Opioides/administração & dosagem
Anestésicos Locais/administração & dosagem
Bupivacaína/administração & dosagem
Morfina/administração & dosagem
Dor Pós-Operatória/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Analgesia Controlada pelo Paciente
Anestesia Retal
Feminino
Seres Humanos
Infusões Intralesionais
Infusões Intravenosas
Laparotomia/métodos
Masculino
Medição da Dor
Dor Pós-Operatória/etiologia
Dor Pós-Operatória/fisiopatologia
Pico do Fluxo Expiratório/efeitos dos fármacos
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Anesthetics, Local); 76I7G6D29C (Morphine); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:0705
[Cu] Atualização por classe:140907
[Lr] Data última revisão:
140907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070331
[St] Status:MEDLINE


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[PMID]:15989026
[Au] Autor:Pushkar' DIu; Govorov AV
[Ti] Título:[Complications of transrectal biopsy of the prostate].
[So] Source:Urologiia;(2):40-2, 2005 Mar-Apr.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The aim of the study was to assess frequency of various complications of transrectal multifocal biopsy of the prostate (TMBP), to specify prophylactic measures against such complications. Primary TMBP under US guidance was made in 612 patients (mean age 65.8 years, mean level of PSA 12.6 ng/ml). TMBP complications include: hematuria (220 patients, 35.9%), hemospermia (166 patients, 27.1%), pain in the perineum and the rectum (189, 30.9%), acute prostatitis (21 patients, 3.4%), acute orchiepididymitis (7 patients, 1.1%), acute urine retention (9 patients, 1.5%), long-term rectal hemorrhage (13 patients, 2.1%), loss of consciousness during the biopsy (7 patients, 1.1%). The analysis of TMBP complications leads to the conclusion that adequate preparation of the patients and accurate conduction of the prostatic biopsy technique under US guidance make this invasive manipulation diagnostically effective and safe.
[Mh] Termos MeSH primário: Biópsia por Agulha/efeitos adversos
Próstata/patologia
Neoplasias da Próstata/patologia
Ultrassom Focalizado Transretal de Alta Intensidade/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Anestesia Retal
Anestésicos Locais
Biópsia por Agulha/métodos
Seres Humanos
Lidocaína
Masculino
Próstata/diagnóstico por imagem
Neoplasias da Próstata/diagnóstico por imagem
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 98PI200987 (Lidocaine)
[Em] Mês de entrada:0507
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050702
[St] Status:MEDLINE


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[PMID]:15192345
[Au] Autor:Choi H; Lee K; Lee H; Lee Y; Chang D; Eom K; Youn H; Choi M; Yoon J
[Ad] Endereço:Department of Radiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
[Ti] Título:Quantification of mitral regurgitation using proximal isovelocity surface area method in dogs.
[So] Source:J Vet Sci;5(2):163-71, 2004 Jun.
[Is] ISSN:1229-845X
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The present study was performed to determine the accuracy and reproducibility of calculating the mitral regurgitant orifice area with the proximal isovelocity surface area (PISA) method in dogs with experimental mitral regurgitation and in canine patients with chronic mitral insufficiency and to evaluate the effect of general anesthesia on mitral regurgitation. Eight adult, Beagle dogs for experimental mitral regurgitation and 11 small breed dogs with spontaneous mitral regurgitation were used. In 8 Beagle dogs, mild mitral regurgitation was created by disrupting mitral chordae or leaflets. Effective regurgitant orifice (ERO) area was measured by the PISA method and compared with the measurements simultaneously obtained by quantitative Doppler echocardiography 4 weeks after creation of mitral regurgitation. The same procedure was performed in 11 patients with isolated mitral regurgitation and in 8 Beagle dogs under two different protocols of general anesthesia. ERO and regurgitant stroke volume (RSV) by the PISA method correlated well with values by the quantitative Doppler technique with a small error in experimental dogs (r = 0.914 and r = 0.839) and 11 patients (r = 0.990 and r = 0.996). The isoflurane anesthetic echocardiography demonstrated a significant decrease of RSV, and there was no significant change in fractional shortening (FS), ERO area, LV end-diastolic and LV end-systolic volume. ERO area showed increasing tendency after ketamine-xylazine administration, but not statistically significant. RSV, LV end-systolic and LV end-diastolic volume increased significantly (p < 0.01), whereas FS significantly decreased (p < 0.01). The PISA method is accurate and reproducible in experimental mitral regurgitation model and in a clinical setting. ERO area is considered and preferred as a hemodynamic-nondependent factor than other traditional measurements.
[Mh] Termos MeSH primário: Mapeamento Potencial de Superfície Corporal/veterinária
Doenças do Cão/fisiopatologia
Insuficiência da Valva Mitral/veterinária
Valva Mitral/fisiopatologia
[Mh] Termos MeSH secundário: Anestesia Retal
Animais
Cordas Tendinosas/fisiopatologia
Cordas Tendinosas/cirurgia
Doenças do Cão/diagnóstico
Cães
Ecocardiografia Doppler/veterinária
Eletrocardiografia/veterinária
Insuficiência da Valva Mitral/diagnóstico
Insuficiência da Valva Mitral/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0408
[Cu] Atualização por classe:090821
[Lr] Data última revisão:
090821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040612
[St] Status:MEDLINE


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[PMID]:11265587
[Au] Autor:Gajewska M; Sznitowska M; Janicki S
[Ad] Endereço:Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland.
[Ti] Título:Diazepam submicron emulsions containing soya-bean oil and intended for oral or rectal delivery.
[So] Source:Pharmazie;56(3):220-2, 2001 Mar.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Physically stable diazepam submicron emulsions were prepared using soya-bean oil. Diazepam concentration 4 mg/ml, suitable for rectal or oral delivery, was achieved in 20% emulsions. Mixture of egg lecithin (1.2%) and poloxamer (2.0%) has been chosen as the most suitable emulsifying agent. Composition of the emulsion may be supplemented with alpha-tocopherol and parabens. However, the system was not stable when either phenylethanol or chlorhexidine gluconate was added. Taste masking agents commonly used as food additives decreased stability of the preparation and were not efficient in elimination of a bitter taste of the drug-loaded emulsions.
[Mh] Termos MeSH primário: Ansiolíticos/administração & dosagem
Diazepam/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Anestesia Retal
Emulsões
Aromatizantes
Tamanho da Partícula
Fosfatidilcolinas
Conservantes Farmacêuticos
Solubilidade
Óleo de Soja
Vitamina E
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Emulsions); 0 (Flavoring Agents); 0 (Phosphatidylcholines); 0 (Preservatives, Pharmaceutical); 1406-18-4 (Vitamin E); 8001-22-7 (Soybean Oil); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:0105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010327
[St] Status:MEDLINE


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[PMID]:8732611
[Au] Autor:Kotiniemi LH; Ryhänen PT
[Ad] Endereço:Department of Anaesthesiology, Oulu University Hospital, Finland.
[Ti] Título:Behavioural changes and children's memories after intravenous, inhalation and rectal induction of anaesthesia.
[So] Source:Paediatr Anaesth;6(3):201-7, 1996.
[Is] ISSN:1155-5645
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Ninety two-to-seven-year-old children admitted for routine day case ENT operations were randomly allocated to have either intravenous thiopentone (group I), halothane inhalation (group II) or rectal methohexitone (group III) for anaesthesia induction. Using a postoperative questionnaire, the parents evaluated the changes in the child's behaviour one day, one week and one month after the operation. Problematic changes were detected in 17 (59%) children in group I, 14 (50%) in group II and 17 (58%) in group III (NS). Although the children in group II behaved most calmly during the induction they had significantly more negative memories of the induction of anaesthesia (six children in group II vs two in group I and one in group III) and of the hospital in general (17 in group II vs 11 in group I and eight in group III) than children in the other groups. Judging from memories of young children, intravenous and rectal inductions are less distressing to them than inhalational induction.
[Mh] Termos MeSH primário: Anestesia por Inalação
Anestesia Intravenosa
Anestesia Retal
Comportamento Infantil
Memória
[Mh] Termos MeSH secundário: Administração Retal
Anestésicos/administração & dosagem
Anestésicos Inalatórios/administração & dosagem
Anestésicos Intravenosos/administração & dosagem
Atitude Frente à Saúde
Criança
Comportamento Infantil/efeitos dos fármacos
Pré-Escolar
Feminino
Seguimentos
Halotano/administração & dosagem
Hospitais
Seres Humanos
Masculino
Metoexital/administração & dosagem
Otorrinolaringopatias/cirurgia
Tiopental/administração & dosagem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics); 0 (Anesthetics, Inhalation); 0 (Anesthetics, Intravenous); E5B8ND5IPE (Methohexital); JI8Z5M7NA3 (Thiopental); UQT9G45D1P (Halothane)
[Em] Mês de entrada:9610
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960101
[St] Status:MEDLINE


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[PMID]:8693248
[Au] Autor:Bissonnette B
[Ad] Endereço:Service d'anesthésiologie, Centre hospitalier universitaire vaudois, Lausanne, Suisse.
[Ti] Título:[Pediatric anesthesia. Induction, sustaining, awakening].
[Ti] Título:Anesthésie pédiatrique. Induction, maintien et réveil de l'enfant..
[So] Source:Rev Med Suisse Romande;116(4):239-42, 1996 Apr.
[Is] ISSN:0035-3655
[Cp] País de publicação:Switzerland
[La] Idioma:fre
[Mh] Termos MeSH primário: Anestesia/métodos
[Mh] Termos MeSH secundário: Anestesia/psicologia
Período de Recuperação da Anestesia
Anestesia por Inalação
Anestesia Intravenosa
Anestesia Retal
Criança
Seres Humanos
Hipnose Anestésica
Psicologia da Criança
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:9608
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960401
[St] Status:MEDLINE


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[PMID]:7478053
[Au] Autor:Ceriana P; Maurelli M
[Ad] Endereço:Servizio di Anestesia e Rianimazione I, IRCCS Policlinico San Matteo, Pavia.
[Ti] Título:[Rectal administration of anesthetic agents].
[Ti] Título:La somministrazione di farmaci anestetici per via rettale..
[So] Source:Minerva Anestesiol;61(5):219-28, 1995 May.
[Is] ISSN:0375-9393
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:OBJECTIVES: To collect data in the current literature dealing with the diffusion, the reliability and the effectiveness of the rectal administration of anaesthetic drugs. To evaluate differences with parenteral administration. DATA SOURCES: Pharmacokinetics and clinical studies published in recent years in indexed journals. STUDY SELECTION: Based on the study methodology, drugs employed and pharmacokinetic parameters evaluated. DATA EXTRACTION: Factors involved in absorption of drugs from the rectal mucosa, clinical effect and pharmacokinetic data of the following drugs: diazepam, flunitrazepam, midazolam, ketamin and methohexital, then a brief evaluation of other drugs: thiopental, etomidate, morphine and chloral hydrate. DATA SYNTHESIS: The most widely used drugs are benzodiazepines: they are safe, easy to manage and highly effective; among them midazolam has the best kinetic and dynamic pattern. Ketamin is useful during painful diagnostic procedures; with the use of barbiturates there is a greater risk of respiratory depression and more caution must be employed. CONCLUSIONS: Wide intervariability of rate of absorption, achievement of plasma levels and clinical effect is a relevant drawback of this technique, such to make it not preferable to the parenteral route, when both are feasible. It deserves, anyway, more consideration, and maintains its validity for the preparation of the paediatric patient to general anaesthesia.
[Mh] Termos MeSH primário: Anestesia Retal
Anestésicos/farmacocinética
[Mh] Termos MeSH secundário: Administração Retal
Anestesia Retal/métodos
Anestésicos/administração & dosagem
Seres Humanos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anesthetics)
[Em] Mês de entrada:9512
[Cu] Atualização por classe:100324
[Lr] Data última revisão:
100324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950501
[St] Status:MEDLINE


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[PMID]:7817152
[Au] Autor:Lökken P; Bakstad OJ; Fonnelöp E; Skogedal N; Hellsten K; Bjerkelund CE; Storhaug K; Oye I
[Ad] Endereço:Section of Dental Pharmacology and Pharmacotherapeutics, University of Oslo, Norway.
[Ti] Título:Conscious sedation by rectal administration of midazolam or midazolam plus ketamine as alternatives to general anesthesia for dental treatment of uncooperative children.
[So] Source:Scand J Dent Res;102(5):274-80, 1994 Oct.
[Is] ISSN:0029-845X
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The trial included 24 children (aged 2-7 yr) referred for dental treatment under general anesthesia, since conventional behavioral management methods had failed to achieve treatment acceptance. As an alternative, they received, on two separate occasions with "identical" dental treatment, conscious sedation by rectal administration of either midazolam (0.3 mg/kg body weight (bwt)) or midazolam (0.3 mg/kg bwt) plus ketamine (1.0 mg/kg bwt). This allowed a double-blind, crossover design. The aims were to assess conscious sedation, combined with local anesthesia, as an alternative to general anesthesia, and further to evaluate the effects obtained by addition of a low dose of ketamine to rectally administered midazolam. The feasibility of dental treatment was rated as excellent or good for 16 of the 24 children when premedicated with midazolam, and for 18 of the 24 children when ketamine was added to midazolam. At least some treatment could be given to all children. Verbal contact was maintained with all children throughout both treatment sessions. The children were significantly less anxious when they arrived for the second session. Amnesia and drowsiness were significantly increased when ketamine was added to midazolam. The combination also tended to be more efficient in relief of anxiety and prevention of pain, but there were large variations in the children's responses to the drugs. Midazolam significantly reduced the blood oxygen level, but not with ketamine added. For most children, both regimens proved to be appropriate as alternatives to general anesthesia.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Anestesia Dentária
Anestesia Retal
Comportamento Infantil
Sedação Consciente
Comportamento Cooperativo
Assistência Odontológica/psicologia
Ketamina/administração & dosagem
Midazolam/administração & dosagem
[Mh] Termos MeSH secundário: Anestesia Local
Terapia Comportamental
Criança
Pré-Escolar
Ansiedade ao Tratamento Odontológico/prevenção & controle
Relações Dentista-Paciente
Método Duplo-Cego
Interações Medicamentosas
Estudos de Viabilidade
Feminino
Seres Humanos
Ketamina/farmacologia
Masculino
Memória/efeitos dos fármacos
Midazolam/farmacologia
Oxigênio/sangue
Dor/prevenção & controle
Fases do Sono/efeitos dos fármacos
[Pt] Tipo de publicação:CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
690G0D6V8H (Ketamine); R60L0SM5BC (Midazolam); S88TT14065 (Oxygen)
[Em] Mês de entrada:9502
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:941001
[St] Status:MEDLINE


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[PMID]:1733529
[Au] Autor:Daniels AL; Coté CJ; Polaner DM
[Ad] Endereço:Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
[Ti] Título:Continuous oxygen saturation monitoring following rectal methohexitone induction in paediatric patients.
[So] Source:Can J Anaesth;39(1):27-30, 1992 Jan.
[Is] ISSN:0832-610X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rectal methohexitone has been used to induce anaesthesia in paediatric patients for a number of years. This study was conducted in order to confirm the safety of this method of induction for uncomplicated routine paediatric patients. Children between the ages of six months and six years were considered candidates for induction with methohexitone (10%, 25-30 mg.kg-1). Patients were monitored with a continuous oxygen saturation recording. Forty-nine patients participated in this study and anaesthesia was induced successfully in 44. The mean age of the patients was 2.7 +/- 1.6 yr. The mean weight was 13.8 +/- 4.3 kg and the mean dose of methohexitone for successful induction was 27.0 +/- 3.0 mg.kg-1. Continuous oximeter recordings were available in 31 of the 42 patients who allowed oximeter placement prior to administration of methohexitone. No major desaturation events were noted in any patient. Two brief episodes of desaturation occurred. One with a nadir of 90% which lasted for 45 sec and another with a nadir of 86% which lasted for 26 sec. Both children had their heads flexed over their parents' shoulders at the time of the event resulting in partial airway obstruction. Both of these episodes were the result of upper airway obstruction which was clinically diagnosed by the anesthetist and readily corrected by repositioning the head. This study confirms the efficacy and safety of rectal methohexitone for induction of general anaesthesia in children. Mechanical obstruction of the airway following induction seems to be the most likely cause for oxygen desaturation. Monitoring of pulse oximetry does not appear necessary provided the child is carefully observed for adequacy of air exchange.
[Mh] Termos MeSH primário: Anestesia Retal
Metoexital
Monitorização Intraoperatória/métodos
Oxigênio/sangue
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Seres Humanos
Lactente
Oximetria
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
E5B8ND5IPE (Methohexital); S88TT14065 (Oxygen)
[Em] Mês de entrada:9203
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920101
[St] Status:MEDLINE



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