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[PMID]:29377901
[Au] Autor:Shin S; Jung CH; Choi JY; Kwon HW; Jung JH; Kim YH; Han DJ
[Ad] Endereço:Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
[Ti] Título:Long-term effects of pancreas transplant alone on nephropathy in type 1 diabetic patients with optimal renal function.
[So] Source:PLoS One;13(1):e0191421, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Limited data are available regarding optimal selection criteria for pancreas transplant alone (PTA) to minimize aggravation of diabetic nephropathy. METHODS: A total of 87 type 1 diabetic patients were evaluated before and after PTA at a single center from January, 1999 to December, 2015, together with 87 matched non-transplanted type 1 diabetic subjects who were candidates for PTA to compare deterioration of native kidney function. A total of 163 patients (79 in the transplanted group and 84 in the nontransplanted group) were finally enrolled after excluding nine patients with estimated glomerular filtration rate less than 60 mL/min/1.73 m2 and two patients with moderate proteinuria (≥ 1.5 g/day). RESULTS: A total of seven recipients (8.9%) had end-stage renal disease post-transplant whereas only one patient (1.2%) developed end-stage renal disease in the nontransplanted group during their follow-up period (median 12.0, range 6-96 months) (p = 0.03). Furthermore, a composite of severe renal dysfunction and end-stage renal disease (31.6% vs 2.4%) was significantly higher in the transplanted group (p < 0.001). Multivariate Cox regression analysis revealed that a higher level of tacrolimus at six months post-transplant (HR = 1.648, CI = 1.140-2.385, p = 0.008) was the only significant factor associated with end-stage renal disease. CONCLUSIONS: There is a considerable risk for deterioration of renal function in PTA recipients post-transplant compared with non-transplant diabetic patients. With rather strict selection criteria such as preoperative proteinuria and estimated glomerular filtration rate, PTA should be considered in diabetic patients to minimize post-transplant aggravation of diabetic nephropathy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/complicações
Nefropatias Diabéticas/fisiopatologia
Nefropatias Diabéticas/cirurgia
Rim/fisiopatologia
Transplante de Pâncreas
[Mh] Termos MeSH secundário: Adulto
Nefropatias Diabéticas/complicações
Progressão da Doença
Seres Humanos
Masculino
Proteinúria/complicações
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191421


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[PMID]:28784219
[Au] Autor:Mittel AM; Wagener G
[Ad] Endereço:Department of Anesthesiology, Columbia University Medical Center, College of Physicians & Surgeons, Columbia University, PH 527-B, 630 West 168th Street, New York, NY 10032, USA.
[Ti] Título:Anesthesia for Kidney and Pancreas Transplantation.
[So] Source:Anesthesiol Clin;35(3):439-452, 2017 Sep.
[Is] ISSN:1932-2275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kidney transplants are the most common solid organ abdominal transplant and are occasionally performed simultaneously with pancreas transplants in diabetic patients. Preoperative evaluation of potential transplant recipients should focus on the potential for occult cardiovascular disease while also screening for other signs of end-organ dysfunction. Intraoperatively, it is of utmost importance to ensure adequate graft perfusion to limit the risk of postoperative graft dysfunction or rejection. Postoperative care of the kidney or pancreas transplant patient should focus on ensuring normalization of volume status, electrolyte concentrations, and glycemic control.
[Mh] Termos MeSH primário: Anestesia
Hidratação/métodos
Transplante de Rim
Transplante de Pâncreas
[Mh] Termos MeSH secundário: Fármacos Cardiovasculares/administração & dosagem
Diabetes Mellitus
Cardiopatias/terapia
Seres Humanos
Complicações Pós-Operatórias/prevenção & controle
Diálise Renal
Insuficiência Renal/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cardiovascular Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE


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[PMID]:28683901
[Au] Autor:Kim J; Schulman-Marcus J; Watkins AC; Feldman DN; Swaminathan R; Lee JB; Muthukumar T; Serur D; Kim L; Hartono C
[Ad] Endereço:Division of Transplant Surgery, Weill Cornell Medicine, New York, New York. Electronic address: jik9021@med.cornell.edu.
[Ti] Título:In-Hospital Cardiovascular Complications After Pancreas Transplantation in the United States from 2003 to 2012.
[So] Source:Am J Cardiol;120(4):682-687, 2017 Aug 15.
[Is] ISSN:1879-1913
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Large database studies detailing the risk of perioperative cardiovascular complications after pancreas transplant has been limited, perhaps because these outcomes are not captured by transplant registries. Greater data on the incidence and risks of such outcomes could provide additional insight for referring physicians and inform potential recipients of their risk. We performed a serial, cross-sectional analysis of the National Inpatient Sample, the largest publicly available inpatient database in the United States, to assess for the risk of cardiovascular complications after pancreas transplants in the United States from 2003 to 2012 (n = 13,399). Using multivariable logistic regression models, the risk of cardiovascular outcomes after simultaneous pancreas-kidney transplants (SPK) was compared with solitary pancreas transplants (pancreas after kidney and pancreas transplant alone [PAK + PTA]). The unadjusted prevalence of in-hospital cardiovascular complications was higher in SPK than PAK + PTA (5.5% vs 3.7%, p <0.001). After multivariable adjustment, SPK remained associated with significantly higher odds of any cardiovascular complication (odds ratio [OR] 1.48, 95% confidence interval [CI] 1.21 to 1.80, p = 0.01), and particularly stroke (OR 13.41, 95% CI 4.78 to 37.63, p <0.001), compared with PAK + PTA. However, there was no difference in perioperative mortality (OR 0.78, 95% CI 0.54 to 1.12, p = 0.18). In conclusion, these findings highlight the association between uremia and stroke in pancreas transplant patients, as well as the need for improved preoperative cardiac risk assessment and perioperative management, especially in those who underwent SPK.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Rejeição de Enxerto/epidemiologia
Hospitais/estatística & dados numéricos
Transplante de Pâncreas/efeitos adversos
Sistema de Registros
[Mh] Termos MeSH secundário: Adulto
Doenças Cardiovasculares/etiologia
Estudos Transversais
Feminino
Sobrevivência de Enxerto
Mortalidade Hospitalar/tendências
Seres Humanos
Incidência
Masculino
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28601322
[Au] Autor:Kim Y; Dhar VK; Wima K; Jung AD; Xia BT; Hoehn RS; Diwan TS; Shah SA
[Ad] Endereço:Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Cincinnati, Ohio.
[Ti] Título:The center volume-outcome effect in pancreas transplantation: a national analysis.
[So] Source:J Surg Res;213:25-31, 2017 Jun 01.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although increased hospital volume has been correlated with improved outcomes in certain surgical procedures, the effect of center volume on pancreas transplantation (PT) is less understood. Our study aims to establish whether a volume-outcome effect exists for PT. METHODS: Through an established linkage between the University HealthSystem Consortium and the Scientific Registry of Transplant Recipients (SRTR) databases, we performed a retrospective cohort analysis of adult PT recipients between 2009 and 2012. Surgical volume was divided equally into low volume (LV), middle volume (MV), and high volume (HV) tertiles for each year that was studied. Hospital outcomes were measured through University HealthSystem Consortium, and long-term outcomes were measured through Scientific Registry of Transplant Recipients. Statistical analysis was performed using regression analyses and the Kaplan-Meier method. Median follow-up period was 2 y. RESULTS: Among the 2309 PT recipients included, 815 (35.3%) were performed at LV centers, 755 (32.7%) at MV centers, and 739 (32.0%) at HV centers. Compared with MV and LV centers, organs transplanted at HV centers were more frequently donation after cardiac death (5.1% versus 2.4% versus 3.3%, P = 0.01) and from older donors (2.8% [>50 y] versus 0.8% versus 0.1%, P < 0.001). In addition, HV recipients were older (31.5% [>50 y] versus 20.9% versus 19.7%, P < 0.001) and had worse functional status (39.5% dependent versus 9.7% versus 9.9%, P < 0.001). Patient and graft survival were similar across hospital volume tertiles. Center volume was not predictive of readmission rates, total length of stay, intensive care unit length of stay, or total direct cost on multivariate analysis (all P > 0.05). CONCLUSIONS: Short- and long-term outcomes after PT are not affected by hospital volume. Although LV centers confine their cases to low-risk patients, HV centers transplant a higher percentage of high-risk donor and recipient combinations with equivalent outcomes.
[Mh] Termos MeSH primário: Hospitais com Alto Volume de Atendimentos/estatística & dados numéricos
Hospitais com Baixo Volume de Atendimentos/estatística & dados numéricos
Transplante de Pâncreas
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bases de Dados Factuais
Feminino
Seguimentos
Sobrevivência de Enxerto
Seres Humanos
Estimativa de Kaplan-Meier
Tempo de Internação/estatística & dados numéricos
Masculino
Meia-Idade
Avaliação de Resultados (Cuidados de Saúde)
Transplante de Pâncreas/mortalidade
Transplante de Pâncreas/estatística & dados numéricos
Readmissão do Paciente/estatística & dados numéricos
Estudos Retrospectivos
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE


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[PMID]:28478590
[Au] Autor:Gruessner AC; Laftavi MR; Pankewycz O; Gruessner RWG
[Ad] Endereço:Department of Surgery, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA. gruessna@upstate.edu.
[Ti] Título:Simultaneous Pancreas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry.
[So] Source:Curr Diab Rep;17(6):44, 2017 Jun.
[Is] ISSN:1539-0829
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). RECENT FINDINGS: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/terapia
Internacionalidade
Transplante de Rim
Transplante de Pâncreas
Sistema de Registros
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Sobrevivência de Enxerto
Seres Humanos
Rim/fisiopatologia
Masculino
Fatores de Risco
Taxa de Sobrevida
Doadores de Tecidos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE
[do] DOI:10.1007/s11892-017-0864-5


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[PMID]:28373161
[Au] Autor:Dean PG; Kukla A; Stegall MD; Kudva YC
[Ad] Endereço:Division of Transplantation Surgery, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55902, USA dean.patrick2@mayo.edu.
[Ti] Título:Pancreas transplantation.
[So] Source:BMJ;357:j1321, 2017 Apr 03.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The treatment of patients with diabetes mellitus (DM) presents many challenges to care providers and represents a major proportion of healthcare expenditure worldwide. Successful pancreas transplantation provides durable glycemic control and improves survival for patients with diabetes. Progress in the field has mainly been based on large single center studies and the cumulative analyses of registry data from the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry. This review focuses on the outcomes of pancreas transplantation for patients with and without end stage renal disease. It describes the current state of pancreas transplantation, gaps in knowledge, and future studies needed to enable more patients to benefit from this treatment. A common theme that emerges is the need for multicenter randomized trials in pancreas transplantation to define clearly the efficacy, risks, and long term benefits.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/cirurgia
Transplante de Pâncreas
[Mh] Termos MeSH secundário: Diabetes Mellitus Tipo 1/epidemiologia
Nefropatias Diabéticas/cirurgia
Seres Humanos
Transplante de Rim/estatística & dados numéricos
Transplante de Pâncreas/efeitos adversos
Transplante de Pâncreas/estatística & dados numéricos
Transplante de Pâncreas/tendências
Pâncreas Artificial
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j1321


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[PMID]:28330678
[Au] Autor:Tsai FY; Lau LI; Li AF; Chen SJ; Wang SE; Lee FL; Liu CJ; Shyr YM
[Ad] Endereço:Department of Ophthalmology, Taipei Municipal Wanfang Hospital, Taipei, Taiwan, ROC.
[Ti] Título:Acute macular edema and peripapillary soft exudate after pancreas transplantation with accelerated progression of diabetic retinopathy.
[So] Source:J Chin Med Assoc;80(5):319-325, 2017 May.
[Is] ISSN:1728-7731
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled. The complete ophthalmic course and medical records of the patients were retrospectively reviewed. Diabetic retinopathy and progression following treatment after pancreas transplantation were measured. RESULTS: Six Chinese women with type 1 DM were enrolled in this study. Mean hemoglobin (Hb) A1c was 13.4% prior to transplantation and decreased rapidly to 6.5% within 2 months postsurgery. The patients had no or mild pretransplant diabetic retinopathy and developed acute symptomatic macular edema and peripapillary soft exudate in both eyes after pancreas transplantation. All macular edema resolved either with or without treatment. Five cases progressed to proliferative diabetic retinopathy and received panretinal photocoagulation. Diabetic retinopathy remained stable in all eyes after treatment, and the visual prognosis was good, except in one eye that had macular branch retinal artery occlusion with foveal involvement. CONCLUSION: Acute macular edema after pancreas transplantation has a favorable treatment outcome despite rapid progression to proliferative diabetic retinopathy. High pretransplant HbA1c and abrupt blood sugar normalization may be related to the disease course.
[Mh] Termos MeSH primário: Retinopatia Diabética/complicações
Edema Macular/etiologia
Transplante de Pâncreas/efeitos adversos
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Progressão da Doença
Feminino
Hemoglobina A Glicada/análise
Seres Humanos
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


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[PMID]:28325064
[Au] Autor:Seo DK; Lee HS; Park J; Ryu CH; Han DJ; Seo SG
[Ad] Endereço:1 Department of Orthopedic Surgery, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
[Ti] Título:Diabetic Foot Complications Despite Successful Pancreas Transplantation.
[So] Source:Foot Ankle Int;38(6):656-661, 2017 Jun.
[Is] ISSN:1944-7876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is known that successful pancreas transplantation enables patients with diabetes to maintain a normal glucose level without insulin and reduces diabetes-related complications. However, we have little information about the foot-specific morbidity in patients who have undergone successful pancreas transplantation. The purpose of this study was to investigate the prevalence and predisposing factors for foot complications after successful pancreas transplantation. METHODS: This retrospective study included 218 patients (91 males, 127 females) who had undergone pancreas transplantation for diabetes. The mean age was 40.7 (range, 15-76) years. Diabetes type, transplantation type, body mass index, and diabetes duration before transplantation were confirmed. After pancreas transplantation, the occurrence and duration of foot and ankle complications were assessed. RESULTS: Twenty-two patients (10.1%) had diabetic foot complications. Fifteen patients (6.9%) had diabetic foot ulcer and 7 patients (3.2%) had Charcot arthropathy. Three patients had both diabetic foot ulcer and Charcot arthropathy. Three insufficiency fractures (1.4%) were included. Mean time of complications after transplantation was 18.5 (range, 2-77) months. Creatinine level 1 year after surgery was higher in the complication group rather than the noncomplication group ( P = .02). CONCLUSION: Complications of the foot and ankle still occurred following pancreas transplantation in patients with diabetes. LEVEL OF EVIDENCE: Level III, comparative study.
[Mh] Termos MeSH primário: Tornozelo/fisiologia
Artropatia Neurogênica/cirurgia
Pé Diabético/cirurgia
/cirurgia
Transplante de Pâncreas/normas
[Mh] Termos MeSH secundário: Pé Diabético/fisiopatologia
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1177/1071100717696246


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[PMID]:28319566
[Au] Autor:Spaggiari M; Bissing M; Campara M; Yeh CC; Tzvetanov I; Jeon H; Benedetti E
[Ad] Endereço:1 Department of Surgery, University of Illinois, Chicago, IL. 2 Department of Pharmacy Practice, University of Illinois, Chicago, IL. 3 Department of Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.
[Ti] Título:Pancreas Transplantation From Pediatric Donors: A United Network for Organ Sharing Registry Analysis.
[So] Source:Transplantation;101(10):2484-2491, 2017 Oct.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pancreas grafts from pediatric donors are still considered "not ideal." Perceived concerns are related to low islet mass and potential for graft thrombosis. METHODS: The study evaluated all pancreas transplants from January 2000 to May 2015 using the Organ Procurement and Transplant Network database. Comparative analysis of recipient and graft survival was performed between pediatric (≤18 years) and adult donors. In the pediatric group, the outcomes were stratified based on donor age (≤6, 7-12, and 13-18 years) and weight (<30, 30-95, and >95 kg). RESULTS: In the selected era, 18 430 pancreas transplants were performed from 4915 pediatric donors (27%). Short-term graft and patient survivals were comparable between pediatric and adult donors. Ten-year patient and graft survivals were higher in the pediatric donor group: (70% and 54% vs 68% and 51%, P = 0.001). However, very-low-weight pediatric donors (<30 kg) resulted in worse graft survival in the long term (44% at 10 years, P = 0.006). CONCLUSIONS: Pediatric donor pancreas transplants had comparable patient and graft survival to the adult donor transplants. However, the islet mass of very small donors could influence long-term graft survival if the weights of donors and recipients are not properly matched. Usage of "very small" pediatric donors was not associated with higher incidence of technical complications or early graft loss.
[Mh] Termos MeSH primário: Sobrevivência de Enxerto
Transplante de Pâncreas/normas
Sistema de Registros
Doadores de Tecidos
Obtenção de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001736


  10 / 7080 MEDLINE  
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[PMID]:28260466
[Au] Autor:Ulyanova O; Baigenzhin A; Taubaldieva Z; Tuganbekova S; Kozina L; Saparbayev S
[Ad] Endereço:Department of Internal Medicine, National Scientific Medical Research Center, Astana, Kazakhstan.
[Ti] Título:Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.
[So] Source:Exp Clin Transplant;15(Suppl 1):194-195, 2017 Feb.
[Is] ISSN:2146-8427
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant. MATERIALS AND METHODS: Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion. The quantity of fetal stem cells infused was ≥ 5 × 106, and the cells were of 12 to 14 weeks of gestation. We analyzed the levels of leptin, C-peptide, and antibodies to the islets of Langerhans before and 3 months after the transplant procedure. RESULTS: Fetal pancreatic stem cell transplant led to significant increases in leptin and C-peptide levels, from 4.63 ± 1.17 ng/mL and 0.09 ± 0.02 ng/mL to 7.71 ± 1.45 ng/mL (P < .05) and 0.22 ± 0.05 ng/mL (P < .005), respectively, without an increase in antibodies to the islets of Langerhans, which measured 0.64 ± 0.13 U/mL before transplant and 0.57 ± 0.18 U/mL 3 months later (P > .05). CONCLUSIONS: Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/cirurgia
Células-Tronco Fetais/transplante
Leptina/sangue
Transplante de Pâncreas/métodos
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Peptídeo C/sangue
Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 1/diagnóstico
Feminino
Seres Humanos
Masculino
Fatores de Tempo
Resultado do Tratamento
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (C-Peptide); 0 (Leptin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde