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  1 / 18949 MEDLINE  
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[PMID]:29368468
[Au] Autor:Dyck E
[Ti] Título:A Eugenics Experiment: Sterilization, Hyperactivity and Degeneration.
[So] Source:Clio Med;95:260-80, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Eugenia (Ciência)/história
Pessoas com Deficiência Mental/história
Esterilização Reprodutiva/história
[Mh] Termos MeSH secundário: Alberta
Castração/história
Feminino
História do Século XX
Seres Humanos
Masculino
Ovariectomia/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 18949 MEDLINE  
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[PMID]:28958218
[Au] Autor:Fischer MM; Kessler AM; Kieffer DA; Knotts TA; Kim K; Wei A; Ramsey JJ; Fascetti AJ
[Ad] Endereço:1Department of Veterinary Medicine,Centro Universitário Ritter dos Reis - UniRitter,Porto Alegre,RS 91240-261,Brazil.
[Ti] Título:Effects of obesity, energy restriction and neutering on the faecal microbiota of cats.
[So] Source:Br J Nutr;118(7):513-524, 2017 Oct.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Surveys report that 25-57 % of cats are overweight or obese. The most evinced cause is neutering. Weight loss often fails; thus, new strategies are needed. Obesity has been associated with altered gut bacterial populations and increases in microbial dietary energy extraction, body weight and adiposity. This study aimed to determine whether alterations in intestinal bacteria were associated with obesity, energy restriction and neutering by characterising faecal microbiota using 16S rRNA gene sequencing in eight lean intact, eight lean neutered and eight obese neutered cats before and after 6 weeks of energy restriction. Lean neutered cats had a bacterial profile similar to obese rodents and humans, with a greater abundance (P<0·05) of Firmicutes and lower abundance (P<0·05) of Bacteroidetes compared with the other groups. The greater abundance of Firmicutes in lean neutered cats was due to a bloom in Peptostreptococcaceae. Obese cats had an 18 % reduction in fat mass after energy restriction (P<0·05). Energy reduction was concurrent with significant shifts in two low-abundance bacterial genera and trends in four additional genera. The greatest change was a reduction in the Firmicutes genus, Sarcina, from 4·54 to 0·65 % abundance after energy restriction. The short duration of energy restriction may explain why few bacterial changes were observed in the obese cats. Additional work is needed to understand how neutering, obesity and weight loss are related to changes in feline microbiota and how these microbial shifts affect host physiology.
[Mh] Termos MeSH primário: Restrição Calórica
Castração
Fezes/microbiologia
Microbioma Gastrointestinal
Obesidade/veterinária
[Mh] Termos MeSH secundário: Animais
Bacteroidetes/isolamento & purificação
Composição Corporal
Peso Corporal
Gatos
DNA Bacteriano/isolamento & purificação
Dieta/veterinária
Feminino
Bactérias Gram-Positivas/isolamento & purificação
Masculino
Análise Multivariada
Obesidade/microbiologia
RNA Ribossômico 16S/isolamento & purificação
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002379


  3 / 18949 MEDLINE  
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[PMID]:28847874
[Au] Autor:Kinsman RH; Gruffydd-Jones TJ; Clements J; Murray JK
[Ad] Endereço:School of Veterinary Science, University of Bristol, Bristol, UK.
[Ti] Título:Risk factors for redemption of feline neutering vouchers issued by welfare organisations.
[So] Source:Vet Rec;181(16):427, 2017 Oct 21.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Animal welfare organisations in the UK invest substantial resources to fund subsidised neutering vouchers to increase feline neutering rates. Little evidence exists to quantify factors influencing voucher redemption. This cross-sectional study assessed risk factors (including voucher value and expiry period) for redemption of neutering vouchers issued by staff of the feline welfare charity Cats Protection. Data were collected using telephone interview-administered questionnaires of cat owners who were issued a neutering voucher(s) and from Cats Protection voucher payment records. During the four-month study 2655 owners were issued 3935 vouchers. Multivariable logistic regression analysis revealed that owners of cats that had produced ≥1 litter before voucher request, owners eligible for a voucher due to receiving benefits and owners who rented their homes or lived with family were less likely to redeem vouchers than owners whose cats had not had a litter, were eligible for a voucher for other reasons and/or owners who owned their home, respectively.
[Mh] Termos MeSH primário: Bem-Estar do Animal/economia
Castração/economia
Castração/veterinária
Gatos/cirurgia
[Mh] Termos MeSH secundário: Animais
Castração/estatística & dados numéricos
Estudos Transversais
Feminino
Seres Humanos
Masculino
Propriedade/estatística & dados numéricos
Fatores de Risco
Inquéritos e Questionários
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1136/vr.104379


  4 / 18949 MEDLINE  
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[PMID]:28494009
[Au] Autor:Arai KY; Hara T; Nagatsuka T; Kudo C; Tsuchiya S; Nomura Y; Nishiyama T
[Ad] Endereço:Scleroprotein Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
[Ti] Título:Postnatal changes and sexual dimorphism in collagen expression in mouse skin.
[So] Source:PLoS One;12(5):e0177534, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate sexual dimorphism and postnatal changes in skin collagen expression, mRNA levels of collagens and their regulatory factors in male and female skin were examined during the first 120 days of age by quantitative realtime PCR. Levels of mRNAs encoding extracellular matrices did not show any differences between male and female mice until day 15. Col1a1 and Col1a2 mRNAs noticeably increased at day 30 and remained at high levels until day 120 in male mice, while those in female mice remained at low levels during the period. Consistent with the mRNA expression, pepsin-soluble type I collagen contents in skin was very high in mature male as compared to female. Col3a1 mRNA in male mice also showed significantly high level at day 120 as compared to female. On the other hand, expression of mRNAs encoding TGF-ßs and their receptors did not show apparent sexual dimorphism although small significant differences were observed at some points. Castration at 60 days of age resulted in a significant decrease in type I collagen mRNA expression within 3 days, and noticeably decreased expression of all fibril collagen mRNAs examined within 14 days, while administration of testosterone tube maintained the mRNA expression at high levels. Despite the in vivo effect of testosterone, administration of physiological concentrations of testosterone did not affect fibril collagen mRNA expression in either human or mouse skin fibroblasts in vitro, suggesting that testosterone does not directly affect collagen expression in fibroblasts. In summary, present study demonstrated dynamic postnatal changes in expression of collagens and their regulatory factors, and suggest that testosterone and its effects on collagen expression are responsible for the skin sexual dimorphism but the effects of testosterone is not due to direct action on dermal fibroblasts.
[Mh] Termos MeSH primário: Colágeno/genética
Regulação da Expressão Gênica no Desenvolvimento
Caracteres Sexuais
Pele/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Castração
Colágeno/metabolismo
Reagentes para Ligações Cruzadas/metabolismo
Derme/efeitos dos fármacos
Derme/crescimento & desenvolvimento
Derme/metabolismo
Matriz Extracelular/efeitos dos fármacos
Matriz Extracelular/metabolismo
Feminino
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Seres Humanos
Recém-Nascido
Masculino
Camundongos Endogâmicos C57BL
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Pele/efeitos dos fármacos
Testosterona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (RNA, Messenger); 3XMK78S47O (Testosterone); 9007-34-5 (Collagen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177534


  5 / 18949 MEDLINE  
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[PMID]:28484078
[Au] Autor:Laffont S; Blanquart E; Savignac M; Cénac C; Laverny G; Metzger D; Girard JP; Belz GT; Pelletier L; Seillet C; Guéry JC
[Ad] Endereço:Centre de Physiopathologie de Toulouse Purpan (CPTP), Université de Toulouse, Institut National de la Santé et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UPS, 31300 Toulouse, France.
[Ti] Título:Androgen signaling negatively controls group 2 innate lymphoid cells.
[So] Source:J Exp Med;214(6):1581-1592, 2017 Jun 05.
[Is] ISSN:1540-9538
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33-driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33-mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33-driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.
[Mh] Termos MeSH primário: Androgênios/metabolismo
Imunidade Inata/imunologia
Linfócitos/imunologia
Transdução de Sinais
[Mh] Termos MeSH secundário: Androgênios/farmacologia
Animais
Asma/complicações
Asma/imunologia
Asma/patologia
Castração
Proliferação Celular/efeitos dos fármacos
Suscetibilidade a Doenças
Feminino
Hipersensibilidade/complicações
Hipersensibilidade/imunologia
Hipersensibilidade/patologia
Interleucina-33/metabolismo
Pulmão/imunologia
Pulmão/patologia
Contagem de Linfócitos
Masculino
Camundongos Endogâmicos C57BL
Pneumonia/complicações
Pneumonia/imunologia
Pneumonia/patologia
Pyroglyphidae/imunologia
Receptores Androgênicos/metabolismo
Sexismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens); 0 (Interleukin-33); 0 (Receptors, Androgen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1084/jem.20161807


  6 / 18949 MEDLINE  
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Biondo, Alexander Welker
Texto completo
[PMID]:28364830
[Au] Autor:Dias Costa E; Martins CM; Cunha GR; Catapan DC; Ferreira F; Oliveira ST; Garcia RC; Biondo AW
[Ad] Endereço:Department of Veterinary Medicine, Federal University of Paraná, Curitiba, Paraná, 80035-050, Brazil. Electronic address: ise_bcr@hotmail.com.
[Ti] Título:Impact of a 3-year pet management program on pet population and owner's perception.
[So] Source:Prev Vet Med;139(Pt A):33-41, 2017 Apr 01.
[Is] ISSN:1873-1716
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Although pet population management programs have been established worldwide, few reports on program evaluation have been carried out to date. Accordingly, a 3-year longitudinal study has been carried out in a 4000 household neighborhood located within the metropolitan area of Curitiba, the eighth most populated city of Brazil. Visits were conducted and questionnaires completed to estimate and characterize the local pet population (animal sex, reproductive and vaccination status, street access). Care provided by owners, community perception on stray dog management and the possible changes were compared in these variables over time (2010 and 2013) were evaluated, after the establishment of a city pet population management program. In addition, associations between having children, owning dogs and cats, responsible pet ownership education and owner's perception on stray dogs were statistically tested. A total of 354/4000 (8.9%) household families were interviewed in 2010 and 70/354 (19.8%) of the same families again in 2013. No significant changes were found in overall number of dogs and cats and average pet age, animal care and owner's perception on stray dogs following the 3-year population management program. In 2010, an average of 1.6 dogs and 0.3 cats were found per family, with slightly more females (51.3% dogs and 51.1% cats), adults (4.0±3.5years for dogs and 2.1±2.4 for cats), intact (not neutered; 94.2% dogs and 84.0% cats) and lacking regular visit to veterinarian (71.6%). Although more families (53.1%) had children under 12 years old, no association was found between having children and having dogs and cats. Questionnaires revealed that owners perceived neutering/spaying to be the best pet population control method (42.4%), with "society" (50%) and "government" (49.4%) as responsible for pet population management. A significant positive association has been found between education level and the best way to control stray dogs (p=0.03), between having dogs and in favor of neutering/spaying (p=0.04) and considering neutering/spaying as the best control method (p=0.02). The chances of thinking the best way to control stray dogs by neutering/spaying and adoption were almost 2.0 fold higher than other methods. In conclusion, the present study has provided indicators (education level, having dogs) for pet population control program assessment and effectiveness evaluation. Moreover, this study may serve as a warning on the real long-term effect of such programs, which should be periodically evaluated to identify necessary adjustments and/or improvements.
[Mh] Termos MeSH primário: Atitude
Castração/psicologia
Gatos
Cães
Propriedade/estatística & dados numéricos
Animais de Estimação
[Mh] Termos MeSH secundário: Bem-Estar do Animal
Animais
Brasil
Castração/veterinária
Feminino
Seres Humanos
Modelos Logísticos
Estudos Longitudinais
Masculino
Controle da População/métodos
Controle da População/estatística & dados numéricos
Dinâmica Populacional
Percepção Social
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


  7 / 18949 MEDLINE  
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[PMID]:28256950
[Au] Autor:Atallah A; Mhaouty-Kodja S; Grange-Messent V
[Ad] Endereço:Sorbonne Universités, CNRS, Neurosciences Paris Seine-Institut de Biologie Paris Seine (NPS-IBPS), Paris, France.
[Ti] Título:Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice.
[So] Source:J Cereb Blood Flow Metab;37(9):3161-3175, 2017 Sep.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A dysfunction in the blood-brain barrier (BBB) is associated with many neurological and metabolic disorders. Although sex steroid hormones have been shown to impact vascular tone, endothelial function, oxidative stress, and inflammatory responses, there are still no data on the role of testosterone in the regulation of BBB structure and function. In this context, we investigated the effects of gonadal testosterone depletion on the integrity of capillary BBB and the surrounding parenchyma in male mice. Our results show increased BBB permeability for different tracers and endogenous immunoglobulins in chronically testosterone-depleted male mice. These results were associated with disorganization of tight junction structures shown by electron tomography and a lower amount of tight junction proteins such as claudin-5 and ZO-1. BBB leakage was also accompanied by activation of astrocytes and microglia, and up-regulation of inflammatory molecules such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1ß), and tumor necrosis factor (TNF). Supplementation of castrated male mice with testosterone restored BBB selective permeability, tight junction integrity, and almost completely abrogated the inflammatory features. The present demonstration that testosterone transiently impacts cerebrovascular physiology in adult male mice should help gain new insights into neurological and metabolic diseases linked to hypogonadism in men of all ages.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiopatologia
Permeabilidade Capilar/fisiologia
Testículo/metabolismo
Testosterona/deficiência
[Mh] Termos MeSH secundário: Animais
Barreira Hematoencefálica/efeitos dos fármacos
Barreira Hematoencefálica/ultraestrutura
Permeabilidade Capilar/efeitos dos fármacos
Castração
Claudina-5/metabolismo
Ciclo-Oxigenase 2/biossíntese
Interleucina-1beta/biossíntese
Masculino
Camundongos Endogâmicos C57BL
Microscopia Eletrônica de Transmissão
Óxido Nítrico Sintase Tipo II/biossíntese
Testículo/fisiopatologia
Testosterona/administração & dosagem
Testosterona/sangue
Testosterona/farmacologia
Junções Íntimas/efeitos dos fármacos
Junções Íntimas/metabolismo
Junções Íntimas/ultraestrutura
Regulação para Cima
Proteína da Zônula de Oclusão-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Claudin-5); 0 (Cldn5 protein, mouse); 0 (Interleukin-1beta); 0 (Tjp1 protein, mouse); 0 (Zonula Occludens-1 Protein); 3XMK78S47O (Testosterone); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1177/0271678X16683961


  8 / 18949 MEDLINE  
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[PMID]:28255271
[Au] Autor:Wang K; Li W; Bai Y; Yang W; Ling Y; Fang M
[Ad] Endereço:Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, MOA Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
[Ti] Título:ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targeting gene.
[So] Source:Int J Biol Sci;13(2):189-197, 2017.
[Is] ISSN:1449-2288
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Castration of male pigs is a common practice used to reduce boar taint in commercial pork production, but it also significantly results in fat accumulation in carcass. Our previous study revealed a miRNA gene, ssc-miR-7134-3p that was implicated in adipogenesis. However, the relationship between ssc-miR-7134-3p and fat deposition due to castration is unknown. In the present study, we observed that ssc-miR-7134-3p targets the coding sequence (CDS) region of MARK4 based on bioinformatics analysis and dual-luciferase assays. Experiments using silent mutations and sub-cloning showed that ssc-miR-7134-3p binds independently to two adjacent sites in the MARK4 CDS. Subsequently, ssc-miR-7134-3p inhibits MARK4 protein expression in pig fibroblast cells, being consistent with the targeting demonstrated in vitro. We found higher MARK4 protein levels in the back fat of castrated pigs than in intact pigs, providing further evidence that MARK4 is involved in regulation of fat deposition. In addition, one SNP (g.2581A>G) in MARK4 was significantly associated with the back fat trait in Chinese and European pig populations. Taken together, we would conclude that ssc-miR-7134-3p targets the MARK4 gene for fat accumulation in the castrated male pigs.
[Mh] Termos MeSH primário: Gorduras/metabolismo
MicroRNAs/metabolismo
Proteínas Serina-Treonina Quinases/metabolismo
[Mh] Termos MeSH secundário: Animais
Castração
Biologia Computacional/métodos
Fibroblastos/metabolismo
Genótipo
Células HEK293
Seres Humanos
Masculino
MicroRNAs/genética
Polimorfismo de Nucleotídeo Único/genética
Proteínas Serina-Treonina Quinases/genética
Reação em Cadeia da Polimerase em Tempo Real
Carne Vermelha
Suínos
Proteínas Quinases p38 Ativadas por Mitógeno/genética
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fats); 0 (MicroRNAs); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.7150/ijbs.17386


  9 / 18949 MEDLINE  
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[PMID]:28239028
[Au] Autor:Koga D; Bochimoto H; Kusumi S; Ushiki T; Watanabe T
[Ad] Endereço:Department of Microscopic Anatomy and Cell Biology, Asahikawa Medical University.
[Ti] Título:Changes in the three-dimensional ultrastructure of membranous organelles in male rat pituitary gonadotropes after castration.
[So] Source:Biomed Res;38(1):1-18, 2017.
[Is] ISSN:1880-313X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The increased discharge of gonadotropin releasing hormone (GnRH) from hypothalamic neurons after castration specifically stimulates pituitary gonadotropes. To elucidate the putative effects of GnRH on the three-dimensional ultrastructure of gonadotropes, we examined osmium-macerated pituitary tissues of male rats at various time points after castration by high resolution scanning electron microscopy (SEM) combined with immunocytochemistry. Two days after castration, the Golgi apparatus was disassembled into small stacks; patch-like, tubuloreticular clusters of endoplasmic reticulum (ER) membranes were present; and spherically enlarged mitochondria were accumulated in the central area of the stimulated gonadotropes. These acute changes were indiscernible by 1 week after castration, and then the pituitary gonadotropes of castrated animals gradually became hypertrophic, finally exhibiting the characteristic "signet-ring" appearance, with markedly dilated cisterns of the rough ER. Upon SEM observation, the inner surface of the cavity was mostly flat, and openings connecting adjacent lumens of the ER were sparse. Proliferation of the osmiophilic tubular network of the ER-Golgi intermediate compartment was observed in the persistently stimulated gonadotropes, indicating a marked increase in trafficking of secretory proteins between the Golgi and ER. The acute and chronic changes in the gonadotropes after castration revealed in the present study by SEM provide evidence for a putative link between the intracellular signaling events evoked by GnRH and the ultrastructural dynamics of the organelles of the secretory pathway.
[Mh] Termos MeSH primário: Castração
Complexo de Golgi/ultraestrutura
Gonadotrofos/ultraestrutura
Imagem Tridimensional
[Mh] Termos MeSH secundário: Animais
Hormônio Liberador de Gonadotropina/fisiologia
Masculino
Microscopia Eletrônica de Varredura
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.2220/biomedres.38.1


  10 / 18949 MEDLINE  
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[PMID]:28216684
[Au] Autor:Reimann J; Dewey C; Bateman SW; Kerr C; Johnson R
[Ad] Endereço:Department of Population Medicine (Reimann, Dewey); Department of Clinical Studies (Bateman, Kerr); Department of Biomedical Sciences (Johnson), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
[Ti] Título:Perioperative analgesic use by Ontario veterinarians, 2012.
[So] Source:Can Vet J;58(2):149-156, 2017 Feb.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The objectives of this study were to describe the routine use of analgesics by Ontario veterinarians for common surgeries in dogs and cats, and to compare routine use of analgesics between species and surgeries, using Chi-square analyses. In total, 239 veterinarians responded to the questionnaires; a response rate of 13.1%. Fifty-two percent to 79% of veterinarians used meloxicam for both species and all surgeries. Approximately 9% of veterinarians did not use analgesics for dog ovariohysterectomy and castration, while 16% to 22% did not use analgesics for these surgeries in cats. Veterinarians used and dispensed analgesics to dogs more often than to cats ( < 0.05). Many (60% or more) veterinarians administered analgesics pre-emptively to both dogs and cats for all surgeries. Continuing education for veterinarians needs to focus on understanding of pre-emptive analgesia, preventive analgesia, and the importance of dispensing analgesic drugs after surgery for all surgeries.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Dor Pós-Operatória/veterinária
Dor/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/administração & dosagem
Castração/veterinária
Gatos
Cães
Feminino
Histerectomia/veterinária
Masculino
Ontário
Ovariectomia/veterinária
Dor/veterinária
Dor Pós-Operatória/tratamento farmacológico
Inquéritos e Questionários
Tiazinas/administração & dosagem
Tiazóis/administração & dosagem
Médicos Veterinários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Thiazines); 0 (Thiazoles); VG2QF83CGL (meloxicam)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE



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