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[PMID]:29428033
[Au] Autor:Lauerman M; Kolesnik O; Park H; Buchanan LS; Chiu W; Tesoriero RB; Stein D; Scalea T; Henry S
[Ti] Título:Definitive Wound Closure Techniques in Fournier's Gangrene.
[So] Source:Am Surg;84(1):86-92, 2018 Jan 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Necrotizing soft tissue infection of the perineum, or Fournier's gangrene (FG), is a morbid and mortal diagnosis. Despite the severity of FG, the optimal definitive wound closure strategy is unknown, as are long-term wound outcomes. A retrospective review was performed over a 3-year period at a single trauma center. Patients were managed according to our institutional approach focusing on primary wound closure and secondary intention healing in residual wounds. Overall 168 patients were included. Complete primary wound closure was accomplished in 39.9 per cent of patients. Patients undergoing primary wound closure were primarily male (89.6 vs 64.4%, P < 0.001), had lower mean sequential organ failure assessment (SOFA) scores (1.70 ± 2.30 vs 2.98 ± 3.36, P = 0.004), more often had perineum-limited FG (67.2 vs 42.6%, P = 0.003), and required fewer debridements (2.40 vs 2.79, P = 0.02). On logistic regression, predictors of primary closure included gender (odds ratio 4.643, 95% confidence interval 1.885-11.437, P = 0.001) and SOFA score (odds ratio 0.834, 95% confidence interval 0.727-0.957, P = 0.01). Wound healing rates increased over time, to an 82.1 per cent wound healing rate without further intervention at greater than six months of follow-up. Wounds healed with secondary intention ranged from 70 to 9520 cm3 and primary closure ranged from 126 to 6912 cm3, whereas wounds requiring skin grafts ranged from 405 to 16,170 cm3. Complete primary wound closure is often achievable in FG patients. Using this standardized approach to FG wound management, even large wounds and wounds undergoing secondary intention healing will often close with long-term wound care and do not require flap creation or early skin grafting.
[Mh] Termos MeSH primário: Gangrena de Fournier/cirurgia
Técnicas de Fechamento de Ferimentos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Desbridamento/métodos
Feminino
Seguimentos
Gangrena de Fournier/mortalidade
Seres Humanos
Masculino
Meia-Idade
Orquiectomia/métodos
Orquidopexia/métodos
Estudos Retrospectivos
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  2 / 12737 MEDLINE  
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[PMID]:29304181
[Au] Autor:Lemos Teixeira D; Larraín R; Melo O; Hötzel MJ
[Ad] Endereço:Departamento de Ciencias Animales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago, Chile.
[Ti] Título:Public opinion towards castration without anaesthesia and lack of access to pasture in beef cattle production.
[So] Source:PLoS One;13(1):e0190671, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent publications have shown that citizens in developing nations are gaining interest in farm animal welfare. The aims of this study were to assess the opinion of Chilean citizens about surgical castration without anaesthesia and lack of access to pasture in beef cattle production, to investigate how involvement in livestock production influences opinions, and to evaluate if different types of information would affect their opinion towards these management practices. The study was carried out in the Metropolitan Region of Santiago, Chile, and consisted of two surveys with 400 participants in each study. The first one used an online, self-administered questionnaire and the second one used a face to face questionnaire. The second questionnaire had four information treatments assigned randomly to survey participants (no information; negative information; negative and positive information; positive information). Most participants were aware that the two management practices are common in beef production systems and were opposed to them. Involvement in animal production was associated with greater acceptance of both management practices and participants that had visited a beef production farm before the study were more likely to support castration without anaesthesia in Survey 1. Belonging to any socioeconomic group and providing negative or positive information had no impact on participants' opinion. The results show a disconnection between the views of participants recruited for this study and beef production systems that do not provide pain control for male cattle surgical castration or provide little or no access to pasture.
[Mh] Termos MeSH primário: Anestesia
Orquiectomia/métodos
Opinião Pública
Carne Vermelha
[Mh] Termos MeSH secundário: Animais
Conscientização
Bovinos
Chile
Masculino
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190671


  3 / 12737 MEDLINE  
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[PMID]:29314802
[Au] Autor:Prelevic R; Milev B; Milovic N; Ignjatovic M; Spasic A; Petrovic N
[Ti] Título:Gigantic spermatocytic seminoma: A rare tumor of germ cell origin.
[So] Source:Vojnosanit Pregl;73(7):679-81, 2016 Jul.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Spermatocytic seminoma represents a rare hystologic type of malignant testicular germ cell tumor with slow course and low malignant potential. Case report: We presented a 69-year-old patient with atypical clinical presentation of spermatocytic seminoma initially diagnosed as gigantic hydrocoellae which compromised walking. After long term evolution clincal picture presented with signs and symptoms of acute scrotum. Preoperative echosonography was performed and the diagnosis of testicular infiltrative tumor was established. After that left scrotal orchiectomy was performed. Patohistological examination revealed spermatocytic seminoma Conclusion: Inspite good prognosis there is a low probability of development of high grade malignancy sinchronous sarcoma within the testis with a high potential for lymphogenic and hematogenic dissemination. Individual approach is necessary in accordance with the pathohistological diagnosis.
[Mh] Termos MeSH primário: Seminoma/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Masculino
Orquiectomia/métodos
Seminoma/cirurgia
Hidrocele Testicular/diagnóstico
Neoplasias Testiculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150527081P


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[PMID]:29216311
[Au] Autor:Morimoto M; Amano Y; Oka M; Harada A; Fujita H; Hikichi Y; Tozawa R; Yamaoka M; Hara T
[Ad] Endereço:Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
[Ti] Título:Amelioration of sexual behavior and motor activity deficits in a castrated rodent model with a selective androgen receptor modulator SARM-2f.
[So] Source:PLoS One;12(12):e0189480, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that a novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory effect on prostate weight compared with testosterone, in rat Hershberger assays and cancer cachexia models. In this study, we studied the mechanism of action for SARM-2f selectivity and also assessed whether the muscle increase by this compound might lead to improvement of muscle function and physical activity. First, we examined the tissue distribution of SARM-2f. Tissue concentration was 1.2-, 1.6-, and 1.9-fold as high as the plasma concentration in the levator ani muscle, brain, and prostate, respectively. This result showed that the tissue-selective pharmacological effect did not depend on SARM-2f concentration in the tissues. The ability of SARM-2f to influence androgen receptor (AR)-mediated transcriptional activation was examined by reporter assays using human normal prostate epithelial cells (PrEC) and skeletal muscle cells (SKMC). SARM-2f exerted higher activity against AR in SKMC than in PrEC. Mammalian two hybrid assays showed different co-factor recruitment patterns between SARM-2f and dihydrotestosterone. Next, we studied the effect of SARM-2f on motivation and physical functions such as sexual behavior and motor activities in castrated rat or mouse models. SARM-2f restored the sexual behavior that was lost by castration in male rats. SARM-2f also increased voluntary running distance and locomotor activities. These results suggest that tissue-specific AR regulation by SARM-2f, but not tissue distribution, might account for its tissue specific androgenic effect, and that the muscle mass increase by SARM-2f leads to improvement of physical function. Together, these findings suggest that SARM-2f might represent an effective treatment for sarcopenia and cachexia.
[Mh] Termos MeSH primário: Atividade Motora
Orquiectomia
Pirrolidinonas/farmacologia
Receptores Androgênicos/efeitos dos fármacos
Comportamento Sexual Animal
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Pirrolidinonas/farmacocinética
Ratos
Ratos Sprague-Dawley
Receptores Androgênicos/fisiologia
Distribuição Tecidual
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-(2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile); 0 (Pyrrolidinones); 0 (Receptors, Androgen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189480


  5 / 12737 MEDLINE  
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[PMID]:29246339
[Au] Autor:Arevalo MK; Sheth KR; Menon VS; Ostrov L; Hennes H; Singla N; Koral K; Schlomer BJ; Baker LA
[Ad] Endereço:Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX.
[Ti] Título:Straight to the Operating Room: An Emergent Surgery Track for Acute Testicular Torsion Transfers.
[So] Source:J Pediatr;192:178-183, 2018 Jan.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the effect of implementing an emergency surgery track for testicular torsion transfers. We hypothesized that transferring children from other facilities diagnosed with torsion straight to the operating room (STOR) would decrease ischemia time, lower costs, and reduce testicular loss. STUDY DESIGN: Demographics, arrival to incision time, hospital cost in dollars, and testicular outcome (determined by testicular ultrasound) at follow-up were retrospectively compared in all patients transferred to our tertiary care children's hospital with a diagnosis of testicular torsion from 2012 to 2016. Clinical data for STOR and non-STOR patients were compared by Wilcoxon rank-sum, 2-tailed t test, or Fisher exact test as appropriate. RESULTS: Sixty-eight patients met inclusion criteria: 35 STOR and 33 non-STOR. Children taken STOR had a shorter median arrival to incision time (STOR: 54 minutes vs non-STOR: 94 minutes, P < .0001) and lower median total hospital costs (STOR: $3882 vs non-STOR: $4419, P < .0001). However, only 46.8% of STOR patients and 48.4% of non-STOR patients achieved surgery within 6 hours of symptom onset. Testicular salvage rates in STOR and non-STOR patients were not significantly different (STOR: 68.4% vs non-STOR: 36.8%, P = .1), but follow-up was poor. CONCLUSIONS: STOR decreased arrival to incision time and hospital cost but did not affect testicular loss. The bulk of ischemia time in torsion transfers occurred before arrival at our tertiary care center. Further interventions addressing delays in diagnosis and transfer are needed to truly improve testicular salvage rates in these patients.
[Mh] Termos MeSH primário: Transferência de Pacientes/métodos
Melhoria de Qualidade
Torção do Cordão Espermático/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Protocolos Clínicos
Diagnóstico Tardio/economia
Diagnóstico Tardio/prevenção & controle
Diagnóstico Precoce
Emergências
Seguimentos
Custos Hospitalares/estatística & dados numéricos
Hospitais Pediátricos/economia
Hospitais Pediátricos/normas
Seres Humanos
Lactente
Masculino
Salas Cirúrgicas
Orquiectomia/economia
Transferência de Pacientes/economia
Transferência de Pacientes/normas
Melhoria de Qualidade/economia
Estudos Retrospectivos
Torção do Cordão Espermático/diagnóstico
Torção do Cordão Espermático/economia
Centros de Atenção Terciária/economia
Centros de Atenção Terciária/normas
Fatores de Tempo
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  6 / 12737 MEDLINE  
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[PMID]:28977609
[Au] Autor:Morishita M; Maejima S; Tsukahara S
[Ad] Endereço:Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
[Ti] Título:Gonadal Hormone-Dependent Sexual Differentiation of a Female-Biased Sexually Dimorphic Cell Group in the Principal Nucleus of the Bed Nucleus of the Stria Terminalis in Mice.
[So] Source:Endocrinology;158(10):3512-3525, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We recently reported a female-biased sexually dimorphic area in the mouse brain in the boundary region between the preoptic area and the bed nucleus of the stria terminalis (BNST). We reexamined this area and found that it is a ventral part of the principal nucleus of the BNST (BNSTp). The BNSTp is a male-biased sexually dimorphic nucleus, but the ventral part of the BNSTp (BNSTpv) exhibits female-biased sex differences in volume and neuron number. The volume and neuron number of the BNSTpv were increased in males by neonatal orchiectomy and decreased in females by treatment with testosterone, dihydrotestosterone, or estradiol within 5 days after birth. Sex differences in the volume and neuron number of the BNSTpv emerged before puberty. These sex differences became prominent in adulthood with increasing volume in females and loss of neurons in males during the pubertal/adolescent period. Prepubertal orchiectomy did not affect the BNSTpv, although prepubertal ovariectomy reduced the volume increase and induced loss of neurons in the female BNSTpv. In contrast, the volume and neuron number of male-biased sexually dimorphic nuclei that are composed of mainly calbindin neurons and are located in the preoptic area and BNST were decreased by prepubertal orchiectomy but not affected by prepubertal ovariectomy. Testicular testosterone during the postnatal period may defeminize the BNSTpv via binding directly to the androgen receptor and indirectly to the estrogen receptor after aromatization, although defeminization may proceed independently of testicular hormones in the pubertal/adolescent period. Ovarian hormones may act to feminize the BNSTpv during the pubertal/adolescent period.
[Mh] Termos MeSH primário: Neurônios/citologia
Área Pré-Óptica/anatomia & histologia
Núcleos Septais/anatomia & histologia
Diferenciação Sexual
[Mh] Termos MeSH secundário: Androgênios/farmacologia
Animais
Animais Recém-Nascidos
Calbindinas/metabolismo
Contagem de Células
Di-Hidrotestosterona/farmacologia
Estradiol/farmacologia
Estrogênios/farmacologia
Feminino
Imagem Tridimensional
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Masculino
Camundongos
Proteínas do Tecido Nervoso/metabolismo
Neurônios/efeitos dos fármacos
Proteínas Nucleares/metabolismo
Orquiectomia
Tamanho do Órgão
Ovariectomia
Área Pré-Óptica/citologia
Área Pré-Óptica/efeitos dos fármacos
RNA Mensageiro/metabolismo
Núcleos Septais/citologia
Núcleos Septais/efeitos dos fármacos
Testosterona/farmacologia
Quinases Ativadas por p21/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens); 0 (Calbindins); 0 (Estrogens); 0 (Nerve Tissue Proteins); 0 (NeuN protein, mouse); 0 (Nuclear Proteins); 0 (RNA, Messenger); 08J2K08A3Y (Dihydrotestosterone); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); EC 2.7.11.1 (Pak3 protein, mouse); EC 2.7.11.1 (p21-Activated Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00240


  7 / 12737 MEDLINE  
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[PMID]:28968462
[Au] Autor:Villalpando DM; Rojas MM; García HS; Ferrer M
[Ad] Endereço:Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
[Ti] Título:Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats.
[So] Source:PLoS One;12(10):e0185805, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Testosterone deficiency has been correlated with increased cardiovascular diseases, which in turn has been associated with increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as oxidative stress biomarkers, since some of them play pro-oxidant and pro-inflammatory roles. We have previously described the cardioprotective effects of a dosahexaenoic acid (DHA) supplemented diet on the aortic and mesenteric artery function of orchidectomized rats. The aim of this study was to investigate whether impaired gonadal function alters the formation of COPs, as well as the potential preventive role of a DHA-supplemented diet on that effect. For this purpose, aortic and mesenteric artery segments obtained from control and orchidectomized rats, fed with a standard or supplemented with DHA, were used. The content of the following COPs: 7α-hydroxycholesterol, 7ß-hydroxycholesterol, 7-ketocholesterol, 5,6α-epoxycholesterol, 5,6ß-epoxycholesterol, cholestanetriol and 25-hydroxycholesterol, were analyzed by gas chromatography. The results showed that orchidectomy increased the formation of COPs in arteries from orchidectomized rats, which may participate in the orchidectomy-induced structural and functional vascular alterations already reported. The fact that the DHA-supplemented diet prevented the orchidectomy-induced COPs increase confirms the cardiovascular protective actions of DHA, which could be of special relevance in mesenteric arterial bed, since it importantly controls the systemic vascular resistance.
[Mh] Termos MeSH primário: Artérias/metabolismo
Colesterol/metabolismo
Suplementos Nutricionais
Ácidos Docosa-Hexaenoicos/administração & dosagem
Orquiectomia
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Masculino
Oxirredução
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
25167-62-8 (Docosahexaenoic Acids); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185805


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[PMID]:28968166
[Au] Autor:Chen DY; See LC; Liu JR; Chuang CK; Pang ST; Hsieh IC; Wen MS; Chen TH; Lin YC; Liaw CC; Hsu CL; Chang JW; Kuo CF; Huang WK
[Ad] Endereço:Dong-Yi Chen, Lai-Chu See, Jia-Rou Liu, Cheng-Keng Chuang, See-Tong Pang, I-Chang Hsieh, Ming-Shien Wen, Yung-Chang Lin, Chuang-Chi Liaw, Cheng-Lung Hsu, John Wen-Cheng Chang, Chang-Fu Kuo and Wen-Kuan Huang, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine; Taoyuan; T
[Ti] Título:Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study.
[So] Source:J Clin Oncol;35(32):3697-3705, 2017 Nov 10.
[Is] ISSN:1527-7755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose Our aim was to determine whether cardiovascular (CV) risk in patients with prostate cancer (PCa) differs between those who receive androgen-deprivation therapy by surgical castration and those who receive gonadotropin-releasing hormone agonist (GnRHa) therapy. Patients and Methods By using the Taiwan National Health Insurance Research Database, we analyzed data from 14,715 patients with PCa diagnosed from January 1, 1997, through December 31, 2011. The patients were treated with bilateral orchiectomy or GnRHa therapy. We used inverse probability of treatment weighting with propensity scores to adjust for the imbalance in covariate baseline values between these two groups. Cox regression models were used to identify risk factors for myocardial infarction (MI), ischemic stroke (IS), and cardiac-related complications. Results Overall, 3,578 patients with PCa (24.3%) underwent bilateral orchiectomy and 11,137 patients (75.7%) received GnRHa therapy. Both groups had a similar risk of CV ischemic events (ie, MI or IS; hazard ratio, 1.16; 95% CI, 0.97 to 1.38) during a median follow-up time of 3.3 years. However, during the first 1.5 years of follow-up, there were higher CV ischemic events in the orchiectomy group than in the GnRHa group (hazard ratio, 1.40; 95% CI, 1.04 to 1.88), particularly in patients who were ≥ 65 years of age, had hypertension, had a Charlson comorbidity index score ≥ 3, and had a previous history of MI, IS, or coronary heart disease. Conclusion Compared with bilateral orchiectomy, use of GnRHa does not increase the risk of CV ischemic events in patients with PCa. Nonetheless, orchiectomy is associated with higher rates of CV ischemic events in older patients and those with a history of CV comorbidities within 1.5 years of initiating androgen-deprivation therapy. These findings can help clinicians decide on the optimal castration strategy for individual patients.
[Mh] Termos MeSH primário: Antagonistas de Androgênios/uso terapêutico
Isquemia Encefálica/epidemiologia
Doença das Coronárias/epidemiologia
Hormônio Liberador de Gonadotropina/agonistas
Infarto do Miocárdio/epidemiologia
Orquiectomia/efeitos adversos
Neoplasias da Próstata/tratamento farmacológico
Neoplasias da Próstata/cirurgia
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Antagonistas de Androgênios/efeitos adversos
Terapia Combinada
Seres Humanos
Incidência
Masculino
Meia-Idade
Risco
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgen Antagonists); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1200/JCO.2016.71.4204


  9 / 12737 MEDLINE  
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[PMID]:28938398
[Au] Autor:Vanacker C; Moya MR; DeFazio RA; Johnson ML; Moenter SM
[Ad] Endereço:Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109.
[Ti] Título:Long-Term Recordings of Arcuate Nucleus Kisspeptin Neurons Reveal Patterned Activity That Is Modulated by Gonadal Steroids in Male Mice.
[So] Source:Endocrinology;158(10):3553-3564, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulsatile release of gonadotropin-releasing hormone (GnRH) is key to fertility. Pulse frequency is modulated by gonadal steroids and likely arises subsequent to coordination of GnRH neuron firing activity. The source of rhythm generation and the site of steroid feedback remain critical unanswered questions. Arcuate neurons that synthesize kisspeptin, neurokinin B, and dynorphin (KNDy) may be involved in both of these processes. We tested the hypotheses that action potential firing in KNDy neurons is episodic and that gonadal steroids regulate this pattern. Targeted extracellular recordings were made of green fluorescent protein-identified KNDy neurons in brain slices from adult male mice that were intact, castrated, or castrated and treated with estradiol or dihydrotestosterone (DHT). KNDy neurons exhibited marked peaks and nadirs in action potential firing activity during recordings lasting 1 to 3.5 hours. Peaks, identified by Cluster analysis, occurred more frequently in castrated than intact mice, and either estradiol or DHT in vivo or blocking neurokinin type 3 receptor in vitro restored peak frequency to intact levels. The frequency of peaks in firing rate and estradiol regulation of this frequency is similar to that observed for GnRH neurons, whereas DHT suppressed firing in KNDy but not GnRH neurons. We further examined the patterning of action potentials to identify bursts that may be associated with increased neuromodulator release. Burst frequency and duration are increased in castrated compared with intact and steroid-treated mice. The observation that KNDy neurons fire in an episodic manner that is regulated by steroid feedback is consistent with a role for these neurons in GnRH pulse generation and regulation.
[Mh] Termos MeSH primário: Potenciais de Ação/efeitos dos fármacos
Androgênios/farmacologia
Núcleo Arqueado do Hipotálamo/citologia
Di-Hidrotestosterona/farmacologia
Estradiol/farmacologia
Estrogênios/farmacologia
Neurônios/efeitos dos fármacos
Orquiectomia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Encéfalo/fisiologia
Análise por Conglomerados
Dinorfinas/metabolismo
Hormônio Liberador de Gonadotropina/metabolismo
Proteínas de Fluorescência Verde/genética
Kisspeptinas/genética
Kisspeptinas/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Neurocinina B/metabolismo
Neurônios/metabolismo
Neurônios/fisiologia
Técnicas de Patch-Clamp
Receptores da Neurocinina-3/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens); 0 (Estrogens); 0 (Kiss1 protein, mouse); 0 (Kisspeptins); 0 (Receptors, Neurokinin-3); 08J2K08A3Y (Dihydrotestosterone); 147336-22-9 (Green Fluorescent Proteins); 33515-09-2 (Gonadotropin-Releasing Hormone); 4TI98Z838E (Estradiol); 74913-18-1 (Dynorphins); 86933-75-7 (Neurokinin B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00382


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[PMID]:28870416
[Au] Autor:Hennequin C; Fumagalli I; Martin V; Quero L
[Ad] Endereço:Service de cancérologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris, France. Electronic address: christophe.hennequin2@ap-hop-paris.fr.
[Ti] Título:[Combination of radiotherapy and androgen deprivation therapy for localized prostate cancer].
[Ti] Título:Associations d'hormonothérapie et de radiothérapie pour le cancer de prostate..
[So] Source:Cancer Radiother;21(6-7):462-468, 2017 Oct.
[Is] ISSN:1769-6658
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Combination of radiotherapy and androgen deprivation is now considered as the standard of care for patients with a localized prostate cancer but poor prognosis factors. Two groups of randomized trials have led to this recommendation: some have compared radiotherapy alone versus hormonal treatment and radiotherapy: these trials demonstrated, now with a long follow-up, an improvement in 10-year survival for the combined treatment. Three recent trials compared androgen deprivation alone or combined with radiotherapy; a benefit in survival was also demonstrated in favour of the combination. Some questions remained concerning the optimal duration of hormonal treatment, in view of its potential side effects. Patients in the intermediate prognostic groups could receive a short-term androgen deprivation, but those with a high Gleason score must be treated with a long-term hormonal treatment. Modalities of radiotherapy, regarding volumes and dose must also be précised in the next years.
[Mh] Termos MeSH primário: Neoplasias da Próstata/terapia
[Mh] Termos MeSH secundário: Antagonistas de Androgênios/uso terapêutico
Terapia Combinada/métodos
Hormônio Liberador de Gonadotropina/agonistas
Seres Humanos
Masculino
Orquiectomia
Neoplasias da Próstata/radioterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgen Antagonists); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE



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