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[PMID]:29190687
[Au] Autor:da Silva AA; Hall JE; do Carmo JM
[Ad] Endereço:Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
[Ti] Título:Leptin reverses hyperglycemia and hyperphagia in insulin deficient diabetic rats by pituitary-independent central nervous system actions.
[So] Source:PLoS One;12(11):e0184805, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hypothalamic-pituitary-adrenal (HPA) axis has been postulated to play a major role in mediating the antidiabetic effects of leptin. We tested if the pituitary is essential for the chronic central nervous system mediated actions of leptin on metabolic and cardiovascular function in insulin-dependent diabetic and non-diabetic rats. Male 12-week-old hypophysectomized Sprague-Dawley rats (Hypo, n = 5) were instrumented with telemetry probes for determination of mean arterial pressure (MAP) and heart rate (HR) 24-hrs/day and an intracerebroventricular (ICV) cannula was placed into the brain lateral ventricle for continuous leptin infusion. In additional groups of Hypo and control rats (n = 5/group), diabetes was induced by single injection of streptozotocin (50 mg/kg, IP). Hypo rats were lighter, had lower MAP and HR (83±4 and 317±2 vs 105±4 mmHg and 339±4 bpm), with similar caloric intake per kilogram of body weight and fasting plasma glucose levels (84±4 vs 80±4 mg/dl) compared to controls. Chronic ICV leptin infusion (7 days, 0.62 µg/hr) in non-diabetic rats reduced caloric intake and body weight (-10%) in Hypo and control rats and markedly increased HR in control rats (~25 bpm) while causing only modest HR increases in Hypo rats (8 bpm). In diabetic Hypo and control rats, leptin infusion reduced caloric intake, body weight and glucose levels (323±74 to 99±20 and 374±27 to 108±10 mg/dl), respectively; however, the effects of leptin on HR were abolished in Hypo rats. These results indicate that hypophysectomy attenuates leptin's effect on HR regulation without altering leptin's ability to suppress appetite or normalize glucose levels in diabetes.
[Mh] Termos MeSH primário: Sistema Nervoso Central/fisiopatologia
Diabetes Mellitus Experimental/complicações
Hiperglicemia/tratamento farmacológico
Hiperfagia/tratamento farmacológico
Leptina/uso terapêutico
Hipófise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Pressão Sanguínea
Bradicardia/tratamento farmacológico
Bradicardia/etiologia
Ingestão de Energia
Frequência Cardíaca
Hiperglicemia/complicações
Hiperfagia/complicações
Hipofisectomia
Infusões Intraventriculares
Insulina/sangue
Leptina/administração & dosagem
Masculino
Hipófise/cirurgia
Ratos
Ratos Sprague-Dawley
Estreptozocina
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Leptin); 5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184805


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[PMID]:29056398
[Au] Autor:Owen TJ; Martin LG; Chen AV
[Ad] Endereço:Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, PO Box 647060, Pullman, WA 99164-7060, USA. Electronic address: tinajoowen@vetmed.wsu.edu.
[Ti] Título:Transsphenoidal Surgery for Pituitary Tumors and Other Sellar Masses.
[So] Source:Vet Clin North Am Small Anim Pract;48(1):129-151, 2018 Jan.
[Is] ISSN:1878-1306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transsphenoidal surgery is an option for dogs and cats with functional and nonfunctional pituitary masses or other sellar and parasellar masses. An adrenocorticotropic hormone-secreting tumor causing Cushing disease is the most common clinically relevant pituitary tumor in dogs, and the most common pituitary tumor seen in cats is a growth hormone-secreting tumor causing acromegaly. Transsphenoidal surgery can lead to rapid resolution of clinical signs and provide a cure for these patients. Because of the risks associated with this surgery, it should only be attempted by a cohesive pituitary surgery group with a sophisticated medical and surgical team.
[Mh] Termos MeSH primário: Adenoma/veterinária
Doenças do Gato/cirurgia
Doenças do Cão/cirurgia
Hipofisectomia/veterinária
Meningioma/veterinária
Neoplasias Hipofisárias/veterinária
[Mh] Termos MeSH secundário: Adenoma/diagnóstico
Adenoma/cirurgia
Animais
Doenças do Gato/diagnóstico
Gatos
Doenças do Cão/diagnóstico
Cães
Hipofisectomia/métodos
Meningioma/diagnóstico
Meningioma/cirurgia
Neoplasias Hipofisárias/diagnóstico
Neoplasias Hipofisárias/cirurgia
Complicações Pós-Operatórias/veterinária
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE


  3 / 9770 MEDLINE  
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[PMID]:28348112
[Au] Autor:Fahrenkrug J; Georg B; Hannibal J; Jørgensen HL
[Ad] Endereço:Department of Clinical BiochemistryBispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark jan.fahrenkrug@regionh.dk.
[Ti] Título:Hypophysectomy abolishes rhythms in rat thyroid hormones but not in the thyroid clock.
[So] Source:J Endocrinol;233(3):209-216, 2017 Jun.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The endocrine body rhythms including the hypothalamic-pituitary-thyroid axis seem to be regulated by the circadian timing system, and daily rhythmicity of circulating thyroid-stimulating hormone (TSH) is well established. The circadian rhythms are generated by endogenous clocks in the central brain oscillator located in the hypothalamic suprachiasmatic nucleus (SCN) as well as multiple peripheral clocks, but information on the existence and function of a thyroid clock is limited. The molecular machinery in all clock cells is composed of a number of clock genes and their gene products are connected by autoregulatory feedback loops. Here, we provide evidence for a thyroid clock in the rat by demonstrating 24-h antiphase oscillations for the mRNA of the canonical clock genes and , which was unaffected by hypophysectomy. By immunostaining, we supported the existence of a core oscillator in the individual thyroid cells by demonstrating a daily cytoplasmatic-nuclear shuttling of PER1 protein. In normal rats, we found a significant daily rhythmicity in the circulating thyroid hormones preceded by a peak in TSH. In hypophysectomised rats, although the thyroid clock was not affected, the oscillations in circulating thyroid hormones were abolished and the levels were markedly lowered. No daily oscillations in the expression of TSH receptor mRNA were observed in neither control rats nor hypophysectomised rats. Our findings indicate that the daily rhythm of thyroid hormone secretion is governed by SCN signalling via the rhythmic TSH secretion rather than by the local thyroid clock, which was still ticking after hypophysectomy.
[Mh] Termos MeSH primário: Relógios Biológicos/fisiologia
Hipofisectomia/métodos
Glândula Tireoide/fisiologia
Tiroxina/fisiologia
Tri-Iodotironina/fisiologia
[Mh] Termos MeSH secundário: Fatores de Transcrição ARNTL/genética
Fatores de Transcrição ARNTL/metabolismo
Animais
Feminino
Regulação da Expressão Gênica/fisiologia
Masculino
Proteínas Circadianas Period/genética
Proteínas Circadianas Period/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ARNTL Transcription Factors); 0 (Bmal1 protein, rat); 0 (Per1 protein, rat); 0 (Period Circadian Proteins); 0 (RNA, Messenger); 06LU7C9H1V (Triiodothyronine); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-17-0111


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[PMID]:28275169
[Au] Autor:Walser M; Schiöler L; Oscarsson J; Åberg MA; Wickelgren R; Svensson J; Isgaard J; Åberg ND
[Ad] Endereço:Department of Internal MedicineInstitute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden marion.walser@medic.gu.se.
[Ti] Título:Mode of GH administration and gene expression in the female rat brain.
[So] Source:J Endocrinol;233(2):187-196, 2017 May.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The endogenous secretion of growth hormone (GH) is sexually dimorphic in rats with females having a more even and males a more pulsatile secretion and low trough levels. The mode of GH administration, mimicking the sexually dimorphic secretion, has different systemic effects. In the brains of male rats, we have previously found that the mode of GH administration differently affects neuron-haemoglobin beta ( ) expression whereas effects on other transcripts were moderate. The different modes of GH administration could have different effects on brain transcripts in female rats. Hypophysectomised female rats were given GH either as injections twice daily or as continuous infusion and GH-responsive transcripts were assessed by quantitative reverse transcription polymerase chain reaction in the hippocampus and parietal cortex (cortex). The different modes of GH-administration markedly increased and 5'-aminolevulinate synthase 2 ( ) in both brain regions. As other effects were relatively moderate, a mixed model analysis (MMA) was used to investigate general effects of the treatments. In the hippocampus, MMA showed that GH-infusion suppressed glia- and neuron-related transcript expression levels, whereas GH-injections increased expression levels. In the cortex, GH-infusion instead increased neuron-related transcripts, whereas GH-injections had no significant effect. Interestingly, this contrasts to previous results obtained from male rat cortex where GH-infusion generally decreased expression levels. In conclusion, the results indicate that there is a small but significant difference in response to mode of GH administration in the hippocampus as compared to the cortex. For both modes of GH administration, there was a robust effect on and .
[Mh] Termos MeSH primário: Regulação da Expressão Gênica/fisiologia
Hormônio do Crescimento/administração & dosagem
[Mh] Termos MeSH secundário: 5-Aminolevulinato Sintetase/genética
5-Aminolevulinato Sintetase/metabolismo
Animais
Córtex Cerebral/metabolismo
Feminino
Hormônio do Crescimento/genética
Hormônio do Crescimento/metabolismo
Hormônio do Crescimento/farmacologia
Hipocampo/metabolismo
Hipofisectomia
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-72-6 (Growth Hormone); EC 2.3.1.37 (5-Aminolevulinate Synthetase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-16-0656


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[PMID]:28072724
[Au] Autor:Li CZ; Li CC; Hsieh CC; Lin MC; Hueng DY; Liu FC; Chen YH
[Ad] Endereço:aDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei bDepartment of Surgery, Kaohsiung Armed Forces General Hospital cDepartment of Surgery, Zoying Branch, Kaoshiung Armed Forces General Hospital dDivision of Rheumatology, Immunology, and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
[Ti] Título:Fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery for a pituitary tumor: A case report.
[So] Source:Medicine (Baltimore);96(1):e5774, 2017 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The fatal type of antiphospholipid syndrome is a rare but life-threating condition. It may be triggered by surgery or infection. Endoscopic transnasal-transsphenoidal surgery is a common procedure for pituitary tumor. We report a catastrophic case of a young woman died of fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery. METHODS AND RESULT: A 31-year-old woman of a history of stroke received endoscopic transnasal-transsphenoidal surgery for a pituitary tumor. The whole procedure was smooth. However, the patient suffered from acute delirium on postoperative day 4. Then, her consciousness became comatose state rapidly with dilatation of pupils. Urgent magnetic resonance imaging of brain demonstrated multiple acute lacunar infarcts. The positive antiphosphoipid antibody and severe thrombocytopenia were also noted. Fatal antiphospholipid syndrome was diagnosed. Plasma exchange, corticosteroids, anticoagulant agent were prescribed. The hemodynamic condition was gradually stable. However, the consciousness was still in deep coma. The patient died of organ donation 2 months later. CONCLUSION: If patients have a history of cerebral stroke in their early life, such as a young stroke, the APS and higher risk of developing fatal APS after major surgery should be considered. The optimal management of APS remains controversial. The best treatment strategies are only early diagnosis and aggressive therapies combing of anticoagulant, corticosteroid, and plasma exchange. The intravenous immunoglobulin is prescribed for patients with refractory APS.
[Mh] Termos MeSH primário: Anticoagulantes/administração & dosagem
Infarto Encefálico
Glucocorticoides/administração & dosagem
Hipofisectomia
Neoplasias Hipofisárias/cirurgia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adulto
Síndrome Antifosfolipídica/sangue
Síndrome Antifosfolipídica/diagnóstico
Síndrome Antifosfolipídica/etiologia
Síndrome Antifosfolipídica/fisiopatologia
Infarto Encefálico/sangue
Infarto Encefálico/diagnóstico por imagem
Infarto Encefálico/etiologia
Evolução Fatal
Feminino
Seres Humanos
Hipofisectomia/efeitos adversos
Hipofisectomia/métodos
Imagem por Ressonância Magnética
Cirurgia Endoscópica por Orifício Natural/métodos
Neoplasias Hipofisárias/patologia
Troca Plasmática/métodos
Complicações Pós-Operatórias/sangue
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/fisiopatologia
Trombocitopenia/sangue
Trombocitopenia/diagnóstico
Trombocitopenia/etiologia
Trombocitopenia/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Glucocorticoids)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005774


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[PMID]:28008629
[Au] Autor:Hanba C; Svider PF; Jacob JT; Guthikonda M; Liu JK; Eloy JA; Folbe AJ
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, U.S.A.
[Ti] Título:Lower airway disease and pituitary surgery: Is there an association with postoperative cerebrospinal fluid leak?
[So] Source:Laryngoscope;127(7):1543-1550, 2017 Jul.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: To explore the relationship between lower airway disease and postoperative cerebrospinal fluid (CSF) rhinorrhea among patients undergoing pituitary surgery STUDY DESIGN: Retrospective review. METHODS: A retrospective review of the Healthcare Cost and Utilization Project's 2013 National Inpatient Sample was conducted to characterize the hospital stay and surgical outcomes of patients undergoing pituitary surgery. Patients with lower airway disease (including chronic obstructive pulmonary disease and asthma) were compared to a disease-free population identifying demographics and complications over-represented in the lower airway group. RESULTS: The majority of hypophysectomies (92.1%) were performed via a transsphenoidal approach. Among transsphenoidal patients, individuals with asthma (92.8% of the lower airway disease cohort) harbored a greater postoperative CSF leak rate (4.7% vs. 2.7%, P = .022), and were more likely to develop postoperative diabetes insipidus (6.2% vs. 4.1%, P = .024) and neurological complications (13.0% vs. 9.6%, P = .010) when compared to a lower airway disease-free cohort. Patients with CSF rhinorrhea had longer lengths of stay (7.8 days vs. 4.5 days, P < .001) and higher discharge costs ($148,309 vs. $76,246, P < .001). A binary logistic regression model identified having asthma (P = .042), being female (P = .011), and having gastroesophageal reflux disease (P = .006) as independent predictors of postoperative CSF rhinorrhea. CONCLUSIONS: Several patient comorbidities including asthma are associated with a greater risk of postoperative CSF rhinorrhea. Perioperative lower airway assessment and disease control may potentially decrease one's risk of this complication, although further inquiry is urgently needed to identify optimal preventive strategies. LEVEL OF EVIDENCE: 2c. Laryngoscope, 127:1543-1550, 2017.
[Mh] Termos MeSH primário: Asma/complicações
Rinorreia de Líquido Cefalorraquidiano/etiologia
Hipofisectomia
Complicações Pós-Operatórias/etiologia
Doença Pulmonar Obstrutiva Crônica/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Asma/economia
Asma/epidemiologia
Rinorreia de Líquido Cefalorraquidiano/economia
Rinorreia de Líquido Cefalorraquidiano/epidemiologia
Criança
Pré-Escolar
Estudos de Coortes
Comorbidade
Estudos Transversais
Diabetes Insípido/economia
Diabetes Insípido/epidemiologia
Diabetes Insípido/etiologia
Feminino
Seres Humanos
Hipofisectomia/economia
Lactente
Recém-Nascido
Tempo de Internação/economia
Masculino
Meia-Idade
Doenças do Sistema Nervoso/economia
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/etiologia
Razão de Chances
Complicações Pós-Operatórias/economia
Complicações Pós-Operatórias/epidemiologia
Doença Pulmonar Obstrutiva Crônica/economia
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Estados Unidos
United States Agency for Healthcare Research and Quality
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26364


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[PMID]:27593773
[Au] Autor:Postalci L; Erdim I; Demirgil B; Gunaldi O; Asilturk M; Demirci H; Kina H; Erdogan U; Yazici M; Emel E
[Ad] Endereço:Bakirkoy Research and Training Hospital for Neurology, Psychiatry and Neurosurgery, Neurosurgery Clinic, Istanbul, Turkey.
[Ti] Título:Late Postoperative Rhinological Complications After Microscopic Transnasal Hypophysectomy.
[So] Source:Turk Neurosurg;27(2):182-186, 2017.
[Is] ISSN:1019-5149
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:AIM: Major complications of microscopic transnasal hypophyseal surgery (MTHS), such as cerebrospinal fluid rhinorrhea, carotid injury, and optic nerve injury, are very rare. However, late rhinological complications can be ignored because they are a minor cause of morbidity compared with major complications. In this study, we extensively examined postoperative rhinological complications in patients who underwent MTHS for pituitary adenoma. MATERIAL AND METHODS: Thirty-one patients diagnosed with pituitary adenoma, who underwent MTHS and whose preoperative nasal examinations were recorded between January 2007 and January 2014, were included in the study. A detailed rhinological examination of the patients was performed. RESULTS: A total of 12 of 31 patients (38.7%) had a perforated nasal septum, and synechiae were detected in the nasal cavities of 13 patients (42%). Anosmia occurred in three patients, hyposmia in two, and a nasal tip deflection and saddle nose deformity were detected in one patient with a perforated nasal septum. No perinasal loss of sense, oronasal fistula, or purulent secretion in the nasal cavity was found in any patient. CONCLUSION: The nasal structures, particularly the nasal septum mucosa, should be treated gently during MTHS. The nasal stages of the operation should be performed with the help of an otolaryngologist until adequate experience is gained.
[Mh] Termos MeSH primário: Rinorreia de Líquido Cefalorraquidiano/complicações
Hipofisectomia/efeitos adversos
Microcirurgia/efeitos adversos
Neoplasias Hipofisárias/cirurgia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Cavidade Nasal/cirurgia
Neoplasias Hipofisárias/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.5137/1019-5149.JTN.15754-15.1


  8 / 9770 MEDLINE  
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[PMID]:27449341
[Au] Autor:Douros JD; Baltzegar DA; Mankiewicz J; Taylor J; Yamaguchi Y; Lerner DT; Seale AP; Grau EG; Breves JP; Borski RJ
[Ad] Endereço:Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695-7617, United States.
[Ti] Título:Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia (Oreochromis mossambicus).
[So] Source:Gen Comp Endocrinol;240:227-237, 2017 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leptin is an important cytokine for regulating energy homeostasis, however, relatively little is known about its function and control in teleost fishes or other ectotherms, particularly with regard to interactions with the growth hormone (GH)/insulin-like growth factors (IGFs) growth regulatory axis. Here we assessed the regulation of LepA, the dominant paralog in tilapia (Oreochromis mossambicus) and other teleosts under altered nutritional state, and evaluated how LepA might alter pituitary growth hormone (GH) and hepatic insulin-like growth factors (IGFs) that are known to be disparately regulated by metabolic state. Circulating LepA, and lepa and lepr gene expression increased after 3-weeks fasting and declined to control levels 10days following refeeding. This pattern of leptin regulation by metabolic state is similar to that previously observed for pituitary GH and opposite that of hepatic GHR and/or IGF dynamics in tilapia and other fishes. We therefore evaluated if LepA might differentially regulate pituitary GH, and hepatic GH receptors (GHRs) and IGFs. Recombinant tilapia LepA (rtLepA) increased hepatic gene expression of igf-1, igf-2, ghr-1, and ghr-2 from isolated hepatocytes following 24h incubation. Intraperitoneal rtLepA injection, on the other hand, stimulated hepatic igf-1, but had little effect on hepatic igf-2, ghr1, or ghr2 mRNA abundance. LepA suppressed GH accumulation and gh mRNA in pituitaries in vitro, but had no effect on GH release. We next sought to test if abolition of pituitary GH via hypophysectomy (Hx) affects the expression of hepatic lepa and lepr. Hypophysectomy significantly increases hepatic lepa mRNA abundance, while GH replacement in Hx fish restores lepa mRNA levels to that of sham controls. Leptin receptor (lepr) mRNA was unchanged by Hx. In in vitro hepatocyte incubations, GH inhibits lepa and lepr mRNA expression at low concentrations, while higher concentration stimulates lepa expression. Taken together, these findings indicate LepA gene expression and secretion increases with fasting, consistent with the hormones function in promoting energy expenditure during catabolic stress. It would also appear that LepA might play an important role in stimulating GHR and IGFs to potentially spare declines in these factors during catabolism. Evidence also suggests for the first time in teleosts that GH may exert important regulatory effects on hepatic LepA production, insofar as physiological levels (0.05-1 nM) suppresse lepa mRNA accumulation. Leptin A, may in turn exert negative feedback effects on basal GH mRNA abundance, but not secretion.
[Mh] Termos MeSH primário: Hormônio do Crescimento/metabolismo
Fator de Crescimento Insulin-Like II/metabolismo
Fator de Crescimento Insulin-Like I/metabolismo
Leptina/metabolismo
Fígado/metabolismo
Receptores da Somatotropina/metabolismo
Tilápia/metabolismo
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Jejum
Comportamento Alimentar/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Hepatócitos/metabolismo
Hipofisectomia
Masculino
Hipófise/efeitos dos fármacos
Hipófise/metabolismo
RNA Mensageiro/genética
Receptores da Somatotropina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 0 (RNA, Messenger); 0 (Receptors, Somatotropin); 67763-96-6 (Insulin-Like Growth Factor I); 67763-97-7 (Insulin-Like Growth Factor II); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


  9 / 9770 MEDLINE  
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[PMID]:27303060
[Au] Autor:Choy KW; Teng J; Wijeratne N; Tan CY; Doery JC
[Ad] Endereço:1 Department of Pathology, Monash Medical Centre, Victoria, Australia.
[Ti] Título:Immunoassay interference complicating management of Cushing's disease: the onus is on the clinician and the laboratory.
[So] Source:Ann Clin Biochem;54(1):183-184, 2017 Jan.
[Is] ISSN:1758-1001
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/sangue
Hipofisectomia
Imunoensaio/efeitos adversos
Hipersecreção Hipofisária de ACTH/diagnóstico
[Mh] Termos MeSH secundário: Competência Clínica
Gerenciamento Clínico
Reações Falso-Positivas
Feminino
Hormônio Foliculoestimulante/sangue
Seres Humanos
Hidrocortisona/sangue
Hormônio Luteinizante/sangue
Meia-Idade
Hipersecreção Hipofisária de ACTH/sangue
Hipersecreção Hipofisária de ACTH/patologia
Hipersecreção Hipofisária de ACTH/cirurgia
Hipófise/metabolismo
Hipófise/patologia
Hipófise/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9002-60-2 (Adrenocorticotropic Hormone); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1177/0004563216657362


  10 / 9770 MEDLINE  
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[PMID]:27763976
[Au] Autor:Yazici H; Dogan S; Sönmez MA; Eser O
[Ad] Endereço:*Ear Nose Throat Clinic, Faculty of Medicine, Balikesir University, Balikesir†Ear Nose Throat Clinic, Faculty of Medicine, Adiyaman University, Adiyaman‡Neurosurgery Clinic, Faculty of Medicine, Balikesir University, Balikesir, Turkey.
[Ti] Título:Transseptal Subperichondrial Endoscopic Hypophysectomy With Preservation of Vital Nasal Structures.
[So] Source:J Craniofac Surg;27(7):1834-1836, 2016 Oct.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Pituitary surgery involving different techniques is often applied to the excision of benign adenomas. Operative interventions involved various approaches and techniques. Endoscopic transsphenoidal approach is the less traumatic route to the sella turcica, avoiding brain retraction, and also permitting good visualization, with lower rates of morbidity and mortality. Although mortality of pituitary surgery decreased by advances in surgical techniques morbidities such as synechiae formation, anosmia, bleeding, nasal septal perforations, drying, and incrustation due to traumatization of the nasal structures such as septum, nasal mucosa, and middle concha are the current problems in pituitary surgery. Here, the authors described an endoscopic transseptal subpericondrial hypophysectomy with minimal damage to normal anatomy and physiology and discussed advantages of this technique. METHODS: The authors performed endoscopic transseptal subpericondrial hypophysectomy to 2 patients and evaluated intraoperative and postoperative results. RESULTS: No complication was noted during surgery or postoperative period with endoscopic transseptal subpericondrial hypophysectomy technique. CONCLUSIONS: Endoscopic transseptal subpericondrial hypophysectomy is a safe technique and, requires only a short surgery time and does not require the removal of any physiological tissue or cause any bleeding.
[Mh] Termos MeSH primário: Endoscopia/métodos
Hipofisectomia/métodos
Perfuração do Septo Nasal/prevenção & controle
Neoplasias Hipofisárias/cirurgia
Sela Túrcica/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Duração da Cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE



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