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  1 / 709 MEDLINE  
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Teixeira, Manoel Jacobsen
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[PMID]:27989972
[Au] Autor:Wen HT; Da Róz LM; Rhoton AL; Castro LH; Teixeira MJ
[Ad] Endereço:Division of Neurosurgery, Hospital das Clínicas, College of Medicine, University of São Paulo, Brazil. Electronic address: wenht@uol.com.br.
[Ti] Título:Frontal Lobe Decortication (Frontal Lobectomy with Ventricular Preservation) in Epilepsy-Part 1: Anatomic Landmarks and Surgical Technique.
[So] Source:World Neurosurg;98:347-364, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An extensive frontal resection is a frequently performed neurosurgical procedure, especially for treating brain tumor and refractory epilepsy. However, there is a paucity of reports available regarding its surgical anatomy and technique. OBJECTIVES: We sought to present the anatomic landmarks and surgical technique of the frontal lobe decortication (FLD) in epilepsy. The goals were to maximize the gray matter removal, spare primary and supplementary motor areas, and preserve the frontal horn. MATERIAL AND METHODS: The anatomic study was based on dissections performed in 15 formalin-fixed adult cadaveric heads. The clinical experience with 15 patients is summarized. RESULT: FLD consists of 5 steps: 1) coagulation and section of arterial branches of lateral surface; 2) paramedian subpial resection 3 cm ahead of the precentral sulcus to reach the genu of corpus callosum; 3) resection of gray matter of lateral surface, preserving the frontal horn; 4) removal of gray matter of basal surface preserving olfactory tract; 5) removal of gray matter of the medial surface under the rostrum of corpus callosum. The frontal horn was preserved in all 15 patients; 12 patients (80%) had no complications; 2 patients presented temporary hemiparesis; and 1 Rasmussen syndrome patient developed postoperative fever. The best seizure control was in cases with focal magnetic resonance imaging abnormalities limited to the frontal lobe. CONCLUSION: FLD is an anatomy-based surgical technique for extensive frontal lobe resection. It presents reliable anatomic landmarks, selective gray matter removal, preservation of frontal horn, and low complication rate in our series. It can be an alternative option to the classical frontal lobectomy.
[Mh] Termos MeSH primário: Descorticação Cerebral/métodos
Ventrículos Cerebrais/anatomia & histologia
Epilepsia/cirurgia
Lobo Frontal/anatomia & histologia
Lobo Frontal/cirurgia
Psicocirurgia/métodos
[Mh] Termos MeSH secundário: Adolescente
Descorticação Cerebral/efeitos adversos
Ventrículos Cerebrais/diagnóstico por imagem
Criança
Pré-Escolar
Epilepsia/diagnóstico por imagem
Feminino
Seguimentos
Lobo Frontal/diagnóstico por imagem
Seres Humanos
Lactente
Masculino
Posicionamento do Paciente/métodos
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/etiologia
Psicocirurgia/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE


  2 / 709 MEDLINE  
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[PMID]:25490135
[Au] Autor:Yoshikawa A; Nakamachi T; Shibato J; Rakwal R; Shioda S
[Ad] Endereço:Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan. yoshi-aki@med.showa-u.ac.jp.
[Ti] Título:Comprehensive analysis of neonatal versus adult unilateral decortication in a mouse model using behavioral, neuroanatomical, and DNA microarray approaches.
[So] Source:Int J Mol Sci;15(12):22492-517, 2014 Dec 05.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Previously, studying the development, especially of corticospinal neurons, it was concluded that the main compensatory mechanism after unilateral brain injury in rat at the neonatal stage was due in part to non-lesioned ipsilateral corticospinal neurons that escaped selection by axonal elimination or neuronal apoptosis. However, previous results suggesting compensatory mechanism in neonate brain were not correlated with high functional recovery. Therefore, what is the difference among neonate and adult in the context of functional recovery and potential mechanism(s) therein? Here, we utilized a brain unilateral decortication mouse model and compared motor functional recovery mechanism post-neonatal brain hemisuction (NBH) with adult brain hemisuction (ABH). Three analyses were performed: (1) Quantitative behavioral analysis of forelimb movements using ladder walking test; (2) neuroanatomical retrograde tracing analysis of unlesioned side corticospinal neurons; and (3) differential global gene expressions profiling in unlesioned-side neocortex (rostral from bregma) in NBH and ABH on a 8 × 60 K mouse whole genome Agilent DNA chip. Behavioral data confirmed higher recovery ability in NBH over ABH is related to non-lesional frontal neocortex including rostral caudal forelimb area. A first inventory of differentially expressed genes genome-wide in the NBH and ABH mouse model is provided as a resource for the scientific community.
[Mh] Termos MeSH primário: Córtex Cerebral/anatomia & histologia
Córtex Cerebral/fisiologia
Descorticação Cerebral
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Comportamento Animal
Modelos Animais de Doenças
Feminino
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Masculino
Camundongos
Atividade Motora
Neurônios/metabolismo
Análise de Sequência com Séries de Oligonucleotídeos
Proteína Quinase C/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 2.7.1.- (protein kinase C gamma); EC 2.7.11.13 (Protein Kinase C)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141210
[St] Status:MEDLINE
[do] DOI:10.3390/ijms151222492


  3 / 709 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:25387671
[Au] Autor:Shang JL; Cheng Q; Yang WF; Zhang M; Cui Y; Wang YF
[Ad] Endereço:Neurology Department, Peace Hospital Attached to Changzhi Medical College, Changzhi, China.
[Ti] Título:Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice.
[So] Source:Braz J Med Biol Res;47(12):1050-6, 2014 Dec.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:People who suffer from traumatic brain injury (TBI) often experience cognitive deficits in spatial reference and working memory. The possible roles of cyclooxygenase-1 (COX-1) in learning and memory impairment in mice with TBI are far from well known. Adult mice subjected to TBI were treated with the COX-1 selective inhibitor SC560. Performance in the open field and on the beam walk was then used to assess motor and behavioral function 1, 3, 7, 14, and 21 days following injury. Acquisition of spatial learning and memory retention was assessed using the Morris water maze on day 15 post-TBI. The expressions of COX-1, prostaglandin E2 (PGE2), interleukin (IL)-6, brain-derived neurotrophic factor (BDNF), platelet-derived growth factor BB (PDGF-BB), synapsin-I, and synaptophysin were detected in TBI mice. Administration of SC560 improved performance of beam walk tasks as well as spatial learning and memory after TBI. SC560 also reduced expressions of inflammatory markers IL-6 and PGE2, and reversed the expressions of COX-1, BDNF, PDGF-BB, synapsin-I, and synaptophysin in TBI mice. The present findings demonstrated that COX-1 might play an important role in cognitive deficits after TBI and that selective COX-1 inhibition should be further investigated as a potential therapeutic approach for TBI.
[Mh] Termos MeSH primário: Lesões Encefálicas/complicações
Córtex Cerebral/lesões
Ciclo-Oxigenase 1/fisiologia
Inibidores de Ciclo-Oxigenase/uso terapêutico
Aprendizagem/efeitos dos fármacos
Transtornos da Memória/tratamento farmacológico
Pirazóis/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Western Blotting
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Descorticação Cerebral
Ciclo-Oxigenase 1/metabolismo
Dinoprostona/análise
Dinoprostona/metabolismo
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Hipocampo/metabolismo
Interleucina-6/sangue
Aprendizagem em Labirinto/efeitos dos fármacos
Transtornos da Memória/etiologia
Transtornos da Memória/metabolismo
Camundongos Endogâmicos C57BL
Proteínas Proto-Oncogênicas c-sis/metabolismo
Recuperação de Função Fisiológica/efeitos dos fármacos
Sinaptofisina/análise
Sinaptofisina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Cyclooxygenase Inhibitors); 0 (Interleukin-6); 0 (Proto-Oncogene Proteins c-sis); 0 (Pyrazoles); 0 (SC 560); 0 (Synaptophysin); 1B56C968OA (becaplermin); EC 1.14.99.1 (Cyclooxygenase 1); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141113
[St] Status:MEDLINE


  4 / 709 MEDLINE  
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[PMID]:24807550
[Au] Autor:Ono Y; Hisamatsu Y; Kuramoto S; Katsumata A; Kawauchi M; Kanai K; Nakamura S; Hirose T
[Ad] Endereço:Department of Neurosurgery, Kagawa Prefectural Central Hospital.
[Ti] Título:[A case of intracranial invasion from sinonasal small cell neuroendocrine carcinoma].
[So] Source:No Shinkei Geka;42(5):453-9, 2014 May.
[Is] ISSN:0301-2603
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Sinonasal neuroendocrine carcinomas (NECs) are rare tumors. We present a rare case of intracranial invasion of sinonasal small-cell NEC. A 61-year-old woman with nasal obstruction and bleeding was referred to our hospital. Computed tomography showed a polyp-like tumor occupying her left nasal cavity and extending to the paranasal sinuses and anterior cranial fossa. The tumor was removed using a transfacial approach by otolaryngologists and a bifrontal cranial approach by neurosurgeons. In histopathological analyses, we found that the tumor presented with both an epithelial and neuroendocrine nature, and was diagnosed as a small-cell NEC. Post-surgery, she received localized radiation therapy and chemotherapy, and is alive, 18 months after diagnosis. In cases where it is difficult to perform a differential diagnosis of tumors arising from the frontal cranial base and extending to the nasal and cranial sides, NEC should be considered as a possibility.
[Mh] Termos MeSH primário: Carcinoma Neuroendócrino/cirurgia
Neoplasias dos Seios Paranasais/cirurgia
[Mh] Termos MeSH secundário: Carcinoma Neuroendócrino/radioterapia
Descorticação Cerebral
Terapia Combinada
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Meia-Idade
Invasividade Neoplásica
Neoplasias dos Seios Paranasais/patologia
Neoplasias dos Seios Paranasais/radioterapia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140508
[Lr] Data última revisão:
140508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140509
[St] Status:MEDLINE


  5 / 709 MEDLINE  
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[PMID]:24807549
[Au] Autor:Arai T; Hasegawa Y; Tanaka T; Kato N; Watanabe M; Nakamura A; Murayama Y
[Ad] Endereço:Department of Neurosurgery, Jikei University School of Medicine Kashiwa Hospital.
[Ti] Título:[Transient charles bonnet syndrome after excision of a right occipital meningioma: a case report].
[So] Source:No Shinkei Geka;42(5):445-51, 2014 May.
[Is] ISSN:0301-2603
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Charles Bonnet syndrome is a condition characterized by visual hallucinations. These simple or complex visual hallucinations are more common in elderly individuals with impaired peripheral vision. The current report describes a case of transient Charles Bonnet syndrome appearing after the removal of a meningioma. The patient was a 61-year-old man who already had impaired visual acuity due to diabetic retinopathy. Brain MRI revealed a cystic tumor severely compressing the right occipital lobe. Starting on day 2 postoperatively, the patient was troubled by recurring visual hallucinations involving people, flowers, pictures, and familiar settings(the train and a coffee shop). These continued for 3.5 months. This period roughly coincided with the time for the occipital lobe to recover from the compression caused by the tumor, a fact that was confirmed by several MRI scans. ¹²³I-IMP SPECT performed 1 month after the surgical operation showed an area of hypoperfusion in the right parieto-occipital lobe. Based on the patient's clinical course and MRI findings, the mechanism of onset of visual hallucinations in this patient was put forward. The release of pressure in the brain by tumor removal and subsequent recovery changed the blood flow to the brain. This triggered visual hallucinations in the patient, who was already predisposed to developing Charles Bonnet syndrome because of diabetic retinopathy. This case is interesting since it indicates that central neurological factors, as well as visual deficits, may induce the appearance of visual hallucinations in Charles Bonnet syndrome.
[Mh] Termos MeSH primário: Descorticação Cerebral/efeitos adversos
Alucinações/etiologia
Neoplasias Meníngeas/cirurgia
Meningioma/cirurgia
Lobo Occipital/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neoplasias Meníngeas/irrigação sanguínea
Meningioma/irrigação sanguínea
Meia-Idade
Recidiva Local de Neoplasia
Neovascularização Patológica
Lobo Occipital/irrigação sanguínea
Testes de Campo Visual
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140508
[Lr] Data última revisão:
140508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140509
[St] Status:MEDLINE


  6 / 709 MEDLINE  
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[PMID]:24702622
[Au] Autor:Villani F; Didato G; Deleo F; Tringali G; Garbelli R; Granata T; Marras CE; Cordella R; Spreafico R
[Ad] Endereço:Division of Clinical Epileptology & Experimental Neurophysiology, Foundation IRCCS Neurological Institute "Carlo Besta", Milan, Italy.
[Ti] Título:Long-term outcome after limited cortical resections in two cases of adult-onset Rasmussen encephalitis.
[So] Source:Epilepsia;55(5):e38-43, 2014 May.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rasmussen encephalitis (RE) is a progressive inflammatory disorder characterized by brain hemiatrophy, unilateral focal deficits, and drug-refractory focal epilepsy. Epilepsia partialis continua (EPC) is a hallmark of the disease. Several immunomodulatory treatments may slow but not halt the disease progression. The treatment of choice still relies on surgical hemispheric disconnection, which is burdened by heavy neurologic morbidity. More limited cortical resections, although more tolerable, are usually considered to be, at best, only transiently effective in RE. Hemispheric disconnections may be not feasible when neurologic functions are preserved and the dominant hemisphere is affected. Adult patients with a milder RE course that preserves neurologic function for a long period are particularly at risk of developing severe deficits after surgery. In this study we present the histories of two patients with adult-onset RE who have undergone selective cortical resections to control EPC, avoiding, at the same time, the severe postsurgical deficits that may be induced by hemispheric disconnective surgery. The good result obtained on EPC has been stable over a prolonged period; however, this result was not paralleled by the stop of neurologic progression in one of the two cases. A PowerPoint slide summarizing this article is available for download in the Supporting Information section http://dx.doi.org/10.1111/epi.12596/supinfo.
[Mh] Termos MeSH primário: Córtex Cerebral/cirurgia
Encefalite/cirurgia
[Mh] Termos MeSH secundário: Adulto
Atrofia
Córtex Cerebral/patologia
Descorticação Cerebral
Progressão da Doença
Eletroencefalografia
Encefalite/diagnóstico
Encefalite/patologia
Epilepsia Parcial Contínua/diagnóstico
Epilepsia Parcial Contínua/patologia
Epilepsia Parcial Contínua/cirurgia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Complicações Pós-Operatórias/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140521
[Lr] Data última revisão:
140521
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140408
[St] Status:MEDLINE
[do] DOI:10.1111/epi.12596


  7 / 709 MEDLINE  
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[PMID]:22380856
[Au] Autor:Ibrahim GM; Barry BW; Fallah A; Snead OC; Drake JM; Rutka JT; Bernstein M
[Ad] Endereço:Division of Neurosurgery, Hospital for Sick Children, and Toronto Western Hospital, Ontario, Canada.
[Ti] Título:Inequities in access to pediatric epilepsy surgery: a bioethical framework.
[So] Source:Neurosurg Focus;32(3):E2, 2012 Mar.
[Is] ISSN:1092-0684
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epilepsy is a common childhood condition associated with a considerable medical and psychosocial burden. Children in whom medical treatment fails to reduce seizure burden represent an especially vulnerable patient population because prolonged, uncontrolled seizures are associated with poor developmental and neurocognitive outcomes. Surgical treatment in the form of cortical resection, functional disconnection, or neuromodulation may alleviate or significantly reduce the disease burden for a subset of these patients. However, there remains a dichotomy between the perceived benefits of surgery and the implementation of surgical strategies in the management of medically intractable epilepsy. The current paper presents an analysis of the bioethical implications of existing inequities in access to pediatric epilepsy surgery that result from inconsistent referral practices and discrepant evaluation techniques. The authors provide a basic bioethical framework composed of 5 primary expectations to inform public, institutional, and personal policies toward the provision of epilepsy surgery to afflicted children.
[Mh] Termos MeSH primário: Epilepsia/etiologia
Epilepsia/cirurgia
Pediatria
Especialidades Cirúrgicas
[Mh] Termos MeSH secundário: Descorticação Cerebral
Intervalo Livre de Doença
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1206
[Cu] Atualização por classe:120302
[Lr] Data última revisão:
120302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120303
[St] Status:MEDLINE
[do] DOI:10.3171/2011.12.FOCUS11315


  8 / 709 MEDLINE  
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[PMID]:22286753
[Au] Autor:Yoshikawa A; Atobe Y; Takeda A; Kamiya Y; Takiguchi M; Funakoshi K
[Ad] Endereço:Department of Neuroanatomy, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
[Ti] Título:A retrograde tracing study of compensatory corticospinal projections in rats with neonatal hemidecortication.
[So] Source:Dev Neurosci;33(6):539-47, 2011.
[Is] ISSN:1421-9859
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:To examine the compensatory mechanisms in rats that underwent left decortication at postnatal day 7 (P7), we injected the retrograde tracers fluorescein isothiocyanate-cholera toxin B subunit (FITC-CTB) and Fast Blue (FB) into the right and left upper cervical spinal cord, respectively, at postoperative weeks 2, 3, 4, and 5 and counted the number of retrogradely labeled corticospinal neurons in the right cerebral cortex compared with that in normally developed rats. Significantly more ipsilaterally projecting neurons were labeled with FITC-CTB in the decorticated rats compared with normal rats at all time points examined. The number of labeled neurons was similar to that at P7 in normal rats. There were also some FITC-CTB and FB double-labeled neurons in both decorticated and normal rats. The number of double-labeled neurons in the decorticated rats increased each week and was significantly greater than that in normal rats at postoperative weeks 4 and 5. The present results suggest that the elimination of ipsilaterally projecting axons observed in normal rats was prevented in the decorticated rats, so that the cerebral cortex neurons on the unlesioned side projected corticospinal tracts to the ipsilateral spinal cord. Furthermore, the collaterals of the corticospinal tracts originating from the cerebral cortex on the unlesioned side also project to the ipsilateral spinal cord. These compensatory mechanisms might underlie the acquisition of motor function in these animals.
[Mh] Termos MeSH primário: Descorticação Cerebral
Regeneração Nervosa/fisiologia
Tratos Piramidais/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Imunofluorescência
Lateralidade Funcional/fisiologia
Vias Neurais/fisiologia
Tratos Piramidais/citologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1207
[Cu] Atualização por classe:120321
[Lr] Data última revisão:
120321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120131
[St] Status:MEDLINE
[do] DOI:10.1159/000335526


  9 / 709 MEDLINE  
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[PMID]:22034976
[Au] Autor:Umeda T; Isa T
[Ad] Endereço:Department of Developmental Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, Japan. umeda@nips.ac.jp
[Ti] Título:Differential contributions of rostral and caudal frontal forelimb areas to compensatory process after neonatal hemidecortication in rats.
[So] Source:Eur J Neurosci;34(9):1453-60, 2011 Nov.
[Is] ISSN:1460-9568
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Following brain damage, especially in juvenile animals, large-scale reorganization is known to occur in the remaining brain structures to compensate for functional deficits. In rats with neonatal hemidecortication, corticospinal fibers originating from the undamaged side of the sensorimotor cortex issue collateral sprouts to the ipsilateral spinal gray matter that mediate cortical excitation to ipsilateral forelimb motoneurons and compensate for the deficit in forelimb movements. The present study was designed to investigate the origins of the ipsilateral corticospinal projection in neonatally hemidecorticated rats. Corticospinal neurons (CSNs) were labeled in adults by injecting retrograde neural tracers, cholera toxin subunit B with different fluorescent probes, into either side of the cervical spinal gray matter. In the undamaged cortex, double-labeled neurons were rarely found. CSNs with contralateral projections (contra-CSNs) and those with ipsilateral projections (ipsi-CSNs) were distributed both in the rostral forelimb motor area (RFA) and the caudal forelimb motor area (CFA). However, there was a difference in the distributions of the ipsi-CSNs between the two forelimb areas. Whereas the distribution of the ipsi-CSNs largely overlapped with that of the contra-CSNs in the RFA, the ipsi-CSNs tended to be segregated from the contra-CSNs in the CFA. The results suggested that the RFA and the CFA contribute to the compensatory process in different ways.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Descorticação Cerebral
Membro Anterior/fisiologia
Lateralidade Funcional/fisiologia
Córtex Motor/fisiologia
Tratos Piramidais/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Toxina da Cólera/metabolismo
Masculino
Vias Neurais/fisiologia
Neurônios/fisiologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9012-63-9 (Cholera Toxin)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:111031
[Lr] Data última revisão:
111031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111101
[St] Status:MEDLINE
[do] DOI:10.1111/j.1460-9568.2011.07866.x


  10 / 709 MEDLINE  
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[PMID]:21273319
[Au] Autor:Li HL; Asante CO
[Ad] Endereço:Department of Neuroscience, Columbia University, New York, NY 10032, USA. hl428@columbia.edu
[Ti] Título:Developmental plasticity of descending motor pathways.
[So] Source:J Neurophysiol;105(5):1963-5, 2011 May.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Juvenile animal brains are highly plastic and thus often achieve better functional recovery after injury compared with adult brains. Recently, Umeda et al. (Umeda T, Takahashi M, Isa K, Isa T. J Neurophysiol 104: 1707-1716, 2010) have shown that the remodeling of both corticospinal and extra-pyramidal pathways can contribute to the recovery of grasping and reaching ability in hemidecorticated juvenile rats. They have further unveiled the strengthening of the cortico-reticulo-spinal pathway after injury, that mediates the fast excitation of ipsilateral motoneurons for functional recovery.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiologia
Descorticação Cerebral
Membro Anterior/fisiologia
Neurônios Motores/fisiologia
Tratos Piramidais/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1204
[Cu] Atualização por classe:110518
[Lr] Data última revisão:
110518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110129
[St] Status:MEDLINE
[do] DOI:10.1152/jn.01104.2010



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