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[PMID]:28705805
[Au] Autor:Diepenbroek C; Quinn D; Stephens R; Zollinger B; Anderson S; Pan A; de Lartigue G
[Ad] Endereço:The John B. Pierce Laboratory, New Haven, Connecticut.
[Ti] Título:Validation and characterization of a novel method for selective vagal deafferentation of the gut.
[So] Source:Am J Physiol Gastrointest Liver Physiol;313(4):G342-G352, 2017 Oct 01.
[Is] ISSN:1522-1547
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a lack of tools that selectively target vagal afferent neurons (VAN) innervating the gut. We use saporin (SAP), a potent neurotoxin, conjugated to the gastronintestinal (GI) hormone cholecystokinin (CCK-SAP) injected into the nodose ganglia (NG) of male Wistar rats to specifically ablate GI-VAN. We report that CCK-SAP ablates a subpopulation of VAN in culture. In vivo, CCK-SAP injection into the NG reduces VAN innervating the mucosal and muscular layers of the stomach and small intestine but not the colon, while leaving vagal efferent neurons intact. CCK-SAP abolishes feeding-induced c-Fos in the NTS, as well as satiation by CCK or glucagon like peptide-1 (GLP-1). CCK-SAP in the NG of mice also abolishes CCK-induced satiation. Therefore, we provide multiple lines of evidence that injection of CCK-SAP in NG is a novel selective vagal deafferentation technique of the upper GI tract that works in multiple vertebrate models. This method provides improved tissue specificity and superior separation of afferent and efferent signaling compared with vagotomy, capsaicin, and subdiaphragmatic deafferentation. We develop a new method that allows targeted lesioning of vagal afferent neurons that innervate the upper GI tract while sparing vagal efferent neurons. This reliable approach provides superior tissue specificity and selectivity for vagal afferent over efferent targeting than traditional approaches. It can be used to address questions about the role of gut to brain signaling in physiological and pathophysiological conditions.
[Mh] Termos MeSH primário: Vias Aferentes/efeitos dos fármacos
Denervação Autônoma/métodos
Trato Gastrointestinal/efeitos dos fármacos
Bloqueio Nervoso/métodos
Proteínas Inativadoras de Ribossomos Tipo 1/administração & dosagem
Nervo Vago/efeitos dos fármacos
[Mh] Termos MeSH secundário: Vias Aferentes/fisiologia
Animais
Trato Gastrointestinal/fisiologia
Masculino
Neurotoxinas/administração & dosagem
Neurotoxinas/farmacologia
Ratos
Ratos Wistar
Resultado do Tratamento
Nervo Vago/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Neurotoxins); 0 (Ribosome Inactivating Proteins, Type 1); EC 3.2.2.22 (saporin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1152/ajpgi.00095.2017


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[PMID]:28212603
[Au] Autor:Feng Q; Lu C; Wang L; Song L; Li C; Uppada RC
[Ad] Endereço:First Center Clinic College of Tianjin Medical University, Tianjin First Central Hospital, Tianjin, China.
[Ti] Título:Effects of renal denervation on cardiac oxidative stress and local activity of the sympathetic nervous system and renin-angiotensin system in acute myocardial infracted dogs.
[So] Source:BMC Cardiovasc Disord;17(1):65, 2017 Feb 17.
[Is] ISSN:1471-2261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded. Additionally, haemodynamic parameters such as left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and heart rate (HR) were measured. Cardiac oxidative stress levels were evaluated based on the expression of p47 mRNA, malondialdehyde (MDA), anti-superoxide anion free radical (ASAFR) and activity of superoxide dismutase (SOD). To measure the local activity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS), the levels of tyrosine hydroxylase (TH), angiotensin II (AngII), angiotensin-converting enzyme 2 (ACE2), angiotensin (1-7) [Ang(1-7)] and Mas receptor (MasR) in myocardial tissues were recorded. The expression of TH in renal tissue and serum creatinine were used to assess the effectiveness of the RDN procedure and renal function, respectively. RESULTS: We found that MI deteriorated heart function and activated cardiac oxidative stress and the local neurohumoral system, while RDN partially reversed these changes. Compared with the control group, parameters including LVEDD, LVESD, LVEDP and the levels of ASAFR, MDA, p47 ,ACE2, Ang(1-7), MasR, AngII and TH-positive nerves were increased (all P < 0.05) in myocardial infracted dogs; meanwhile, LVEF, FS, LVSP and SOD expression were decreased (all P < 0.05). However, after RDN therapy, these changes were significantly improved (P < 0.05), except that there were no significant differences observed in FS or LVSP between the two groups (P = 0.092 and 0.931, respectively). Importantly, the expression of TH, AngII and Ang(1-7) was positively correlated with MDA and negatively correlated with SOD. Between-group comparisons demonstrated no differences in serum creatinine (P = 0.706). CONCLUSIONS: RDN attenuated cardiac remodelling and improved heart function by decreasing the level of cardiac oxidative stress and the local activity of the SNS and RAS in cardiac tissues. Additionally, the safety of the RDN procedure was established, as no significant decrease in LVSP or rise in serum creatinine was observed in our study.
[Mh] Termos MeSH primário: Denervação Autônoma
Coração/inervação
Rim/inervação
Infarto do Miocárdio/cirurgia
Miocárdio/metabolismo
Estresse Oxidativo
Sistema Renina-Angiotensina
Sistema Nervoso Simpático/cirurgia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Modelos Animais de Doenças
Cães
Feminino
Frequência Cardíaca
Masculino
Infarto do Miocárdio/metabolismo
Infarto do Miocárdio/fisiopatologia
Miocárdio/patologia
Recuperação de Função Fisiológica
Volume Sistólico
Sistema Nervoso Simpático/metabolismo
Sistema Nervoso Simpático/fisiopatologia
Fatores de Tempo
Função Ventricular Esquerda
Pressão Ventricular
Remodelação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE
[do] DOI:10.1186/s12872-017-0498-1


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[PMID]:28202630
[Au] Autor:Rivarola EW; Hachul D; Wu T; Pisani C; Hardy C; Raimundi F; Melo S; Darrieux F; Scanavacca M
[Ad] Endereço:From the Unidade Clínica de Arritmia, Heart Institute, University of São Paulo Medical School, Brazil.
[Ti] Título:Targets and End Points in Cardiac Autonomic Denervation Procedures.
[So] Source:Circ Arrhythm Electrophysiol;10(2):e004638, 2017 Feb.
[Is] ISSN:1941-3084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autonomic denervation is an alternative approach for patients with symptomatic bradycardia. No consensus exists on the critical targets and end points of the procedure. The aim of this study was to identify immediate end points and critical atrial regions responsible for vagal denervation. METHODS AND RESULTS: We enrolled 14 patients (50% men; age: 34.0±13.8 years) with cardioinhibitory syncope, advanced atrioventricular block or sinus arrest, and no structural heart disease. Anatomic mapping of ganglionated plexuses was performed, followed by radiofrequency ablation. Heart rate, sinus node recovery time, Wenckebach cycle length, and atrial-His (AH) interval were measured before and after every radiofrequency pulse. Wilcoxon signed-rank test was used for comparison. Significant shortening of the R-R interval ( =0.0009), Wenckebach cycle length ( =0.0009), and AH intervals ( =0.0014) was observed after ablation. The heart rate elevation was 23.8±12.5%, and the Wenckebach cycle length and AH interval shortening was 18.1±11% and 24.6±19%, respectively. Atropine bolus injection (0.04 mg/kg) did not increase heart rate further. Targeting a single spot of the left side (64% of the patients) or right side (36%) of the interatrial septum was observed to be responsible for ≥80% of the final R-R and AH interval shortening during ablation. CONCLUSIONS: Targeting specific sites of the interatrial septum is followed by an increase in heart rate and atrioventricular nodal conduction properties and might be critical for vagal attenuation. The R-R interval, Wenckebach cycle length, and AH interval shortening, associated with a negative response to atropine, could be considered immediate end points of the procedure.
[Mh] Termos MeSH primário: Denervação Autônoma/métodos
Bradicardia/cirurgia
Sistema de Condução Cardíaco/cirurgia
Septos Cardíacos/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bloqueio Atrioventricular/cirurgia
Eletrocardiografia
Determinação de Ponto Final
Feminino
Frequência Cardíaca
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Nó Sinoatrial/cirurgia
Síncope Vasovagal/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1161/CIRCEP.116.004638


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[PMID]:28159317
[Au] Autor:Casteleijn NF; van Gastel MD; Blankestijn PJ; Drenth JP; de Jager RL; Leliveld AM; Stellema R; Wolff AP; Groen GJ; Gansevoort RT; DIPAK Consortium
[Ad] Endereço:Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
[Ti] Título:Novel treatment protocol for ameliorating refractory, chronic pain in patients with autosomal dominant polycystic kidney disease.
[So] Source:Kidney Int;91(4):972-981, 2017 Apr.
[Is] ISSN:1523-1755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autosomal dominant polycystic kidney disease (ADPKD) patients can suffer from chronic pain that can be refractory to conventional treatment, resulting in a wish for nephrectomy. This study aimed to evaluate the effect of a multidisciplinary treatment protocol with sequential nerve blocks on pain relief in ADPKD patients with refractory chronic pain. As a first step a diagnostic, temporary celiac plexus block with local anesthetics was performed. If substantial pain relief was obtained, the assumption was that pain was relayed via the celiac plexus and major splanchnic nerves. When pain recurred, patients were then scheduled for a major splanchnic nerve block with radiofrequency ablation. In cases with no pain relief, it was assumed that pain was relayed via the aortico-renal plexus, and catheter-based renal denervation was performed. Sixty patients were referred, of which 44 were eligible. In 36 patients the diagnostic celiac plexus block resulted in substantial pain relief with a change in the median visual analogue scale (VAS) score pre-post intervention of 50/100. Of these patients, 23 received a major splanchnic nerve block because pain recurred, with a change in median VAS pre-post block of 53/100. In 8 patients without pain relief after the diagnostic block, renal denervation was performed in 5, with a borderline significant change in the median VAS pre-post intervention of 20/100. After a median follow-up of 12 months, 81.8% of the patients experienced a sustained improvement in pain intensity, indicating that our treatment protocol is effective in obtaining pain relief in ADPKD patients with refractory chronic pain.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Denervação Autônoma/métodos
Ablação por Cateter
Plexo Celíaco/efeitos dos fármacos
Dor Crônica/terapia
Rim/inervação
Bloqueio Nervoso/métodos
Rim Policístico Autossômico Dominante/complicações
Nervos Esplâncnicos/cirurgia
[Mh] Termos MeSH secundário: Adulto
Anestésicos Locais/efeitos adversos
Denervação Autônoma/efeitos adversos
Ablação por Cateter/efeitos adversos
Dor Crônica/diagnóstico
Dor Crônica/etiologia
Dor Crônica/fisiopatologia
Protocolos Clínicos
Feminino
Seres Humanos
Masculino
Meia-Idade
Bloqueio Nervoso/efeitos adversos
Medição da Dor
Rim Policístico Autossômico Dominante/diagnóstico
Recidiva
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28143710
[Au] Autor:Mai TH; Garland EM; Diedrich A; Robertson D
[Ad] Endereço:Department of Pharmacology, Vanderbilt University, Nashville, TN, United States; Department of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.
[Ti] Título:Hepatic and renal mechanisms underlying the osmopressor response.
[So] Source:Auton Neurosci;203:58-66, 2017 Mar.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Increased blood pressure (BP) is observed in patients with impaired baroreflexes after water drinking. The stimulus for this effect is low blood osmolality, and it has been termed the osmopressor response (OPR). The BP increase is associated with activation of the sympathetic nervous system and a requirement for transient receptor potential vanilloid 4 (TRPV4) channels. However, the mechanisms underlying the OPR are poorly understood. We tested the hypothesis that hypotonicity is sensed in the portal area to initiate the OPR. Sino-aortic denervated mice were used and BP was monitored for 30min after fluid infusion while mice were under anesthesia. Infusion of hypotonic fluid (0.45% saline), but not of isotonic 0.9% saline, directly into the portal vein, produced an immediate OPR (increase in BP with saline 0.45%: 15±13 vs. 0.9%: -7±2mmHg, p=0.003; AUC: 0.45%: 150±99, n=7 vs. 0.9%: -74±60mmHg·min, n=5, p=0.003). However, 0.45% saline was not able to trigger a similar response in TRPV4 mice (ΔBP : -2±5mmHg, n=8, p=0.009). Hypotonic saline did not raise BP when infused at the same speed and volume into the jugular vein (jugular: -5±6mmHg, p=0.002, compared to portal). Denervation of the splanchnic nerve by celiac ganglionectomy (CGX) did not abolish the OPR (CGX: 15±11 vs. Sham: 16±6mmHg, p=0.34). Renal denervation diminished the OPR elicited by duodenal water infusion (denervation: 9±4 vs. sham: 31±15mmHg, p=0.016). Therefore, hypotonicity in the portal circulation, probably sensed by TRPV4 channels, triggers the OPR and intact renal nerves are needed for the full response.
[Mh] Termos MeSH primário: Barorreflexo/fisiologia
Pressão Sanguínea/fisiologia
Ingestão de Líquidos/fisiologia
Rim/metabolismo
Fígado/metabolismo
[Mh] Termos MeSH secundário: Animais
Denervação Autônoma
Água Potável/administração & dosagem
Duodeno/metabolismo
Soluções Hipotônicas/administração & dosagem
Veias Jugulares/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Modelos Animais
Concentração Osmolar
Veia Porta/metabolismo
Cloreto de Sódio na Dieta/administração & dosagem
Nervos Esplâncnicos/metabolismo
Canais de Cátion TRPV/genética
Canais de Cátion TRPV/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Hypotonic Solutions); 0 (Sodium Chloride, Dietary); 0 (TRPV Cation Channels); 0 (Trpv4 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE


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[PMID]:28091707
[Au] Autor:Sabbatini M; Grossini E; Molinari C; Mary DA; Vacca G; Cannas M
[Ad] Endereço:Department of Science and Technology Innovation, University of Eastern Piedmont, UPO, T. Michel, 11, Alessandria, 15121, Italia. maurizio.sabbatini@uniupo.it.
[Ti] Título:Gastric distension causes changes in heart rate and arterial blood pressure by affecting the crosstalk between vagal and splanchnic systems in anesthetised rats.
[So] Source:Exp Brain Res;235(4):1081-1095, 2017 Apr.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Various hindbrain nuclei have been demonstrated to be involved in the control of the cardiovascular reflexes elicited by both non-noxious and noxious gastric distension, through parasympathetic and sympathetic activation. The different role played by the branches of autonomic nervous system in exerting these effects and their crosstalk in relation to low-/high-pressure distension rate has not been examined yet. Therefore, in the present work, monolateral and bilateral vagotomy and splanchnicotomy were performed in anesthetised rats to analyse the involvement of hindbrain nuclei in haemodynamic changes caused by gastric distension at high (80 mmHg) and low (15 mmHg) pressure. The analysis of c-Fos expression in neuronal areas involved in cardiovascular control allowed us to examine their recruitment in response to various patterns of gastric distension and the crosstalk between vagal and splanchnic systems. The results obtained show that the low-pressure (non-noxious) gastric distension increases both heart rate and arterial blood pressure. In addition, the vagus nerve and hindbrain nuclei, such as nucleus ambiguous, ventrolateral medulla and lateral reticular nucleus, appear to be primarily involved in observed responses. In particular, we have found that although vagus nerve plays a central role in exerting those cardiovascular reflex changes at low gastric distension, for its functional expression an intact splanchnic system is mandatory. Hence, the absence of splanchnic input attenuates pressor responses or turns them into depressor responses. Instead at high-pressure (noxious) gastric distension, the splanchnic nerve represents the primary component in regulating the reflex cardiovascular effects.
[Mh] Termos MeSH primário: Anestesia
Pressão Sanguínea/fisiologia
Frequência Cardíaca/fisiologia
Nervos Esplâncnicos/fisiologia
Estômago/inervação
Nervo Vago/fisiologia
[Mh] Termos MeSH secundário: Animais
Denervação Autônoma
Bulbo/citologia
Bulbo/metabolismo
Neurônios/metabolismo
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos
Ratos Sprague-Dawley
Fluxo Sanguíneo Regional/fisiologia
Fibras Aferentes Viscerais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-fos)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1007/s00221-016-4819-x


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[PMID]:27884235
[Au] Autor:Bennett AL; Ventura HO
[Ad] Endereço:Department of Internal Medicine, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address: amanda.bennett@ochsner.org.
[Ti] Título:Hypertension in Patients with Cardiac Transplantation.
[So] Source:Med Clin North Am;101(1):53-64, 2017 Jan.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertension is a common complication among post cardiac transplant recipients affecting more than 95% of patients. Increased blood pressure poses a significant cardiovascular morbidity and mortality in these patients; it should be identified quickly and needs to be managed appropriately. Understanding the pathophysiology and contributing factors to this disease in these complex and unique patients is the key to appropriate treatment selection.
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Inibidores de Calcineurina/efeitos adversos
Transplante de Coração/efeitos adversos
Hipertensão/tratamento farmacológico
Hipertensão/fisiopatologia
[Mh] Termos MeSH secundário: Corticosteroides/efeitos adversos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Denervação Autônoma/efeitos adversos
Inibidores de Calcineurina/farmacologia
Bloqueadores dos Canais de Cálcio/uso terapêutico
Diuréticos/uso terapêutico
Coração/inervação
Hemodinâmica
Seres Humanos
Hipertensão/etiologia
Imunossupressores/efeitos adversos
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Antihypertensive Agents); 0 (Calcineurin Inhibitors); 0 (Calcium Channel Blockers); 0 (Diuretics); 0 (Immunosuppressive Agents); 0 (Vasodilator Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE


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[PMID]:27194540
[Au] Autor:Fukunaga M; Wichterle D; Peichl P; Aldhoon B; Cihák R; Kautzner J
[Ad] Endereço:Department of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Vídenská 1958/9, Prague 140 21, Czech Republic.
[Ti] Título:Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block.
[So] Source:Europace;19(1):119-126, 2017 Jan.
[Is] ISSN:1532-2092
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: In patients with severe neurally mediated syncope (NMS), radiofrequency catheter ablation (RFA) of ganglionic plexi (GP) has been proposed as a new therapeutic approach. Cardio-inhibitory response during NMS is usually related to the sinoatrial (SA) and less frequently to atrioventricular (AV) node. Differential effect of GP ablation on SA and AV node is poorly understood. METHODS AND RESULTS: We report a case of a 35-year-old female with frequent symptomatic episodes of advanced AV block treated by anatomically guided RFA at empirical sites of GPs. After RFA at the septal portion of the right atrium-superior vena cava junction, heart rate accelerated from 62 to 91 beats/min and PR interval prolonged from 213 to 344 ms. Sustained first-degree AV block allowed to observe directly the effects of subsequent RFA on the AV nodal properties. Subsequent RFA at right- and left-sided aspects of the inter-atrial septum had no further effect on heart rate and PR interval. Ablation at the inferior left GP was critical for restoration of normal AV conduction (final PR interval of 187 ms). No bradycardia episodes were observed by implantable loop recorder during the follow-up of 10 months and the patient was symptomatically improved. CONCLUSION: This is the first clinical case showing the differential effect of GP ablation on SA and AV nodal function, and critical importance of targeting the GP at the postero-inferior left atrium. The successful procedure corroborates clinical utility of ablation treatment instead of pacemaker implantation in selected patients with cardio-inhibitory NMS.
[Mh] Termos MeSH primário: Bloqueio Atrioventricular/cirurgia
Nó Atrioventricular/fisiopatologia
Denervação Autônoma/métodos
Ablação por Cateter
Gânglios Autônomos/cirurgia
Nó Sinoatrial/fisiopatologia
Síncope Vasovagal/cirurgia
[Mh] Termos MeSH secundário: Potenciais de Ação
Adulto
Bloqueio Atrioventricular/diagnóstico
Bloqueio Atrioventricular/fisiopatologia
Eletrocardiografia
Técnicas Eletrofisiológicas Cardíacas
Feminino
Gânglios Autônomos/fisiopatologia
Frequência Cardíaca
Seres Humanos
Recidiva
Índice de Gravidade de Doença
Síncope Vasovagal/diagnóstico
Síncope Vasovagal/fisiopatologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1093/europace/euw100


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[PMID]:27716558
[Au] Autor:Cianci R; Barbano B; Gigante A; Rosato E; Zaccaria A; Mangialardi N
[Ad] Endereço:Department of Clinical Medicine, Sapienza University of Rome, Italy.
[Ti] Título:Early pre-occlusive bilateral renal artery stenosis after renal denervation.
[So] Source:Int J Cardiol;225:96-98, 2016 Dec 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Denervação Autônoma/efeitos adversos
Ablação por Cateter/efeitos adversos
Hipertensão/diagnóstico por imagem
Hipertensão/cirurgia
Obstrução da Artéria Renal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Angiografia/métodos
Denervação Autônoma/métodos
Ablação por Cateter/métodos
Feminino
Seguimentos
Seres Humanos
Rim/irrigação sanguínea
Rim/inervação
Rim/cirurgia
Artéria Renal/diagnóstico por imagem
Artéria Renal/inervação
Artéria Renal/cirurgia
Obstrução da Artéria Renal/etiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27550916
[Au] Autor:Asirvatham-Jeyaraj N; Fiege JK; Han R; Foss J; Banek CT; Burbach BJ; Razzoli M; Bartolomucci A; Shimizu Y; Panoskaltsis-Mortari A; Osborn JW
[Ad] Endereço:From the Department of Integrative Biology and Physiology (N.A.-J., R.H., J.F., C.T.B., M.R., A.B., J.W.O.), Laboratory Medicine and Pathology (J.K.F., B.J.B., Y.S.), and Pediatrics (A.P.-M.), University of Minnesota, Minneapolis.
[Ti] Título:Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice.
[So] Source:Hypertension;68(4):929-36, 2016 Oct.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertension often occurs in concurrence with obesity and diabetes mellitus, commonly referred to as metabolic syndrome. Renal denervation (RDNx) lowers arterial pressure (AP) and improves glucose metabolism in drug-resistant hypertensive patients with high body mass index. In addition, RDNx has been shown to reduce renal inflammation in the mouse model of angiotensin II hypertension. The present study tested the hypothesis that RDNx reduces AP and renal inflammation and improves glucose metabolism in obesity-induced hypertension. Eight-week-old C57BL/6J mice were fed either a low-fat diet (10 kcal%) or a high-fat diet (45 kcal%) for 10 weeks. Body weight, food intake, fasting blood glucose, and glucose metabolism (glucose tolerance test) were measured. In a parallel study, radiotelemeters were implanted in mice for AP measurement. High fat-fed C57BL/6J mice exhibited an inflammatory and metabolic syndrome phenotype, including increased fat mass, increased AP, and hyperglycemia compared with low-fat diet mice. RDNx, but not Sham surgery, normalized AP in high-fat diet mice (115.8±1.5 mm Hg in sham versus 96.6±6.7 mm Hg in RDNx). RDNx had no significant effect on AP in low-fat diet mice. Also, RDNx had no significant effect on glucose metabolism or renal inflammation as measured by the number of CD8, CD4, and T helper cells or levels of inflammatory cytokines in the kidneys. These results indicate that although renal nerves play a role in obesity-induced hypertension, they do not contribute to impaired glucose metabolism or renal inflammation in this model.
[Mh] Termos MeSH primário: Pressão Arterial/fisiologia
Denervação Autônoma/métodos
Hipertensão/fisiopatologia
Rim/cirurgia
Nefrite/patologia
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Peso Corporal
Citocinas/metabolismo
Dieta Hiperlipídica
Modelos Animais de Doenças
Citometria de Fluxo
Hipertensão/etiologia
Imuno-Histoquímica
Rim/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Nefrite/fisiopatologia
Obesidade/complicações
Distribuição Aleatória
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cytokines)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.116.07993



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