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[PMID]:29194069
[Au] Autor:Napier ML; Azuara-Blanco A
[Ad] Endereço:Ophthalmology Department, Royal Victoria Hospital.
[Ti] Título:Changing patterns in treatment of angle closure glaucoma.
[So] Source:Curr Opin Ophthalmol;29(2):130-134, 2018 Mar.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Angle closure glaucoma is a leading cause of blindness globally and trends of how best to treat this disease are evolving. The advent of anterior segment imaging aids our understanding of pathogenesis and allows more robust and objective measurement of treatment modalities. We will also review recent literature regarding the role of laser and surgical interventions for the treatment of primary angle closure disease. RECENT FINDINGS: Recent studies evaluating the efficacy of laser peripheral iridotomy (LPI) in primary angle closure suspects (PACs) show that while it is a safe intervention and initially anterior chamber angle widens following the laser treatment, the effect is lost with time. Only a small minority of PACs patients develop primary angle closure (PAC) or primary angle closure glaucoma (PACG). Trials evaluating argon laser peripheral iridoplasty (ALPI) have failed to show a substantial clinical benefit. In patients with early or moderate PACG and those with PAC with IOP over 30 mmHg, clear lens extraction is associated with better clinical and quality of life outcomes than LPI. SUMMARY: Recent evidence supports initial clear lens extraction in the context of PACG or primary angle closure with IOP more than 30 mmHg.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Fechado/cirurgia
Iridectomia/métodos
Iris/cirurgia
Terapia a Laser/métodos
[Mh] Termos MeSH secundário: Glaucoma de Ângulo Fechado/fisiopatologia
Seres Humanos
Pressão Intraocular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000453


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[PMID]:28887116
[Au] Autor:Baskaran M; Yang E; Trikha S; Kumar RS; Wong HT; He M; Chew PTK; Foster PJ; Friedman D; Aung T
[Ad] Endereço:Singapore Eye Research Institute and Singapore National Eye Center, Singapore; Duke-NUS Medical School, Singapore.
[Ti] Título:Residual Angle Closure One Year After Laser Peripheral Iridotomy in Primary Angle Closure Suspects.
[So] Source:Am J Ophthalmol;183:111-117, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the incidence and baseline clinical and anterior segment optical coherence tomography (AS-OCT) predictors associated with residual angle closure as assessed by gonioscopy 1 year after laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS). DESIGN: Subanalysis of randomized controlled trial data. METHODS: AS-OCT images from 181 PACS subjects ≥50 years of age were analyzed using customized software before and 1 year after LPI. Other parameters assessed were intraocular pressure (IOP) and axial length (Axl). Residual angle closure was defined as the inability to see the posterior trabecular meshwork for at least 2 quadrants on gonioscopy after LPI. Multivariate regression analysis determined the baseline predictors of residual angle closure 1 year after LPI. RESULTS: The mean age of participants was 62.4 (standard deviation 9.9) years. The majority were female (137, 75.7%) and Chinese (174, 96.1%). At 1 year post LPI, 148 (81.8%) subjects had gonioscopic residual angle closure. Univariate analysis showed that baseline Axl, anterior chamber area, anterior chamber volume, angle opening distance at 750 µm from the scleral spur, and angle recess area were smaller while baseline lens vault and iris curvature were larger in residual angle closure subjects (all P < .05). Multivariate analysis revealed that baseline iris volume (B = -0.08, P = .035) and baseline IOP (B = 0.23, P = .032) were predictors for residual angle closure. CONCLUSIONS: One year after LPI, >80% of PACS had gonioscopic residual angle closure. Greater baseline iris volume and higher IOP at baseline are independent risk factors for residual gonioscopic angle closure.
[Mh] Termos MeSH primário: Câmara Anterior/diagnóstico por imagem
Glaucoma de Ângulo Fechado/cirurgia
Pressão Intraocular
Iridectomia/métodos
Terapia a Laser/métodos
Lasers de Estado Sólido/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Glaucoma de Ângulo Fechado/diagnóstico
Glaucoma de Ângulo Fechado/fisiopatologia
Gonioscopia
Seres Humanos
Iris/diagnóstico por imagem
Iris/cirurgia
Masculino
Meia-Idade
Período Pós-Operatório
Estudos Prospectivos
Fatores de Tempo
Tomografia de Coerência Óptica
Tonometria Ocular
Malha Trabecular/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE


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[PMID]:28650856
[Au] Autor:Grover IG; Senthil S; Murthy S; Reddy JC
[Ad] Endereço:LV Prasad Eye Institute, Hyderabad, India.
[Ti] Título:A Rare Case of Pupillary Block Glaucoma Following CentraFLOW Implantable Collamer Lens Surgery.
[So] Source:J Glaucoma;26(8):694-696, 2017 Aug.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 28-year-old lady with a refractive error of -11.0 D sphere/-1.50 D cylinder at 160 degrees in the right eye underwent an uneventful Implantable Collamer Lens surgery (ICL) with a V4c model, which uses a central Aquaport. This ICL does not require preoperative laser iridotomy or surgical iridectomy, as the centraflow opening is designed to prevent pupillary block. At postoperative day 1, her visual acuity in the right eye was 20/400, with diffuse microcystic corneal edema with fixed, dilated pupil and high intraocular pressure. Following intravenous mannitol, the corneal edema resolved. It was then noted that the ICL was anteriorly displaced, creating acute pupillary block, presumably due to obstruction of the central Aquaport with viscoelastic and inflammatory debris. She underwent AC wash the same day that helped in IOP control; however, the pupil remained permanently dilated and fixed because of extensive sphincter atrophy as a result of acute pupillary block. By 1 month, the visual acuity was 20/30 with an IOP of 14 mm Hg, which was maintained at 1-year follow-up. We report the first case of pupillary block glaucoma with this particular ICL design, suggesting the need for careful attention to complete removal of viscoelastic in the anterior chamber and behind the ICL, to prevent such complications and their cosmetically unacceptable sequelae.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Fechado/etiologia
Implante de Lente Intraocular/efeitos adversos
Lentes Intraoculares Fácicas/efeitos adversos
Distúrbios Pupilares/etiologia
[Mh] Termos MeSH secundário: Adulto
Edema da Córnea/etiologia
Feminino
Glaucoma de Ângulo Fechado/fisiopatologia
Seres Humanos
Pressão Intraocular/fisiologia
Iridectomia
Cristalino
Miopia/cirurgia
Distúrbios Pupilares/fisiopatologia
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000705


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[PMID]:28557825
[Au] Autor:Tognetto D; De Giacinto C; Cirigliano G
[Ad] Endereço:Eye Clinic, University of Trieste, Trieste, Italy.
[Ti] Título:Suture of Symptomatic YAG Laser Peripheral Iridotomies Following Phakic Intraocular Lens Implantation.
[So] Source:J Glaucoma;26(7):675-677, 2017 Jul.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 45-year-old woman complained of glare and photophobia after iris-fixated phakic intraocular lens (IFPIOL) implantation in her left eye. The patient underwent prophylactic laser peripheral iridotomies (LPIs) 2 days before surgery. The uncorrected visual acuity after surgery was 20/20 and the intraocular pressure was 14 mm Hg. The slit-lamp examination showed a well-centered IFPIOL and 2 LPIs at 10 and 2 o'clock partially covered by the upper lid. Twenty days after IFPIOL implantation, as symptoms persisted and were intolerable to the patient, we decide to suture iridotomies using a modified Siepser slip-knot technique. Postoperatively, visual acuity remains 20/20 and patient reported a complete disappearance of symptoms. No intraoperative and postoperative complications were noted. Experiencing glare and photophobia is a rare side effect due to LPI. Suture of iridotomies using a modified Siepser slip-knot technique can be considered a safe and effective procedure to solve this annoying complication.
[Mh] Termos MeSH primário: Iridectomia
Iris/cirurgia
Lasers de Estado Sólido/uso terapêutico
Implante de Lente Intraocular
Lentes Intraoculares Fácicas
Técnicas de Sutura
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Pressão Intraocular
Terapia a Laser/métodos
Meia-Idade
Miopia/complicações
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000688


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[PMID]:28356143
[Au] Autor:Bang SP; Joo CK; Jun JH
[Ad] Endereço:Department of Ophthalmology, Dongsan Medical Center, Keimyung University School of Medicine, #56, Dalseong-ro, Jung-gu, 41931, Daegu, South Korea.
[Ti] Título:Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study.
[So] Source:BMC Ophthalmol;17(1):35, 2017 Mar 29.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To report the clinical features of patients with reverse pupillary block (RPB) after scleral-sutured posterior chamber intraocular lens (PC IOL) implantation and biometric changes after laser peripheral iridotomy (LPI). METHODS: Eight patients attending our hospital's ophthalmology outpatient clinic, who developed RPB after implantation of a scleral-sutured PC IOL due to subluxation of the crystalline lens or IOL, were investigated in this retrospective, observational study. RESULTS: Preoperative evaluations showed angle pigmentation in all cases and iridodonesis in 2 cases. Two subjects had used an α -adrenoceptor antagonist for benign prostatic hyperplasia. Pars plana or anterior partial vitrectomy was performed in all cases. All eyes showed an extremely deep anterior chamber, a concave iris configuration, and contact between the IOL optic and the iris at the pupillary margin. Pupil capture was detected in 2 cases. The mean (± SD) anterior chamber angle (ACA) was 89.91 ± 10.06°, and the anterior chamber depth (ACD) was 4.42 ± 0.16 mm before LPI. After LPI, the iris immediately became flat with a decreased ACA (51.70 ± 2.59°; P = 0.018) and ACD (4.14 ± 0.15 mm; P = 0.012). After LPI, the intraocular pressure decreased from 19.75 ± 3.77 mmHg to 15.63 ± 4.30 mmHg (P = 0.011), and the spherical equivalent decreased from -0.643 ± 0.385 D to - 0.875 ± 0.505 D (P = 0.016). CONCLUSION: Concomitant vitrectomy, angle pigmentation, and iridodonesis may be risk factors for RPB after scleral-sutured PC IOL implantation. LPI is effective for relieving the RPB.
[Mh] Termos MeSH primário: Iris/cirurgia
Terapia a Laser/efeitos adversos
Lentes Intraoculares
Distúrbios Pupilares/etiologia
Esclera/cirurgia
Técnicas de Sutura
Acuidade Visual
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Pressão Intraocular
Iridectomia
Masculino
Meia-Idade
Distúrbios Pupilares/diagnóstico
Estudos Retrospectivos
Vitrectomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0427-1


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[PMID]:28234682
[Au] Autor:Peracha-Riyaz MH; Peracha ZH; Spaulding J; Baciu P; Ahmed S; Imami NR; Darnley-Fisch D; Desai U
[Ad] Endereço:Henry Ford Health System Department of Ophthalmology, Detroit, MI.
[Ti] Título:First Described Case of Anterior and Posterior Segment Crystals in Phacolytic Glaucoma.
[So] Source:J Glaucoma;26(5):e171-e173, 2017 May.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phacolytic glaucoma is an open-angle glaucoma that occurs when lens proteins from hypermature cataracts seep through an intact anterior capsule and induce obstruction of the trabecular meshwork by inflammatory cells. We review the case of a 66-year-old man who presented with acute pain, a hypermature cataract, prominent anterior chamber crystals, and elevated intraocular pressure. After cataract surgery was performed, iridescent crystals were noted in the posterior chamber. Anterior chamber crystals have been associated with phacolytic glaucoma, but this is the first case demonstrating crystals in the posterior chamber as well.
[Mh] Termos MeSH primário: Segmento Anterior do Olho/patologia
Catarata/complicações
Cristalinas/efeitos adversos
Glaucoma de Ângulo Aberto/etiologia
Segmento Posterior do Olho/patologia
[Mh] Termos MeSH secundário: Idoso
Cristalização
Dor Ocular/etiologia
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Ângulo Aberto/cirurgia
Seres Humanos
Pressão Intraocular
Iridectomia
Masculino
Facoemulsificação
Tonometria Ocular
Malha Trabecular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Crystallins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000642


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[PMID]:27939562
[Au] Autor:Snyder ME; Osher RH; Wladecki TM; Perez MA; Augsburger JJ; Corrêa Z
[Ad] Endereço:Department of Ophthalmology, University of Cincinnati and Cincinnati Eye Institute, Cincinnati, Ohio. Electronic address: msnyder@cincinnatieye.com.
[Ti] Título:Results in Combined Cataract Surgery With Prosthetic Iris Implantation in Patients With Previous Iridocyclectomy for Iris Melanoma.
[So] Source:Am J Ophthalmol;175:45-51, 2017 Mar.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To present visual and functional results following implantation of iris prosthesis combined with cataract surgery in eyes with previous iridocyclectomy for iris melanoma or presumed iris melanoma. DESIGN: Retrospective noncomparative case series. METHODS: Sixteen patients (16 eyes) with iris defects after iridocyclectomy for iris melanoma in 15 cases and iris adenoma in 1 case underwent prosthetic iris device implantation surgery. Prosthetic iris implantation was combined with phacoemulsification and intraocular lens (IOL) implantation. The visual acuity, subjective glare and photophobia reduction, anatomic outcome, and complications were reviewed. RESULTS: Best-corrected visual acuity was improved in 13 eyes (81.25%), remained stable in 2 eyes (12.25%), and decreased in 1 eye (6.25%). Photophobia and glare improved in every case except for 1 (93.75%). Notably, after surgery 12 patients (75.00%) reported no photophobia and 10 patients (62.50%) reported no glare. The median postoperative follow-up was 29.5 months, with a minimum of 5 months and a maximum of 189 months. All iris devices were in the correct position, and all eyes achieved the desired anatomic result. The IOL optic edges were covered in all areas by either residual iris or opaque portions of a prosthetic iris device. CONCLUSIONS: In patients who have undergone previous iridocyclectomy for presumed iris melanoma, combined cataract surgery and iris prosthesis placement, with or without iris reconstruction, can lead to visual improvement as well as reduction of both glare and photophobia.
[Mh] Termos MeSH primário: Extração de Catarata/métodos
Catarata/complicações
Iridectomia/métodos
Neoplasias da Íris/cirurgia
Iris/cirurgia
Melanoma/cirurgia
Implante de Prótese/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Neoplasias da Íris/complicações
Neoplasias da Íris/diagnóstico
Melanoma/complicações
Melanoma/diagnóstico
Meia-Idade
Desenho de Prótese
Estudos Retrospectivos
Resultado do Tratamento
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27927679
[Au] Autor:Bourne RRA; Zhekov I; Pardhan S
[Ad] Endereço:Vision & Eye Research Unit, Postgraduate Medical Institute, Anglia Ruskin University, Cambridge, UK.
[Ti] Título:Temporal ocular coherence tomography-measured changes in anterior chamber angle and diurnal intraocular pressure after laser iridoplasty: IMPACT study.
[So] Source:Br J Ophthalmol;101(7):886-891, 2017 Jul.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To evaluate temporal change in anterior chamber angle anatomy following argon laser peripheral iridoplasty (ALPI) in eyes with occludable angles postlaser peripheral iridotomy (LPI) compared with control eyes. Additionally, the effect on diurnal intraocular pressure (DIOP) fluctuation (maximum-minimum IOP) was investigated. METHODS: Twenty-two patients with bilateral primary angle closure/suspects with gonioscopically occludable anterior chamber angles following LPI were randomised to receive ALPI (n=11) or no further treatment (n=11). Angle opening distance (AOD), trabecular-iris angle, angle recess area and trabecular-iris space area were measured over eight sections with swept-source anterior segment optical coherence tomography and DIOP was measured pre-LPI and repeated at 3 months after ALPI (hourly measures). RESULTS: All angle parameters increased following ALPI. This change was maintained for 3 months in seven of the eight sections (eg, inferotemporal AOD500 increased by 0.063 mm, p=0.004 at 1 day; 0.051 mm, p=0.029 at 1 week; 0.059 mm, p=0.006 at 6 weeks and 0.056 mm, p=0.011 at 3 months). The only exception was in the inferior sector (eg, AOD500 increased by 0.041 mm, p=0.025 at 1 day and by 0.029 mm, p=0.054 at 3 months). DIOP at 3 months was significantly reduced (5.04 mm Hg; ±1.61 mm Hg) compared with controls (6.61 mm Hg; ±1.63 mm Hg). Maximum IOP was significantly greater in the non-ALPI group (1.87 mm Hg, p=0.026). CONCLUSIONS: ALPI widened all angle sections in eyes that remained occludable post-LPI. Changes were maintained for 3 months. ALPI decreased DIOP fluctuation in the treated eyes by lowering the maximum IOP value.
[Mh] Termos MeSH primário: Câmara Anterior/diagnóstico por imagem
Ritmo Circadiano/fisiologia
Glaucoma de Ângulo Aberto/cirurgia
Pressão Intraocular/fisiologia
Iridectomia/métodos
Terapia a Laser/métodos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Câmara Anterior/fisiopatologia
Câmara Anterior/cirurgia
Método Duplo-Cego
Feminino
Seguimentos
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Ângulo Aberto/fisiopatologia
Gonioscopia
Seres Humanos
Lasers de Estado Sólido/uso terapêutico
Masculino
Meia-Idade
Período Pós-Operatório
Estudos Prospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-308720


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[PMID]:27911450
[Au] Autor:Kaliki S; Shields CL
[Ad] Endereço:The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.
[Ti] Título:Uveal melanoma: relatively rare but deadly cancer.
[So] Source:Eye (Lond);31(2):241-257, 2017 Feb.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation. Currently, the most widely used first-line treatment options for this malignancy are resection, radiation therapy, and enucleation. There are two main types of radiation therapy: plaque brachytherapy (iodine-125, ruthenium-106, or palladium-103, or cobalt-60) and teletherapy (proton beam, helium ion, or stereotactic radiosurgery using cyber knife, gamma knife, or linear accelerator). The alternative to radiation is enucleation. Although these therapies achieve satisfactory local disease control, long-term survival rate for patients with uveal melanoma remains guarded, with risk for liver metastasis. There have been advances in early diagnosis over the past few years, and with the hope survival rates could improve as smaller tumors are treated. As in many other cancer indications, both early detection and early treatment could be critical for a positive long-term survival outcome in uveal melanoma. These observations call attention to an unmet medical need for the early treatment of small melanocytic lesions or small melanomas in the eye to achieve local disease control and vision preservation with the possibility to prevent metastases and improve overall patient survival.
[Mh] Termos MeSH primário: Melanoma
Neoplasias Uveais
[Mh] Termos MeSH secundário: Distribuição por Idade
Terapia Combinada
Seres Humanos
Incidência
Iridectomia/métodos
Melanoma/epidemiologia
Melanoma/etiologia
Melanoma/patologia
Melanoma/terapia
Radiocirurgia/métodos
Radioterapia/métodos
Fatores de Risco
Distribuição por Sexo
Proteínas Supressoras de Tumor/genética
Ubiquitina Tiolesterase/genética
Raios Ultravioleta/efeitos adversos
Neoplasias Uveais/epidemiologia
Neoplasias Uveais/etiologia
Neoplasias Uveais/patologia
Neoplasias Uveais/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Tumor Suppressor Proteins); EC 3.1.2.15 (BAP1 protein, human); EC 3.4.19.12 (Ubiquitin Thiolesterase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2016.275


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[PMID]:27758063
[Au] Autor:Lorenz K; Beck S; Keilani MM; Wasielica-Poslednik J; Pfeiffer N; Grus FH
[Ad] Endereço:Department of Experimental Ophthalmology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
[Ti] Título:Course of serum autoantibodies in patients after acute angle-closure glaucoma attack.
[So] Source:Clin Exp Ophthalmol;45(3):280-287, 2017 Apr.
[Is] ISSN:1442-9071
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of our investigation was to analyze the autoantibody -reactivities of patients after acute angle-closure glaucoma (AACG) by means of a protein microarray approach to identify intraocular pressure(IOP)-dependent antibodies. METHODS: Collected sera from different study time points (AACG n = 6, 0, 2, 4 and 12 weeks) and control group (CTRL n = 11, 0 and 12 weeks) were analyzed. Protein-microarrays were incubated with sera, and occurring immunoreactivities were visualized with fluorescence labeled secondary antibodies. To detect changes, spot intensities were digitized and compared with statistical techniques. RESULTS: Three autoantibodies with significant level-alteration in the time course of the survey could be identified. Immunoreactivities to heat shock 27-kDa protein (HSP27), tubulin-tyrosine ligase-like protein 12 (TTLL12), and neuron-specific enolase (NSE) show an increasing linear trend from week 0 up to week 12 with a positive correlation coefficient (P ≤ 0.05, r ≥ 0.4). In the CTRL- group, no significant alterations could be detected in corresponding autoantibody-level. Analysis of variance revealed significant changes of antibody-level between certain time points (anti-HSP27 antibody [week 0 vs. 2], anti-TTLL12 antibody [week 0 vs. 12], and anti-NSE antibody [week 4 vs. 12] [P ≤ 0.05, respectively]) in AACG group. CONCLUSIONS: With this autoantibodies profiling approach, we were able to detect autoimmune reactivities in sera of patients without former indication for glaucomatous damage after rise of IOP due to AACG attack. After further validation in subsequent studies, this autoantibodies could give further insights into the pathogenesis of glaucoma and could possibly help to understand the effect of IOP on glaucomatous optic neuropathy.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Autoantígenos/imunologia
Glaucoma de Ângulo Fechado/imunologia
Proteínas de Choque Térmico HSP27/imunologia
Peptídeo Sintases/imunologia
Fosfopiruvato Hidratase/imunologia
[Mh] Termos MeSH secundário: Doença Aguda
Feminino
Glaucoma de Ângulo Fechado/cirurgia
Seres Humanos
Pressão Intraocular/fisiologia
Iridectomia
Iris/cirurgia
Lasers de Estado Sólido/uso terapêutico
Masculino
Meia-Idade
Projetos Piloto
Análise Serial de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Autoantigens); 0 (HSP27 Heat-Shock Proteins); 0 (HSPB1 protein, human); EC 4.2.1.11 (Phosphopyruvate Hydratase); EC 6.3.2.- (Peptide Synthases); EC 6.3.2.- (TTLL12 protein, human)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1111/ceo.12864



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