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[PMID]:29231624
[Au] Autor:Brean A
[Ti] Título:The resurrection of the body and the life everlasting.
[Ti] Título:Legemets oppstandelse og det evige liv..
[So] Source:Tidsskr Nor Laegeforen;137(23-24), 2017 12 12.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Mh] Termos MeSH primário: Criopreservação/tendências
Cabeça/cirurgia
Transplante/tendências
[Mh] Termos MeSH secundário: Seres Humanos
Transplante/ética
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.1062


  2 / 5470 MEDLINE  
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[PMID]:29381954
[Au] Autor:Chen Z; Zhang L; Yang C; Jiang Z; Shen H; Gui G
[Ad] Endereço:Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan.
[Ti] Título:Effect of MDR1 C1236T polymorphism on cyclosporine pharmacokinetics: A systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);96(47):e8700, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cyclosporine (CsA) is one of the immunosuppressive drugs, whose pharmacokinetic characteristics vary greatly among individuals. The published data reveal conflicting effects of the polymorphism of MDR1 exon 12 SNP C1236T on the pharmacokinetics of cyclosporine.This study aims to conduct a meta-analysis to investigate the effect of SNP C1236T on the pharmacokinetics of cyclosporine. METHODS: A literature retrieval was conducted to find the relevant papers in databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wan Fang), Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) electronic source for published studies until January 2017. The pharmacokinetic parameters, including C0 (trough blood concentration), C2 (whole-blood levels at 2 hours after drug intake), Cmax (the maximum concentration), and daily dose were extracted and a meta-analysis was performed by RevMan 5.3. RESULTS: A total of 11 papers concerning 1361 individuals were included in the meta-analysis. As for dose adjusted C0, the results showed difference between subjects carrying CC genotypes and TT genotypes (MD: 6.76, 95% CI [2.38, 11.14], P = .02]. As for C2, the results showed significant difference between subjects carrying CC genotypes and CT genotypes (MD: -18.50, 95% CI [-35.49, -1.52], P = .03), as well as CC genotypes and TT genotypes (MD: -19.01, 95% CI (-35.85, -2.16), P = .03). As for Cmax, daily dose, and C0, the overall results showed no major influence. CONCLUSIONS: MDR1 C1236T polymorphism may have a minor effect on cyclosporine pharmacokinetics in transplantation patients.
[Mh] Termos MeSH primário: Ciclosporina/farmacocinética
Imunossupressores/farmacocinética
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/genética
China
Resinas Compostas
Ciclosporina/administração & dosagem
Relação Dose-Resposta a Droga
Genótipo
Seres Humanos
Imunossupressores/administração & dosagem
Polimorfismo Genético
Polimorfismo de Nucleotídeo Único
Transplante/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (ABCB1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (Composite Resins); 0 (Immunosuppressive Agents); 0 (maximum cure); 83HN0GTJ6D (Cyclosporine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008700


  3 / 5470 MEDLINE  
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[PMID]:28462527
[Au] Autor:Li KP; Shanmuganad S; Carroll K; Katz JD; Jordan MB; Hildeman DA
[Ad] Endereço:Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
[Ti] Título:Dying to protect: cell death and the control of T-cell homeostasis.
[So] Source:Immunol Rev;277(1):21-43, 2017 05.
[Is] ISSN:1600-065X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T-cell receptors and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions and maintaining immune memory, they also can cause autoimmunity or neoplasia if misdirected or dysregulated. Thus, T cells must be tightly regulated from their development onward. Maintenance of appropriate T-cell homeostasis is essential to promote protective immunity and limit autoimmunity and neoplasia. This review will focus on the role of cell death in maintenance of T-cell homeostasis and outline novel therapeutic strategies tailored to manipulate cell death to limit T-cell survival (eg, autoimmunity and transplantation) or enhance T-cell survival (eg, vaccination and immune deficiency).
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Rejeição de Enxerto/imunologia
Síndromes de Imunodeficiência/imunologia
Imunoterapia/métodos
Linfócitos T/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças Autoimunes/terapia
Morte Celular
Sobrevivência Celular
Rejeição de Enxerto/prevenção & controle
Homeostase
Seres Humanos
Síndromes de Imunodeficiência/terapia
Transplante
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/imr.12538


  4 / 5470 MEDLINE  
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[PMID]:29365389
[Au] Autor:Cui PC
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
[Ti] Título:[Advances in tracheal transplantation].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):73-75, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The length of tracheal defect or stenosis exceeded 5 cm could not be treated by simple resection and end-to-end anastomosis of the remaining trachea. Various ways of tracheal replacement had appeared sequentially, such as radial forearm free flap with cartilage grafts, tracheal tissue-engineering and tracheal allotransplantation. Among these methods, tracheal allotransplantation displayed a better long-term result. In this review, we are focused on recent advances in tracheal allotransplantation, particularly on revascularization and reepithelialization of graft, as well as on the application of immunosuppressive agents.
[Mh] Termos MeSH primário: Traqueia/transplante
[Mh] Termos MeSH secundário: Aloenxertos
Seres Humanos
Estenose Traqueal/cirurgia
Transplante/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.019


  5 / 5470 MEDLINE  
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[PMID]:29020112
[Au] Autor:Burkhalter H; Denhaerynck K; Huynh-Do U; Binet I; Hadaya K; De Geest S; Psychosocial Interest Group, Swiss Transplant Cohort Study
[Ad] Endereço:Institute of Nursing Science, Department Public Health, University of Basel, Basel, Switzerland.
[Ti] Título:Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study.
[So] Source:PLoS One;12(10):e0185036, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Poor sleep quality (SQ) is common after solid organ transplantation; however, very little is known about its natural history. We assessed the changes in SQ from pre- to 3 years post-transplant in adult heart, kidney, liver and lung recipients included in the prospective nation-wide Swiss Transplant Cohort Study. We explored associations with selected variables in patients suffering persistent poor SQ compared to those with good or variable SQ. METHODS: Adult single organ transplant recipients enrolled in the Swiss Transplant Cohort Study with pre-transplant and at least 3 post-transplant SQ assessment data were included. SQ was self-reported pre-transplant (at listing), then at 6, 12, 24 and 36 months post-transplant. A single SQ item was used to identify poor (0-5) and good sleepers (6-10). Between organ groups, SQ was compared via logistic regression analysis with generalized estimating equations. Within the group reporting persistently poor SQ, we used logistic regression or Kaplan-Meier analysis as appropriate to check for differences in global quality of life and survival. RESULTS: In a sample of 1173 transplant patients (age: 52.1±13.2 years; 65% males; 66% kidney, 17% liver, 10% lung, 7% heart) transplanted between 2008 and 2012, pre- transplant poor SQ was highest in liver (50%) and heart (49%) recipients. Overall, poor SQ decreased significantly from pre-transplant (38%) to 24 months post-transplant (26%) and remained stable at 3 years (29%). Patients reporting persistently poor SQ had significantly more depressive symptomatology and lower global quality of life. CONCLUSION: Because self-reported poor SQ is related to poorer global quality of life, these results emphasize the need for further studies to find suitable treatment options for poor SQ in transplant recipients.
[Mh] Termos MeSH primário: Sono/fisiologia
Transplante
[Mh] Termos MeSH secundário: Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Qualidade de Vida
Análise de Sobrevida
Suíça
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185036


  6 / 5470 MEDLINE  
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[PMID]:28771616
[Au] Autor:Sharon E; Shi H; Kharbanda S; Koh W; Martin LR; Khush KK; Valantine H; Pritchard JK; De Vlaminck I
[Ad] Endereço:Department of Genetics, Stanford University, Stanford, California, United States of America.
[Ti] Título:Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype.
[So] Source:PLoS Comput Biol;13(8):e1005629, 2017 Aug.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quantification of cell-free DNA (cfDNA) in circulating blood derived from a transplanted organ is a powerful approach to monitoring post-transplant injury. Genome transplant dynamics (GTD) quantifies donor-derived cfDNA (dd-cfDNA) by taking advantage of single-nucleotide polymorphisms (SNPs) distributed across the genome to discriminate donor and recipient DNA molecules. In its current implementation, GTD requires genotyping of both the transplant recipient and donor. However, in practice, donor genotype information is often unavailable. Here, we address this issue by developing an algorithm that estimates dd-cfDNA levels in the absence of a donor genotype. Our algorithm predicts heart and lung allograft rejection with an accuracy that is similar to conventional GTD. We furthermore refined the algorithm to handle closely related recipients and donors, a scenario that is common in bone marrow and kidney transplantation. We show that it is possible to estimate dd-cfDNA in bone marrow transplant patients that are unrelated or that are siblings of the donors, using a hidden Markov model (HMM) of identity-by-descent (IBD) states along the genome. Last, we demonstrate that comparing dd-cfDNA to the proportion of donor DNA in white blood cells can differentiate between relapse and the onset of graft-versus-host disease (GVHD). These methods alleviate some of the barriers to the implementation of GTD, which will further widen its clinical application.
[Mh] Termos MeSH primário: DNA/análise
Técnicas de Genotipagem/métodos
Transplante
[Mh] Termos MeSH secundário: Medula Óssea/química
DNA/classificação
DNA/genética
Feminino
Genótipo
Rejeição de Enxerto/prevenção & controle
Seres Humanos
Masculino
Modelos Estatísticos
Análise de Sequência de DNA
Doadores de Tecidos
Transplantes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005629


  7 / 5470 MEDLINE  
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[PMID]:28730990
[Au] Autor:Wall WJ
[Ad] Endereço:From Western University, London, Ont.
[Ti] Título:In memoriam of Dr. David White, PhD, FRCPath (1946-2017).
[So] Source:Can J Surg;60(4):E2, 2017 Aug.
[Is] ISSN:1488-2310
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Transplante/história
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
Ontário
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:White D
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


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[PMID]:28612477
[Au] Autor:Guerra-García P; Hirsch S; Levine DS; Taj MM
[Ad] Endereço:Pediatric Oncology, The Royal Marsden Hospital, Sutton, UK.
[Ti] Título:Preliminary experience on the use of PET/CT in the management of pediatric post-transplant lymphoproliferative disorder.
[So] Source:Pediatr Blood Cancer;64(12), 2017 Dec.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication following prolonged immunosuppression. Contrary to other lymphomas, there is no standardized imaging approach to assess PTLD either at staging or for response to therapy. Positron emission tomography/computed tomography (PET/CT) is an imaging modality that has proven to be useful in lymphoma. However, there is still limited data concerning its use in pediatric PTLD. Our study evaluates the use of PET/CT in pediatric PTLD at our institution. METHODS: To assess the role of PET/CT in pediatric PTLD, we reviewed the pediatric patients with PTLD who had undergone PET/CT at our institution between 2000 and 2016. RESULTS: Nine patients were identified. Six had PET/CT at diagnosis. All lesions seen on CT were identified with PET/CT. Fourteen PET/CTs were done during treatment. Eight PET/CTs were negative, including three where CT showed areas of uncertain significance. In these cases, PET/CT helped us to stop treatment and the patients remain in remission after a long follow-up (mean 74.3 months; range 12.4-180.9 months). PET/CT revealed additional disease in two cases, therefore treatment was intensified. Six biopsies and close follow-up was done to confirm PET/CT results. In one case, PET/CT did not identify central nervous system involvement demonstrated on magnetic resonance imaging. CONCLUSION: PET/CT may have an important role in the staging and follow-up of pediatric PTLD. In our cohort, PET/CT was helpful in staging and assessing treatment response and in clarifying equivocal findings on other imaging modalities.
[Mh] Termos MeSH primário: Transtornos Linfoproliferativos/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Complicações Pós-Operatórias/diagnóstico por imagem
Transplante/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Transtornos Linfoproliferativos/etiologia
Masculino
Estadiamento de Neoplasias
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26685


  9 / 5470 MEDLINE  
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[PMID]:28570217
[Au] Autor:Greig PD
[Ad] Endereço:Division of General Surgery, University of Toronto, Toronto, Ont.
[Ti] Título:In memoriam of Dr. Tom Starzl.
[So] Source:Can J Surg;60(3):E1, 2017 Jun.
[Is] ISSN:1488-2310
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Transplante/história
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
Transplante/educação
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Starzl T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


  10 / 5470 MEDLINE  
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[PMID]:28445362
[Au] Autor:Moltó-García R; González-Alonso V; Villaverde-Doménech ME; Novella-Maestre E
[Ad] Endereço:Valencia, Spain From the Plastic and Reconstructive Service and Genetic Unit, Hospital Universitario y Politécnico La Fe; the Dr. Moltó Plastic Surgery Clinic; and the Instituto de Investigación Sanitaria La Fe.
[Ti] Título:Effect of Human Fat Graft on Breast Cancer Metastasis in a Murine Model.
[So] Source:Plast Reconstr Surg;139(5):1119-1128, 2017 May.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Isolated adipose stem cells have been reported to encourage migration and early metastasis of breast cancer. Mimicking a surgical situation, the authors developed a human breast cancer model to evaluate in vivo whether human adipose tissue promotes tumor growth and invasion. METHODS: Human adipose tissue was obtained from four patients. The MDA-MB-468 cell line was cultured with a lentiviral vector encoding a puromycin resistance gene and mCherry fluorescent protein. Virus-infected cells were selected. Animals were injected in the left renal capsule and divided into three experimental groups: group A, MDA-MB-468 cells (n = 4); group B, MDA-MB-468 cells/human adipose tissue (n = 4); and group C, Dulbecco's Modified Eagle Medium/F-12 medium (negative control, n = 4). Metastatic development was monitored using an in vivo imaging system. Small breast epithelial mucin (SBEM), human hypoxanthine-guanine phosphoribosyltransferase (HPRTh), and murine hypoxanthine-guanine phosphoribosyltransferase (HPRTm) expression were analyzed by real-time polymerase chain reaction to detect multifocal metastases in right/left renal capsule, liver, spleen, and pancreas. RESULTS: Metastasis was observed between postinjection days 37 and 44. No significant differences were found in survival rates between groups (group A, 157 ± 42.60 days; group B, 169 ± 40.17 days). All samples expressed HPRTm. HPRTh and SBEM were expressed in left renal capsules from all group A and B mice, whereas in spleen, liver, pancreas, and right renal capsule the HPRTm and SBEM expression was not constant in all samples of group A and B mice. Differences were found between groups in HPRTh and SBEM expression but were not statistically significant. CONCLUSION: Human adipose tissue used to restore breast defects after oncologic resection did not increase metastasis development risk when there were residual breast cancer cells in proximity.
[Mh] Termos MeSH primário: Tecido Adiposo/transplante
Neoplasias da Mama/patologia
[Mh] Termos MeSH secundário: Adulto
Animais
Modelos Animais de Doenças
Feminino
Seres Humanos
Camundongos
Meia-Idade
Metástase Neoplásica
Transplante/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003274



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