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| [PMID]: | 28457402 |
| [Au] Autor: | de Freitas RAP; de Lima ML; Mazzali M |
| [Ad] Endereço: | Renal Transplant Unit, Clinics Hospital, State University of Campinas, Campinas, São Paulo, Brazil; Division of Urology, Department of Surgery, State University of Campinas, Campinas, São Paulo, Brazil. |
| [Ti] Título: | Early Vascular Thrombosis After Kidney Transplantation: Can We Predict Patients at Risk? |
| [So] Source: | Transplant Proc;49(4):817-820, 2017 May. | | [Is] ISSN: | 1873-2623 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | BACKGROUND: Renal transplant is the therapy of choice for patients with chronic renal disease. In recent years, improvement in immunosuppressive drugs reduced early graft loss associated with acute rejection. However, vascular thrombosis, accounting for 5% of early graft loss, can sensitize the recipient for human leukocyte antibodies, reducing the chance for a second transplant. The aim of this study was to identify risk factors for vascular thrombosis in a single transplant center, to design specific prevention protocol. METHODS: This was a retrospective, case-control study. From the Renal Transplant Unit database, we identified 21 cases of vascular thrombosis in recipients of kidneys from deceased donors. Recipients from the contralateral kidney from the same donor, without vascular complications, were assigned to the control group. Data analyzed included donor, recipient, transplant surgery, and post-operative follow-up. The local ethics committee approved the protocol. RESULTS: Thrombosis and control groups were comparable for recipient characteristics, cold ischemia time, organ side (right or left), and site of arterial anastomosis. We observed an increased risk for vascular thrombosis in kidneys with multiple veins (odds ratio, 11.32; P = .03). Organ retrieval surgery complications, such as vascular lesions or heterogeneous perfusion, despite normal pre-implantation biopsy, were considered risk factors for vascular thrombosis within the first post-operative day (odds ratio, 7.1; P = .03). CONCLUSIONS: In this series, multiple renal vein and organ retrieval surgery complications were risk factors for early vascular thrombosis. |
| [Mh] Termos MeSH primário: |
Transplante de Rim/efeitos adversos
Trombose/epidemiologia
Trombose/etiologia
Coleta de Tecidos e Órgãos/efeitos adversos
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| [Mh] Termos MeSH secundário: |
Adulto
Estudos de Casos e Controles
Isquemia Fria/efeitos adversos
Feminino
Seres Humanos
Falência Renal Crônica/cirurgia
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Doadores de Tecidos
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
| [Em] Mês de entrada: | 1712 |
| [Cu] Atualização por classe: | 171220 |
[Lr] Data última revisão:
| 171220 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 170502 |
| [St] Status: | MEDLINE |
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