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[PMID]:29300076
[Au] Autor:Gilbert S; Singh D; Sivakumar MK
[Ad] Endereço:Department of cardiothoracic surgery. Kovai medical center and hospital limited. Post box no. 3209, Avanashi road, Coimbatore - 641014, Tamil Nadu, India.
[Ti] Título:Modified carbodissection: A new technique for harvesting the internal mammary artery.
[So] Source:Multimed Man Cardiothorac Surg;2017, 2017 Oct 29.
[Is] ISSN:1813-9175
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The modified carbodissection technique is a new technique for harvesting the internal mammary artery during coronary artery bypass graft surgery. It is performed using an improvised instrument that consists of an electrocautery device and a carbon dioxide blower/mister. It combines electrocautery dissection and continuous controlled gas blow dissection along with saline irrigation mist. Gas dissection causes vasodilation and maintains the artery in a dilated state during dissection. Saline flow reduces the amount of heat generated at the cautery site and prevents drying and desiccation of the tissues. This technique is safe in terms of reduced thermal injury, and reduced early arterial spasm and myocardial ischemia, and it improves vision during harvest and shortens the duration of the harvesting procedure.
[Mh] Termos MeSH primário: Ponte de Artéria Coronária
Dissecação/métodos
Eletrocirurgia/métodos
Artéria Torácica Interna/cirurgia
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Dióxido de Carbono/uso terapêutico
Gases/uso terapêutico
Seres Humanos
Artéria Torácica Interna/transplante
[Pt] Tipo de publicação:VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Gases); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1510/mmcts.2017.018


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[PMID]:29300070
[Au] Autor:Durko A; Mahtab E; Romeo J; Bogers A
[Ad] Endereço:Department of Cardio-Thoracic Surgery Erasmus University Medical Center 's-Gravendijkwal 230 Rotterdam 3015CE The Netherlands.
[Ti] Título:Skeletonized internal mammary artery harvest with diathermy and cold dissection.
[So] Source:Multimed Man Cardiothorac Surg;2017, 2017 Dec 12.
[Is] ISSN:1813-9175
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This surgical tutorial demonstrates the technique of skeletonized internal mammary artery harvesting for coronary artery bypass grafting, using diathermy and cold dissection [1]. The procedure is performed on the left internal mammary artery, but is also applicable for harvesting the right internal mammary artery.
[Mh] Termos MeSH primário: Ponte de Artéria Coronária/métodos
Doença da Artéria Coronariana/cirurgia
Artéria Torácica Interna/cirurgia
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Diatermia
Dissecação/métodos
Eletrocoagulação
Seres Humanos
Artéria Torácica Interna/transplante
[Pt] Tipo de publicação:VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1510/mmcts.2017.023


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[PMID]:27775870
[Au] Autor:Alghamdi T; Viebahn C; Justinger C; Lorf T
[Ad] Endereço:Department of General and Visceral Surgery, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
[Ti] Título:Arterial Blood Supply of Liver Segment IV and Its Possible Surgical Consequences.
[So] Source:Am J Transplant;17(4):1064-1070, 2017 04.
[Is] ISSN:1600-6143
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The risk of ischemia of segment IV after split liver resection is high. This anatomical study was done to identify the arterial blood supply and the intrahepatic distribution of liver segment IV. The anatomy of segment IV was studied in 29 livers from adult cadavers. To identify the arterial blood supply of segment IV, water and ink were injected into the various branches of the hepatic artery and the outflow through segment IV and discoloration of the liver parenchyma were observed. In 23 of the 29 livers (79.3%), the arterial perfusion of segment IV was separated by a line drawn from the left side of the inferior vena cava at the top of and lateral to the falciform ligament to the medial point of the gallbladder bed. The area lateral to this line was supplied mainly by the right hepatic artery, and the area medial to it was supplied mainly by the left hepatic artery. In addition to the classification system of Couinaud, we describe here a new division of liver segment IV based on arterial blood supply. These anatomical findings may be useful in defining the resection line for split liver to prevent necrosis of segment IV.
[Mh] Termos MeSH primário: Hepatectomia
Artéria Hepática/cirurgia
Veias Hepáticas/cirurgia
Fígado/irrigação sanguínea
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Cadáver
Seres Humanos
Transplante de Fígado
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/ajt.14089


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[PMID]:28457402
[Au] Autor:de Freitas RAP; de Lima ML; Mazzali M
[Ad] Endereço:Renal Transplant Unit, Clinics Hospital, State University of Campinas, Campinas, São Paulo, Brazil; Division of Urology, Department of Surgery, State University of Campinas, Campinas, São Paulo, Brazil.
[Ti] Título:Early Vascular Thrombosis After Kidney Transplantation: Can We Predict Patients at Risk?
[So] Source:Transplant Proc;49(4):817-820, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Renal transplant is the therapy of choice for patients with chronic renal disease. In recent years, improvement in immunosuppressive drugs reduced early graft loss associated with acute rejection. However, vascular thrombosis, accounting for 5% of early graft loss, can sensitize the recipient for human leukocyte antibodies, reducing the chance for a second transplant. The aim of this study was to identify risk factors for vascular thrombosis in a single transplant center, to design specific prevention protocol. METHODS: This was a retrospective, case-control study. From the Renal Transplant Unit database, we identified 21 cases of vascular thrombosis in recipients of kidneys from deceased donors. Recipients from the contralateral kidney from the same donor, without vascular complications, were assigned to the control group. Data analyzed included donor, recipient, transplant surgery, and post-operative follow-up. The local ethics committee approved the protocol. RESULTS: Thrombosis and control groups were comparable for recipient characteristics, cold ischemia time, organ side (right or left), and site of arterial anastomosis. We observed an increased risk for vascular thrombosis in kidneys with multiple veins (odds ratio, 11.32; P = .03). Organ retrieval surgery complications, such as vascular lesions or heterogeneous perfusion, despite normal pre-implantation biopsy, were considered risk factors for vascular thrombosis within the first post-operative day (odds ratio, 7.1; P = .03). CONCLUSIONS: In this series, multiple renal vein and organ retrieval surgery complications were risk factors for early vascular thrombosis.
[Mh] Termos MeSH primário: Transplante de Rim/efeitos adversos
Trombose/epidemiologia
Trombose/etiologia
Coleta de Tecidos e Órgãos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Isquemia Fria/efeitos adversos
Feminino
Seres Humanos
Falência Renal Crônica/cirurgia
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28457385
[Au] Autor:Baroncelli F; Alberione MC; Cacciotti V; Artusio D; Vergano M; Livigni S
[Ad] Endereço:Scuola di Specializzazione in Anestesia, Rianimazione e Terapia Intensiva, Università degli Studi di Torino, Torino, Italy.
[Ti] Título:Blood Lactate Concentrations Before and After Withdrawal of Life-Sustaining Treatments in Controlled Donation After Circulatory Death: A Case Report From Italy.
[So] Source:Transplant Proc;49(4):740-742, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 20-minute hands-off period with isoelectric electrocardiography (ECG) monitoring is currently required for the declaration of cardiac death in Italy, thus prolonging the warm ischemia time (WIT) during donation after circulatory death (DCD). Normothermic regional perfusion (NRP) can be a valid tool to optimize organ perfusion as a bridge to donation. A 62-year-old woman with catastrophic brain injury due to massive intracranial hemorrage, not fulfilling brain death criteria, underwent controlled DCD after withdrawal of life-sustaining therapies (WLST). NRP was established after a functional WIT of 43 minutes. Despite concerns regarding a prolonged WIT imposed by the national legislation on declaration of cardiac death, NRP was successful in restoring an adequate perfusion to liver and kidneys, as evidenced by a sustained reduction in blood lactate concentration. Liver and kidneys were successfully transplanted after ex vivo machine perfusion.
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico
Ácido Láctico/sangue
Preservação de Órgãos/métodos
Coleta de Tecidos e Órgãos/métodos
Isquemia Quente
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Itália
Meia-Idade
Perfusão
Doadores de Tecidos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28457361
[Au] Autor:Giacomoni A; Centonze L; Di Sandro S; Lauterio A; Ciravegna AL; Buscemi V; Ferla F; Tripepi M; Concone G; De Carlis R; Colussi G; Gregorini M; De Carlis L
[Ad] Endereço:Department of Surgery-Niguarda Transplant Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy. Electronic address: alessandro.giacomoni@ospedaleniguarda.it.
[Ti] Título:Robot-Assisted Harvesting of Kidneys for Transplantation and Global Complications for the Donor.
[So] Source:Transplant Proc;49(4):632-637, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Robot-assisted kidney harvesting from living donors is feasible and safe. We report the results of a mono-centric experience relative to 98 consecutive robotic nephrectomies with emphasis on global donor complications. MATERIALS AND METHODS: This is a retrospective cohort study. Donors underwent robot-assisted kidney harvesting. The preferred kidney was the left one even in the presence of vascular anomalies. In the first cases we used a robotic hand-assisted technique, then the totally robotic technique, and finally the modified totally robot-assisted technique. Postoperative complications were ranked according to the five-grade Clavien-Dindo classification. RESULTS: Between November 2009 and November 2016, 98 living donors underwent nephrectomy. We experienced 14 complications. The 3 intraoperative ones (3.06%) were 1 pneumothorax and 2 acute bleedings, 1 of them requiring transfusion. The 11 postoperative complications (11.22%) were as follows: 5 wound seromas, 1 rhabdomyolisis (Clavien I), 1 paretic ileum, 1 anemia requiring transfusion, 1 hypertensive crisis (Clavien II), and 2 chylus collections drained by interventional radiologists (Clavien III). Transfusion rate was 2.1%; conversions, reoperations, and mortality were nil. No statistically significant difference was observed between the patients with complications and without in terms of gender, age, anatomical anomalies, body mass index (BMI), and learning curve. We observed a longer global operation length of time in patients with complications. CONCLUSION: Robotic assistance results in shorter and simpler learning curves for the harvesting of kidneys from living donors. It enables an easier and more efficient management of possible intraoperative complications. The rate of postoperative complications is comparable with the rate of complications encountered in traditional laparoscopic series with high numbers of harvestings.
[Mh] Termos MeSH primário: Transplante de Rim/métodos
Doadores Vivos
Nefrectomia/métodos
Robótica/métodos
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Complicações Intraoperatórias/epidemiologia
Masculino
Meia-Idade
Complicações Pós-Operatórias/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29176414
[Au] Autor:van Veldhuisen CL; Kamali P; Wu W; Becherer BE; Sinno HH; Ashraf AA; Ibrahim AMS; Tobias A; Lee BT; Lin SJ
[Ad] Endereço:Boston, Mass.; and New Orleans, La. From the Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School; and the Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center.
[Ti] Título:Prospective, Double-Blind Evaluation of Umbilicoplasty Techniques Using Conventional and Crowdsourcing Methods.
[So] Source:Plast Reconstr Surg;140(6):1151-1162, 2017 Dec.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Umbilical reconstruction is an important component of deep inferior epigastric perforator (DIEP) flap breast reconstruction. This study evaluated the aesthetics of three different umbilical reconstruction techniques during DIEP flap breast reconstruction. METHODS: From January to April of 2013, a total of 29 consecutive patients undergoing DIEP flap breast reconstruction were randomized intraoperatively to receive one of three umbilicoplasty types: a diamond, an oval, or an inverted V incision. Independent plastic surgeons and members of the general public, identified using an online "crowdsourcing" platform, evaluated aesthetic outcomes in a blinded fashion. Reviewers were shown postoperative photographs of the umbilicus of all patients and a four-point Likert scale was used to rate the new umbilicus on the size, scar formation, shape, localization, and overall appearance. RESULTS: Results for the focus group of independent plastic surgeons and 377 members of the public were retrieved (n = 391). A total of 10 patients (34.5 percent) were randomized into having the diamond incision, 10 (34.5 percent) had the oval incision, and nine (31.0 percent) had the inverted V incision. Patients were well matched in terms of overall characteristics. The general public demonstrated a significant preference for the oval incision in all five parameters. There was no preference identified among surgeons. CONCLUSION: This study provides evidence that a sample of the U.S. general public prefers the aesthetics of the oval umbilicoplasty incision, which contrasted with the lack of preference identified within this focus group of plastic surgeons. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
[Mh] Termos MeSH primário: Crowdsourcing
Mamoplastia/métodos
Umbigo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias da Mama/cirurgia
Método Duplo-Cego
Feminino
Seres Humanos
Meia-Idade
Satisfação do Paciente
Retalho Perfurante
Estudos Prospectivos
Coleta de Tecidos e Órgãos/métodos
Sítio Doador de Transplante
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003839


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[PMID]:27777123
[Au] Autor:Schwarz C; Aldrich BT; Burckart KA; Schmidt GA; Zimmerman MB; Reed CR; Greiner MA; Sander EA
[Ad] Endereço:Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
[Ti] Título:Descemet membrane adhesion strength is greater in diabetics with advanced disease compared to healthy donor corneas.
[So] Source:Exp Eye Res;153:152-158, 2016 Dec.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Descemet membrane endothelial keratoplasty (DMEK) is an increasingly popular surgical procedure for treating ocular diseases that require a corneal transplant. Previous studies have found that tissue tearing during surgical preparation is more likely elevated in eyes from donors with a history of diabetes mellitus. To quantify these potential differences, we established an experimental technique for quantifying the force required to separate the endothelium-Descemet membrane complex (EDM) from stroma in human donor corneal tissue, and we assessed differences in adhesion strength between diabetic and non-diabetic donor corneas. Transplant suitable corneas were obtained from 23 donors 50-75 years old with an average preservation to assay time of 11.5 days. Corneas were classified from a medical records review as non-diabetic (ND, n = 9), diabetic without evidence of advanced disease (NAD, n = 8), or diabetic with evidence of advanced disease (AD, n = 10). Corneas were sectioned into 3 mm wide strips and the EDM peeled from the stroma. Using the force-extension data obtained from mechanical peel testing, EDM elastic peel tension (T ), elastic stiffness (S ), average delamination tension (T ), and maximum tension (T ) were calculated. Mean T , S , T , and T values for ND corneas were 0.78 ± 0.07 mN/mm, 0.37 ± 0.05 mN/mm/mm, 0.78 ± 0.08 mN/mm, and 0.94 ± 0.17 mN/mm, respectively. NAD values did not differ significantly. However, AD values for T (1.01 ± 0.18 mN/mm), T (1.09 ± 0.21 mN/mm), and T (1.37 ± 0.24 mN/mm) were greater than ND and NAD corneas (P < 0.05). S did not differ significantly between groups. These findings provide proof of the concept that chronic hyperglycemia from diabetes mellitus results in a phenotypically more adhesive interface between Descemet membrane and the posterior stroma in donor corneal tissue. Results of this study provide a foundation for further investigations into the impact of diabetes on the posterior cornea, eye banking, and keratoplasty.
[Mh] Termos MeSH primário: Doenças da Córnea/cirurgia
Lâmina Limitante Posterior/fisiologia
Ceratoplastia Endotelial com Remoção da Lâmina Limitante Posterior/métodos
Diabetes Mellitus
Doadores de Tecidos
[Mh] Termos MeSH secundário: Idoso
Doenças da Córnea/fisiopatologia
Bancos de Olhos
Sobrevivência de Enxerto
Seres Humanos
Meia-Idade
Reprodutibilidade dos Testes
Coleta de Tecidos e Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:29064980
[Au] Autor:Avram MR; Finney R; Rogers N
[Ad] Endereço:*Private Practice, Dermatology, New York, New York; †Weill Cornell Medical Center, New York, New York; ‡Heights Dermatology, Brooklyn, New York; §Tulane Health Sciences Center, New Orleans, Louisiana; ‖Private Practice, Old Metairie Dermatology, Metairie, Louisiana.
[Ti] Título:Hair Transplantation Controversies.
[So] Source:Dermatol Surg;43 Suppl 2:S158-S162, 2017 Nov.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss. OBJECTIVE: To review some current controversies in hair transplant surgery. MATERIALS AND METHODS: Review of the English PubMed literature and specialty literature in hair transplant surgery. RESULTS: Some of the controversies in hair transplant surgery include appropriate donor harvesting technique including elliptical donor harvesting versus follicular unit extraction whether manual versus robotic, the role of platelet-rich plasma and low-level light surgery in hair transplant surgery. CONCLUSION: Hair transplant surgery creates consistently natural appearing hair. As with all techniques, there are controversies regarding the optimal method for performing the procedure. Some of the current controversies in hair transplant surgery include optimal donor harvesting techniques, elliptical donor harvesting versus follicular unit extraction, the role of low-level light therapy and the platelet-rich plasma therapy in the procedure. Future studies will further clarify their role in the procedure.
[Mh] Termos MeSH primário: Alopecia/terapia
Técnicas Cosméticas
Folículo Piloso/transplante
[Mh] Termos MeSH secundário: Seres Humanos
Terapia a Laser
Masculino
Plasma Rico em Plaquetas
Coleta de Tecidos e Órgãos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001316


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[PMID]:28976432
[Au] Autor:Patterson TE; Boehm C; Nakamoto C; Rozic R; Walker E; Piuzzi NS; Muschler GF
[Ad] Endereço:1Departments of Orthopaedic Surgery (T.E.P., N.S.P., and G.F.M.) and Biomedical Engineering (T.E.P., C.B., C.N., R.R., E.W., N.S.P., and G.F.M.), Cleveland Clinic, Cleveland, Ohio.
[Ti] Título:The Efficiency of Bone Marrow Aspiration for the Harvest of Connective Tissue Progenitors from the Human Iliac Crest.
[So] Source:J Bone Joint Surg Am;99(19):1673-1682, 2017 Oct 04.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The rational design and optimization of tissue engineering strategies for cell-based therapy requires a baseline understanding of the concentration and prevalence of osteogenic progenitor cell populations in the source tissues. The aim of this study was to (1) define the efficiency of, and variation among individuals in, bone marrow aspiration as a means of osteogenic connective tissue progenitor (CTP-O) harvest compared with harvest from iliac cancellous bone, and (2) determine the location of CTP-Os within native cancellous bone and their distribution between the marrow-space and trabecular-surface tissue compartments. METHODS: Eight 2-mL bone marrow aspiration (BMA) samples and one 7-mm transcortical biopsy sample were obtained from the anterior iliac crest of 33 human subjects. Two cell populations were obtained from the iliac cancellous bone (ICB) sample. The ICB sample was placed into αMEM (alpha-minimal essential medium) with antibiotic-antimycotic and minced into small pieces (1 to 2 mm in diameter) with a sharp osteotome. Cells that could be mechanically disassociated from the ICB sample were defined as marrow-space (IC-MS) cells, and cells that were disassociated only after enzymatic digestion were defined as trabecular-surface (IC-TS) cells. The 3 sources of bone and marrow-derived cells were compared on the basis of cellularity and the concentration and prevalence of CTP-Os through colony-forming unit (CFU) analysis. RESULTS: Large variation was seen among patients with respect to cell and CTP-O yield from the IC-MS, IC-TS, and BMA samples and in the relative distribution of CTP-Os between the IC-MS and IC-TS fractions. The CTP-O prevalence was highest in the IC-TS fraction, which was 11.4-fold greater than in the IC-MS fraction (p < 0.0001) and 1.7-fold greater than in the BMA fraction. However, the median concentration of CTP-Os in the ICB (combining MS and TS fractions) was only 3.04 ± 1.1-fold greater than that in BMA (4,265 compared with 1,402 CTP/mL; p = 0.00004). CONCLUSIONS: Bone marrow aspiration of a 2-mL volume at a given needle site is an effective means of harvesting CTP-Os, albeit diluted with peripheral blood. However, the median concentration of CTP-Os is 3-fold less than from native iliac cancellous bone. The distribution of CTP-Os between the IC-MS and IC-TS fractions varies widely among patients. CLINICAL RELEVANCE: Bone marrow aspiration is an effective means of harvesting CTP-Os but is associated with dilution with peripheral blood. Overall, we found that 63.5% of all CTP-Os within iliac cancellous bone resided on the trabecular surface; however, 48% of the patients had more CTP-Os contributed by the IC-MS than the IC-TS fraction.
[Mh] Termos MeSH primário: Células da Medula Óssea
Ílio/citologia
Sucção
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Artroplastia de Quadril
Transplante de Medula Óssea
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.17.00094



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde