Base de dados : MEDLINE
Pesquisa : E04.950.300.399 [Categoria DeCS]
Referências encontradas : 24159 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2416 ir para página                         

  1 / 24159 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29480826
[Au] Autor:Zhou J; Chen Y; Xu X; Yan D; Lou H
[Ad] Endereço:Key Laboratory of Radiation Oncology of Zhejiang Province.
[Ti] Título:Postoperative clinicopathological factors affecting cervical adenocarcinoma: Stages I-IIB.
[So] Source:Medicine (Baltimore);97(2):e9323, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Currently, cervical adenocarcinoma (ADC) receives the same standard treatment as squamous cell carcinoma, but this treatment regimen is not wholly suited for ADC. The present study was conducted to assess the prognostic role of postoperative clinicopathological factors in patients with stage I-IIB cervical ADC.The study examined 312 patients with stage I-IIB cervical ADC who underwent radical hysterectomy, including pelvic lymphadenectomy, at our institutions between October 2006 and September 2014. Overall survival (OS) and relapse-free survival (RFS) was analyzed by the Kaplan-Meier method. Sites of recurrence were classified as local and distant locations.The 5-year OS and RFS rates were 88.2% and 83.8%, respectively. The 5-year OS rates for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA, IB, IIA, and IIB were 100.0%, 90.7%, 82.8%, and 55.6%, respectively. The Cox model identified number of positive pelvic nodes and age at surgery as independent prognostic factors for survival, and number of positive pelvic nodes and postoperative tumor diameter (≥4 cm) as independent prognostic factors for relapse. Cancer recurrence developed in 35 women. The top three recurrence sites were pelvis, vaginal stump, and lung.A more aggressive therapeutic strategy different from current practice in cervical cancer is urgently required for cervical ADC. As a new prognostic factor, postoperative tumor diameter should receive special attention in ADC treatment.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Neoplasias do Colo do Útero/patologia
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico
Adulto
Fatores Etários
Idoso
Intervalo Livre de Doença
Feminino
Seguimentos
Seres Humanos
Histerectomia
Estimativa de Kaplan-Meier
Excisão de Linfonodo
Meia-Idade
Estadiamento de Neoplasias
Prognóstico
Modelos de Riscos Proporcionais
Resultado do Tratamento
Carga Tumoral
Neoplasias do Colo do Útero/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009323


  2 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29424975
[Au] Autor:López-Vera EA; Reynosa-Oviedo Y; Treviño-Báez JD; Martínez-Salazar GJ; González-Díaz OA; Cortés-Flores R
[Ti] Título:[Subsequent reoperation obstetric hysterectomy and selective ligation of hypogastric arteries].
[Ti] Título:Reintervención posterior a histerectomía obstétrica y ligadura selectiva de arterias hipogástricas..
[So] Source:Ginecol Obstet Mex;84(9):562-6, 2016 Sep.
[Is] ISSN:0300-9041
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Background: Bleeding in pregnancy, childbirth or postpartum period is an emergency. Selective internal iliac (hypogastric) arteries ligation is a surgical therapy in selected cases of obstetric massive hemorrhage. It had proven to be safe. Objetive: To evaluate the risk for re-intervention for post-operatory bleeding in patients with obstetric hysterectomy and selective hypogastric arteries ligation. Material and method: Cross-sectional study including women diagnosed with obstetric hysterectomy with and without selective arterial ligation as a factor to assess the risk of re-intervention, from December 2013 to December 2014, at High Specialty Medical Unit 23 of Gynaecology and Obstetrics, in Monterrey, which is a tertiary care medical center. Those patients with 28 weeks of gestation or more were selected. The postoperative blood loss was quantified by open drainage system (Penrose). Results: We performed 88 hysterectomies in the study period. We included 45 women according to selection criteria. The average was 31.9 ± 5.48 years old. Performing a selective hypogastric arteries ligation may be a protective factor (p<0.05) for re-intervention as a consequence of postoperative bleeding. Conclusion: Selective arterial ligation is a factor that could help to prevent a re-intervention. A continuous training of physicians and residents of Gynecology and Obstetrics is essential to ensure the reduction in morbidity and maternal mortality.
[Mh] Termos MeSH primário: Histerectomia/métodos
Artéria Ilíaca/cirurgia
Hemorragia Pós-Parto/cirurgia
[Mh] Termos MeSH secundário: Adulto
Perda Sanguínea Cirúrgica
Estudos Transversais
Feminino
Seres Humanos
Ligadura
Gravidez
Reoperação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  3 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29424510
[Au] Autor:Solórzano-Vázquez JF; Hernández-Higareda S; Segura-Zavala JM; OsegueraTorres LF; De la Rosa-Hernández SS
[Ti] Título:[Blood loss and use of blood products in cases of cesarean hysterectomy for placenta accrete].
[Ti] Título:Pérdida sanguínea e indicación de hemoderivados en pacientes con cesárea-histerectomía por acretismo placentario..
[So] Source:Ginecol Obstet Mex;84(8):491-7, 2016 08.
[Is] ISSN:0300-9041
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Background: Placenta accreta (abnormal insertion of the placenta or part of the myometrium ) endangers the lives of pregnant women. It is a public health problem because it can be complicated by obstetric hemorrhage , the latter being the main cause of maternal death worldwide. Objetive: To estimate the blood loss and the use of blood products in patients who underwent cesarean ­ hysterectomy for placenta accreta. Material and methods: A descriptive study was conducted in HGO UMAE CMNO IMSS in patients who underwent cesarean ­ hysterectomy for placenta accreta in a period of 4 years. Results: 106 cases of placenta accreta were studied, 23% had a massive bleeding of > 3000 cc. Packed red blood cells were transfused in 68% of events, fresh frozen plasma in platelet concentrates 29% and 6%. The history of uterine curettage was observed in 64 % and cesarean section 1 or 2 occasions in 76 % of cases. Conclusion: An early detection of placenta accreta in patients with risk factors to avoid emergency surgery is desired. Being prepared with blood products and appropriate use is a cornerstone in the management of this condition. The average blood loss was determined in cases of accreta in cesarean hysterectomy was 2523 milliliters.
[Mh] Termos MeSH primário: Perda Sanguínea Cirúrgica
Cesárea/métodos
Histerectomia/métodos
Placenta Acreta/cirurgia
[Mh] Termos MeSH secundário: Adulto
Transfusão de Sangue/métodos
Feminino
Seres Humanos
México
Gravidez
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  4 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29293635
[Au] Autor:Knight S; Aggarwal R; Agostini A; Loundou A; Berdah S; Crochet P
[Ad] Endereço:Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, Aix Marseille Université, France.
[Ti] Título:Development of an objective assessment tool for total laparoscopic hysterectomy: A Delphi method among experts and evaluation on a virtual reality simulator.
[So] Source:PLoS One;13(1):e0190580, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Total Laparoscopic hysterectomy (LH) requires an advanced level of operative skills and training. The aim of this study was to develop an objective scale specific for the assessment of technical skills for LH (H-OSATS) and to demonstrate feasibility of use and validity in a virtual reality setting. MATERIAL AND METHODS: The scale was developed using a hierarchical task analysis and a panel of international experts. A Delphi method obtained consensus among experts on relevant steps that should be included into the H-OSATS scale for assessment of operative performances. Feasibility of use and validity of the scale were evaluated by reviewing video recordings of LH performed on a virtual reality laparoscopic simulator. Three groups of operators of different levels of experience were assessed in a Marseille teaching hospital (10 novices, 8 intermediates and 8 experienced surgeons). Correlations with scores obtained using a recognised generic global rating tool (OSATS) were calculated. RESULTS: A total of 76 discrete steps were identified by the hierarchical task analysis. 14 experts completed the two rounds of the Delphi questionnaire. 64 steps reached consensus and were integrated in the scale. During the validation process, median time to rate each video recording was 25 minutes. There was a significant difference between the novice, intermediate and experienced group for total H-OSATS scores (133, 155.9 and 178.25 respectively; p = 0.002). H-OSATS scale demonstrated high inter-rater reliability (intraclass correlation coefficient [ICC] = 0.930; p<0.001) and test retest reliability (ICC = 0.877; p<0.001). High correlations were found between total H-OSATS scores and OSATS scores (rho = 0.928; p<0.001). CONCLUSION: The H-OSATS scale displayed evidence of validity for assessment of technical performances for LH performed on a virtual reality simulator. The implementation of this scale is expected to facilitate deliberate practice. Next steps should focus on evaluating the validity of the scale in the operating room.
[Mh] Termos MeSH primário: Histerectomia/métodos
Laparoscopia/métodos
Realidade Virtual
[Mh] Termos MeSH secundário: Competência Clínica
Técnica Delfos
Estudos de Viabilidade
Feminino
Seres Humanos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190580


  5 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27779566
[Au] Autor:Lai JC; Chen HH; Chu KH; Wang KL; Huang N; Hu HY; Chou YJ
[Ad] Endereço:1Institute of Public Health and Department of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan 2Department of Nursing, Ching Kuo Institute of Management and Health, Keelung, Taiwan 3Department of Nursing, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan 4Department of Obstetrics and Gynecology, Taitung Mackay Memorial Hospital, Taitung, Taiwan 5Department of Obstetrics and Gynecology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan 6Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan 7Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.
[Ti] Título:In-hospital complications of bilateral salpingo-oophorectomy at benign hysterectomy: a population-based cohort study.
[So] Source:Menopause;24(2):187-195, 2017 Feb.
[Is] ISSN:1530-0374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The study compared the in-hospital complications and related outcomes between women who underwent bilateral salpingo-oophorectomy at hysterectomy for benign diseases and those who had hysterectomy only. METHODS: We conducted a population-based, retrospective cohort study using data from Taiwan's National Health Insurance program. Women who underwent concurrent bilateral salpingo-oophorectomy at hysterectomy for benign indications (n = 34,509) were compared with those who had hysterectomy only (n = 176,305). Separate models were estimated to account for the effect of baseline comorbid condition, age, and hysterectomy approach on the relationship between bilateral salpingo-oophorectomy and study outcomes. A secondary analysis was also performed to evaluate the association of inpatient readmission within 30 days and complications among women who underwent bilateral salpingo-oophorectomy. RESULTS: The addition of a bilateral salpingo-oophorectomy to hysterectomy was associated with a lower risk of surgical complications, a longer length of hospital stay, and an increased risk of inpatient readmission within 30 days. Among women who underwent bilateral salpingo-oophorectomy, women with complications were also more likely to require inpatient readmission within 30 days than those without complications. Our data also suggested that bilateral salpingo-oophorectomy was not associated with an overall risk of medical complications, with the exception of urethral obstruction. The relationships remained even after adjustments by age, surgical indications, hysterectomy approach, and health-related risk factors, such as baseline comorbid condition and status of any prior catastrophic illness. CONCLUSIONS: Bilateral salpingo-oophorectomy at hysterectomy for benign conditions is not associated with an increased risk of in-hospital complications.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/cirurgia
Hospitalização/estatística & dados numéricos
Histerectomia/efeitos adversos
Complicações Pós-Operatórias/epidemiologia
Salpingo-Ooforectomía/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Terapia Combinada
Feminino
Seres Humanos
Histerectomia/métodos
Meia-Idade
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
Fatores de Risco
Salpingo-Ooforectomía/métodos
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1097/GME.0000000000000746


  6 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390473
[Au] Autor:Zhao H; Yao Y; Yang H; Ma D; Chen A
[Ad] Endereço:Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, PR China.
[Ti] Título:Hormone therapy as a management strategy for lung metastasis after 5 years of endometrial cancer: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9223, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Endometrial cancer patients with lung metastases are rare, and more rarely with long-term management of progesterone after recurrence. PATIENT CONCERNS: Informed consent of the patients and their families. DIAGNOSES: Endometrial cancer (IVB) (Refer to 2009 FIGO stag of endometrial cancer). INTERVENTIONS: the patient was treated with Megestrol Acetate Dispersible Tablets (trade name Yilizhi), 160 mg, orally, once daily, without interruption. OUTCOMES: The patient has been treated with progesterone therapy for stable conditions and her survival time is already roughly a decade (December 2006-October 2016). LESSONS: Hormone therapy may as a long-term management for hormone receptor-positive patients with recurrent endometrial cancer.
[Mh] Termos MeSH primário: Adenocarcinoma/cirurgia
Neoplasias do Endométrio/cirurgia
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/secundário
Megestrol/uso terapêutico
[Mh] Termos MeSH secundário: Adenocarcinoma/secundário
Administração Oral
Antineoplásicos Hormonais/uso terapêutico
Biópsia por Agulha
Neoplasias do Endométrio/diagnóstico
Feminino
Seguimentos
Seres Humanos
Histerectomia/métodos
Imuno-Histoquímica
Neoplasias Pulmonares/diagnóstico por imagem
Meia-Idade
Invasividade Neoplásica/patologia
Recidiva Local de Neoplasia/tratamento farmacológico
Recidiva Local de Neoplasia/patologia
Estadiamento de Neoplasias
Medição de Risco
Fatores de Tempo
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Hemorragia Uterina/diagnóstico
Hemorragia Uterina/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Hormonal); EA6LD1M70M (Megestrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009223


  7 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28463949
[Au] Autor:Peters A; Sadecky AM; Winger DG; Guido RS; Lee TTM; Mansuria SM; Donnellan NM
[Ad] Endereço:*Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, PA; †Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR; and ‡Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA.
[Ti] Título:Characterization and Preoperative Risk Analysis of Leiomyosarcomas at a High-Volume Tertiary Care Center.
[So] Source:Int J Gynecol Cancer;27(6):1183-1190, 2017 Jul.
[Is] ISSN:1525-1438
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Uterine morcellation in minimally invasive surgery has recently come under scrutiny because of inadvertent dissemination of malignant tissue, including leiomyosarcomas commonly mistaken for fibroids. Identification of preoperative risk factors is crucial to ensure that oncologic care is delivered when suspicion for malignancy is high, while offering minimally invasive hysterectomies to the remaining patients. OBJECTIVES: The aim of this study was to characterize risk factors for uterine leiomyosarcomas by reviewing preoperative, intraoperative, and postoperative data with an emphasis on the presence of concurrent fibroids. METHODS: A retrospective case-control study of women undergoing hysterectomy with pathologic diagnosis of uterine leiomyosarcoma at a tertiary care center between January 2005 and April 2014. RESULTS: Thirty-one women were identified with leiomyosarcoma and matched to 124 controls. Cases with leiomyosarcoma were more likely to have undergone menopause and to present with larger uteri (19- vs 9-week sized), with the most common presenting complaint being a pelvic mass (35.5% vs 8.9%). Controls were ten times more likely to have undergone a tubal ligation (30.6% vs 3.2%). Endometrial sampling detected malignancy preoperatively in only 50% of cases. Leiomyosarcomas were more commonly present when pelvic masses were identified in addition to fibroids on preoperative imaging. Most leiomyosarcoma cases (77.4%) were performed by oncologists via an abdominal approach (83.9%), with only 2 of 31 leiomyosarcomas being morcellated. Comparative analysis of preoperative imaging and postoperative pathology showed that in patients with leiomyosarcoma, fibroids were misdiagnosed 58.1% of the time, and leiomyosarcomas arose directly from fibroids in only 6.5% of cases. CONCLUSIONS: Leiomyosarcoma risk factors include older age/postmenopausal status, enlarged uteri of greater than 10 weeks, and lack of previous tubal ligation. Preoperative testing failed to definitively identify leiomyosarcomas, although the presence of synchronous pelvic masses in fibroid uteri should raise clinical suspicion. Given the difficulty of preoperative identification, future efforts should focus on the development of safer minimally invasive techniques for uterine morcellation.
[Mh] Termos MeSH primário: Leiomiossarcoma/patologia
Leiomiossarcoma/cirurgia
Neoplasias Uterinas/patologia
Neoplasias Uterinas/cirurgia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Seres Humanos
Histerectomia/efeitos adversos
Histerectomia/métodos
Leiomioma/patologia
Leiomioma/cirurgia
Meia-Idade
Inoculação de Neoplasia
Cuidados Pós-Operatórios
Cuidados Pré-Operatórios
Estudos Retrospectivos
Medição de Risco
Centros de Atenção Terciária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1097/IGC.0000000000000940


  8 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29233120
[Au] Autor:Obrzut B; Kusy M; Semczuk A; Obrzut M; Kluska J
[Ad] Endereço:Department of Gynaecology and Obstetrics, Faculty of Medicine, University of Rzeszow, Lwowska 60, Rzeszow, 35-301, Poland.
[Ti] Título:Prediction of 5-year overall survival in cervical cancer patients treated with radical hysterectomy using computational intelligence methods.
[So] Source:BMC Cancer;17(1):840, 2017 12 12.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer treated by radical hysterectomy. METHODS: The data set was collected from 102 patients with cervical cancer FIGO stage IA2-IIB, that underwent primary surgical treatment. Twenty-three demographic, tumor-related parameters and selected perioperative data of each patient were collected. The simulations involved six computational intelligence methods: the probabilistic neural network (PNN), multilayer perceptron network, gene expression programming classifier, support vector machines algorithm, radial basis function neural network and k-Means algorithm. The prediction ability of the models was determined based on the accuracy, sensitivity, specificity, as well as the area under the receiver operating characteristic curve. The results of the computational intelligence methods were compared with the results of linear regression analysis as a reference model. RESULTS: The best results were obtained by the PNN model. This neural network provided very high prediction ability with an accuracy of 0.892 and sensitivity of 0.975. The area under the receiver operating characteristics curve of PNN was also high, 0.818. The outcomes obtained by other classifiers were markedly worse. CONCLUSIONS: The PNN model is an effective tool for predicting 5-year overall survival in cervical cancer patients treated with radical hysterectomy.
[Mh] Termos MeSH primário: Histerectomia/estatística & dados numéricos
Redes Neurais (Computação)
Neoplasias do Colo do Útero/mortalidade
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Complicações Pós-Operatórias
Curva ROC
Máquina de Vetores de Suporte
Análise de Sobrevida
Neoplasias do Colo do Útero/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3806-3


  9 / 24159 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28454573
[Au] Autor:Kim SW; Chun M; Ryu HS; Chang SJ; Kong TW; Oh YT; Kang SH
[Ad] Endereço:Department of Radiation Oncology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea.
[Ti] Título:Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy.
[So] Source:BMC Cancer;17(1):297, 2017 04 28.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of the present study was to investigate the long-term survival outcomes and toxicities associated with our experienced early administration of adjuvant concurrent chemoradiotherapy (CCRT). METHODS: Ninety-eight patients with pelvic lymph node metastasis, positive resection margin, and/or parametrial invasion who received adjuvant CCRT between 1995 and 2011 were analyzed retrospectively. The first cycle of platinum-based adjuvant chemotherapy was initiated within 2-3 weeks after surgery (median, 12 days) and continued every 4 weeks for a total of 4 cycles. Adjuvant radiotherapy was performed during the second and third cycles of chemotherapy. RESULTS: After a median follow-up period of 119 months for survivors, 13 patients (13.3%) experienced recurrence and 11 patients died of cancer during the follow-up period. The 5-year recurrence-free survival and cancer specific survival rates were 87.6% and 90.6%, respectively. Ninety-four patients (95.9%) received ≥3 cycles of chemotherapy. Total radiation dose of ≥45 Gy was delivered in 91 patients (92.9%). Grade 3-4 hematologic and gastrointestinal toxicities developed in 37 (37.8%) and 14 (14.3%) patients during CCRT, respectively. CONCLUSION: The present study confirmed the long-term safety and encouraging survival outcomes of early administration of adjuvant CCRT, suggesting the benefits of early time to initiation of adjuvant treatments.
[Mh] Termos MeSH primário: Histerectomia/métodos
Avaliação de Resultados (Cuidados de Saúde)/métodos
Neoplasias do Colo do Útero/cirurgia
Neoplasias do Colo do Útero/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Quimiorradioterapia Adjuvante/efeitos adversos
Quimiorradioterapia Adjuvante/métodos
Diarreia/etiologia
Feminino
Seres Humanos
Histerectomia/efeitos adversos
Estimativa de Kaplan-Meier
Leucopenia/etiologia
Metástase Linfática
Meia-Idade
Análise Multivariada
Estadiamento de Neoplasias
Avaliação de Resultados (Cuidados de Saúde)/estatística & dados numéricos
Fatores de Tempo
Neoplasias do Colo do Útero/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3299-0


  10 / 24159 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28461392
[Au] Autor:Yang C; Whitmire WM; Sturdevant GL; Bock K; Moore I; Caldwell HD
[Ad] Endereço:Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
[Ti] Título:Infection of Hysterectomized Mice with Chlamydia muridarum and Chlamydia trachomatis.
[So] Source:Infect Immun;85(7), 2017 07.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We studied infection and immunity of hysterectomized mice infected with and to determine if there were differences between these species in their ability to infect vaginal squamous epithelial cells independently of proximal upper genital tract tissues. We found that readily colonized and infected vaginal squamous epithelial cells, whereas did not. Primary infection of the vaginal epithelium with produced infections of a duration longer than that reported for normal mice. Infection resulted in an inflammatory response in the vagina characterized by neutrophils and infiltrating submucosal plasma cells consisting primarily of T cells. Despite the delayed clearance, rechallenged -infected mice were highly immune. Mice vaginally infected with produced serum and vaginal wash antibodies and an antigen-specific gamma interferon-dominated Th1-biased T cell response. By comparison, mice vaginally infected with exhibited transient low-burden infections, produced no detectable tissue inflammatory response, and failed to seroconvert. We discuss how these marked differences in the biology of vaginal infection between these otherwise genetically similar species are possibly linked to pathogen-specific virulence genes and how they may influence pathology and immunity in the upper genital tract.
[Mh] Termos MeSH primário: Infecções por Chlamydia/microbiologia
Infecções por Chlamydia/patologia
Chlamydia muridarum/crescimento & desenvolvimento
Chlamydia muridarum/imunologia
Chlamydia trachomatis/crescimento & desenvolvimento
Histerectomia
Vagina/microbiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/análise
Anticorpos Antibacterianos/sangue
Infecções por Chlamydia/imunologia
Feminino
Interferon gama/secreção
Camundongos Endogâmicos C57BL
Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE



página 1 de 2416 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde