Base de dados : MEDLINE
Pesquisa : E05.111 [Categoria DeCS]
Referências encontradas : 241 [refinar]
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  1 / 241 MEDLINE  
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[PMID]:29236765
[Au] Autor:Apelgren P; Amoroso M; Lindahl A; Brantsing C; Rotter N; Gatenholm P; Kölby L
[Ad] Endereço:Department of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Sahlgrenska Academy, Göteborg, Sweden.
[Ti] Título:Chondrocytes and stem cells in 3D-bioprinted structures create human cartilage in vivo.
[So] Source:PLoS One;12(12):e0189428, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cartilage repair and replacement is a major challenge in plastic reconstructive surgery. The development of a process capable of creating a patient-specific cartilage framework would be a major breakthrough. Here, we described methods for creating human cartilage in vivo and quantitatively assessing the proliferative capacity and cartilage-formation ability in mono- and co-cultures of human chondrocytes and human mesenchymal stem cells in a three-dimensional (3D)-bioprinted hydrogel scaffold. The 3D-bioprinted constructs (5 × 5 × 1.2 mm) were produced using nanofibrillated cellulose and alginate in combination with human chondrocytes and human mesenchymal stem cells using a 3D-extrusion bioprinter. Immediately following bioprinting, the constructs were implanted subcutaneously on the back of 48 nude mice and explanted after 30 and 60 days, respectively, for morphological and immunohistochemical examination. During explantation, the constructs were easy to handle, and the majority had retained their macroscopic grid appearance. Constructs consisting of human nasal chondrocytes showed good proliferation ability, with 17.2% of the surface areas covered with proliferating chondrocytes after 60 days. In constructs comprising a mixture of chondrocytes and stem cells, an additional proliferative effect was observed involving chondrocyte production of glycosaminoglycans and type 2 collagen. This clinically highly relevant study revealed 3D bioprinting as a promising technology for the creation of human cartilage.
[Mh] Termos MeSH primário: Bioimpressão/métodos
Cartilagem/citologia
Condrócitos/citologia
Células Mesenquimais Estromais/citologia
Impressão Tridimensional
[Mh] Termos MeSH secundário: Animais
Proliferação Celular
Feminino
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189428


  2 / 241 MEDLINE  
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[PMID]:28734756
[Au] Autor:Jessop ZM; Al-Sabah A; Gardiner MD; Combellack E; Hawkins K; Whitaker IS
[Ad] Endereço:Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Science, Swansea University Medical School, Swansea, UK; The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.
[Ti] Título:3D bioprinting for reconstructive surgery: Principles, applications and challenges.
[So] Source:J Plast Reconstr Aesthet Surg;70(9):1155-1170, 2017 Sep.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Despite the increasing laboratory research in the growing field of 3D bioprinting, there are few reports of successful translation into surgical practice. This review outlines the principles of 3D bioprinting including software and hardware processes, biocompatible technological platforms and suitable bioinks. The advantages of 3D bioprinting over traditional tissue engineering techniques in assembling cells, biomaterials and biomolecules in a spatially controlled manner to reproduce native tissue macro-, micro- and nanoarchitectures are discussed, together with an overview of current progress in bioprinting tissue types relevant for plastic and reconstructive surgery. If successful, this platform technology has the potential to biomanufacture autologous tissue for reconstruction, obviating the need for donor sites or immunosuppression. The biological, technological and regulatory challenges are highlighted, with strategies to overcome these challenges by using an integrated approach from the fields of engineering, biomaterial science, cell biology and reconstructive microsurgery.
[Mh] Termos MeSH primário: Bioimpressão
Impressão Tridimensional
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


  3 / 241 MEDLINE  
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[PMID]:28711892
[Au] Autor:Pashkov V; Harkusha A
[Ad] Endereço:Poltava Law Institute Of Yaroslav Mudryi National Law University, Poltava, Ukraine.
[Ti] Título:3-D bioprinting law regulation perspectives.
[So] Source:Wiad Lek;70(3 pt 1):480-482, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Achieved level of technical progress moves us closer and closer to practical use of 3-d bioprinting technologies in real life. Such perspective raise a wide variety of crucial legal issues from the acceptable model of regulation of the science and its' societal effects to problems of the commercialization of the technology and potential restrictions of its use. Some key points on concept of legal regulation of abovementioned sphere is a base of this study. MATERIAL AND METHODS: Scientific discussion on 3-D bioprinting, European Union`s and US experience in patenting of 3-D bioprinting technologies, European Medicine Agency (EMA) or the US Food and Drug Administration (FDA) regulations, European Medical Technology Industry Association (EUCOMED) Acts. Article is based on dialectical, comparative, analytic, synthetic and comprehensive research methods. DISCUSSION: General debate of last few years comes down to an attempt to resolve hesitation between legal attempts for regulation of 3-D biobrinting and concept of complete prohibition of such activities. An adequate response to the mentioned challenge is a reasonable position between some aspects of prohibition and self-regulation, resulting in a moderate number of regulations and standards for developing and marketing. Such regulations may concern an intellectual property (IP) rights, regulation of distribution, premarket restrictions, control mechanism etc. CONCLUSION: Scientific approach and regulatory settlement of 3-D bioprinting sphere must unite to achieve a fair balance between the interests of humanity and of individuals - on the one hand, and development of science and business benefits for stakeholders - on the other. The main instruments for this must be balanced regulation of intellectual property (IP) rights, regulation of access and distribution, premarket restrictions, control mechanism etc.
[Mh] Termos MeSH primário: Bioimpressão/legislação & jurisprudência
Patentes como Assunto
[Mh] Termos MeSH secundário: União Europeia
Seres Humanos
Estados Unidos
United States Food and Drug Administration/legislação & jurisprudência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  4 / 241 MEDLINE  
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[PMID]:28662187
[Au] Autor:Rodríguez-Salvador M; Rio-Belver RM; Garechana-Anacabe G
[Ad] Endereço:Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, Mexico.
[Ti] Título:Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting.
[So] Source:PLoS One;12(6):e0180375, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This research proposes an innovative data model to determine the landscape of emerging technologies. It is based on a competitive technology intelligence methodology that incorporates the assessment of scientific publications and patent analysis production, and is further supported by experts' feedback. It enables the definition of the growth rate of scientific and technological output in terms of the top countries, institutions and journals producing knowledge within the field as well as the identification of main areas of research and development by analyzing the International Patent Classification codes including keyword clusterization and co-occurrence of patent assignees and patent codes. This model was applied to the evolving domain of 3D bioprinting. Scientific documents from the Scopus and Web of Science databases, along with patents from 27 authorities and 140 countries, were retrieved. In total, 4782 scientific publications and 706 patents were identified from 2000 to mid-2016. The number of scientific documents published and patents in the last five years showed an annual average growth of 20% and 40%, respectively. Results indicate that the most prolific nations and institutions publishing on 3D bioprinting are the USA and China, including the Massachusetts Institute of Technology (USA), Nanyang Technological University (Singapore) and Tsinghua University (China), respectively. Biomaterials and Biofabrication are the predominant journals. The most prolific patenting countries are China and the USA; while Organovo Holdings Inc. (USA) and Tsinghua University (China) are the institutions leading. International Patent Classification codes reveal that most 3D bioprinting inventions intended for medical purposes apply porous or cellular materials or biologically active materials. Knowledge clusters and expert drivers indicate that there is a research focus on tissue engineering including the fabrication of organs, bioinks and new 3D bioprinting systems. Our model offers a guide to researchers to understand the knowledge production of pioneering technologies, in this case 3D bioprinting.
[Mh] Termos MeSH primário: Bioimpressão
Impressão Tridimensional
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180375


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[PMID]:28621834
[Au] Autor:Groen WM; Diloksumpan P; van Weeren PR; Levato R; Malda J
[Ad] Endereço:Department of Orthopaedics, University Medical Centre Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
[Ti] Título:From intricate to integrated: Biofabrication of articulating joints.
[So] Source:J Orthop Res;35(10):2089-2097, 2017 Oct.
[Is] ISSN:1554-527X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self-healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology. Herein, we address the current challenges to recapitulate the complexity of articulating joints and how biofabrication could overcome them. The combination of multiple materials, biological cues and cells in a layer-by-layer fashion, can assist in reproducing both the zonal organization of cartilage and the gradual transition from resilient cartilage toward the subchondral bone in biofabricated osteochondral grafts. In this way, optimal integration of engineered constructs with the natural surrounding tissues can be obtained. Mechanical characteristics, including the smoothness and low friction that are hallmarks of the articular surface, can be tuned with multi-head or hybrid printers by controlling the spatial patterning of printed structures. Moreover, biofabrication can use digital medical images as blueprints for printing patient-specific implants. Finally, the current rapid advances in biofabrication hold significant potential for developing joint-on-a-chip models for personalized medicine and drug testing or even for the creation of implants that may be used to treat larger parts of the articulating joint. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 35:2089-2097, 2017.
[Mh] Termos MeSH primário: Bioimpressão
Cartilagem Articular
Prótese Articular
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Regeneração
Engenharia Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1002/jor.23602


  6 / 241 MEDLINE  
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[PMID]:28594678
[Au] Autor:Ravnic DJ; Leberfinger AN; Koduru SV; Hospodiuk M; Moncal KK; Datta P; Dey M; Rizk E; Ozbolat IT
[Ad] Endereço:*Department of Surgery, Penn State University, Hershey, PA†Department of Engineering Science and Mechanics, Penn State University, University Park, PA‡Huck Institutes of the Life Sciences, Penn State University, University Park, PA§Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology Shibpur, Howrah, West Bengal, India¶Department of Chemistry, Penn State University, University Park, PA||Department of Neurosurgery, Penn State University, Hershey, PA**Department of Biomedical Engineering, Penn State University, University Park, PA††Materials Research Institute, Penn State University, University Park, PA.
[Ti] Título:Transplantation of Bioprinted Tissues and Organs: Technical and Clinical Challenges and Future Perspectives.
[So] Source:Ann Surg;266(1):48-58, 2017 Jul.
[Is] ISSN:1528-1140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:: Three-dimensional (3D) bioprinting is a revolutionary technology in building living tissues and organs with precise anatomic control and cellular composition. Despite the great progress in bioprinting research, there has yet to be any clinical translation due to current limitations in building human-scale constructs, which are vascularized and readily implantable. In this article, we review the current limitations and challenges in 3D bioprinting, including in situ techniques, which are one of several clinical translational models to facilitate the application of this technology from bench to bedside. A detailed discussion is made on the technical barriers in the fabrication of scalable constructs that are vascularized, autologous, functional, implantable, cost-effective, and ethically feasible. Clinical considerations for implantable bioprinted tissues are further expounded toward the correction of end-stage organ dysfunction and composite tissue deficits.
[Mh] Termos MeSH primário: Bioimpressão
Engenharia Tecidual/métodos
Engenharia Tecidual/tendências
[Mh] Termos MeSH secundário: Bioimpressão/economia
Bioimpressão/ética
Previsões
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1097/SLA.0000000000002141


  7 / 241 MEDLINE  
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[PMID]:28586346
[Au] Autor:Poldervaart MT; Goversen B; de Ruijter M; Abbadessa A; Melchels FPW; Öner FC; Dhert WJA; Vermonden T; Alblas J
[Ad] Endereço:Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the Netherlands.
[Ti] Título:3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity.
[So] Source:PLoS One;12(6):e0177628, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In bone regenerative medicine there is a need for suitable bone substitutes. Hydrogels have excellent biocompatible and biodegradable characteristics, but their visco-elastic properties limit their applicability, especially with respect to 3D bioprinting. In this study, we modified the naturally occurring extracellular matrix glycosaminoglycan hyaluronic acid (HA), in order to yield photo-crosslinkable hydrogels with increased mechanical stiffness and long-term stability, and with minimal decrease in cytocompatibility. Application of these tailor-made methacrylated hyaluronic acid (MeHA) gels for bone tissue engineering and 3D bioprinting was the subject of investigation. Visco-elastic properties of MeHA gels, measured by rheology and dynamic mechanical analysis, showed that irradiation of the hydrogels with UV light led to increased storage moduli and elastic moduli, indicating increasing gel rigidity. Subsequently, human bone marrow derived mesenchymal stromal cells (MSCs) were incorporated into MeHA hydrogels, and cell viability remained 64.4% after 21 days of culture. Osteogenic differentiation of MSCs occurred spontaneously in hydrogels with high concentrations of MeHA polymer, in absence of additional osteogenic stimuli. Addition of bone morphogenetic protein-2 (BMP-2) to the culture medium further increased osteogenic differentiation, as evidenced by increased matrix mineralisation. MeHA hydrogels demonstrated to be suitable for 3D bioprinting, and were printed into porous and anatomically shaped scaffolds. Taken together, photosensitive MeHA-based hydrogels fulfilled our criteria for cellular bioprinted bone constructs within a narrow window of concentration.
[Mh] Termos MeSH primário: Bioimpressão
Hidrogel de Polietilenoglicol-Dimetacrilato/farmacologia
Células Mesenquimais Estromais/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Regeneração Óssea
Diferenciação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas/efeitos dos fármacos
Glicosaminoglicanos/síntese química
Glicosaminoglicanos/química
Glicosaminoglicanos/farmacologia
Seres Humanos
Ácido Hialurônico/síntese química
Ácido Hialurônico/química
Ácido Hialurônico/farmacologia
Hidrogel de Polietilenoglicol-Dimetacrilato/síntese química
Hidrogel de Polietilenoglicol-Dimetacrilato/química
Ácidos Polimetacrílicos/síntese química
Ácidos Polimetacrílicos/química
Ácidos Polimetacrílicos/farmacologia
Reologia
Engenharia Tecidual
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosaminoglycans); 0 (Polymethacrylic Acids); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177628


  8 / 241 MEDLINE  
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[PMID]:28412790
[Au] Autor:Xu J; Hu M
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
[Ti] Título:[A preliminary study of three-dimensional bio-printing by polycaprolactone and periodontal ligament stem cells].
[So] Source:Zhonghua Kou Qiang Yi Xue Za Zhi;52(4):238-242, 2017 Apr 09.
[Is] ISSN:1002-0098
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the technical scheme of three-dimensional (3D) bio-printing by polycaprolactone (PCL) and periodontal ligament stem cells (PDLSC). To manufacture a 3D bio-printing body, PDLSC were used as seed cells, and polycaprolactone (PCL) was used as the 3D printing scaffold material. Print size was designed at 13.0 mm×13.0 mm, and mesh size was 0.25 mm×0.25 mm (group A) and 0.75 mm×0.75 mm (group B). Cell counting kit-8 was used to detect the proliferation of PDLSC on day 1, day 3 and day 5 respectively. The state of the cells in the 3D printing structure was observed by scanning electron microscope (SEM). Osteoblastic ability of the 3D printing mixture was observed after 14 days of culture by alizarin red mineralized nodule staining method. Using PDLSC as seed cells and PCL as a scaffold to print two mesh-sized 3D bodies. The body thickness and porosity of group A and group B were 1.1 mm, 1.5 mm and 49.3%, 72.5% respectively. SEM showed that PDLSC proliferated significantly on two sets of 3D structure which was more obvious in group A. osteogenic induction, a large number of red mineralized nodules formed on the 3D structure. A 3D structure with a self-defined shape and size was successfully printed using 3D bio-printing equipment. PDLSC can grow and proliferate on the structure.
[Mh] Termos MeSH primário: Bioimpressão/métodos
Proliferação Celular
Ligamento Periodontal/citologia
Poliésteres
Impressão Tridimensional
Células-Tronco/fisiologia
Tecidos Suporte
[Mh] Termos MeSH secundário: Seres Humanos
Microscopia Eletrônica de Varredura
Osteogênese
Porosidade
Fatores de Tempo
Engenharia Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyesters); 24980-41-4 (polycaprolactone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1002-0098.2017.04.009


  9 / 241 MEDLINE  
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[PMID]:28412784
[Au] Autor:Hu M
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
[Ti] Título:[Three-dimensional printing and oral medicine].
[So] Source:Zhonghua Kou Qiang Yi Xue Za Zhi;52(4):206-211, 2017 Apr 09.
[Is] ISSN:1002-0098
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:After 30 years of development, three-dimensional printing technology has made great progress, and the model and surgical guide have been clinically applied. The three-dimensional printing of titanium and other metal prosthesis and dental crown after adequate research will be applied clinically, and three-dimensional bioprinting and related biological materials need further study. Three-dimensional printing provides opportunities for the development of oral medicine, which will change the way of clinical work, teaching and research. The dentists should integrate multi-disciplinary knowledge and understand the essence of new technology to meet the challenges of the era of digital medicine.
[Mh] Termos MeSH primário: Bioimpressão/tendências
Planejamento de Prótese Dentária/tendências
Prótese Dentária
Medicina Bucal/tendências
Impressão Tridimensional/tendências
[Mh] Termos MeSH secundário: Bioimpressão/métodos
Planejamento de Prótese Dentária/métodos
Seres Humanos
Medicina Bucal/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1002-0098.2017.04.003


  10 / 241 MEDLINE  
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[PMID]:28333087
[Au] Autor:Souza GR; Tseng H; Gage JA; Mani A; Desai P; Leonard F; Liao A; Longo M; Refuerzo JS; Godin B
[Ad] Endereço:Nano3D Biosciences, Houston, TX 77030, USA. GSouza@n3dbio.com.
[Ti] Título:Magnetically Bioprinted Human Myometrial 3D Cell Rings as A Model for Uterine Contractility.
[So] Source:Int J Mol Sci;18(4), 2017 Mar 23.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Deregulation in uterine contractility can cause common pathological disorders of the female reproductive system, including preterm labor, infertility, inappropriate implantation, and irregular menstrual cycle. A better understanding of human myometrium contractility is essential to designing and testing interventions for these important clinical problems. Robust studies on the physiology of human uterine contractions require in vitro models, utilizing a human source. Importantly, uterine contractility is a three-dimensionally (3D)-coordinated phenomenon and should be studied in a 3D environment. Here, we propose and assess for the first time a 3D in vitro model for the evaluation of human uterine contractility. Magnetic 3D bioprinting is applied to pattern human myometrium cells into rings, which are then monitored for contractility over time and as a function of various clinically relevant agents. Commercially available and patient-derived myometrium cells were magnetically bioprinted into rings in 384-well formats for throughput uterine contractility analysis. The bioprinted uterine rings from various cell origins and patients show different patterns of contractility and respond differently to clinically relevant uterine contractility inhibitors, indomethacin and nifedipine. We believe that the novel system will serve as a useful tool to evaluate the physiology of human parturition while enabling high-throughput testing of multiple agents and conditions.
[Mh] Termos MeSH primário: Bioimpressão/métodos
Miométrio/fisiologia
Contração Uterina
[Mh] Termos MeSH secundário: Células Cultivadas
Feminino
Seres Humanos
Indometacina/farmacologia
Imãs
Miométrio/citologia
Miométrio/efeitos dos fármacos
Nifedipino/farmacologia
Medicina de Precisão/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I9ZF7L6G2L (Nifedipine); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170507
[Lr] Data última revisão:
170507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE



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