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Pesquisa : E05.196.620 [Categoria DeCS]
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  1 / 9882 MEDLINE  
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[PMID]:28541344
[Au] Autor:Medina-Sánchez M; Schmidt OG
[Ad] Endereço:Micro and Nano-biomedical Engineering Group at the Leibniz IFW in Dresden, Germany.
[Ti] Título:Medical microbots need better imaging and control.
[So] Source:Nature;545(7655):406-408, 2017 05 24.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Materiais Biocompatíveis/análise
Materiais Biocompatíveis/normas
Equipamentos para Diagnóstico
Microquímica/instrumentação
Robótica/instrumentação
Terapêutica/instrumentação
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Seres Humanos
Movimento (Física)
Nanomedicina/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Biocompatible Materials)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1038/545406a


  2 / 9882 MEDLINE  
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[PMID]:28476957
[Au] Autor:Korrapati S; Pullela PK; Vijayalakshmi U
[Ad] Endereço:Bigtec Pvt. Ltd., 59th 'C' cross, 4th 'M' Block, Rajajinagar, Bangalore 560 010, India.
[Ti] Título:SPA enhanced FPIA-based detection of pesticide residue with ppb/ppt level detection limit.
[So] Source:IET Nanobiotechnol;11(1):24-31, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pesticide residue in fruits & vegetables is one of the key issues affecting the export of rural products in India. Pesticide exposure or intake causes major nervous system problems in children. The solutions to quantitate them in field are rare and the pesticide residue detection in the parts per billion (ppb) ranges is challenging. Except ELISA, none of the existing methods can detect pesticide residues in ppb range in the field. We employed a new approach of concentrating field samples and used sodium polyacrylate (SPA) as water absorbing material. The SPA beads concentrate the field samples and obtained a sub ppb range detection using an existing FPIA system and could improve overall sensitivity by 10-100 fold. The developed assay can be done in few seconds. We have used three pesticides 2,4-D, atrazine and methyl parathion with 0.1, 0.5 and 3 ppb detection limit respectively. We developed a simple field ready FPIA device and used sodium poly acrylate (SPA) in this biochemical FPIA to enhance sensitivity. Our tests with spiked field samples offers a possibility of using SPA concentration assisted FPIA in field. This study will have far reaching applications of both qualitative & quantitative analysis chemical analytes in field samples.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Imunoensaio de Fluorescência por Polarização/métodos
Microquímica/métodos
Resíduos de Praguicidas/análise
[Mh] Termos MeSH secundário: Absorção Fisiológica
Poluentes Ambientais/química
Resíduos de Praguicidas/química
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Environmental Pollutants); 0 (Pesticide Residues); 4Q93RCW27E (carbopol 940)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0031


  3 / 9882 MEDLINE  
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[PMID]:28237077
[Au] Autor:Andronis C; Evans NJ; McDonald BJ; Nice HE; Gagnon MM
[Ad] Endereço:Department of Environment and Agriculture, Curtin University, P.O. Box U1987, Perth, Western Australia 6845, Australia.
[Ti] Título:Otolith microchemistry: Insights into bioavailable pollutants in a man-made, urban inlet.
[So] Source:Mar Pollut Bull;118(1-2):382-387, 2017 May 15.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Black bream (Acanthopagrus butcheri) were collected from an artificial inlet, Claisebrook Cove, Western Australia. Claisebrook Cove is adjacent to an historic contaminated site that was remediated during the 1990s. It was later identified as a priority area due to elevated levels of sediment contaminants including Zn, Cu, and Pb. Black bream were collected from this cove in 2005 and 2012 and their otoliths were analysed by laser ablation inductively coupled plasma mass spectrometry of the most recent growth zone. Levels of Zn and Mn, which are metabolically regulated, did not correlate with sediment contamination. However, reduction in sediment Cu levels over time coincided with reduced Cu otolith levels from 2005 to 2012. Results indicate that the elemental composition of the marginal edge of Black bream otoliths can identify bioavailable contaminants in an urban estuary and, with monitoring, can be utilized to establish long-term trends.
[Mh] Termos MeSH primário: Metais Pesados/análise
Membrana dos Otólitos/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Baías
Estuários
Sedimentos Geológicos
Microquímica
Perciformes
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


  4 / 9882 MEDLINE  
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[PMID]:28117523
[Au] Autor:Silva PE; Godinho MH
[Ad] Endereço:Departmento de Física/I3N - Universidade de Aveiro, Campus Universitario de Santiago, 3810-193, Aveiro, Portugal.
[Ti] Título:Helical Microfilaments with Alternating Imprinted Intrinsic Curvatures.
[So] Source:Macromol Rapid Commun;38(5), 2017 Mar.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There has been an intense research for developing techniques that can produce filaments with helical shapes, given the widespread of potential applications. In this work, how helices with different curvatures can be precisely imprinted in microfilaments is shown. It is also shown that using this technique, it is possible to produce, in a single fiber, helices with different curvatures. This striking and innovative behavior is observed when one side of the stretched filaments is irradiated with UV light, modifying the mechanical properties at surface. Upon release, the regions with higher curvature start to curl first, while regions with lower intrinsic curvature remain stretched until start to curl later. The results presented here can be important to understand why structures adopt a helical shape in general, which can be of interest in nanotechnology, biomolecular science, or even to understand why plant filaments curl.
[Mh] Termos MeSH primário: Microquímica/métodos
Impressão Molecular
[Mh] Termos MeSH secundário: Elasticidade
Nanotecnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201600700


  5 / 9882 MEDLINE  
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[PMID]:28052443
[Au] Autor:Artus GR; Olveira S; Patra D; Seeger S
[Ad] Endereço:Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
[Ti] Título:Directed In Situ Shaping of Complex Nano- and Microstructures during Chemical Synthesis.
[So] Source:Macromol Rapid Commun;38(4), 2017 Feb.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chemical composition and shape determine the basic properties of any object. Commonly, chemical synthesis and shaping follow each other in a sequence, although their combination into a single process would be an elegant simplification. Here, a pathway of simultaneous synthesis and shaping as applied to polysiloxanes on the micro- and nanoscale is presented. Complex structures such as stars, chalices, helices, volcanoes, rods, or combinations thereof are obtained. Varying the shape-controlling reaction parameters including temperature, water saturation, and the type of substrate allows to direct the reaction toward specific structures. A general mechanism of growth is suggested and analytical evidence and thermodynamic calculations to support it are provided. An aqueous droplet in either gaseous atmosphere or in a liquid organic solvent serves as a spatially confined polymerization volume. By substituting the starting materials, germanium-based nanostructures are also obtained. This transferability marks this approach as a major step toward a generally applicable method of chemical synthesis including in situ shaping.
[Mh] Termos MeSH primário: Microquímica/métodos
Nanoestruturas/química
Siloxanas/síntese química
[Mh] Termos MeSH secundário: Tamanho da Partícula
Siloxanas/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Siloxanes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201600558


  6 / 9882 MEDLINE  
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[PMID]:27981582
[Au] Autor:Phelps QE; Hupfeld RN; Whitledge GW
[Ad] Endereço:Big Rivers and Wetlands Field Station, Missouri Department of Conservation, 3815 East Jackson Boulevard, Jackson, MO, 63755, U.S.A.
[Ti] Título:Lake sturgeon Acipenser fulvescens and shovelnose sturgeon Scaphirhynchus platorynchus environmental life history revealed using pectoral fin-ray microchemistry: implications for interjurisdictional conservation through fishery closure zones.
[So] Source:J Fish Biol;90(2):626-639, 2017 Feb.
[Is] ISSN:1095-8649
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study inferred that the majority of shovelnose sturgeon Scaphirhynchus platorynchus captured in the upper Mississippi River probably originated from locations outside the upper Mississippi River (Missouri River, middle Mississippi River); whereas, lake sturgeon Acipenser fulvescens exhibit infrequent movement outside of the upper Mississippi River, but may move throughout these interconnected large rivers at various life stages. By using pectoral fin-ray microchemistry (a non-lethal alternative to using otoliths), it is suggest that interjurisdictional cooperation will probably be needed to ensure sustainability of the S. platorynchus commercial fishery and the success of A. fulvescens reintroduction in the upper Mississippi River. Additionally, fin-ray microchemistry can provide invaluable data to make informed management decisions regarding large river fishes, that cross jurisdictional boundaries or that move outside of closure zones, without causing further mortality to compromised fish populations (e.g. threatened and endangered species).
[Mh] Termos MeSH primário: Distribuição Animal
Nadadeiras de Animais/química
Conservação dos Recursos Naturais
Peixes/fisiologia
[Mh] Termos MeSH secundário: Animais
Pesqueiros/legislação & jurisprudência
Peixes/crescimento & desenvolvimento
Lagos/química
Estágios do Ciclo de Vida
Microquímica
Rios/química
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.1111/jfb.13242


  7 / 9882 MEDLINE  
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[PMID]:27636538
[Au] Autor:Castells Martínez EM; Del Valle R; González EC; Melchor A; Pérez PL; González I; Carr A; León K
[Ad] Endereço:a Neonatal Screening Laboratory , Immunoassay Center , Havana , Cuba.
[Ti] Título:An enzyme immunoassay for determining epidermal growth factor (EGF) in human serum samples using an ultramicroanalytical system.
[So] Source:J Immunoassay Immunochem;38(2):190-201, 2017.
[Is] ISSN:1532-4230
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human epidermal growth factor is a small peptide consisting of 53 amino acid residues, which stimulates cell proliferation and is associated with several human carcinomas. A simple sandwich-type ultramicroELISA assay (UMELISA), based on the advantages of high affinity reaction between streptavidin and biotin has been developed for the measurement of EGF in human serum samples. Strips coated with a high affinity monoclonal antibody directed against EGF are used as solid phase, to ensure the specificity of the assay. The EGF assay was completed in 18 hr, with a measuring range of 39-2500 pg/mL. The intra- and inter-assay coefficients of variation were 4.4-7.3% and 0-5.1%, respectively, depending on the EGF concentrations evaluated. Percentage recovery ranged from 96-104%. Regression analysis showed a good correlation with the commercially available Human EGF Immunoassay Quantikine ELISA kit (n = 130, r = 0.92, P < 0.01). The analytical performance characteristics of our UMELISA EGF endorse its use for the quantification of EGF in human serum samples.
[Mh] Termos MeSH primário: Ensaio de Imunoadsorção Enzimática/métodos
Fator de Crescimento Epidérmico/sangue
Microquímica/métodos
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/imunologia
Fator de Crescimento Epidérmico/imunologia
Seres Humanos
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 62229-50-9 (Epidermal Growth Factor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.1080/15321819.2016.1236729


  8 / 9882 MEDLINE  
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[PMID]:27214887
[Au] Autor:Constantinou L; Triantis IF; Hickey M; Kyriacou PA
[Ti] Título:On the Merits of Tetrapolar Impedance Spectroscopy for Monitoring Lithium Concentration Variations in Human Blood Plasma.
[So] Source:IEEE Trans Biomed Eng;64(3):601-609, 2017 Mar.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bipolar disorder is characterized as a manic-depressive psychiatric syndrome with life-threatening risks to the patient. Diagnosed individuals undergo long-term lithium therapy which has proven to be effective for mood stabilization. Maintaining blood lithium concentration levels within a narrow therapeutic window between 0.6 and 1.5 mM is vital for the patient as slightly elevated concentrations of the order of 0.1 mM can be toxic. This paper aims to evaluate the merits of tetrapolar electrical impedance spectroscopy as an alternative method in monitoring blood lithium levels. Measurements were performed using a custom-made tetrapolar probe in human blood plasma with lithium concentrations covering the therapeutic range. The results indicate a limit of detection less than 0.1 mM and a response time of less than 5 s. Prediction of lithium concentration levels using impedance values is in good agreement with conventional standard techniques to approximately 0.05 mM. This technique provides a basis for further development of instrumentation for point of care healthcare technologies.
[Mh] Termos MeSH primário: Análise Química do Sangue/instrumentação
Espectroscopia Dielétrica/instrumentação
Monitoramento de Medicamentos/instrumentação
Eletrodos
Compostos de Lítio/sangue
Microquímica/instrumentação
[Mh] Termos MeSH secundário: Análise Química do Sangue/métodos
Projeto Auxiliado por Computador
Espectroscopia Dielétrica/métodos
Monitoramento de Medicamentos/métodos
Condutividade Elétrica
Desenho de Equipamento
Análise de Falha de Equipamento
Seres Humanos
Compostos de Lítio/uso terapêutico
Microquímica/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lithium Compounds)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2570125


  9 / 9882 MEDLINE  
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[PMID]:26955010
[Au] Autor:Demitri N; Zoubir AM
[Ti] Título:Measuring Blood Glucose Concentrations in Photometric Glucometers Requiring Very Small Sample Volumes.
[So] Source:IEEE Trans Biomed Eng;64(1):28-39, 2017 Jan.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucometers present an important self-monitoring tool for diabetes patients and, therefore, must exhibit high accuracy as well as good usability features. Based on an invasive photometric measurement principle that drastically reduces the volume of the blood sample needed from the patient, we present a framework that is capable of dealing with small blood samples, while maintaining the required accuracy. The framework consists of two major parts: 1) image segmentation; and 2) convergence detection. Step 1 is based on iterative mode-seeking methods to estimate the intensity value of the region of interest. We present several variations of these methods and give theoretical proofs of their convergence. Our approach is able to deal with changes in the number and position of clusters without any prior knowledge. Furthermore, we propose a method based on sparse approximation to decrease the computational load, while maintaining accuracy. Step 2 is achieved by employing temporal tracking and prediction, herewith decreasing the measurement time, and, thus, improving usability. Our framework is tested on several real datasets with different characteristics. We show that we are able to estimate the underlying glucose concentration from much smaller blood samples than is currently state of the art with sufficient accuracy according to the most recent ISO standards and reduce measurement time significantly compared to state-of-the-art methods.
[Mh] Termos MeSH primário: Algoritmos
Automonitorização da Glicemia/métodos
Glicemia/análise
Coleta de Amostras Sanguíneas/métodos
Microquímica/métodos
Fotometria/métodos
[Mh] Termos MeSH secundário: Automonitorização da Glicemia/instrumentação
Seres Humanos
Microquímica/instrumentação
Fotometria/instrumentação
Sistemas Automatizados de Assistência Junto ao Leito
Reprodutibilidade dos Testes
Tamanho da Amostra
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2530021


  10 / 9882 MEDLINE  
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[PMID]:27454738
[Au] Autor:Weiner A; Lara-Astiaso D; Krupalnik V; Gafni O; David E; Winter DR; Hanna JH; Amit I
[Ad] Endereço:The Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
[Ti] Título:Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.
[So] Source:Nat Biotechnol;34(9):953-61, 2016 Sep.
[Is] ISSN:1546-1696
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histone modifications play an important role in chromatin organization and transcriptional regulation, but despite the large amount of genome-wide histone modification data collected in different cells and tissues, little is known about co-occurrence of modifications on the same nucleosome. Here we present a genome-wide quantitative method for combinatorial indexed chromatin immunoprecipitation (co-ChIP) to characterize co-occurrence of histone modifications on nucleosomes. Using co-ChIP, we study the genome-wide co-occurrence of 14 chromatin marks (70 pairwise combinations), and find previously undescribed co-occurrence patterns, including the co-occurrence of H3K9me1 and H3K27ac in super-enhancers. Finally, we apply co-ChIP to measure the distribution of the bivalent H3K4me3-H3K27me3 domains in two distinct mouse embryonic stem cell (mESC) states and in four adult tissues. We observe dynamic changes in 5,786 regions and discover both loss and de novo gain of bivalency in key tissue-specific regulatory genes, suggesting a functional role for bivalent domains during different stages of development. These results show that co-ChIP can reveal the complex interactions between histone modifications.
[Mh] Termos MeSH primário: Imunoprecipitação da Cromatina/métodos
Mapeamento Cromossômico/métodos
Genoma/genética
Código das Histonas/genética
Histonas/genética
Microquímica/métodos
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Técnicas de Química Combinatória/métodos
Sequenciamento de Nucleotídeos em Larga Escala
Camundongos
Ligação Proteica
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histones)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1038/nbt.3652



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