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Pesquisa : E05.196.690 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:27731826
[Au] Autor:Wei G; Zhan T; Zhan X; Yu L; Wang X; Tan X; Li C
[Ad] Endereço:Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, PR China.
[Ti] Título:Calculating osmotic pressure of glucose solutions according to ASOG model and measuring it with air humidity osmometry.
[So] Source:Pak J Pharm Sci;29(5):1657-1600, 2016 Sep.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The osmotic pressure of glucose solution at a wide concentration range was calculated using ASOG model and experimentally determined by our newly reported air humidity osmometry. The measurements from air humidity osmometry were compared with the well-established freezing point osmometry and ASOG model calculations at low concentrations and with only ASOG model calculations at high concentrations where no standard experimental method could serve as a reference for comparison. Results indicate that air humidity osmometry measurements are comparable to ASOG model calculations at a wide concentration range, while at low concentrations freezing point osmometry measurements provide better comparability with ASOG model calculations.
[Mh] Termos MeSH primário: Glucose/química
Osmometria/métodos
Água/química
[Mh] Termos MeSH secundário: Ar
Umidade
Modelos Químicos
Pressão Osmótica
Reprodutibilidade dos Testes
Solubilidade
Temperatura de Transição
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


  2 / 27 MEDLINE  
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[PMID]:26808383
[Au] Autor:García N; Melvi G; Pinto-Fraga J; Calonge M; Maldonado MJ; González-García MJ
[Ad] Endereço:*PhD †MSc Ocular Surface Group, Instituto de Oftalmobiología Aplicada (IOBA), University of Valladolid, Valladolid, Spain (NG, GM, JP-F, MC, MJM, MJG-G); and CIBER-BBN, Valladolid, Spain (JP-F, MC, MJG-G).
[Ti] Título:Lack of Agreement among Electrical Impedance and Freezing-Point Osmometers.
[So] Source:Optom Vis Sci;93(5):482-7, 2016 May.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the interchangeability of tear osmolarity measurements between electrical impedance and freezing-point depression osmometers and to analyze inter-eye tear osmolarity variability measured with these osmometers in healthy subjects. METHODS: Tear osmolarity was measured using the TearLab osmometer (OcuSense Inc., San Diego, CA) and the Fiske 210 microsample osmometer (Advanced Instruments Inc., Norwood, MA). We randomly selected one eye in 50 subjects (29 women, 21 men; mean age, 33.16 ± 6.11 years) to analyze whether osmolarity measurements by these osmometers were interchangeable. Both eyes of 25 patients (15 women, 10 men; mean age, 34.32 ± 6.37 years) were included to analyze inter-eye osmolarity variability. RESULTS: The mean tear osmolarity values measured with the TearLab osmometer were higher (305.22 ± 16.06 mOsm/L) than those with the Fiske 210 osmometer (293.40 ± 12.22 mOsm/L), with the intraclass correlation coefficient being 0.23 (p = 0.051). A Bland-Altman plot showed that the systems were not interchangeable because there was a systematic difference, with the limits of agreement being -17.93 to 41.57 mOsm/L. There were no statistically significant differences (p = 0.5006 and p = 0.6533, respectively) between an individual's eyes measured with either osmometer. CONCLUSIONS: Because the TearLab tear osmolarity measurements were higher than those of the Fiske 210 measurements and the limits of agreement were too wide, the two osmolarity values cannot be used interchangeably. In healthy subjects, there is no difference in tear osmolarity between right and left eyes of the same individual measured with both instruments.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Oftalmológico/instrumentação
Osmometria/instrumentação
Lágrimas/química
[Mh] Termos MeSH secundário: Adulto
Síndromes do Olho Seco/etiologia
Impedância Elétrica
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Concentração Osmolar
Reprodutibilidade dos Testes
Temperatura de Transição
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000000817


  3 / 27 MEDLINE  
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[PMID]:26331213
[Au] Autor:Arndt SK; Irawan A; Sanders GJ
[Ad] Endereço:School of Ecosystem and Forest Sciences, The University of Melbourne, Richmond, Victoria, 3121, Australia.
[Ti] Título:Apoplastic water fraction and rehydration techniques introduce significant errors in measurements of relative water content and osmotic potential in plant leaves.
[So] Source:Physiol Plant;155(4):355-68, 2015 Dec.
[Is] ISSN:1399-3054
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Relative water content (RWC) and the osmotic potential (π) of plant leaves are important plant traits that can be used to assess drought tolerance or adaptation of plants. We estimated the magnitude of errors that are introduced by dilution of π from apoplastic water in osmometry methods and the errors that occur during rehydration of leaves for RWC and π in 14 different plant species from trees, grasses and herbs. Our data indicate that rehydration technique and length of rehydration can introduce significant errors in both RWC and π. Leaves from all species were fully turgid after 1-3 h of rehydration and increasing the rehydration time resulted in a significant underprediction of RWC. Standing rehydration via the petiole introduced the least errors while rehydration via floating disks and submerging leaves for rehydration led to a greater underprediction of RWC. The same effect was also observed for π. The π values following standing rehydration could be corrected by applying a dilution factor from apoplastic water dilution using an osmometric method but not by using apoplastic water fraction (AWF) from pressure volume (PV) curves. The apoplastic water dilution error was between 5 and 18%, while the two other rehydration methods introduced much greater errors. We recommend the use of the standing rehydration method because (1) the correct rehydration time can be evaluated by measuring water potential, (2) overhydration effects were smallest, and (3) π can be accurately corrected by using osmometric methods to estimate apoplastic water dilution.
[Mh] Termos MeSH primário: Parede Celular/metabolismo
Osmose/fisiologia
Folhas de Planta/metabolismo
Água/metabolismo
[Mh] Termos MeSH secundário: Osmometria/métodos
Pressão Osmótica
Fenômenos Fisiológicos Vegetais/fisiologia
Poaceae/classificação
Poaceae/metabolismo
Reprodutibilidade dos Testes
Especificidade da Espécie
Árvores/classificação
Árvores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150903
[St] Status:MEDLINE
[do] DOI:10.1111/ppl.12380


  4 / 27 MEDLINE  
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[PMID]:26164315
[Au] Autor:Pena-Verdeal H; García-Resúa C; Miñones M; Giraldez MJ; Yebra-Pimentel E
[Ad] Endereço:*OD, MSc †OD, PhD ‡OD, MSc, PhD Departamento de Física Aplicada, Área de Optometría (Grupo de Optometría), Universidade de Santiago de Compostela, Santiago de Compostela, España (all authors).
[Ti] Título:Accuracy of a Freezing Point Depression Technique Osmometer.
[So] Source:Optom Vis Sci;92(9):e273-83, 2015 Sep.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to examine the precision and accuracy of the Fiske 110 Osmolarity System under different protocols to determine the possible applications of this device in tear film research and clinical practice. METHODS: Three separate studies were performed. In the first, Fiske 110 measurements were made on undiluted and diluted (1:1, 1:4, and 1:9 dilutions) standard samples of different osmolarity values: 50, 290, and 850 mOsm/kg and 297 and 338 mOsm/L. In the second study, measurements were made on different types of contact lens care solutions. Finally, in an agreement study, measurements were made in two sets of 60 subjects to compare TearLab versus Fiske 110 (using both 2- and 4-µL tear sample). RESULTS: Although osmolarity measurements for undiluted solutions differed statistically from reference standard values, all biases were in the tolerance range proposed by the manufacturer except for the 850-mOsm/kg solution. No significant differences from reference osmolarity values were observed for the 1:1 and 1:4 diluted 297- and 338-mOsm/L H2O solutions, respectively, although all diluted solutions showed a possible bias out of the range provided. Osmolarities for the soft contact lens solutions fell within the range 293 to 309 mOsm/kg with the exception of Opti-Free Express (225 mOsm/kg). In the agreement study, significant differences were observed between measurements obtained using the TearLab and both Fiske 110 procedures, although the Fiske 110 (4 µL) procedure was closer to the TearLab than the Fiske (2 µL) procedure. CONCLUSIONS: For undiluted solutions, the Fiske 110 shows good performance, making it a useful device for osmolarity measurements in lens care solutions or eye drops. A worse performance was observed for more diluted standard solution samples. When testing diluted samples, performance was acceptable for osmolarity values close to tear values.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Oftalmológico/instrumentação
Osmometria/instrumentação
Lágrimas/química
[Mh] Termos MeSH secundário: Soluções para Lentes de Contato/química
Lubrificantes Oftálmicos/química
Concentração Osmolar
Reprodutibilidade dos Testes
Cloreto de Sódio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contact Lens Solutions); 0 (Lubricant Eye Drops); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150713
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000000669


  5 / 27 MEDLINE  
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[PMID]:26153711
[Au] Autor:Hong J; Gierasch LM; Liu Z
[Ad] Endereço:School of Life Science, Shanghai University, Shanghai, China. Electronic address: jiangh2@shu.edu.cn.
[Ti] Título:Its preferential interactions with biopolymers account for diverse observed effects of trehalose.
[So] Source:Biophys J;109(1):144-53, 2015 Jul 07.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biopolymer homeostasis underlies the health of organisms, and protective osmolytes have emerged as one strategy used by Nature to preserve biopolymer homeostasis. However, a great deal remains unknown about the mechanism of action of osmolytes. Trehalose, as a prominent example, stabilizes proteins against denaturation by extreme temperature and denaturants, preserves membrane integrity upon freezing or in dry conditions, inhibits polyQ-mediated protein aggregation, and suppresses the aggregation of denatured proteins. The underlying thermodynamic mechanisms of such diverse effects of trehalose remain unclear or controversial. In this study, we applied the surface-additive method developed in the Record laboratory to attack this issue. We characterized the key features of trehalose-biopolymer preferential interactions and found that trehalose has strong unfavorable interactions with aliphatic carbon and significant favorable interactions with amide/anionic oxygen. This dissection has allowed us to elucidate the diverse effects of trehalose and to identify the crucial functional group(s) responsible for its effects. With (semi)quantitative thermodynamic analysis, we discovered that 1) the unfavorable interaction of trehalose with hydrophobic surfaces is the dominant factor in its effect on protein stability, 2) the favorable interaction of trehalose with polar amides enables it to inhibit polyQ-mediated protein aggregation and the aggregation of denatured protein in general, and 3) the favorable interaction of trehalose with phosphate oxygens, together with its unfavorable interaction with aliphatic carbons, enables trehalose to preserve membrane integrity in aqueous solution. These results provide a basis for a full understanding of the role of trehalose in biopolymer homeostasis and the reason behind its evolutionary selection as an osmolyte, as well as for a better application of trehalose as a chemical chaperone.
[Mh] Termos MeSH primário: Biopolímeros/química
Trealose/química
[Mh] Termos MeSH secundário: Carbono/química
Interações Hidrofóbicas e Hidrofílicas
Modelos Químicos
Osmometria
Oxigênio/química
Fosfatos/química
Estabilidade Proteica
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biopolymers); 0 (Phosphates); 7440-44-0 (Carbon); B8WCK70T7I (Trehalose); S88TT14065 (Oxygen)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150709
[St] Status:MEDLINE


  6 / 27 MEDLINE  
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[PMID]:25789693
[Au] Autor:Dutescu RM; Panfil C; Schrage N
[Ad] Endereço:*Aachen Centre of Technology Transfer in Ophthalmology (ACTO e.V.), An-Institute, RWTH Aachen University, Aachen, Germany; and †Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
[Ti] Título:Osmolarity of prevalent eye drops, side effects, and therapeutic approaches.
[So] Source:Cornea;34(5):560-6, 2015 May.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Little is known about how the osmolarity of ophthalmic formulations affects the ocular surface. Because hyperosmolar eye drops could be therapeutic for treating corneal edema, this article presents an ex vivo model of corneal edema for testing ophthalmic drugs based on their osmolarity. The respective osmolarity of common eye drops found in the German market is also analyzed here. METHODS: For modeling corneal edema, an Ex Vivo Eye Irritation Test was used to simulate an ocular anterior chamber with a physiological corneal barrier. To induce corneal edema, the anterior chamber was supplied with a hypoosmolar medium (148 mOsm/L) for 24 hours. Preserved and preservative-free 5% sodium chloride (hyperosmolar Omnisorb and Ocusalin 5% UD) were used for 1 hour, on 5 corneas each, to test their efficiency to reduce corneal edema in this model. Corneal thickness was determined by optical coherence tomography. Osmolarity of 87 common eye drops was measured by freezing point osmometry. RESULTS: Ex vivo, the tested hypoosmolar condition induced corneal edema from 450 µm (±50 µm) at baseline to 851 µm (±94 µm, P < 0.0001). Omnisorb and Ocusalin 5% UD significantly reduced the corneal thickness by 279 µm (±28 µm, P < 0.001) for Omnisorb and 258 µm (±29 µm, P < 0.001) for Ocusalin 5% UD. Forty-three (49%) of the tested products had an osmolarity below and 44 (51%) above the physiological tear osmolarity of 289 mOsm/L. Osmolarity values of less than 200 mOsm/L were found in lubricant drops. The highest osmolarity was detected in Omnisorb (1955 mOsm/L). CONCLUSIONS: The Ex Vivo Eye Irritation Test has proven to be a reliable novel model of corneal edema for evaluating osmotic eye drops. Osmolarity measurements revealed a wide range from hypotonic to hypertonic formulations for commonly marketed ophthalmic drugs.
[Mh] Termos MeSH primário: Edema da Córnea/tratamento farmacológico
Modelos Animais de Doenças
Lubrificantes Oftálmicos
Preparações Farmacêuticas/química
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Química Farmacêutica
Edema da Córnea/induzido quimicamente
Edema da Córnea/diagnóstico
Soluções Hipotônicas/efeitos adversos
Soluções Hipotônicas/química
Soluções Hipotônicas/uso terapêutico
Lubrificantes Oftálmicos/efeitos adversos
Lubrificantes Oftálmicos/química
Lubrificantes Oftálmicos/uso terapêutico
Técnicas de Cultura de Órgãos
Concentração Osmolar
Osmometria
Conservantes Farmacêuticos/efeitos adversos
Conservantes Farmacêuticos/química
Conservantes Farmacêuticos/uso terapêutico
Coelhos
Solução Salina Hipertônica/efeitos adversos
Solução Salina Hipertônica/química
Solução Salina Hipertônica/uso terapêutico
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypotonic Solutions); 0 (Lubricant Eye Drops); 0 (Pharmaceutical Preparations); 0 (Preservatives, Pharmaceutical); 0 (Saline Solution, Hypertonic)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150331
[Lr] Data última revisão:
150331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150320
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000368


  7 / 27 MEDLINE  
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[PMID]:25255132
[Au] Autor:Ozsutcu M; Arslan B; Erdur SK; Gulkilik G; Kocabora SM; Muftuoglu O
[Ad] Endereço:Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
[Ti] Título:Tear osmolarity and tear film parameters in patients with unilateral pterygium.
[So] Source:Cornea;33(11):1174-8, 2014 Nov.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to evaluate the differences in tear osmolarity and tear film parameters between pterygium-affected and healthy fellow eyes. METHODS: The study enrolled 65 patients with unilateral pterygium. Tear osmolarity, tear film break-up time (TBUT), Schirmer I test measurements, fluorescein corneal staining, and conjunctival redness were evaluated. The results were compared between pterygium-affected eyes and healthy fellow eyes of the same patient (controls). The pterygium thickness was measured using optical coherence tomography. We also evaluated the relationship between pterygium thickness and tear osmolarity and between TBUT and Schirmer I test results in eyes with pterygium. RESULTS: The mean tear osmolarity was 307 mOsm/L in pterygium-affected eyes and 294 mOsm/L in control eyes. The mean values of TBUT, Schirmer I test, corneal staining, and conjunctival redness scores were 10.3 ± 3.4 seconds, 14.8 ± 9.2 mm, 1.2 ± 1.1, and 0.9 ± 0.9 in the pterygium group, whereas the mean values were 12.3 ± 4.4 seconds, 16.2 ± 7.2 mm, 0.4 ± 0.8, and 0.4 ± 0.7 in the control group, respectively. Eyes with pterygium had significantly higher tear osmolarity levels, corneal staining, and conjunctival redness scores; and lower tear film TBUT and Schirmer I test values than eyes without pterygium (Wilcoxon signed rank test, P < 0.05). There was no significant correlation between pterygium thickness versus tear osmolarity, TBUT, and Schirmer I test values in eyes with pterygium (r = 0.159, 0.738, 0.321, respectively; P > 0.05). CONCLUSIONS: This study showed that pterygium is associated with tear hyperosmolarity and abnormal tear film function.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/fisiopatologia
Pterígio/fisiopatologia
Lágrimas/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
Impedância Elétrica
Feminino
Fluorofotometria
Seres Humanos
Masculino
Meia-Idade
Concentração Osmolar
Osmometria
Lágrimas/química
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1504
[Cu] Atualização por classe:141007
[Lr] Data última revisão:
141007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140926
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000221


  8 / 27 MEDLINE  
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[PMID]:24927393
[Au] Autor:Wakabayashi S; Kuse M; Kida A; Komeda S; Tatsumi K; Sugihara Y
[Ad] Endereço:Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie 510-0293, Japan. s-waka@suzuka-u.ac.jp.
[Ti] Título:The structure of 3-(diethylborylethynyl)pyridine: a nonplanarly arranged cyclic trimer.
[So] Source:Org Biomol Chem;12(29):5382-7, 2014 Aug 07.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:3-(Diethylborylethynyl)pyridines 2 assemble into a cyclic trimer stabilized via intermolecular boron­nitrogen coordination bonds both in solution and in the crystalline state. The outstanding structural features of the methoxy derivative 2b in the crystalline state are that (1) two pyridine rings (P1 and P2) of the cyclic trimer of 2b are almost coplanar, and the third pyridine ring (P3) is largely bent away from P1 and P2, and (2) P3 of the cyclic trimer stacks in a face-to-face fashion with one of the pyridine rings (P3') of an adjacent cyclic trimer. The crystallographic study revealed that the conformation of the cyclic trimer is flexible enough to be affected by the crystal packing.
[Mh] Termos MeSH primário: Compostos de Boro/química
Piridinas/química
[Mh] Termos MeSH secundário: Compostos de Boro/síntese química
Cristalografia por Raios X
Ciclização
Espectroscopia de Ressonância Magnética
Conformação Molecular
Osmometria
Piridinas/síntese química
Espectrometria de Massas por Ionização por Electrospray
Pressão de Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Boron Compounds); 0 (Pyridines); NH9L3PP67S (pyridine)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140702
[Lr] Data última revisão:
140702
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140614
[St] Status:MEDLINE
[do] DOI:10.1039/c4ob00849a


  9 / 27 MEDLINE  
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[PMID]:24783514
[Au] Autor:Wang XL; Zhan TT; Zhan XC; Tan XY; Qu XY; Wang XY; Li CR
[Ti] Título:Cross-validation of the osmotic pressure based on Pitzer model with air humidity osmometry at high concentration of ammonium sulfate solutions.
[So] Source:Yao Xue Xue Bao;49(1):101-5, 2014 Jan.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The osmotic pressure of ammonium sulfate solutions has been measured by the well-established freezing point osmometry in dilute solutions and we recently reported air humidity osmometry in a much wider range of concentration. Air humidity osmometry cross-validated the theoretical calculations of osmotic pressure based on the Pitzer model at high concentrations by two one-sided test (TOST) of equivalence with multiple testing corrections, where no other experimental method could serve as a reference for comparison. Although more strict equivalence criteria were established between the measurements of freezing point osmometry and the calculations based on the Pitzer model at low concentration, air humidity osmometry is the only currently available osmometry applicable to high concentration, serves as an economic addition to standard osmometry.
[Mh] Termos MeSH primário: Sulfato de Amônio/química
Osmometria/métodos
Pressão Osmótica
[Mh] Termos MeSH secundário: Congelamento
Umidade
Concentração Osmolar
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Solutions); SU46BAM238 (Ammonium Sulfate)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:140501
[Lr] Data última revisão:
140501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140503
[St] Status:MEDLINE


  10 / 27 MEDLINE  
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[PMID]:24745363
[Au] Autor:Yoon D; Gadaria-Rathod N; Oh C; Asbell PA
[Ad] Endereço:Department of Ophthalmology, New York University School of Medicine , New York, NY , USA .
[Ti] Título:Precision and accuracy of TearLab osmometer in measuring osmolarity of salt solutions.
[So] Source:Curr Eye Res;39(12):1247-50, 2014 Dec.
[Is] ISSN:1460-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to examine the inherent precision and accuracy of TearLab Osmolarity System using salt solutions, including solutions of very high osmolarity (>360 mOsm/L). MATERIALS AND METHODS: Ten salt solutions with osmolarity between 286 mOsm/L and 394 mOsm/L (increments of 12 mOsm/L) plus an additional solution of 400 mOsm/L were tested twice on both the TearLab osmometer and a freezing point depression osmometer. For precision, we compared the two repeated osmolarity measurements of 11 solutions obtained from TearLab. For accuracy, we compared the averaged osmolarity measurements obtained from TearLab to those from the freezing point depression osmometer. For both precision and accuracy, Bland-Altman test of agreement was used. RESULTS: For precision, the upper 95% limit of agreement was 4.7 mOsm/L, and the lower 95% limit of agreement was -7.1 mOsm/L. The repeatability coefficient was 5.9 mOsm/L. For accuracy, the upper 95% limit of agreement was 4.8 mOsm/L and the lower 95% limit of agreement was -5.3 mOsm/L. CONCLUSIONS: The present study is the first study to demonstrate that the TearLab in situ osmometer can precisely and accurately measure osmolarity of salt solutions, including those with very high osmolarity. Future studies to evaluate the precision and the accuracy of the machine in measuring complex fluids, such as tears, need to be done, and the clinical significance of measuring tear osmolarity in patients needs to be further determined.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Oftalmológico/instrumentação
Lubrificantes Oftálmicos/química
Concentração Osmolar
Osmometria/instrumentação
Cloreto de Sódio/química
[Mh] Termos MeSH secundário: Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lubricant Eye Drops); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140422
[St] Status:MEDLINE
[do] DOI:10.3109/02713683.2014.906623



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