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Pesquisa : E05.196.712 [Categoria DeCS]
Referências encontradas : 8341 [refinar]
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[PMID]:29431330
[Au] Autor:Deynego VN; Elizarov VB; Kaptsov VA
[Ti] Título:[Hygienic and environmental problems of energy-saving illumination in urbanization of Crimea].
[So] Source:Gig Sanit;95(10):909-13, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article considers the problems offloodlights pollution in the territory of Crimea due to the work of illumination led equipment of the key elements of the international transport artery "China-Europe". There was performed a qualitative assessment of characteristics of led floodlights pollution on the example of the sea surface of the transport crossing through the Kerch Strait. Ichthyologists and oceanographers were shown to estimate the amount of phytoplankton biomass based on sunlight illumination. The excess dose of blue light in the spectrum of led lighting was established to have an impact on phytoplankton greater than solar and lunar light, creating preconditions for the increase of biological mass of phytoplankton and consequently to the formation of the "stern stock". Arising from additional phytoplankton biomass can significantly influence on the schedule offish migration in waters of the Kerch Strait, the biomass of mosquitoes and midges, which are prey for amphibians and birds. The decline of the both light pollution and its negative impact on fauna andflora requires the development of semiconductor sources of white light with a biologically adequate spectrum in the framework of the "Lighting of the lighting equipment of Crimea".
[Mh] Termos MeSH primário: Organismos Aquáticos
Poluição Ambiental
Luz/efeitos adversos
Iluminação
Processos Fototróficos/efeitos da radiação
Urbanização
[Mh] Termos MeSH secundário: Organismos Aquáticos/fisiologia
Organismos Aquáticos/efeitos da radiação
Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Seres Humanos
Iluminação/efeitos adversos
Iluminação/métodos
Iluminação/normas
Fotometria/métodos
Fotometria/normas
Fitoplâncton/fisiologia
Fitoplâncton/efeitos da radiação
Saúde Pública/métodos
Saúde Pública/normas
Federação Russa/epidemiologia
Mudança Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29394012
[Au] Autor:Ludwinski C; Clochard-Bossuet A; Chen T; Norwood K; Oresajo C
[Ti] Título:Use of optical profilometry and visual grading for measurement of longitudinal striations of the nail.
[So] Source:J Cosmet Sci;67(2):93-100, 2016 Mar-Apr.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Consumer perception of longitudinal striations of the nail is one of the drivers of nail cosmetic purchase and use. The following work investigates the use of objective instrumental methods for the characterization of longitudinal striations. Striations are quantified by Ra (the average maximum height of the profile), Rq (the root mean square average of the roughness profile), and Rz (the mean roughness depth), industrial roughness parameters, which are calculated using optical profilometry of the three-dimensional surface structure of the nail. A visual assessment is conducted by cosmetologists in vivo and on images captured in several lighting conditions. With this evaluation, the cosmetologists provide ratings of surface ridges on a 0­5 scale to complement and validate the instrumental method. Both the optical profilometry and the cosmetologist-graded methods are used to evaluate 33 nails of visually-varying levels of ridges from female volunteers. The evaluations from these methods yield well-correlated and repeatable results, and these preliminary findings suggest that this new instrumental method can be used to objectively measure longitudinal striations of the nail.
[Mh] Termos MeSH primário: Unhas/diagnóstico por imagem
Fotometria/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cosméticos/administração & dosagem
Feminino
Seres Humanos
Meia-Idade
Unhas/anatomia & histologia
Fotometria/instrumentação
Reprodutibilidade dos Testes
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29260838
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Medical Devices; General Hospital and Personal Use Devices; Classification of the Image Processing Device for Estimation of External Blood Loss. Final order.
[So] Source:Fed Regist;82(242):60306-8, 2017 Dec 20.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the image processing device for estimation of external blood loss into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the image processing device for estimation of external blood loss' classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Segurança de Equipamentos/classificação
Processamento de Imagem Assistida por Computador/classificação
Processamento de Imagem Assistida por Computador/instrumentação
Fotometria/classificação
Fotometria/instrumentação
[Mh] Termos MeSH secundário: Perda Sanguínea Cirúrgica
Hemoglobinas
Seres Humanos
Tampões de Gaze Cirúrgicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


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[PMID]:29053808
[Au] Autor:Akuffo KO; Beatty S; Peto T; Stack J; Stringham J; Kelly D; Leung I; Corcoran L; Nolan JM
[Ad] Endereço:Macular Pigment Research Group, Nutrition Research Centre Ireland, School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland.
[Ti] Título:The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5347-5360, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61). Visual function was assessed using best-corrected visual acuity, contrast sensitivity (CS), glare disability, retinal straylight, photostress recovery time, reading performance, and the National Eye Institute Visual Function Questionnaire-25. Macular pigment was measured using customized heterochromatic flicker photometry. Results: There was a statistically significant improvement in the primary outcome measure (letter CS at 6 cycles per degree [6 cpd]) over time (P = 0.013), and this observed improvement was statistically comparable between interventions (P = 0.881). Statistically significant improvements in several secondary outcome visual function measures (letter CS at 1.2 and 2.4 cpd; mesopic and photopic CS at all spatial frequencies; mesopic glare disability at 1.5, 3, and 6 cpd; photopic glare disability at 1.5, 3, 6, and 12 cpd; photostress recovery time; retinal straylight; mean and maximum reading speed) were also observed over time (P < 0.05, for all), and were statistically comparable between interventions (P > 0.05, for all). Statistically significant increases in macular pigment at all eccentricities were observed over time (P < 0.0005, for all), and the degree of augmentation was statistically comparable between interventions (P > 0.05). Conclusions: Antioxidant supplementation in patients with nonadvanced age-related macular degeneration results in significant increases in macular pigment and improvements in CS and other measures of visual function. (Clinical trial, http://www.isrctn.com/ISRCTN13894787).
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Luteína/uso terapêutico
Degeneração Macular/tratamento farmacológico
Pigmento Macular/uso terapêutico
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Ácido Ascórbico/administração & dosagem
Sensibilidades de Contraste/fisiologia
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Ofuscação
Seres Humanos
Degeneração Macular/fisiopatologia
Masculino
Meia-Idade
Fotometria/métodos
Leitura
Oligoelementos/administração & dosagem
Vitamina E/administração & dosagem
Zeaxantinas/uso terapêutico
Zinco/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antioxidants); 0 (Macular Pigment); 0 (Trace Elements); 0 (Zeaxanthins); 0 (meso-zeaxanthin); 1406-18-4 (Vitamin E); J41CSQ7QDS (Zinc); PQ6CK8PD0R (Ascorbic Acid); X72A60C9MT (Lutein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21192


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[PMID]:29024667
[Au] Autor:Kupferschmidt DA; Juczewski K; Cui G; Johnson KA; Lovinger DM
[Ad] Endereço:Section on Synaptic Pharmacology & In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, MD, USA; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke
[Ti] Título:Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning.
[So] Source:Neuron;96(2):476-489.e5, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Changes in cortical and striatal function underlie the transition from novel actions to refined motor skills. How discrete, anatomically defined corticostriatal projections function in vivo to encode skill learning remains unclear. Using novel fiber photometry approaches to assess real-time activity of associative inputs from medial prefrontal cortex to dorsomedial striatum and sensorimotor inputs from motor cortex to dorsolateral striatum, we show that associative and sensorimotor inputs co-engage early in action learning and disengage in a dissociable manner as actions are refined. Disengagement of associative, but not sensorimotor, inputs predicts individual differences in subsequent skill learning. Divergent somatic and presynaptic engagement in both projections during early action learning suggests potential learning-related in vivo modulation of presynaptic corticostriatal function. These findings reveal parallel processing within associative and sensorimotor circuits that challenges and refines existing views of corticostriatal function and expose neuronal projection- and compartment-specific activity dynamics that encode and predict action learning.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Aprendizagem/fisiologia
Córtex Motor/fisiologia
Rede Nervosa/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpo Estriado/química
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Córtex Motor/química
Destreza Motora
Rede Nervosa/química
Fotometria/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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[PMID]:28833946
[Au] Autor:Matzel P; Krautschick L; Höhne M
[Ad] Endereço:Protein Biochemistry, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Strasse 4, 17487, Greifswald, Germany.
[Ti] Título:Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae.
[So] Source:Chembiochem;18(20):2022-2027, 2017 Oct 18.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C -C ) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94-96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.
[Mh] Termos MeSH primário: Ensaios Enzimáticos
Iminas/metabolismo
Oxirredutases/metabolismo
Streptomyces/enzimologia
[Mh] Termos MeSH secundário: Aminação
NADP/metabolismo
Fotometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imines); 53-59-8 (NADP); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700257


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[PMID]:28625685
[Au] Autor:Invernizzi A; Marchi S; Aldigeri R; Mastrofilippo V; Viscogliosi F; Soldani A; Adani C; Garoli E; Viola F; Fontana L; McCluskey P; Cimino L
[Ad] Endereço:Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco," Luigi Sacco Hospital, University of Milan, Milan, Italy; Save Sight Institute, University of Sydney, Sydney, Australia. Electronic address: alessandro.invernizzi@gmail.com.
[Ti] Título:Objective Quantification of Anterior Chamber Inflammation: Measuring Cells and Flare by Anterior Segment Optical Coherence Tomography.
[So] Source:Ophthalmology;124(11):1670-1677, 2017 Nov.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the ability of swept-source (SS) optical coherence tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both flare and cells) objectively. To compare OCT-derived inflammatory indices with standard techniques. DESIGN: Prospective evaluation of a diagnostic test. PARTICIPANTS: Patients diagnosed with anterior uveitis (active or inactive) and controls. METHODS: Participants underwent an AC inflammation evaluation including: clinical cell and flare grading and laser flare photometry (LFP). Uveitis patients were divided into active or inactive uveitis status according to clinical grading. Anterior segment SS-OCT scans were obtained for each participant. Tomographic images were analyzed to count the AC cells, and to calculate to absolute measurements of aqueous signal intensity. The absolute values were compared with the signal measured by the scan outside the eye, generating an optical density ratio (aqueous-to-air relative intensity [ARI] index). Correlations between OCT-derived AC inflammatory indexes and LFP, clinical grading, participant category (active or inactive uveitis, control), age, gender, and central corneal thickness (CCT) were assessed. MAIN OUTCOME MEASURES: Correlation between OCT-derived AC inflammatory indexes (ARI index and AC cells on OCT) and standard clinical techniques (LFP, clinical cell grading). RESULTS: Two hundred thirty-seven eyes (70 active uveitis, 97 inactive uveitis, and 70 controls) were included. Anterior chamber cells count on OCT did not differ between inactive uveitis and controls, but was significantly higher in active uveitis compared to the other categories (both P < 0.0001). All groups had different LFP (all P < 0.0001). Active uveitis had significantly higher ARI index compared with inactive uveitis and controls (both P < 0.0001). Interobserver agreement (intraclass correlation coefficient) for ARI index was 0.78. The ARI index correlated positively with age (P = 0.043) and negatively with CCT (P = 0.006). The ARI index correlated with LFP in the active uveitis group (P < 0.0001), but not in the others. Anterior chamber cells on OCT increased among all cell clinical grades (P < 0.0001). The ARI index increased among all flare clinical grades (P < 0.005). CONCLUSIONS: Anterior segment SS-OCT could be used for a comprehensive assessment of AC inflammation, providing objective measurements of inflammatory cells and aqueous flare.
[Mh] Termos MeSH primário: Câmara Anterior/patologia
Humor Aquoso/citologia
Tomografia de Coerência Óptica/métodos
Uveíte Anterior/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Pressão Intraocular/fisiologia
Leucócitos/patologia
Masculino
Meia-Idade
Variações Dependentes do Observador
Fotometria/métodos
Valor Preditivo dos Testes
Estudos Prospectivos
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


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[PMID]:28602690
[Au] Autor:Cho JR; Treweek JB; Robinson JE; Xiao C; Bremner LR; Greenbaum A; Gradinaru V
[Ad] Endereço:Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA.
[Ti] Título:Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.
[So] Source:Neuron;94(6):1205-1219.e8, 2017 Jun 21.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. Using simultaneous fiber photometry and polysomnography, we observed time-delineated dorsal raphe nucleus dopaminergic (DRN ) activity upon exposure to arousal-evoking salient cues, irrespective of their hedonic valence. We also observed broader fluctuations of DRN activity across sleep-wake cycles with highest activity during wakefulness. Both endogenous DRN activity and optogenetically driven DRN activity were associated with waking from sleep, with DA signal strength predictive of wake duration. Conversely, chemogenetic inhibition opposed wakefulness and promoted NREM sleep, even in the face of salient stimuli. Therefore, the DRN population is a critical contributor to wake-promoting pathways and is capable of modulating sleep-wake states according to the outside environment, wherein the perception of salient stimuli prompts vigilance and arousal.
[Mh] Termos MeSH primário: Nível de Alerta/fisiologia
Neurônios Dopaminérgicos/fisiologia
Núcleo Dorsal da Rafe/fisiologia
Vigília/fisiologia
[Mh] Termos MeSH secundário: Animais
Neurônios Dopaminérgicos/citologia
Núcleo Dorsal da Rafe/citologia
Eletroencefalografia
Eletromiografia
Elevação dos Membros Posteriores
Camundongos
Imagem Óptica
Optogenética
Fotometria
Restrição Física
Sono/fisiologia
Sono REM
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28576440
[Au] Autor:Smirnova J; Fernie AR; Spahn CMT; Steup M
[Ad] Endereço:Institute for Biochemistry and Biology, Department of Plant Physiology, University of Potsdam, Building 20, Karl-Liebknecht-Str. 20, 14461 Potsdam, Germany; Institute of Biophysics and Medical Physics of the Charité, Universitätsmedizin Berlin, Campus Berlin Mitte, 10117 Berlin, Germany; Max-Planck-
[Ti] Título:Photometric assay of maltose and maltose-forming enzyme activity by using 4-alpha-glucanotransferase (DPE2) from higher plants.
[So] Source:Anal Biochem;532:72-82, 2017 Sep 01.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maltose frequently occurs as intermediate of the central carbon metabolism of prokaryotic and eukaryotic cells. Various mutants possess elevated maltose levels. Maltose exists as two anomers, (α- and ß-form) which are rapidly interconverted without requiring enzyme-mediated catalysis. As maltose is often abundant together with other oligoglucans, selective quantification is essential. In this communication, we present a photometric maltose assay using 4-alpha-glucanotransferase (AtDPE2) from Arabidopsis thaliana. Under in vitro conditions, AtDPE2 utilizes maltose as glucosyl donor and glycogen as acceptor releasing the other hexosyl unit as free glucose which is photometrically quantified following enzymatic phosphorylation and oxidation. Under the conditions used, DPE2 does not noticeably react with other di- or oligosaccharides. Selectivity compares favorably with that of maltase frequently used in maltose assays. Reducing end interconversion of the two maltose anomers is in rapid equilibrium and, therefore, the novel assay measures total maltose contents. Furthermore, an AtDPE2-based continuous photometric assay is presented which allows to quantify ß-amylase activity and was found to be superior to a conventional test. Finally, the AtDPE2-based maltose assay was used to quantify leaf maltose contents of both Arabidopsis wild type and AtDPE2-deficient plants throughout the light-dark cycle. These data are presented together with assimilatory starch levels.
[Mh] Termos MeSH primário: Arabidopsis/metabolismo
Sistema da Enzima Desramificadora do Glicogênio/metabolismo
Maltose/metabolismo
Fotometria/métodos
Plantas Geneticamente Modificadas/metabolismo
Amido/metabolismo
Sacarose/metabolismo
[Mh] Termos MeSH secundário: Citosol/metabolismo
Ensaios Enzimáticos/métodos
Folhas de Planta/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycogen Debranching Enzyme System); 57-50-1 (Sucrose); 69-79-4 (Maltose); 9005-25-8 (Starch); EC 2.4.1.25 (4 alpha-glucanotransferase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28524927
[Au] Autor:Koh S; Maeda N; Ikeda C; Asonuma S; Ogawa M; Hiraoka T; Oshika T; Nishida K
[Ad] Endereço:Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
[Ti] Título:The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2647-2651, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate the association between visual function and ocular surface regularity in dry eye. Methods: We enrolled 52 eyes of 52 dry eye patients (34 dry eyes with superficial punctate keratopathy [SPK] in the central corneal region [central SPK] and 18 dry eyes without central SPK) and 20 eyes of 20 normal control subjects. All eyes had a best-corrected distance visual acuity better than 20/20. We measured two indices of contrast sensitivity function under photopic conditions: contrast sensitivity and letter contrast sensitivity. The area under the log contrast sensitivity function (AULCSF) was calculated from the obtained contrast sensitivity data. Straylight was quantified using a straylight meter. Results: Dry eyes with central SPK had significantly decreased contrast sensitivity function, including AULCSF and letter contrast sensitivity than those without central SPK and normal eyes (P < 0.05 for each). While the straylight values in both dry eye groups did not differ, straylight values were greater than those in normal eyes (P < 0.05 for both). In dry eye, the AULCSF and letter contrast sensitivity negatively correlated with the central SPK score (R = -0.485, P < 0.001, and R = -0.541, P < 0.001, respectively). Conclusions: In dry eye, reduced contrast sensitivity in part results from central SPK overlying the optical zone and the increased straylight results from tear film instability rather than central SPK.
[Mh] Termos MeSH primário: Sensibilidades de Contraste/fisiologia
Córnea/fisiopatologia
Ceratoconjuntivite Seca/fisiopatologia
Espalhamento de Radiação
Síndrome de Sjogren/fisiopatologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Visão de Cores
Feminino
Fluorofotometria
Ofuscação
Seres Humanos
Luz
Masculino
Meia-Idade
Fotometria
Estudos Prospectivos
Lágrimas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21894



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