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[PMID]:28870953
[Au] Autor:Cicero G; Lo Re G; DE Luca R; Vernuccio F; Picone D; Midiri M; Lagalla R
[Ad] Endereço:Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy giuseppe.cicero@unipa.it.
[Ti] Título:Role of Densitometric Criteria in Evaluation of Effectiveness of Antiangiogenic Therapies in Metastatic Colorectal Cancer: An Italian Clinical Experience.
[So] Source:Anticancer Res;37(9):5187-5192, 2017 09.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: To evaluate the role of densitometric criterion using the Choi Criteria in the assessment of the response to antiangiogenic treatments of metastatic colorectal cancer (mCRC) compared to the RECIST criteria. PATIENTS AND METHODS: Fifty-four patients (mean age=50.6 years) affected by advanced colorectal cancer and with hepatic and possibly peritoneal and pulmonary metastases, that can be treated with bevacizumab, were prospectively evaluated by computerized tomography (CT) scan. Metastases were also evaluated by CT in one-dimensional form according to RECIST. RESULTS: Results show that in 58% of analyzed cases, stable disease according to RECIST coincided with stable disease according to the CHOI criteria, whereas in 42% of analyzed cases disease progression according to RECIST corresponded to stable disease or even partial response according to CHOI criteria. CONCLUSION: By using the densitometric criterion with CHOI criteria, the evaluation of the response to antiangiogenic treatment of mCRC is partially different compared to RECIST criteria.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Neoplasias Colorretais/tratamento farmacológico
Densitometria/métodos
Neoplasias Hepáticas/secundário
[Mh] Termos MeSH secundário: Neoplasias Colorretais/diagnóstico por imagem
Demografia
Feminino
Seres Humanos
Itália
Masculino
Meia-Idade
Tomografia Computadorizada Multidetectores
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28774512
[Au] Autor:Al-Khateeb G; Shajari M; Vunnava K; Petermann K; Kohnen T
[Ad] Endereço:Department of Ophthalmology, Goethe-University, Frankfurt/Main, Germany.
[Ti] Título:Impact of lens densitometry on phacoemulsification parameters and usage of ultrasound energy in femtosecond laser-assisted lens surgery.
[So] Source:Can J Ophthalmol;52(4):331-337, 2017 Aug.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to find the correlation between lens densitometry measurements using Pentacam Scheimpflug imaging system with equivalent average ultrasound power and cumulative dissipated energy (CDE) in femtosecond laser-assisted lens surgery (FLALS). METHODS: One hundred and twenty-four eyes were analyzed retrospectively, of which 109 had undergone cataract surgery and 15 had received refractive lens exchange with FLALS. Using the Pentacam Nucleus Staging (PNS) lens densitometry program, preoperative mean lens density and cataract grading score were evaluated. Average ultrasound power and CDE were recorded during surgery and correlated with the PNS grading and average lens density value. Exclusion criteria included small pupil size, previous ocular surgeries, tumors, optic atrophy, corneal scarring, intraoperative capsular rupture, and zonular dehiscence. RESULTS: Preoperative average lens density compared with CDE showed a weak significant positive linear correlation (p < 0.0001). CDE increased as lens density increased. This was also noticed when CDE and ultrasound time were compared with the PNS grading, demonstrating a significant moderate correlation (p < 0.0001). With increasing average lens density, the equivalent average ultrasound power showed a positive correlation (p < 0.0001). A weak positive correlation between estimated fluid use and PNS was also observed (p < 0.0001). Forty-one cases that did not require ultrasound energy during phacoemulsification had a PNS score between 0 and 1. CONCLUSIONS: The Centurion Phacoemulsification machine has been shown to correlate positively with the Pentacam Scheimpflug System offering an objective and repeatable measure of lens density and cataract grading. This can aid in intraoperative phacodynamics and help reduce phacoemulsification complications, such as corneal endothelial injury.
[Mh] Termos MeSH primário: Catarata/diagnóstico
Densitometria/métodos
Cristalino/diagnóstico por imagem
Facoemulsificação/métodos
Terapia por Ultrassom/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Cristalino/cirurgia
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28759569
[Au] Autor:Gómez-Campos R; Andruske CL; Arruda M; Urra Albornoz C; Cossio-Bolaños M
[Ad] Endereço:Faculty of Physical Education, State University of Campinas, Campinas, Brazil.
[Ti] Título:Proposed equations and reference values for calculating bone health in children and adolescent based on age and sex.
[So] Source:PLoS One;12(7):e0181918, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Dual Energy X-Ray Absorptiometry (DXA) is the gold standard for measuring BMD and bone mineral content (BMC). In general, DXA is ideal for pediatric use. However, the development of specific standards for particular geographic regions limits its use and application for certain socio-cultural contexts. Additionally, the anthropometry may be a low cost and easy to use alternative method in epidemiological contexts. The goal of our study was to develop regression equations for predicting bone health of children and adolescents based on anthropometric indicators to propose reference values based on age and sex. METHODS: 3020 students (1567 males and 1453 females) ranging in ages 4.0 to 18.9 were studied from the Maule Region (Chile). Anthropometric variables evaluated included: weight, standing height, sitting height, forearm length, and femur diameter. A total body scan (without the head) was conducted by means of the Dual Energy X-Ray Absorptiometry. Bone mineral density (BMD) and the bone mineral content (BMC) were also determined. Calcium consumption was controlled for by recording the intake of the three last days prior to the evaluation. Body Mass Index (BMI) was calculated, and somatic maturation was determined by using the years of peak growth rate (APHV). RESULTS: Four regression models were generated to calculate bone health: for males BMD = (R2 = 0.79) and BMC = (R2 = 0.84) and for the females BMD = (R2 = 0.76) and BMC = (R2 = 0.83). Percentiles were developed by using the LMS method (p3, p5, p15, p25, p50, p75, p85, p95 and p97). CONCLUSIONS: Regression equations and reference curves were developed to assess the bone health of Chilean children and adolescents. These instruments help identify children with potential underlying problems in bone mineralization during the growth stage and biological maturation.
[Mh] Termos MeSH primário: Fatores Etários
Osso e Ossos/fisiologia
Valores de Referência
Fatores Sexuais
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adolescente
Antropometria
Estatura
Densidade Óssea
Criança
Pré-Escolar
Chile
Estudos Transversais
Características Culturais
Densitometria
Feminino
Geografia
Seres Humanos
Masculino
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181918


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[PMID]:28734947
[Au] Autor:Kikuchi A; Pradhan-Sundd T; Singh S; Nagarajan S; Loizos N; Monga SP
[Ad] Endereço:Department of Pathology and Medicine and Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[Ti] Título:Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
[So] Source:Am J Pathol;187(10):2273-2287, 2017 Oct.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Platelet-derived growth factor receptor α (PDGFRα), a tyrosine kinase receptor, is up-regulated in hepatic stellate cells (HSCs) during chronic liver injury. HSCs mediate hepatic fibrosis through their activation from a quiescent state partially in response to profibrotic growth factors. HSC activation entails enhanced expression of profibrotic genes, increase in proliferation, and increase in motility, which facilitates migration within the hepatic lobule. We show colocalization of PDGFRα in murine carbon tetrachloride, bile duct ligation, and 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine models of chronic liver injury, and investigate the role of PDGFRα on proliferation, profibrotic gene expression, and migration in primary human HSCs (HHSteCs) using the PDGFRα-specific inhibitory monoclonal antibody olaratumab. Although lacking any effects on HHSteC transdifferentiation assessed by gene expression of ACTA2, TGFB1, COL1A1, SYP1, and FN1, olaratumab specifically reduced HHSteC proliferation (AlamarBlue assay) and cell migration (transwell migration assays). Using phospho-specific antibodies, we show that olaratumab attenuates PDGFRα activation in response to PDGF-BB, and reduced phosphorylation of extracellular signal-regulated kinase 1 and 2, Elk-1, p38, Akt, focal adhesion kinase, mechanistic target of rapamycin, C10 regulator of kinase II, and C10 regulator of kinase-like, suggesting that PDGFRα contributes to mitogenesis and actin reorganization through diverse downstream effectors. Our findings support a distinct contribution of PDGFRα signaling to HSC proliferation and migration and provide evidence that inhibition of PDGFRα signaling could alter the pathogenesis of hepatic fibrosis.
[Mh] Termos MeSH primário: Movimento Celular
Células Estreladas do Fígado/citologia
Células Estreladas do Fígado/metabolismo
Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/farmacologia
Comunicação Autócrina/efeitos dos fármacos
Movimento Celular/efeitos dos fármacos
Movimento Celular/genética
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/genética
Densitometria
Modelos Animais de Doenças
Regulação da Expressão Gênica/efeitos dos fármacos
Células Estreladas do Fígado/efeitos dos fármacos
Seres Humanos
Ligantes
Cirrose Hepática/genética
Cirrose Hepática/metabolismo
Cirrose Hepática/patologia
Camundongos Endogâmicos C57BL
Modelos Biológicos
Fosforilação/efeitos dos fármacos
Fator de Crescimento Derivado de Plaquetas/farmacologia
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Ligands); 0 (Platelet-Derived Growth Factor); EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha); TT6HN20MVF (olaratumab)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28603125
[Au] Autor:Adel-Kader MS; Alwahebi NWH; Alam P
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia / Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria, Egypt.
[Ti] Título:Estimation of yohimbine base in complex mixtures by quantitative HPTLC application.
[So] Source:Pak J Pharm Sci;30(1):149-154, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The indole alkaloid Yohimbine has been used for over two centuries in the treatment of erectly dysfunction. Several formulations containing yohimbine salts, yohimbe bark power or extract are marketed worldwide. Determination of the amount of yohimbine in such formulation is a challenging task due to their complex nature. Extraction followed by acid-base purification resulted in a relatively pure alkaloids containing fractions. The exact amounts of yohimbine free base in different formulations were determined by densitometric HPTLC validated methods using silica gel TLC plates. Standard curve for yohimbine was generated using yohimbine hydrochloride subjected to the same acid-base treatment as the used samples. All formulations found to contain yohimbine though some with less concentration than the labeled amount.
[Mh] Termos MeSH primário: Antagonistas de Receptores Adrenérgicos alfa 2/análise
Cromatografia em Camada Delgada/métodos
Tecnologia Farmacêutica/métodos
Ioimbina/análise
[Mh] Termos MeSH secundário: Calibragem
Cromatografia em Camada Delgada/normas
Densitometria
Formas de Dosagem
Composição de Medicamentos
Limite de Detecção
Modelos Lineares
Padrões de Referência
Reprodutibilidade dos Testes
Sílica Gel/química
Tecnologia Farmacêutica/normas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Adrenergic alpha-2 Receptor Antagonists); 0 (Dosage Forms); 2Y49VWD90Q (Yohimbine); 60650-90-0 (Silica Gel)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28581534
[Au] Autor:Jagielska G; Przedlacki J; Bartoszewicz Z; Kondracka A; Butwicka A; Racicka E; Rowinski O; Brzewski R; Wolanczyk T; Tomaszewicz-Libudzic C; Szymanska U
[Ad] Endereço:Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.
[Ti] Título:Bone mineralization and densitometric evaluation of vertebral fractures in women 6-21 years after the onset of anorexia nervosa symptoms.
[Ti] Título:Mineralizacja kosci i ocena densytometryczna zlaman kregoslupa u kobiet po uplywie 6­21 lat od pojawienia sie objawów jadlowstretu psychicznego..
[So] Source:Psychiatr Pol;51(2):231-246, 2017 Apr 30.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:OBJECTIVES: We attempted to assess bone mineralization and the frequency of fractures occurrence in women with a history of treatment of anorexia nervosa (AN) in adolescence. METHODS: 47 women (age 20-36.8 years) were re-examined 6.33-21,2 years after the onset of AN symptoms. Bone mineral density (BMD) of total body, lumbar spine, femoral neck, total hip (DXA) and densitometric Vertebral Fracture Assessment (VFA) were performed on 46 of women and BAP, P1NP, CTX, estradiol, testosterone, cortisol, IGF-1, leptin, DHEA-S on 45 of women entered for the current study. Current BMD results were compared with available baseline results from the time of hospitalization. RESULTS: Currently BMD Z-score <-1 examined at any location occurred in 28 from 46 women (including Z-score <-2 in 5 women). In 11 from 12 women with reduced BMD at the time of hospitalization current total body BMD was within the normal range. Lumbar spine BMD was normalized or improved respectively in 5 and 6 from 15 women. Currently increased levels/activity of bone formation markers: P1NP in 27 (60%) and BAP in 28 women (62.2%) were observed. In 7 women (15.6%) increased values of bone formation markers with increased marker of bone resorption (CTX) occurred. Osteoporotic fractures and fractures in the spine in VFA were not observed during the observation period. CONCLUSIONS: Despite early treatment of adolescent-onset AN and good outcomes of the treatment, decreased BMD was currently present in 60.9% of women. During follow-up normalization or significant improvement in BMD results (total body, lumbar spine) were observed in majority of cases.
[Mh] Termos MeSH primário: Anorexia Nervosa/complicações
Anorexia Nervosa/fisiopatologia
Desmineralização Patológica Óssea/etiologia
Densidade Óssea/fisiologia
Vértebras Lombares/lesões
Fraturas por Osteoporose/etiologia
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adulto
Desmineralização Patológica Óssea/diagnóstico por imagem
Densitometria
Difosfonatos/uso terapêutico
Feminino
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Meia-Idade
Fraturas por Osteoporose/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphosphonates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28564701
[Au] Autor:Mauschitz MM; Roth F; Holz FG; Breteler MMB; Finger RP
[Ad] Endereço:Department of Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
[Ti] Título:The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS).
[So] Source:Invest Ophthalmol Vis Sci;58(5):2804-2809, 2017 05 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate the impact of lens opacity on retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening (BMO) measurements. Methods: Fifty-nine randomly selected patients without any other relevant ocular pathology undergoing elective routine cataract surgery in two specialized eye clinics were enrolled. RNFLT, BMO area, and BMO minimum rim width (BMO-MRW) were assessed with the Heidelberg Engineering Spectralis OCT using the anatomical positioning system (APS) prior to and 1 day after cataract surgery using a ring scan at different eccentricities of the disc (3.5, 4.1 and 4.7 mm). Lens opacity was quantified using densitometry based on Scheimpflug images (Oculus Pentacam AXL). Results: RNFLT, BMO area, and BMO-MRW were virtually identical before and following removal of the cataractous lens. This held when assessed overall, within the six sectors for the 3.5-mm scan, or at any other eccentricity. Baseline RNFLT was not associated with lens opacity. Conclusions: Using the APS, RNFLT remained unchanged following cataract surgery, contrary to results reported by previous studies. Our results imply that the APS may have contributed to more precise spectral-domain optical coherence measurements, minimizing the influence of cataract on RNFLT and BMO assessments in our cohort.
[Mh] Termos MeSH primário: Lâmina Basilar da Corioide/anatomia & histologia
Catarata/complicações
Fibras Nervosas
Células Ganglionares da Retina/citologia
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Idoso
Densitometria
Feminino
Seres Humanos
Implante de Lente Intraocular
Masculino
Facoemulsificação
Período Pós-Operatório
Período Pré-Operatório
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21675


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[PMID]:28552924
[Au] Autor:Lughmani WA; Farukh F; Bouazza-Marouf K; Ali H
[Ad] Endereço:Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Leicestershire, UK.
[Ti] Título:Drilling resistance: A method to investigate bone quality.
[So] Source:Acta Bioeng Biomech;19(1):55-62, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Bone drilling is a major part of orthopaedic surgery performed during the internal fixation of fractured bones. At present, information related to drilling force, drilling torque, rate of drill-bit penetration and drill-bit rotational speed is not available to orthopaedic surgeons, clinicians and researchers as bone drilling is performed manually. METHODS: This study demonstrates that bone drilling force data if recorded in-vivo, during the repair of bone fractures, can provide information about the quality of the bone. To understand the variability and anisotropic behaviour of cortical bone tissue, specimens cut from three anatomic positions of pig and bovine were investigated at the same drilling speed and feed rate. RESULTS: The experimental results showed that the drilling force does not only vary from one animal bone to another, but also vary within the same bone due to its changing microstructure. Drilling force does not give a direct indication of bone quality; therefore it has been correlated with screw pull-out force to provide a realistic estimation of the bone quality. A significantly high value of correlation (r2 = 0.93 for pig bones and r2 = 0.88 for bovine bones) between maximum drilling force and normalised screw pull-out strength was found. CONCLUSIONS: The results show that drilling data can be used to indicate bone quality during orthopaedic surgery.
[Mh] Termos MeSH primário: Densidade Óssea/fisiologia
Parafusos Ósseos
Densitometria/instrumentação
Densitometria/métodos
Fêmur/fisiologia
Fêmur/cirurgia
Teste de Materiais/métodos
Osteotomia/métodos
[Mh] Termos MeSH secundário: Animais
Bovinos
Remoção de Dispositivo/métodos
Fricção
Técnicas In Vitro
Teste de Materiais/instrumentação
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Especificidade da Espécie
Estresse Mecânico
Suínos
Resistência à Tração
Torque
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28541524
[Au] Autor:McNiff ML; Chadwick JS
[Ad] Endereço:Department of Pharmaceutical Chemistry, University of Kansas, 2093 Constant Ave, Lawrence, KS 66047.
[Ti] Título:Metal-bound claMP Tag inhibits proteolytic cleavage.
[So] Source:Protein Eng Des Sel;30(6):467-475, 2017 Jun 01.
[Is] ISSN:1741-0134
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Biologics can be an improvement to small molecule drugs, providing high specificity for an identified target, lowering toxicity and limiting side effects. To achieve effective delivery, the biologic must have sufficient time to reach the target tissue. A prolonged half-life in the circulating environment is desired, but often serum stability is limited by proteases. Proteolysis in the serum causes degradation and inactivation as the biologic is fragmented and more rapidly cleared from the body. To improve the circulating half-life, large, hydrophilic polymers may be conjugated or stable fusion tags may be engineered to increase the effective size of the peptide and to hinder degradation by proteases. Improved resistance to proteases is essential for effective delivery. Here, a proof of concept study is presented using a metal-binding tripeptide tag known as the claMP Tag to create an inline conjugate and the ability of the tag to inhibit proteolysis was examined.
[Mh] Termos MeSH primário: Oligopeptídeos/química
Oligopeptídeos/metabolismo
Engenharia de Proteínas/métodos
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
[Mh] Termos MeSH secundário: Densitometria
Eletroforese em Gel de Poliacrilamida
Escherichia coli/genética
Concentração de Íons de Hidrogênio
Proteínas Ligantes de Maltose/química
Proteínas Ligantes de Maltose/genética
Proteínas Ligantes de Maltose/metabolismo
Níquel/química
Níquel/metabolismo
Oligopeptídeos/genética
Estabilidade Proteica
Proteólise
Proteínas Recombinantes de Fusão/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Maltose-Binding Proteins); 0 (Oligopeptides); 0 (Recombinant Fusion Proteins); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1093/protein/gzx030


  10 / 11918 MEDLINE  
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[PMID]:28528120
[Au] Autor:Tekin K; Inanc M; Kurnaz E; Bayramoglu E; Aydemir E; Koc M; Aycan Z
[Ad] Endereço:Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey. Electronic address: kemal_htepe@hotmail.com.
[Ti] Título:Objective Evaluation of Corneal and Lens Clarity in Children With Type 1 Diabetes Mellitus.
[So] Source:Am J Ophthalmol;179:190-197, 2017 Jul.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled type 1 DM and to compare the results obtained with those in healthy children. DESIGN: Cross-sectional prospective study. METHODS: This multicenter study enrolled 56 patients with DM and 51 control subjects. The duration of DM and the glycosylated hemoglobin (HbA1c) levels of the patients in the DM group were recorded. The Pentacam HR imaging system was used for corneal densitometry (12-mm corneal diameter) measurements. Furthermore, the lens densitometry and lens thickness (LT) measurements were performed after dilation of the pupils, using the same Pentacam HR device. RESULTS: The corneal densitometry values were similar in all concentric zones and layers in both groups (P > .05, for all). The mean values of the average and maximum lens densitometry measurements of the 2 groups, as well as the mean LT values, were statistically significantly different (P = .021, P = .011, and P < .001, respectively). There were statistically significant correlations between the lens densitometry values and the duration of DM (P < .05, for all). Conversely, no statistically significant relationship was found between the lens densitometry values and HbA1c levels (r = 0.743; P = .084). CONCLUSIONS: The children with type 1 DM had decreased lens clarity and increased LT, even in cases of well-controlled DM, without DR. It is reasonable to think that these changes might have been caused by the type 1 DM.
[Mh] Termos MeSH primário: Córnea/diagnóstico por imagem
Diabetes Mellitus Tipo 1/diagnóstico
Cristalino/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Glicemia/metabolismo
Criança
Córnea/fisiopatologia
Estudos Transversais
Densitometria
Diabetes Mellitus Tipo 1/sangue
Feminino
Seres Humanos
Cristalino/fisiopatologia
Masculino
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE



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