Base de dados : MEDLINE
Pesquisa : E05.196.922.750 [Categoria DeCS]
Referências encontradas : 6072 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 608 ir para página                         

  1 / 6072 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29190078
[Au] Autor:Gonzalez P; Vileno B; Bossak K; El Khoury Y; Hellwig P; Bal W; Hureau C; Faller P
[Ad] Endereço:Institut de Chimie, UMR 7177, CNRS, Université de Strasbourg , 4 rue Blaise Pascal 67000, Strasbourg, France.
[Ti] Título:Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His.
[So] Source:Inorg Chem;56(24):14870-14879, 2017 Dec 18.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peptides and proteins with the N-terminal motifs NH -Xxx-His and NH -Xxx-Zzz-His form well-established Cu(II) complexes. The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively). Cu(II) is bound to NH -Xxx-His via three nitrogens from the peptide and an external ligand in the equatorial plane (called 3N form here). In contrast, Cu(II) is bound to NH -Xxx-Zzz-His via four nitrogens from the peptide in the equatorial plane (called 4N form here). These two motifs are not mutually exclusive, as the peptides with the sequence NH -Xxx-His-His contain both of them. However, this chimera has never been fully explored. In this work, we use a multispectroscopic approach to analyze the Cu(II) binding to the chimeric peptide Ala-His-His (AHH). AHH is capable of forming the 3N- and 4N-type complexes in a pH dependent manner. The 3N form predominates at pH ∼ 4-6.5 and the 4N form at ∼ pH 6.5-10. NMR experiments showed that at pH 8.5, where Cu(II) is almost exclusively bound in the 4N form, the Cu(II)-exchange between AHH or the amidated AHH-NH is fast, in comparison to the nonchimeric 4N form (AAH). Together, the results show that the chimeric AHH can access both Cu(II) coordination types, that minor changes in the second (or further) coordination sphere can impact considerably the equilibrium between the forms, and that Cu kinetic exchange is fast even when Cu-AHH is mainly in the 4N form.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Cobre/química
Oligopeptídeos/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Dimerização
Espectroscopia de Ressonância de Spin Eletrônica
Concentração de Íons de Hidrogênio
Cinética
Espectroscopia de Ressonância Magnética
Potenciometria
Conformação Proteica
Proteínas/química
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ala-His-His); 0 (Coordination Complexes); 0 (Oligopeptides); 0 (Proteins); 789U1901C5 (Copper)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b01996


  2 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28452475
[Au] Autor:Ritacco I; Al Assy M; Abd El-Rahman MK; Fahmy SA; Russo N; Shoeib T; Sicilia E
[Ad] Endereço:Department of Chemistry and Chemical Technologies, University of Calabria , Arcavacata di Rende 87036, Italy.
[Ti] Título:Hydrolysis in Acidic Environment and Degradation of Satraplatin: A Joint Experimental and Theoretical Investigation.
[So] Source:Inorg Chem;56(10):6013-6026, 2017 May 15.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:For the synthesis and selection of active platinum-based anticancer drugs that perform better than cisplatin and its analogues, six-coordinate octahedral Pt(IV) complexes appear to be promising candidates as, being kinetically more inert and more resistant to ligand substitution than four-coordinate Pt(II) centers, they are able to minimize unwanted side reactions with biomolecules prior to DNA binding. Due to their kinetic inertness, Pt(IV) complexes have also been exploited to bypass inconvenient intravenous administration. The most prominent example is satraplatin (Sat.) which is the first platinum antineoplastic agent reported to have oral activity. The present paper deals with a theoretical DFT investigation of the influence that the acidity of the biological environment can have on the activity of satraplatin and analogous octahedral Pt(IV) complexes having two carboxylates as axial ligands. Moreover, here the outcomes of a joint electrospray ionization mass spectrometry and DFT investigation of the fragmentation pathways of the protonated satraplatin are reported. Calculations show that the simulated acidic environment has an important impact on the satraplatin reactivity causing a significant lowering of the barrier that is necessary to overcome for the hydrolysis of the first acetate ligand to occur. Data from electrospray ionization mass spectrometry, H NMR, and potentiometric experiments strongly suggest that the loss of CH COOH from the protonated satraplatin ion [Sat. + H] takes place almost immediately upon dissolution of satraplatin in methanol-water, D O, and water solutions, respectively, at room temperature.
[Mh] Termos MeSH primário: Antineoplásicos/química
Compostos Organoplatínicos/química
Teoria Quântica
[Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio
Hidrólise
Espectrometria de Massas
Potenciometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organoplatinum Compounds); 8D7B37T28G (satraplatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b00945


  3 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29216587
[Au] Autor:Voitechovic E; Korepanov A; Kirsanov D; Legin A
[Ad] Endereço:St. Petersburg State University, St. Petersburg, Russia; Institute of Microelectronics of Barcelona, Barcelona, Spain. Electronic address: voitechovic.edita@gmail.com.
[Ti] Título:Quantification of immobilized protein in pharmaceutical production by bio-assisted potentiometric multisensor system.
[So] Source:J Pharm Biomed Anal;150:67-71, 2018 Feb 20.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Quantification of proteins is a key biochemical assay in molecular biology, biotechnology, medicine and pharmacology. Protein quantification protocols can be based on spectrophotometry, enzyme-linked immunosorbent assay, mass spectrometry or quantitative immunoblotting depending on analyte. In case of immobilized protein these methods require suitable sample preparation. Thus, sophisticated analysis becomes even more complex, expensive and time-consuming. Such drawbacks are highly undesirable in industry. In this study we propose a new approach for evaluation of immobilized protein concentration based on application of bio-assisted potentiometric multisensor system. Surface-immobilized recombinant protein A from Staphylococcus aureus (SpA, expressed in Escherichia coli), which is commonly used as affinity ligand immobilized to stationary phase (сhromatography media) for monoclonal antibody purification was employed as the model object. Chromatography media samples containing different amounts of immobilized SpA were analyzed. Proteinase K from Tritirachium album was employed as a bio-transducer. We demonstrated that the suggested approach provides information about immobilized SpA concentration with 0.8mg/ml accuracy in the range 1-6.7mg/ml and within just 16min. Moreover, the proposed procedure requires no expensive materials and equipment and no bio-transducer immobilization. This method has potential of application for fast monitoring of other immobilized proteins in different tasks.
[Mh] Termos MeSH primário: Ensaio de Imunoadsorção Enzimática/métodos
Proteínas Imobilizadas/química
Potenciometria/métodos
Proteína Estafilocócica A/química
[Mh] Termos MeSH secundário: Endopeptidase K/química
Proteínas Imobilizadas/análise
Proteínas Recombinantes/análise
Proteínas Recombinantes/química
Reprodutibilidade dos Testes
Proteína Estafilocócica A/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immobilized Proteins); 0 (Recombinant Proteins); 0 (Staphylococcal Protein A); EC 3.4.21.64 (Endopeptidase K)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  4 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29207872
[Au] Autor:Cesario D; Furia E; Mazzone G; Beneduci A; De Luca G; Sicilia E
[Ad] Endereço:Department of Chemistry and Chemical Technologies, University of Calabria , Arcavacata di Rende 87036, Italy.
[Ti] Título:Complexation of Al and Ni by l-Ascorbic Acid: An Experimental and Theoretical Investigation.
[So] Source:J Phys Chem A;121(51):9773-9781, 2017 Dec 28.
[Is] ISSN:1520-5215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the potential versatility of Vitamin C as a ligand, only for few metal complexes does full characterization exist. Vitamin C metal complexes, indeed, are difficult to study experimentally because the ligand has multiple protonation and oxidation states, and the metal-ligand complexes are in general not as tight as one might expect and frequently resistant to crystallographic characterization. In most cases, coordination via one of the hypothesized modes is invoked, characterized by monodentate or bidentate coordination via the most acidic oxygen atoms, with the ligand singly or doubly deprotonated. In this study the ability of l-ascorbic acid to form complexes with Al and Ni ions under physiological conditions was investigated by using a combination of potentiometric measurements, H NMR spectroscopy, and DFT computations in order to recognize the structural properties of the resulting complexes in aqueous solution. The comparison between the values of the free energies of complexation obtained by using DFT quantum chemical calculations and estimated from experimental stability constants according to the mass action law and by considering the involved equilibria allows to select structure and preferred coordination modes of formed complexes. The protonation constant of the free ligand was also determined using potentiometric data and its reproduction by using computational approaches was critically commented.
[Mh] Termos MeSH primário: Alumínio/química
Ácido Ascórbico/química
Níquel/química
Compostos Organometálicos/química
Teoria Quântica
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Modelos Moleculares
Estrutura Molecular
Compostos Organometálicos/síntese química
Potenciometria
Espectroscopia de Prótons por Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 7OV03QG267 (Nickel); CPD4NFA903 (Aluminum); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jpca.7b10847


  5 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29045481
[Au] Autor:Xia L; Huang R; Li Y; Song S
[Ad] Endereço:Hubei Key Laboratory of Mineral Resources Processing and Environment, Wuhan, Hubei, China.
[Ti] Título:The effect of growth phase on the surface properties of three oleaginous microalgae (Botryococcus sp. FACGB-762, Chlorella sp. XJ-445 and Desmodesmus bijugatus XJ-231).
[So] Source:PLoS One;12(10):e0186434, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of growth phase on the lipid content and surface properties of oleaginous microalgae Botryococcus sp. FACGB-762, Chlorella sp. XJ-445 and Desmodesmus bijugatus XJ-231 were investigated in this study. The results showed that throughout the growth phases, the lipid content of microalgae increased. The surface properties like particle size, the degree of hydrophobicity, and the total concentration of functional groups increased while net surface zeta potential decreased. The results suggested that the growth stage had significant influence not only on the lipid content but also on the surface characteristics. Moreover, the lipid content was significantly positively related to the concentration of hydroxyl functional groups in spite of algal strains or growth phases. These results provided a basis for further studies on the refinery process using oleaginous microalgae for biofuel production.
[Mh] Termos MeSH primário: Chlorella/crescimento & desenvolvimento
Lipídeos/química
Microalgas/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Biomassa
Interações Hidrofóbicas e Hidrofílicas
Tamanho da Partícula
Potenciometria
Tamanho da Amostra
Eletricidade Estática
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipids)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186434


  6 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28538167
[Au] Autor:Bretti C; Cigala RM; De Stefano C; Lando G; Sammartano S
[Ad] Endereço:Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno d'Alcontres, 31, I-98166 Messina (Vill. S. Agata), Italy. Electronic address: cbretti@unime.it.
[Ti] Título:Understanding the bioavailability and sequestration of different metal cations in the presence of a biodegradable chelant MGDA in biological fluids and natural waters.
[So] Source:Chemosphere;183:107-118, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thermodynamic information about the metal-ligand interaction between Fe , Zn , Cu and Sn , and a biodegradable ligand as MGDA is reported. The speciation scheme was obtained by means of potentiometric measurements and isothermal titration calorimetry (to determine enthalpy changes) in NaCl medium. The formation of the ML and MLOH species was evidenced for all the metal cations, and for Fe also the ML and ML(OH) were found. The relative stability, for the ML species, follows the order: Sn > Fe > Cu > Zn . Stability constants and enthalpy changes were obtained at different ionic strengths, and data were modeled using the Debye-Hückel and SIT approaches to obtain data in a standard state. At infinite dilution, the enthalpy changes are largely negative for Cu (-34.1 kJ mol ) and Sn (-16.6 kJ mol ), slightly negative for Fe (-3.3 kJ mol ) and positive for Zn (8.7 kJ mol ). In all cases, the entropic contribution to the stability is predominant. The sequestering ability of MGDA was evaluated determining the pL values in different conditions. Comparing the data reported in this work and literature ones, some empirical relationships were obtained with predictive purpose. For example, using 11 data in the test set we have: log K (M/MGDA) ± 0.1 = 1.13 + 0.84·log K (M/NTA) Case studies were built up in the conditions of seawater, fresh water and urine to study the possible use of MGDA towards the metal cations here studied. Some considerations were also done in the light of the ocean acidification.
[Mh] Termos MeSH primário: Alanina/análogos & derivados
Monitoramento Ambiental/métodos
Água Doce/química
Glicina/análogos & derivados
Metais Pesados
Modelos Químicos
Água do Mar/química
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Alanina/química
Disponibilidade Biológica
Calorimetria
Cátions
Glicina/química
Seres Humanos
Ligantes
Metais Pesados/análise
Metais Pesados/urina
Concentração Osmolar
Potenciometria
Cloreto de Sódio/química
Termodinâmica
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Ligands); 0 (Metals, Heavy); 0 (Water Pollutants, Chemical); 0 (methylglycinediacetic acid); 451W47IQ8X (Sodium Chloride); OF5P57N2ZX (Alanine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


  7 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28410941
[Au] Autor:Cardiano P; Crea F; Foti C; Giuffrè O; Sammartano S
[Ad] Endereço:Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
[Ti] Título:Potentiometric, UV and H NMR study on the interaction of Cu with ampicillin and amoxicillin in aqueous solution.
[So] Source:Biophys Chem;224:59-66, 2017 May.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A potentiometric, UV and H NMR study on Cu -ampicillin [(2S,5R,6R)-6-([(2R)-2-amino-2-phenylacetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] and -amoxicillin [(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)-acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-24-carboxylic acid] systems in NaCl aqueous solution at I=0.15molL and t=25°C is reported. On the basis of potentiometric results two speciation models were proposed for each system. It was found that spectrophotometric and H NMR measurements are essential for selecting the most reliable speciation models. They included ML, MLOH and ML(OH) species in both systems and, only for Cu -ampicillin, also MLH species. The stability constants obtained by UV and H NMR titrations were comparable to the ones calculated by potentiometry. The sequestering ability of the ligands under study towards Cu by pL empiric parameter (ligand concentration required to sequester 50% of the metal cation present in traces) at several pH values was calculated as well. For ampicillin and amoxicillin, pL =7.19 and 6.67, respectively, at physiological pH, I=0.15molL and t=25°C were obtained.
[Mh] Termos MeSH primário: Amoxicilina/química
Ampicilina/química
Cobre/química
[Mh] Termos MeSH secundário: Potenciometria
Espectroscopia de Prótons por Ressonância Magnética
Soluções
Espectrofotometria Ultravioleta
Titulometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solutions); 789U1901C5 (Copper); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


  8 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28274418
[Au] Autor:Leoterio DM; Paim AP; Belian MF; Galembeck A; Lavorante AF; Pinto E; Amorim CG; Araújo AN; Montenegro MC
[Ad] Endereço:Departamento de Química Fundamental, Universidade Federal de Pernambuco, 50670-901 Recife, Pernambuco, Brazil; Departamento de Química, Universidade Federal Rural de Pernambuco, 52171-900 Recife, PE, Brazil.
[Ti] Título:Potentiometric perchlorate determination at nanomolar concentrations in vegetables.
[So] Source:Food Chem;227:166-172, 2017 Jul 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, an expeditious method based on the multi-commutated flow-analysis concept with potentiometric detection is proposed to perform determinations of the emergent contaminant perchlorate in vegetable matrices down to nanomolar concentration. To accomplish the task, a tubular shaped potentiometric sensor selective to perchlorate ion was constructed with a PVC membrane containing 12mmol/kg of the polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmethane and 2-nitrophenyl phenyl ether 68% (w/w) as plasticizer casted on a conductive epoxy resin. Under optimal flow conditions, the sensor responded linearly in the concentration range of 6.3×10 -1.0×10 mol/L perchlorate. In order to extend the determinations to lower concentrations (4.6(±1.3)×10 mol/L perchlorate), a column packed with 70mg of sodium 2,5,8,11,14-pentaoxa-1-silacyclotetradecane-polymer was coupled to the flow-system thus enabling prior pre-concentration of the perchlorate. The proposed procedure provides a simpler alternative for the determination of perchlorate in foods, nowadays only allowed by sophisticated and expensive equipment and laborious methods.
[Mh] Termos MeSH primário: Naftalenos/análise
Nitrocompostos/análise
Percloratos/análise
Éteres Fenílicos/análise
Poliaminas/análise
Potenciometria/métodos
Verduras/química
[Mh] Termos MeSH secundário: Compostos de Anilina
Naftalenos/química
Nitrocompostos/química
Éteres Fenílicos/química
Plastificantes
Poliaminas/química
Cloreto de Polivinila
Urinálise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-nitrophenyl phenyl ether); 0 (Aniline Compounds); 0 (Naphthalenes); 0 (Nitro Compounds); 0 (Perchlorates); 0 (Phenyl Ethers); 0 (Plasticizers); 0 (Polyamines); 0 (bisnaphthalimidopropyl-4,4'-diaminodiphenylmethane); 9002-86-2 (Polyvinyl Chloride); GG5LL7OBZC (4,4'-diaminodiphenylmethane); VLA4NZX2P4 (perchlorate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


  9 / 6072 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28222604
[Au] Autor:Paolesse R; Nardis S; Monti D; Stefanelli M; Di Natale C
[Ad] Endereço:Department of Chemical Science and Technologies, University of Rome Tor Vergata , via della Ricerca Scientifica 1, 00133 Rome, Italy.
[Ti] Título:Porphyrinoids for Chemical Sensor Applications.
[So] Source:Chem Rev;117(4):2517-2583, 2017 Feb 22.
[Is] ISSN:1520-6890
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Porphyrins and related macrocycles have been intensively exploited as sensing materials in chemical sensors, since in these devices they mimic most of their biological functions, such as reversible binding, catalytic activation, and optical changes. Such a magnificent bouquet of properties allows applying porphyrin derivatives to different transducers, ranging from nanogravimetric to optical devices, also enabling the realization of multifunctional chemical sensors, in which multiple transduction mechanisms are applied to the same sensing layer. Potential applications are further expanded through sensor arrays, where cross-selective sensing layers can be applied for the analysis of complex chemical matrices. The possibility of finely tuning the macrocycle properties by synthetic modification of the different components of the porphyrin ring, such as peripheral substituents, molecular skeleton, coordinated metal, allows creating a vast library of porphyrinoid-based sensing layers. From among these, one can select optimal arrays for a particular application. This feature is particularly suitable for sensor array applications, where cross-selective receptors are required. This Review briefly describes chemical sensor principles. The main part of the Review is divided into two sections, describing the porphyrin-based devices devoted to the detection of gaseous or liquid samples, according to the corresponding transduction mechanism. Although most devices are based on porphyrin derivatives, seminal examples of the application of corroles or other porphyrin analogues are evidenced in dedicated sections.
[Mh] Termos MeSH primário: Porfirinas/química
[Mh] Termos MeSH secundário: Dopamina/análise
Eletrodos
Gases
Peróxido de Hidrogênio/análise
Nanotubos/química
Neurotransmissores/análise
Óxido Nítrico/análise
Potenciometria
Análise Espectral/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gases); 0 (Neurotransmitter Agents); 0 (Porphyrins); 31C4KY9ESH (Nitric Oxide); BBX060AN9V (Hydrogen Peroxide); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrev.6b00361


  10 / 6072 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28208725
[Au] Autor:Miszczyk P; Wieczorek D; Galezowska J; Dziuk B; Wietrzyk J; Chmielewska E
[Ad] Endereço:Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. patrycja.miszczyk@pwr.edu.pl.
[Ti] Título:Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities of the Products.
[So] Source:Molecules;22(2), 2017 Feb 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The reaction of diethyl phosphite with triethyl orthoformate and a primary amine followed by hydrolysis is presented, and the reaction was suitable for the preparation of (aminomethylene)bisphosphonates. 3-Amino-1,2,4-triazole was chosen as an interesting substrate for this reaction because it possesses multiple groups that can serve as the amino component in the reaction-namely, the side-chain and triazole amines. This substrate readily forms 1,2,4-triazolyl-3-yl-aminomethylenebisphosphonic acid (compound ) as a major product, along with -ethylated bisphosphonates as side products. The in vitro antiproliferative effects of the synthesized aminomethylenebisphosphonic acids against J774E macrophages were determined. These compounds exhibit similar activity to zoledronic acid and higher activity than incadronic acid.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/química
Conservadores da Densidade Óssea/farmacologia
Formiatos/química
Fosfitos/química
Triazóis/química
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Conservadores da Densidade Óssea/síntese química
Linhagem Celular Tumoral
Difosfonatos/farmacologia
Imagem por Ressonância Magnética
Camundongos
Modelos Moleculares
Conformação Molecular
Osteoclastos/efeitos dos fármacos
Potenciometria
Triazóis/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Diphosphonates); 0 (Formates); 0 (Phosphites); 0 (Triazoles); 0YIW783RG1 (formic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE



página 1 de 608 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde