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[PMID]:29472187
[Au] Autor:Mansournia MA; Altman DG
[Ad] Endereço:Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran mansournia_ma@yahoo.com.
[Ti] Título:Population attributable fraction.
[So] Source:BMJ;360:k757, 2018 02 22.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Exposição Ambiental
Métodos Epidemiológicos
Saúde Pública
[Mh] Termos MeSH secundário: Interpretação Estatística de Dados
Seres Humanos
Medição de Risco
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180224
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k757


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[PMID]:28465652
[Au] Autor:Gudina EK; Teklu AM; Berhan A; Gebreegziabhier A; Seyoum T; Nega A; Medhin G; Kebede A; Assefa Y
[Ad] Endereço:Department of Internal Medicine, Jimma University, Jimma.
[Ti] Título:Magnitude of Antiretroviral Drug Toxicity in Adult HIV Patients in Ethiopia: A cohort study at seven teaching hospitals.
[So] Source:Ethiop J Health Sci;27(Suppl 1):39-52, 2017 Feb.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The introduction of antiretroviral therapy (ART) has resulted in significant mortality reduction and improvement in the quality of life. However, this has come at a cost of increased drug toxicity. The objective of this study was to assess the patterns and predictors of ART toxicity in adult HIV patients in Ethiopia. METHODS: This is a prospective cohort study conducted at seven teaching hospitals between September 2009 and December 2013 involving 3921 HIV patients on ART. Adverse drug reactions (ADR) due to ART were identified based on clinical assessment and/or laboratory parameters. Multivariable random effects Poisson regression analysis was used to identify factors independently associated with toxicity. RESULT: ADR due to ART drugs was reported in 867 (22.1 %) of the participants; 374 (9.5%) had severe forms. About 87% of reported toxicities were limited to three organ systems - the skin, nervous system and blood. The overall incidence of ADR was 9 per 100 person years. About a third of toxicities occurred during the first six months after ART initiation with the incidence rate of 22.4 per 100 person years. Concomitant anti-tuberculosis treatment was the strongest independent predictor of toxicity. CONCLUSION: ADR was found to be highly prevalent in HIV patients on ART at tertiary hospitals in Ethiopia. Most of these conditions occurred early after ART initiation and in those with concomitant anti-tuberculosis treatment. Thus, routine monitoring of patients on ART should be strengthened with particular emphasis in the first 6 months. Strategies should also be devised to replace older and more toxic agents with newer and safer drugs available.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/efeitos adversos
Terapia Antirretroviral de Alta Atividade/efeitos adversos
Infecções por HIV/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/virologia
Métodos Epidemiológicos
Etiópia/epidemiologia
Feminino
Hospitais de Ensino/estatística & dados numéricos
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:27771142
[Au] Autor:Suzuki E; Tsuda T; Mitsuhashi T; Mansournia MA; Yamamoto E
[Ad] Endereço:Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. Electronic address: etsuji-s@cc.okayama-u.ac.jp.
[Ti] Título:Errors in causal inference: an organizational schema for systematic error and random error.
[So] Source:Ann Epidemiol;26(11):788-793.e1, 2016 Nov.
[Is] ISSN:1873-2585
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To provide an organizational schema for systematic error and random error in estimating causal measures, aimed at clarifying the concept of errors from the perspective of causal inference. METHODS: We propose to divide systematic error into structural error and analytic error. With regard to random error, our schema shows its four major sources: nondeterministic counterfactuals, sampling variability, a mechanism that generates exposure events and measurement variability. RESULTS: Structural error is defined from the perspective of counterfactual reasoning and divided into nonexchangeability bias (which comprises confounding bias and selection bias) and measurement bias. Directed acyclic graphs are useful to illustrate this kind of error. Nonexchangeability bias implies a lack of "exchangeability" between the selected exposed and unexposed groups. A lack of exchangeability is not a primary concern of measurement bias, justifying its separation from confounding bias and selection bias. Many forms of analytic errors result from the small-sample properties of the estimator used and vanish asymptotically. Analytic error also results from wrong (misspecified) statistical models and inappropriate statistical methods. CONCLUSIONS: Our organizational schema is helpful for understanding the relationship between systematic error and random error from a previously less investigated aspect, enabling us to better understand the relationship between accuracy, validity, and precision.
[Mh] Termos MeSH primário: Fatores de Confusão (Epidemiologia)
Métodos Epidemiológicos
Viés de Seleção
[Mh] Termos MeSH secundário: Seres Humanos
Erros Médicos
Modelos Estatísticos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29028799
[Au] Autor:Kracalik IT; Kenu E; Ayamdooh EN; Allegye-Cudjoe E; Polkuu PN; Frimpong JA; Nyarko KM; Bower WA; Traxler R; Blackburn JK
[Ad] Endereço:Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, United States of America.
[Ti] Título:Modeling the environmental suitability of anthrax in Ghana and estimating populations at risk: Implications for vaccination and control.
[So] Source:PLoS Negl Trop Dis;11(10):e0005885, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anthrax is hyper-endemic in West Africa. Despite the effectiveness of livestock vaccines in controlling anthrax, underreporting, logistics, and limited resources makes implementing vaccination campaigns difficult. To better understand the geographic limits of anthrax, elucidate environmental factors related to its occurrence, and identify human and livestock populations at risk, we developed predictive models of the environmental suitability of anthrax in Ghana. We obtained data on the location and date of livestock anthrax from veterinary and outbreak response records in Ghana during 2005-2016, as well as livestock vaccination registers and population estimates of characteristically high-risk groups. To predict the environmental suitability of anthrax, we used an ensemble of random forest (RF) models built using a combination of climatic and environmental factors. From 2005 through the first six months of 2016, there were 67 anthrax outbreaks (851 cases) in livestock; outbreaks showed a seasonal peak during February through April and primarily involved cattle. There was a median of 19,709 vaccine doses [range: 0-175 thousand] administered annually. Results from the RF model suggest a marked ecological divide separating the broad areas of environmental suitability in northern Ghana from the southern part of the country. Increasing alkaline soil pH was associated with a higher probability of anthrax occurrence. We estimated 2.2 (95% CI: 2.0, 2.5) million livestock and 805 (95% CI: 519, 890) thousand low income rural livestock keepers were located in anthrax risk areas. Based on our estimates, the current anthrax vaccination efforts in Ghana cover a fraction of the livestock potentially at risk, thus control efforts should be focused on improving vaccine coverage among high risk groups.
[Mh] Termos MeSH primário: Vacinas contra Antraz
Antraz/epidemiologia
Antraz/veterinária
Surtos de Doenças/veterinária
Gado
[Mh] Termos MeSH secundário: Algoritmos
Animais
Antraz/microbiologia
Antraz/prevenção & controle
Bacillus anthracis/isolamento & purificação
Bovinos
Doenças dos Bovinos/microbiologia
Doenças dos Bovinos/prevenção & controle
Clima
Simulação por Computador
Meio Ambiente
Métodos Epidemiológicos
Gana/epidemiologia
Seres Humanos
Concentração de Íons de Hidrogênio
Gado/microbiologia
Fatores de Risco
Solo/química
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthrax Vaccines); 0 (Soil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005885


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[PMID]:28977082
[Au] Autor:Morais SHO; Segheto W; Silva DCGD; Coelho FA; Reis VG; Ferreira FG; Martinho KO; Rocha ALCD; Pessoa MC; Longo GZ
[Ad] Endereço:Department of Nutrition and Health, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.
[Ti] Título:Chronic joint symptoms in adults: A population-based study.
[So] Source:Rev Assoc Med Bras (1992);63(7):575-582, 2017 Jul.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze factors associated with chronic joint symptoms (CJS) in adults. METHOD: A population-based, cross-sectional study was performed with a sample of 1,217 adults aged between 20 and 59 years, in the city of Viçosa, in 2014. The sampling process was performed by conglomerates and sample was selected using a two-stage cluster-sampling scheme. First, 30 of the 99 census tracts of Viçosa were randomly selected using a random sampling scheme, without replacement. Household questionnaires were applied to obtain CJS data, sociodemographic conditions, behavioral factors and health status. Multivariable analysis was conducted using Poisson regression, adjusted for the sampling design effect, using the svy commands in Stata software. RESULTS: Prevalence of CJS totaled 31.27%, significantly higher in women (18.45). Age ranges 40-49 (PR 1.50; 95CI 1.16-1.92) and 50-59 years (PR 1.55; 95CI 1.07-2.25); overweight (PR 1.60; 95CI 1.28-2.00); obesity (PR 1.60; 95CI 1.11-2.29); and those who self-reported performing heavy work (PR 1.27; 95CI 1.09-1.48) showed higher prevalences of CJS. CONCLUSION: Women and individuals who were older, overweight and performing heavy work had a higher risk of CJS in this adult population residing in Viçosa, MG, Brazil.
[Mh] Termos MeSH primário: Artropatias/epidemiologia
Doenças Reumáticas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Brasil/epidemiologia
Doença Crônica
Métodos Epidemiológicos
Feminino
Seres Humanos
Masculino
Meia-Idade
Obesidade
Sobrepeso
Fatores Sexuais
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE


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[PMID]:28892520
[Au] Autor:Nyakarahuka L; Skjerve E; Nabadda D; Sitali DC; Mumba C; Mwiine FN; Lutwama JJ; Balinandi S; Shoemaker T; Kankya C
[Ad] Endereço:Department of Food Safety and Infection Biology, Norwegian University of Life Sciences, Oslo, Norway.
[Ti] Título:Knowledge and attitude towards Ebola and Marburg virus diseases in Uganda using quantitative and participatory epidemiology techniques.
[So] Source:PLoS Negl Trop Dis;11(9):e0005907, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Uganda has reported five (5) Ebola virus disease outbreaks and three (3) Marburg virus disease outbreaks from 2000 to 2016. Peoples' knowledge and attitude towards Ebola and Marburg virus disease impact on control and prevention measures especially during outbreaks. We describe knowledge and attitude towards Ebola and Marburg virus outbreaks in two affected communities in Uganda to inform future outbreak responses and help in the design of health education and communication messages. METHODS: The study was a community survey done in Luweero, Ibanda and Kamwenge districts that have experienced outbreaks of Ebola and Marburg virus diseases. Quantitative data were collected using a structured questionnaire and triangulated with qualitative participatory epidemiology techniques to gain a communities' knowledge and attitude towards Ebola and Marburg virus disease. RESULTS: Out of 740 respondents, 48.5% (359/740) were categorized as being knowledgeable about Ebola and Marburg virus diseases, whereas 60.5% (448/740) were having a positive attitude towards control and prevention of Ebola and Marburg virus diseases. The mean knowledge and attitude percentage scores were 54.3 (SD = 23.5, 95%CI = 52.6-56.0) and 69.9 (SD = 16.9, 95%CI = 68.9-71.1) respectively. People educated beyond primary school were more likely to be knowledgeable about Ebola and Marburg virus disease than those who did not attain any formal education (OR = 3.6, 95%CI = 2.1-6.1). Qualitative data revealed that communities describe Ebola and Marburg virus diseases as very severe diseases with no cure and they believe the diseases spread so fast. Respondents reported fear and stigma suffered by survivors, their families and the broader community due to these diseases. CONCLUSION: Communities in Uganda affected by filovirus outbreaks have moderate knowledge about these diseases and have a positive attitude towards practices to prevent and control Ebola and Marburg viral diseases. The public health sector should enhance this community knowledge gap to empower them more by supplying educational materials for epidemic preparedness in future using appropriate communication channels as proposed by the communities.
[Mh] Termos MeSH primário: Surtos de Doenças
Métodos Epidemiológicos
Conhecimentos, Atitudes e Prática em Saúde
Doença pelo Vírus Ebola/epidemiologia
Doença do Vírus de Marburg/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Criança
Pré-Escolar
Surtos de Doenças/prevenção & controle
Ebolavirus/isolamento & purificação
Feminino
Doença pelo Vírus Ebola/prevenção & controle
Doença pelo Vírus Ebola/psicologia
Doença pelo Vírus Ebola/virologia
Seres Humanos
Entrevistas como Assunto
Masculino
Doença do Vírus de Marburg/prevenção & controle
Doença do Vírus de Marburg/psicologia
Doença do Vírus de Marburg/virologia
Marburgvirus/isolamento & purificação
Meia-Idade
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Estigma Social
Uganda/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005907


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[PMID]:28833074
[Au] Autor:Cespedes Feliciano EM; Prentice RL; Aragaki AK; Neuhouser ML; Banack HR; Kroenke CH; Ho GYF; Zaslavsky O; Strickler HD; Cheng TD; Chlebowski RT; Saquib N; Nassir R; Anderson G; Caan BJ
[Ad] Endereço:Division of Research, Oakland, Kaiser Permanente Northern California, CA.
[Ti] Título:Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: The example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative.
[So] Source:Int J Cancer;141(11):2281-2290, 2017 Dec 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Often, studies modeling an exposure's influence on time to disease-specific death from study enrollment are incorrectly interpreted as if based on time to death from disease diagnosis. We studied 151,996 postmenopausal women without breast or colorectal cancer in the Women's Health Initiative with weight and height measured at enrollment (1993-1998). Using Cox regression models, we contrast hazard ratios (HR) from two time-scales and corresponding study subpopulations: time to cancer death after enrollment among all women and time to cancer death after diagnosis among only cancer survivors. Median follow-up from enrollment to diagnosis/censoring was 13 years for both breast (7,633 cases) and colorectal cancer (2,290 cases). Median follow-up from diagnosis to death/censoring was 7 years for breast and 5 years for colorectal cancer. In analyses of time from enrollment to death, body mass index (BMI) ≥ 35 kg/m versus 18.5-<25 kg/m was associated with higher rates of cancer mortality: HR = 1.99; 95% CI: 1.54, 2.56 for breast cancer (p trend <0.001) and HR = 1.40; 95% CI: 1.04, 1.88 for colorectal cancer (p trend = 0.05). However, in analyses of time from diagnosis to cancer death, trends indicated no significant association (for BMI ≥ 35 kg/m , HR = 1.25; 95% CI: 0.94, 1.67 for breast [p trend = 0.33] and HR = 1.18; 95% CI: 0.84, 1.86 for colorectal cancer [p trend = 0.39]). We conclude that a risk factor that increases disease incidence will increase disease-specific mortality. Yet, its influence on postdiagnosis survival can vary, and requires consideration of additional design and analysis issues such as selection bias. Quantitative tools allow joint modeling to compare an exposure's influence on time from enrollment to disease incidence and time from diagnosis to death.
[Mh] Termos MeSH primário: Neoplasias da Mama/epidemiologia
Neoplasias Colorretais/epidemiologia
Métodos Epidemiológicos
Obesidade/complicações
[Mh] Termos MeSH secundário: Idoso
Neoplasias da Mama/etiologia
Neoplasias Colorretais/etiologia
Feminino
Seres Humanos
Incidência
Meia-Idade
Modelos Estatísticos
Modelos de Riscos Proporcionais
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30931


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[PMID]:28827142
[Au] Autor:Saunders MJ; Wingfield T; Tovar MA; Baldwin MR; Datta S; Zevallos K; Montoya R; Valencia TR; Friedland JS; Moulton LH; Gilman RH; Evans CA
[Ad] Endereço:Section of Infectious Diseases and Immunity, Imperial College London, London, UK; Wellcome Trust Imperial College Centre for Global Health Research, London, UK; Innovation for Health and Development (IFHAD), Laboratory of Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru; In
[Ti] Título:A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study.
[So] Source:Lancet Infect Dis;17(11):1190-1199, 2017 Nov.
[Is] ISSN:1474-4457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a score to predict risk of tuberculosis in adult contacts of tuberculosis index cases. METHODS: In 2002-06, we recruited contacts aged 15 years or older of index cases with pulmonary tuberculosis who lived in desert shanty towns in Ventanilla, Peru. We followed up contacts for tuberculosis until February, 2016. We used a Cox proportional hazards model to identify index case, contact, and household risk factors for tuberculosis from which to derive a score and classify contacts as low, medium, or high risk. We validated the score in an urban community recruited in Callao, Peru, in 2014-15. FINDINGS: In the derivation cohort, we identified 2017 contacts of 715 index cases, and median follow-up was 10·7 years (IQR 9·5-11·8). 178 (9%) of 2017 contacts developed tuberculosis during 19 147 person-years of follow-up (incidence 0·93 per 100 person-years, 95% CI 0·80-1·08). Risk factors for tuberculosis were body-mass index, previous tuberculosis, age, sustained exposure to the index case, the index case being in a male patient, lower community household socioeconomic position, indoor air pollution, previous tuberculosis among household members, and living in a household with a low number of windows per room. The 10-year risks of tuberculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 2·8% (95% CI 1·7-4·4), 6·2% (4·8-8·1), and 20·6% (17·3-24·4). The 535 (27%) contacts classified as high risk accounted for 60% of the tuberculosis identified during follow-up. The score predicted tuberculosis independently of tuberculin skin test and index-case drug sensitivity results. In the external validation cohort, 65 (3%) of 1910 contacts developed tuberculosis during 3771 person-years of follow-up (incidence 1·7 per 100 person-years, 95% CI 1·4-2·2). The 2·5-year risks of tuberculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 1·4% (95% CI 0·7-2·8), 3·9% (2·5-5·9), and 8·6%· (5·9-12·6). INTERPRETATION: Our externally validated risk score could predict and stratify 10-year risk of developing tuberculosis in adult contacts, and could be used to prioritise tuberculosis control interventions for people most likely to benefit. FUNDING: Wellcome Trust, Department for International Development Civil Society Challenge Fund, Joint Global Health Trials consortium, Bill & Melinda Gates Foundation, Imperial College National Institutes of Health Research Biomedical Research Centre, Foundation for Innovative New Diagnostics, Sir Halley Stewart Trust, WHO, TB REACH, and Innovation for Health and Development.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa
Métodos Epidemiológicos
Tuberculose/epidemiologia
Tuberculose/transmissão
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Peru
Estudos Prospectivos
Medição de Risco
População Rural
População Urbana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28793913
[Au] Autor:Saracci R
[Ad] Endereço:International Agency for Research on Cancer, Lyon, France. saracci@hotmail.com.
[Ti] Título:The hazards of hazard identification in environmental epidemiology.
[So] Source:Environ Health;16(1):85, 2017 Aug 09.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hazard identification is a major scientific challenge, notably for environmental epidemiology, and is often surrounded, as the recent case of glyphosate shows, by debate arising in the first place by the inherently problematic nature of many components of the identification process. Particularly relevant in this respect are components less amenable to logical or mathematical formalization and essentially dependent on scientists' judgment. Four such potentially hazardous components that are capable of distorting the correct process of hazard identification are reviewed and discussed from an epidemiologist perspective: (1) lexical mix-up of hazard and risk (2) scientific questions as distinct from testable hypotheses, and implications for the hierarchy of strength of evidence obtainable from different types of study designs (3) assumptions in prior beliefs and model choices and (4) conflicts of interest. Four suggestions are put forward to strengthen a process that remains in several aspects judgmental, but not arbitrary, in nature.
[Mh] Termos MeSH primário: Saúde Ambiental
Métodos Epidemiológicos
Substâncias Perigosas
[Mh] Termos MeSH secundário: Conflito de Interesses
Projetos de Pesquisa
Risco
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hazardous Substances)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0296-3


  10 / 30486 MEDLINE  
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[PMID]:28728163
[Au] Autor:Wadhwa R; Wang X; Baladandayuthapani V; Liu B; Shiozaki H; Shimodaira Y; Lin Q; Elimova E; Hofstetter WL; Swisher SG; Rice DC; Maru DM; Kalhor N; Bhutani MS; Weston B; Lee JH; Skinner HD; Scott AW; Kaya DM; Harada K; Berry D; Song S; Ajani JA
[Ad] Endereço:Department of Gastrointestinal Medical Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
[Ti] Título:Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients.
[So] Source:Br J Cancer;117(5):648-655, 2017 Aug 22.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Predictive biomarkers or signature(s) for oesophageal cancer (OC) patients undergoing preoperative therapy could help administration of effective therapy, avoidance of ineffective ones, and establishment new strategies. Since the hedgehog pathway is often upregulated in OC, we examined its transcriptional factor, Gli-1, which confers therapy resistance, we wanted to assess Gli-1 as a predictive biomarker for chemoradiation response and validate it. METHODS: Untreated OC tissues from patients who underwent chemoradiation and surgery were assessed for nuclear Gli-1 by immunohistochemistry and labelling indices (LIs) were correlated with pathologic complete response (pathCR) or
[Mh] Termos MeSH primário: Adenocarcinoma/química
Adenocarcinoma/terapia
Carcinoma de Células Escamosas/química
Carcinoma de Células Escamosas/terapia
Núcleo Celular/química
Quimiorradioterapia Adjuvante
Neoplasias Esofágicas/química
Neoplasias Esofágicas/terapia
Proteína GLI1 em Dedos de Zinco/análise
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Biomarcadores Tumorais/análise
Sistemas CRISPR-Cas
Carcinoma de Células Escamosas/patologia
Linhagem Celular Tumoral
Proliferação Celular
Resistência a Medicamentos Antineoplásicos
Métodos Epidemiológicos
Neoplasias Esofágicas/patologia
Esofagectomia
Feminino
Edição de Genes
Proteínas Hedgehog/análise
Proteínas Hedgehog/genética
Seres Humanos
Masculino
Meia-Idade
Terapia Neoadjuvante
RNA Mensageiro/metabolismo
Tolerância a Radiação
Proteína GLI1 em Dedos de Zinco/antagonistas & inibidores
Proteína GLI1 em Dedos de Zinco/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (GLI1 protein, human); 0 (Hedgehog Proteins); 0 (RNA, Messenger); 0 (SHH protein, human); 0 (Zinc Finger Protein GLI1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.225



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