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[PMID]:29458541
[Au] Autor:Kim JH; Kim TS; Song SH; Choi J; Han S; Kim DY; Kwon S; Lee E; Song KH; Choe PG; Bang JH; Kim ES; Park SW; Kim HB; Kim NJ; Park WB; Oh MD
[Ad] Endereço:1​Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Direct rapid antibiotic susceptibility test (dRAST) for blood culture and its potential usefulness in clinical practice.
[So] Source:J Med Microbiol;67(3):325-331, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The direct rapid antibiotic susceptibility test (dRAST), based on analysing changes in bacterial micro-colonies under antibiotic conditions, detects antibiotic resistance within 6 h of direct smear examination results. This study aimed to assess the accuracy of dRAST and evaluate its potential usefulness for improving selection of appropriate antibiotic in real clinical practice settings. METHODOLOGY: We evaluated the accuracy of dRAST by comparing the antibiotic treatments that should have been administered based on dRAST results and the broth microdilution (BMD) test and its potential usefulness via simulation. RESULT: For 49/52 (94.2 %) patients with Gram-positive bacteraemia and 66/67 (98.5 %) patients with Gram-negative bacteraemia, antibiotics indicated by dRAST results were the same as those indicated by the BMD test. Among 34 patients with ineffective and suboptimal treatment, 19 (55.9 %) of patients could have received optimal treatment 1 to 2 days earlier with dRAST results. Among 33 patients given unnecessary broad-spectrum antibiotics, 1 to 2 days earlier de-escalation could have been possible for 27 (81.8 %) patients based on dRAST results. CONCLUSION: The introduction of dRAST could increase the use of optimal antibiotics and reduce unnecessary broad-spectrum antibiotic use in the early period of bacteraemia.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Hemocultura
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Testes de Sensibilidade Microbiana/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bacteriemia/tratamento farmacológico
Bacteriemia/microbiologia
Acurácia dos Dados
Feminino
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Positivas/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000678


  2 / 726 MEDLINE  
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[PMID]:28451691
[Au] Autor:Zvára K; Tomecková M; Peleska J; Svátek V; Zvárová J
[Ti] Título:Tool-supported Interactive Correction and Semantic Annotation of Narrative Clinical Reports.
[So] Source:Methods Inf Med;56(3):217-229, 2017 May 18.
[Is] ISSN:2511-705X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Our main objective is to design a method of, and supporting software for, interactive correction and semantic annotation of narrative clinical reports, which would allow for their easier and less erroneous processing outside their original context: first, by physicians unfamiliar with the original language (and possibly also the source specialty), and second, by tools requiring structured information, such as decision-support systems. Our additional goal is to gain insights into the process of narrative report creation, including the errors and ambiguities arising therein, and also into the process of report annotation by clinical terms. Finally, we also aim to provide a dataset of ground-truth transformations (specific for Czech as the source language), set up by expert physicians, which can be reused in the future for subsequent analytical studies and for training automated transformation procedures. METHODS: A three-phase preprocessing method has been developed to support secondary use of narrative clinical reports in electronic health record. Narrative clinical reports are narrative texts of healthcare documentation often stored in electronic health records. In the first phase a narrative clinical report is tokenized. In the second phase the tokenized clinical report is normalized. The normalized clinical report is easily readable for health professionals with the knowledge of the language used in the narrative clinical report. In the third phase the normalized clinical report is enriched with extracted structured information. The final result of the third phase is a semi-structured normalized clinical report where the extracted clinical terms are matched to codebook terms. Software tools for interactive correction, expansion and semantic annotation of narrative clinical reports has been developed and the three-phase preprocessing method validated in the cardiology area. RESULTS: The three-phase preprocessing method was validated on 49 anonymous Czech narrative clinical reports in the field of cardiology. Descriptive statistics from the database of accomplished transformations has been calculated. Two cardiologists participated in the annotation phase. The first cardiologist annotated 1500 clinical terms found in 49 narrative clinical reports to codebook terms using the classification systems ICD 10, SNOMED CT, LOINC and LEKY. The second cardiologist validated annotations of the first cardiologist. The correct clinical terms and the codebook terms have been stored in a database. CONCLUSIONS: We extracted structured information from Czech narrative clinical reports by the proposed three-phase preprocessing method and linked it to electronic health records. The software tool, although generic, is tailored for Czech as the specific language of electronic health record pool under study. This will provide a potential etalon for porting this approach to dozens of other less-spoken languages. Structured information can support medical decision making, quality assurance tasks and further medical research.
[Mh] Termos MeSH primário: Registros Eletrônicos de Saúde/normas
Aprendizado de Máquina
Processamento de Linguagem Natural
Semântica
Vocabulário Controlado
Processamento de Texto/normas
Redação/normas
[Mh] Termos MeSH secundário: Acurácia dos Dados
Guias como Assunto
Classificação Internacional de Doenças
Uso Significativo/normas
Software
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.3414/ME16-01-0083


  3 / 726 MEDLINE  
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[PMID]:29348126
[Au] Autor:Dendukuri N; Schiller I; de Groot J; Libman M; Moons K; Reitsma J; van Smeden M
[Ad] Endereço:Division of Clinical Epidemiology, McGill University Health Centre-Research Institute, Canada.
[Ti] Título:Concerns about composite reference standards in diagnostic research.
[So] Source:BMJ;360:j5779, 2018 01 18.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/normas
Acurácia dos Dados
Grupos Diagnósticos Relacionados/normas
[Mh] Termos MeSH secundário: Viés
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5779


  4 / 726 MEDLINE  
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[PMID]:29437066
[Au] Autor:Basques BA; McLynn RP; Lukasiewicz AM; Samuel AM; Bohl DD; Grauer JN
[Ad] Endereço:Yale School of Medicine, 47 College Street, 2nd Floor, New Haven, Connecticut 06510, USA.
[Ti] Título:Missing data may lead to changes in hip fracture database studies: a study of the American College of Surgeons National Surgical Quality Improvement Program.
[So] Source:Bone Joint J;100-B(2):226-232, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The aims of this study were to characterize the frequency of missing data in the National Surgical Quality Improvement Program (NSQIP) database and to determine how missing data can influence the results of studies dealing with elderly patients with a fracture of the hip. PATIENTS AND METHODS: Patients who underwent surgery for a fracture of the hip between 2005 and 2013 were identified from the NSQIP database and the percentage of missing data was noted for demographics, comorbidities and laboratory values. These variables were tested for association with 'any adverse event' using multivariate regressions based on common ways of handling missing data. RESULTS: A total of 26 066 patients were identified. The rate of missing data was up to 77.9% for many variables. Multivariate regressions comparing three methods of handling missing data found different risk factors for postoperative adverse events. Only seven of 35 identified risk factors (20%) were common to all three analyses. CONCLUSION: Missing data is an important issue in national database studies that researchers must consider when evaluating such investigations. Cite this article: 2018;100-B:226-32.
[Mh] Termos MeSH primário: Acurácia dos Dados
Bases de Dados Factuais
Fraturas do Quadril/cirurgia
Melhoria de Qualidade
[Mh] Termos MeSH secundário: Idoso
Comorbidade
Demografia
Feminino
Seres Humanos
Tempo de Internação
Masculino
Duração da Cirurgia
Procedimentos Ortopédicos
Complicações Pós-Operatórias
Medição de Risco
Fatores de Risco
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0791.R1


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[PMID]:29296156
[Au] Autor:Shimp L; Mohammed N; Oot L; Mokaya E; Kiyemba T; Ssekitto G; Alminana A
[Ad] Endereço:John Snow, Inc, USA.
[Ti] Título:Immunization review meetings: "Low Hanging Fruit" for capacity building and data quality improvement?
[So] Source:Pan Afr Med J;27(Suppl 3):21, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Although systematic program review meetings are common practice in many health and immunization programs, there is little documentation on their implementation and role. Adult education principles espouse opportunities for peer exchange to build capacity and cross-learning, for which review meetings have been a forum utilized in immunization programs for many years. This study describes the process and use of review meetings to build immunization technical capacity in four African countries since 2011. Methods: A longitudinal case study providing retrospective descriptive analysis and qualitative data collected on immunization program implementation and review meetings conducted within the years of 2011-2016 with district and facility health staff and technical partners from Ethiopia, Kenya, Tanzania and Uganda. Results: Based on summarized findings and analyses from over 200 review meetings conducted in the four countries within the time period of 2011-2016, these meetings have been shown to be effective tools for improving immunization program performance and the capacity of health staff. Conclusion: Review meetings (ideally conducted quarterly) provide health workers with beneficial and low cost opportunities for adult learning, including building skills in data analysis and review, which can be sustained at district and health facility levels. In combination with other performance improvement approaches implemented and supported in countries (such as supportive supervision, training, and on-the-job learning and assessment), review meetings can also contribute to achievement of immunization and health outcomes.
[Mh] Termos MeSH primário: Fortalecimento Institucional
Programas de Imunização/normas
Imunização
[Mh] Termos MeSH secundário: Adulto
África
Acurácia dos Dados
Seres Humanos
Programas de Imunização/organização & administração
Estudos Longitudinais
Melhoria de Qualidade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.supp.2017.27.3.11516


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[PMID]:28748943
[Au] Autor:Sené M; Gilmore I; Janssen JT
[Ti] Título:Metrology is key to reproducing results.
[So] Source:Nature;547(7664):397-399, 2017 07 25.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acurácia dos Dados
Coleta de Dados/métodos
Coleta de Dados/normas
[Mh] Termos MeSH secundário: Animais
Biomassa
Florestas
Mapas como Assunto
Meteorologia
Radioterapia/métodos
Radioterapia/normas
Padrões de Referência
Erro Experimental
América do Sul
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1038/547397a


  7 / 726 MEDLINE  
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[PMID]:29205302
[Au] Autor:Allemani C; Harewood R; Johnson CJ; Carreira H; Spika D; Bonaventure A; Ward K; Weir HK; Coleman MP
[Ad] Endereço:Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
[Ti] Título:Population-based cancer survival in the United States: Data, quality control, and statistical methods.
[So] Source:Cancer;123 Suppl 24:4982-4993, 2017 Dec 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Robust comparisons of population-based cancer survival estimates require tight adherence to the study protocol, standardized quality control, appropriate life tables of background mortality, and centralized analysis. The CONCORD program established worldwide surveillance of population-based cancer survival in 2015, analyzing individual data on 26 million patients (including 10 million US patients) diagnosed between 1995 and 2009 with 1 of 10 common malignancies. METHODS: In this Cancer supplement, we analyzed data from 37 state cancer registries that participated in the second cycle of the CONCORD program (CONCORD-2), covering approximately 80% of the US population. Data quality checks were performed in 3 consecutive phases: protocol adherence, exclusions, and editorial checks. One-, 3-, and 5-year age-standardized net survival was estimated using the Pohar Perme estimator and state- and race-specific life tables of all-cause mortality for each year. The cohort approach was adopted for patients diagnosed between 2001 and 2003, and the complete approach for patients diagnosed between 2004 and 2009. RESULTS: Articles in this supplement report population coverage, data quality indicators, and age-standardized 5-year net survival by state, race, and stage at diagnosis. Examples of tables, bar charts, and funnel plots are provided in this article. CONCLUSIONS: Population-based cancer survival is a key measure of the overall effectiveness of services in providing equitable health care. The high quality of US cancer registry data, 80% population coverage, and use of an unbiased net survival estimator ensure that the survival trends reported in this supplement are robustly comparable by race and state. The results can be used by policymakers to identify and address inequities in cancer survival in each state and for the United States nationally. Cancer 2017;123:4982-93. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
[Mh] Termos MeSH primário: Acurácia dos Dados
Neoplasias/mortalidade
Vigilância em Saúde Pública
Controle de Qualidade
Estatística como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.31025


  8 / 726 MEDLINE  
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[PMID]:28450290
[Au] Autor:Doshi P; Godlee F
[Ti] Título:The wider role of regulatory scientists.
[So] Source:BMJ;357:j1991, 2017 04 27.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Tomada de Decisões/ética
Sociedades Científicas/legislação & jurisprudência
[Mh] Termos MeSH secundário: Celecoxib/farmacologia
Inibidores de Ciclo-Oxigenase 2/farmacologia
Acurácia dos Dados
Ética em Pesquisa
Seres Humanos
Lactonas/farmacologia
Paroxetina/farmacologia
Medição de Risco
Inibidores da Captação de Serotonina/farmacologia
Sociedades Científicas/normas
Sulfonas/farmacologia
Resultado do Tratamento
Estados Unidos
United States Food and Drug Administration/legislação & jurisprudência
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Cyclooxygenase 2 Inhibitors); 0 (Lactones); 0 (Serotonin Uptake Inhibitors); 0 (Sulfones); 0QTW8Z7MCR (rofecoxib); 41VRH5220H (Paroxetine); JCX84Q7J1L (Celecoxib)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j1991


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[PMID]:29069004
[Au] Autor:Liu H; Yang ZM; Geng Y; Yang H; Zhao DH; Xiao WD; Wang GH
[Ad] Endereço:aDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan bCenter for Drug Evaluation, China Food and Drug Administration, Beijing, China.
[Ti] Título:Selection and measurement of control antidepressants in clinical tests for Chinese: A systematic review.
[So] Source:Medicine (Baltimore);96(43):e8327, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The study aims to help domestic application units and research institutions improve their research quality of antidepressant clinical tests by studying and analyzing the current status and problems in selecting control drugs during domestic antidepressant clinical tests and illustrating some key problems that should be noted when selecting the control drug in such researches. METHODS: Considering the current domestic and overseas status of control drug selection in antidepressant clinical tests, various considerations, and misunderstandings on control drug selection in domestic antidepressant clinical tests were clarified and described, and possible factors that may influence the absolute effect of antidepressants were analyzed. Furthermore, problems that should be noted in selecting control drugs for the antidepressant clinical test, especially the placebo control, were stated. RESULTS: During the antidepressant clinical research, selecting placebo controls conform to moral philosophy and safety requirements. To verify the absolute effect of a test drug, a placebo control should be set or 3-arm tests should be conducted as far as possible. Possible factors that may affect the absolute effect of the test drug, including illness severity of the subject at baseline and research scale, should be given consideration. CONCLUSIONS: Application units and research institutions should consider the selection of subjects, control the failure rate, strengthen safety risks, and control and intensify quality control to further improve the overall quality and research level of domestic antidepressant clinical tests.
[Mh] Termos MeSH primário: Antidepressivos
Ensaios Clínicos como Assunto
Acurácia dos Dados
Seleção de Pacientes
[Mh] Termos MeSH secundário: Antidepressivos/análise
Antidepressivos/farmacologia
China
Ensaios Clínicos como Assunto/ética
Ensaios Clínicos como Assunto/métodos
Ensaios Clínicos como Assunto/normas
Depressão/tratamento farmacológico
Monitoramento de Medicamentos/métodos
Seres Humanos
Controle de Qualidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidepressive Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008327


  10 / 726 MEDLINE  
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[PMID]:29036172
[Au] Autor:Abrahamczyk S; Lozada-Gobilard S; Ackermann M; Fischer E; Krieger V; Redling A; Weigend M
[Ad] Endereço:Nees-Institute for Biodiversity of Plants, University of Bonn, Meckenheimer Allee 170, Bonn, Germany.
[Ti] Título:A question of data quality-Testing pollination syndromes in Balsaminaceae.
[So] Source:PLoS One;12(10):e0186125, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pollination syndromes and their predictive power regarding actual plant-animal interactions have been controversially discussed in the past. We investigate pollination syndromes in Balsaminaceae, utilizing quantitative respectively categorical data sets of flower morphometry, signal and reward traits for 86 species to test for the effect of different types of data on the test patterns retrieved. Cluster Analyses of the floral traits are used in combination with independent pollinator observations. Based on quantitative data we retrieve seven clusters, six of them corresponding to plausible pollination syndromes and one additional, well-supported cluster comprising highly divergent floral architectures. This latter cluster represents a non-syndrome of flowers not segregated by the specific data set here used. Conversely, using categorical data we obtained only a rudimentary resolution of pollination syndromes, in line with several earlier studies. The results underscore that the use of functional, exactly quanitified trait data has the power to retrieve pollination syndromes circumscribed by the specific data used. Data quality can, however, not be replaced by sheer data volume. With this caveat, it is possible to identify pollination syndromes from large datasets and to reliably extrapolate them for taxa for which direct observations are unavailable.
[Mh] Termos MeSH primário: Balsaminaceae/anatomia & histologia
Flores/anatomia & histologia
Polinização
[Mh] Termos MeSH secundário: Animais
Análise por Conglomerados
Acurácia dos Dados
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186125



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