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[PMID]:28454556
[Au] Autor:Daw MA; El-Bouzedi A; Ahmed MO; Dau AA; In association with the Libyan Study Group of Hepatitis & HIV
[Ad] Endereço:Department of Medical Microbiology, Faculty of Medicine, University of Tripoli, CC 82668, Tripoli, Libya. mohamedadaw@gmail.com.
[Ti] Título:Molecular and epidemiological characterization of HIV-1 subtypes among Libyan patients.
[So] Source:BMC Res Notes;10(1):170, 2017 Apr 28.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The epidemiological and clinical aspects of human immunodeficiency virus subtypes are of great interest worldwide. These subtypes are rarely studied in North African countries. Libya is a large country with the longest coast on the Mediterranean Sea, facing the Southern European countries. Studies on the characterization of HIV-1 subtypes are limited in Libya. This study aimed to determine the magnitude of the HIV problem among the Libyan population and to better understand the genetic diversity and the epidemiologic dynamics of HIV 1, as well as to correlate that with the risk factors involved. METHODS: A total of 159 HIV-1 strains were collected from 814 HIV positive patients from the four Libyan regions during a 16-year period (1995-2010). To determine the HIV-1 subtypes, genetic analysis and molecular sequencing were carried out using provirus polygene. Epidemiologic and demographic information was obtained from each participant and correlated with HIV-1 subtypes using logistic regression. RESULTS: The overall prevalence of HIV among Libyans ranged from 5 to 10 per 100,000 during the study period. It was higher among intravenous drug users (IVDUs) (53.9%), blood recipients (25.9%) and heterosexuals (17.6%) than by vertical transmission (2.6%). Prevalence was higher among males aged 20-40 years (M:F 1:6, P > 0.001). Among the 159 strains of HIV-1 available for typing, 117 strains (73.6%) were subtype B, 29 (18.2%) were CRF02_AG, and 13 (8.2%) were subtype A. HIV-1 subtype B was the most prevalent all over the country, and it was more prevalent in the Northern region, particularly among IVDUs (P < 0.001). GRF02_AG was common in the Eastern region, particularly among blood recipients while subtype A emerged in the Western region, particularly among IVDUs. CONCLUSIONS: HIV-1 infection is emerging in Libya with a shifting prevalence of subtypes associated with the changing epidemiology of HIV-1 among risk groups. A genetic analysis of HIV-1 strains demonstrated low subtype heterogeneity with the evolution of subtype B, and CRF_20 AG, as well as HIV-1 subtype A. Our study highlights the importance of expanded surveillance programs to control HIV infection and the necessity of introducing public health strategies to target the risk groups, particularly IVDUs.
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
Infecções por HIV/transmissão
HIV-1/genética
Transmissão Vertical de Doença Infecciosa/estatística & dados numéricos
Filogenia
Abuso de Substâncias por Via Intravenosa/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Transfusão de Sangue
Feminino
Infecções por HIV/complicações
Infecções por HIV/virologia
HIV-1/classificação
HIV-1/isolamento & purificação
Seres Humanos
Líbia/epidemiologia
Masculino
Meia-Idade
Epidemiologia Molecular
Tipagem Molecular
Prevalência
Vigilância em Saúde Pública
Fatores de Risco
Fatores Sexuais
Abuso de Substâncias por Via Intravenosa/complicações
Abuso de Substâncias por Via Intravenosa/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2491-2


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[PMID]:28464900
[Au] Autor:Bahri P; Fogd J; Morales D; Kurz X; ADVANCE consortium
[Ad] Endereço:European Medicines Agency, 30 Churchill Place, Canary Wharf, London, E14 5EU, UK. priya.bahri@ema.europa.eu.
[Ti] Título:Application of real-time global media monitoring and 'derived questions' for enhancing communication by regulatory bodies: the case of human papillomavirus vaccines.
[So] Source:BMC Med;15(1):91, 2017 05 02.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral procedure assessing the potential causality of complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) reported to the authorities as suspected adverse reactions. METHODS: To evaluate the utility of media monitoring in real life, prospective real-time monitoring of worldwide online news was conducted from September to December 2015 with inductive content analysis, generating 'derived questions'. The evaluation was performed through the validation of the predictive capacity of these questions against journalists' queries, review of the EMA's public statement and feedback from EU regulators. RESULTS: A total of 4230 news items were identified, containing personal stories, scientific and policy/process-related topics. Explicit and implicit concerns were identified, including those raised due to lack of knowledge or anticipated once more information would be published. Fifty derived questions were generated and categorised into 12 themes. The evaluation demonstrated that providing the media monitoring findings to assessors and communicators resulted in (1) confirming that public concerns regarding CRPS and POTS would be covered by the assessment; (2) meeting specific information needs proactively in the public statement; (3) predicting all queries from journalists; and (4) altering the tone of the public statement with respectful acknowledgement of the health status of patients with CRSP or POTS. CONCLUSIONS: The study demonstrated the potential utility of media monitoring for regulatory bodies to support communication proactivity and preparedness, intended to support trusted safe and effective vaccine use. Derived questions seem to be a familiar and effective format for presenting media monitoring results in the scientific-regulatory environment. It is suggested that media monitoring could form part of regular surveillance for medicines of high public interest. Future work is recommended to develop efficient monitoring strategies for that purpose.
[Mh] Termos MeSH primário: Comunicação
Meios de Comunicação de Massa
Vacinas contra Papillomavirus
Vigilância em Saúde Pública/métodos
[Mh] Termos MeSH secundário: Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Estudos Prospectivos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12916-017-0850-4


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[PMID]:28453148
[Au] Autor:Guzmán-Barragán BL; Días Bevilacqua P; Nava-Tovar G
[Ad] Endereço:Instituto Nacional de Salud, Bogotá, D.C, Colombia, sivicap@ins.gov.co.
[Ti] Título:[Local contexts of drinking-water quality surveillance: Brazil and Colombia].
[Ti] Título:Contextos locales de la vigilancia de calidad del agua para consumo humano: Brasil y Colombia..
[So] Source:Rev Salud Publica (Bogota);17(6):961-972, 2015 Dec.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective This article aims to analyze comparatively the national surveillance systems of water quality for human consumption (DWQS) of Brazil and Colombia, seeking to understand how practices are organized in these countries, along with their limits and possibilities. Methods The National Cross Comparison methodology was used with document analysis of secondary sources, with the purpose of discussing the similarities and differences between the two systems using the WHO’s Guidelines for Drinking Water Quality. Results The legal framework on DWQS in Brazil and Colombia was defined in the 70s and 80s, coinciding with the international visibility of this issue. Thereafter, DWQS practices in Brazil have been defined and organized in a national program, which has only recently started in Colombia. The current Brazilian and Colombian legislations show progress in technical elements that guide surveillance practices, such as the incorporation of risk assessment methodologies. The Colombian legislation defines the regulation of water supply services provision, which is not contemplated in Brazilian legislation. Elements such as decentralization, intersectionality, universality and right to information are included in the legislations of both countries, although further action on DWQS is needed. Conclusions Brazil and Colombia have similarities in the implementation of DWQS, despite being at different points in the implementation timeline. Actions on drinking-water quality surveillance are necessary to guarantee human rights related to the protection of the environment, such as universal access to drinking water, contributing to the promotion of health.
[Mh] Termos MeSH primário: Água Potável/normas
Saúde Ambiental/métodos
Vigilância em Saúde Pública/métodos
Qualidade da Água/normas
[Mh] Termos MeSH secundário: Brasil
Colômbia
Saúde Ambiental/normas
Política de Saúde
Seres Humanos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:27776493
[Au] Autor:Benson FG; Musekiwa A; Blumberg L; Rispel LC
[Ad] Endereço:National Department of Health, Private Bag X828, Pretoria, 0001, South Africa. frewbenson@gmail.com.
[Ti] Título:Survey of the perceptions of key stakeholders on the attributes of the South African Notifiable Diseases Surveillance System.
[So] Source:BMC Public Health;16(1):1120, 2016 10 25.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An effective and efficient notifiable diseases surveillance system (NDSS) is essential for a rapid response to disease outbreaks, and the identification of priority diseases that may cause national, regional or public health emergencies of international concern (PHEICs). Regular assessments of country-based surveillance system are needed to enable countries to respond to outbreaks before they become PHEICs. As part of a broader evaluation of the NDSS in South Africa, the aim of the study was to determine the perceptions of key stakeholders on the national NDSS attributes of acceptability, flexibility, simplicity, timeliness and usefulness. METHODS: During 2015, we conducted a nationally representative cross-sectional survey of communicable diseases coordinators and surveillance officers, as well as members of NDSS committees. Individuals with less than 1 year experience of the NDSS were excluded. Consenting participants completed a self-administered questionnaire. The questionnaire elicited information on demographic information and perceptions of the NDSS attributes. Data were analysed using descriptive statistics and the unconditional logistic regression model. RESULTS: Most stakeholders interviewed (53 %, 60/114) were involved in disease control and response. The median number of years of experience with the NDSS was 11 years (inter-quartile range (IQR): 5 to 20 years). Regarding the NDSS attributes, 25 % of the stakeholders perceived the system to be acceptable, 51 % to be flexible, 45 % to be timely, 61 % to be useful, and 74 % to be simple. Health management stakeholders perceived the system to be more useful and timely compared to the other stakeholders. Those with more years of experience were less likely to perceive the NDSS system as acceptable (OR 0.91, 95 % CI: 0.84-1.00, p = 0.041); those in disease detection were less likely to perceive it as timely (OR 0.10, 95 % CI: 0.01-0.96, p = 0.046) and those participating in National Outbreak Response Team were less likely to perceive it as useful (OR 0.38, 95 % CI: 0.16-0.93, p = 0.034). CONCLUSION: The overall poor perceptions of key stakeholder on the system attributes are a cause for concern. The study findings should inform the revitalisation and reform of the NDSS in South Africa, done in consultation and partnership with the key stakeholders.
[Mh] Termos MeSH primário: Controle de Doenças Transmissíveis/métodos
Pessoal de Saúde/psicologia
Percepção
Vigilância em Saúde Pública/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Doenças Transmissíveis/epidemiologia
Doenças Transmissíveis/psicologia
Estudos Transversais
Surtos de Doenças
Feminino
Seres Humanos
Masculino
Meia-Idade
África do Sul
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:27773759
[Au] Autor:Wielders CCH; van Hoek AHAM; Hengeveld PD; Veenman C; Dierikx CM; Zomer TP; Smit LAM; van der Hoek W; Heederik DJ; de Greeff SC; Maassen CBM; van Duijkeren E
[Ad] Endereço:Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment, Bilthoven, The Netherlands. Electronic address: lieke.wielders@rivm.nl.
[Ti] Título:Extended-spectrum ß-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area.
[So] Source:Clin Microbiol Infect;23(2):120.e1-120.e8, 2017 Feb.
[Is] ISSN:1469-0691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of extended-spectrum ß-lactamase and/or plasmid-mediated AmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E. METHODS: A cross-sectional study was performed among 2432 adults (aged 20-72 years) in 12 temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression. RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2432; 95% CI 3.7-5.4) ranging from 1.4% to 10.9% among the research centres. ESBL/pAmpC resistance genes were detected in Escherichia coli and Klebsiella pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were bla , bla and bla , originating from 76 participants. Travel in the previous 12 months to Africa, Asia or Latin America (OR 2.82; 95% CI 1.71-4.63), having kept cows for a hobby in the previous 5 years (OR 3.77; 95% CI 1.22-11.64), usage of proton-pump inhibitors (OR 1.84; 95% CI 1.05-3.23), and living within 1000 m of a mink farm (OR 2.26; 95% CI 1.28-3.98) were identified as risk factors. Exposure to poultry was not identified as a risk factor. CONCLUSIONS: Overall, living in close proximity to livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Infecções por Enterobacteriaceae/epidemiologia
Infecções por Enterobacteriaceae/microbiologia
Enterobacteriaceae/genética
Gado
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Comorbidade
Estudos Transversais
Enterobacteriaceae/efeitos dos fármacos
Exposição Ambiental
Geografia
Seres Humanos
Meia-Idade
Países Baixos/epidemiologia
Prevalência
Vigilância em Saúde Pública
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); EC 3.5.2.6 (AmpC beta-lactamases); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29205307
[Au] Autor:White MC; Babcock F; Hayes NS; Mariotto AB; Wong FL; Kohler BA; Weir HK
[Ad] Endereço:Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Título:The history and use of cancer registry data by public health cancer control programs in the United States.
[So] Source:Cancer;123 Suppl 24:4969-4976, 2017 Dec 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Because cancer registry data provide a census of cancer cases, registry data can be used to: 1) define and monitor cancer incidence at the local, state, and national levels; 2) investigate patterns of cancer treatment; and 3) evaluate the effectiveness of public health efforts to prevent cancer cases and improve cancer survival. The purpose of this article is to provide a broad overview of the history of cancer surveillance programs in the United States, and illustrate the expanding ways in which cancer surveillance data are being made available and contributing to cancer control programs. The article describes the building of the cancer registry infrastructure and the successful coordination of efforts among the 2 federal agencies that support cancer registry programs, the Centers for Disease Control and Prevention and the National Cancer Institute, and the North American Association of Central Cancer Registries. The major US cancer control programs also are described, including the National Comprehensive Cancer Control Program, the National Breast and Cervical Cancer Early Detection Program, and the Colorectal Cancer Control Program. This overview illustrates how cancer registry data can inform public health actions to reduce disparities in cancer outcomes and may be instructional for a variety of cancer control professionals in the United States and in other countries. Cancer 2017;123:4969-76. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
[Mh] Termos MeSH primário: Neoplasias/epidemiologia
Vigilância em Saúde Pública
Saúde Pública/história
Sistema de Registros
[Mh] Termos MeSH secundário: Centers for Disease Control and Prevention (U.S.)
História do Século XX
História do Século XXI
Seres Humanos
Neoplasias/prevenção & controle
Neoplasias/terapia
Programa de SEER/história
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30905


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[PMID]:29205302
[Au] Autor:Allemani C; Harewood R; Johnson CJ; Carreira H; Spika D; Bonaventure A; Ward K; Weir HK; Coleman MP
[Ad] Endereço:Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
[Ti] Título:Population-based cancer survival in the United States: Data, quality control, and statistical methods.
[So] Source:Cancer;123 Suppl 24:4982-4993, 2017 Dec 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Robust comparisons of population-based cancer survival estimates require tight adherence to the study protocol, standardized quality control, appropriate life tables of background mortality, and centralized analysis. The CONCORD program established worldwide surveillance of population-based cancer survival in 2015, analyzing individual data on 26 million patients (including 10 million US patients) diagnosed between 1995 and 2009 with 1 of 10 common malignancies. METHODS: In this Cancer supplement, we analyzed data from 37 state cancer registries that participated in the second cycle of the CONCORD program (CONCORD-2), covering approximately 80% of the US population. Data quality checks were performed in 3 consecutive phases: protocol adherence, exclusions, and editorial checks. One-, 3-, and 5-year age-standardized net survival was estimated using the Pohar Perme estimator and state- and race-specific life tables of all-cause mortality for each year. The cohort approach was adopted for patients diagnosed between 2001 and 2003, and the complete approach for patients diagnosed between 2004 and 2009. RESULTS: Articles in this supplement report population coverage, data quality indicators, and age-standardized 5-year net survival by state, race, and stage at diagnosis. Examples of tables, bar charts, and funnel plots are provided in this article. CONCLUSIONS: Population-based cancer survival is a key measure of the overall effectiveness of services in providing equitable health care. The high quality of US cancer registry data, 80% population coverage, and use of an unbiased net survival estimator ensure that the survival trends reported in this supplement are robustly comparable by race and state. The results can be used by policymakers to identify and address inequities in cancer survival in each state and for the United States nationally. Cancer 2017;123:4982-93. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
[Mh] Termos MeSH primário: Acurácia dos Dados
Neoplasias/mortalidade
Vigilância em Saúde Pública
Controle de Qualidade
Estatística como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.31025


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[PMID]:29205301
[Au] Autor:Allemani C; Coleman MP
[Ad] Endereço:Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
[Ti] Título:Public health surveillance of cancer survival in the United States and worldwide: The contribution of the CONCORD programme.
[So] Source:Cancer;123 Suppl 24:4977-4981, 2017 Dec 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONCORD is a programme for the global surveillance of cancer survival. In 2015, the second cycle of the program (CONCORD-2) established long-term surveillance of cancer survival worldwide, for the first time, in the largest cancer survival study published to date. CONCORD-2 provided cancer survival trends for 25,676,887 patients diagnosed during the 15-year period between 1995 and 2009 with 1 of 10 common cancers that collectively represented 63% of the global cancer burden in 2009. Herein, the authors summarize the past, describe the present, and outline the future of the CONCORD programme. They discuss the difference between population-based studies and clinical trials, and review the importance of international comparisons of population-based cancer survival. This study will focus on the United States. The authors explain why population-based survival estimates are crucial for driving effective cancer control strategies to reduce the wide and persistent disparities in cancer survival between white and black patients, which are likely to be attributable to differences in access to early diagnosis and optimal treatment. Cancer 2017;123:4977-81. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
[Mh] Termos MeSH primário: Neoplasias/mortalidade
Vigilância em Saúde Pública
[Mh] Termos MeSH secundário: Afroamericanos
Detecção Precoce de Câncer
Grupo com Ancestrais do Continente Europeu
Acesso aos Serviços de Saúde
Disparidades nos Níveis de Saúde
Disparidades em Assistência à Saúde/etnologia
Seres Humanos
Neoplasias/diagnóstico
Neoplasias/terapia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30854


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[PMID]:29073137
[Au] Autor:Saha S; Islam M; Uddin MJ; Saha S; Das RC; Baqui AH; Santosham M; Black RE; Luby SP; Saha SK
[Ad] Endereço:Child Health Research Foundation, Department of Microbiology, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh.
[Ti] Título:Integration of enteric fever surveillance into the WHO-coordinated Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) platform: A low cost approach to track an increasingly important disease.
[So] Source:PLoS Negl Trop Dis;11(10):e0005999, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lack of surveillance systems and accurate data impede evidence-based decisions on treatment and prevention of enteric fever, caused by Salmonella Typhi/Paratyphi. The WHO coordinates a global Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) surveillance network but does not monitor enteric fever. We evaluated the feasibility and sustainability of integrating enteric fever surveillance into the ongoing IB-VPD platform. METHODOLOGIES: The IB-VPD surveillance system uses WHO definitions to enroll 2-59 month children hospitalized with possible pneumonia, sepsis or meningitis. We expanded this surveillance system to additionally capture suspect enteric fever cases during 2012-2016, in two WHO sentinel hospitals of Bangladesh, by adding inclusion criteria of fever ≥102°F for ≥3 days, irrespective of other manifestations. Culture-positive enteric fever cases from in-patient departments (IPD) detected in the hospital laboratories but missed by the expanded surveillance, were also enrolled to assess completion. Costs for this integration were calculated for the additional personnel and resources required. PRINCIPAL FINDINGS: In the IB-VPD surveillance, 5,185 cases were enrolled; 3% (N = 171/5185) were positive for microbiological growth, of which 55% (94/171) were culture-confirmed cases of enteric fever (85 Typhi and 9 Paratyphi A). The added inclusion criteria for enteric fever enrolled an additional 1,699 cases; 22% (358/1699) were positive, of which 85% (349/358) were enteric fever cases (305 Typhi and 44 Paratyphi A). Laboratory surveillance of in-patients of all ages enrolled 311 additional enteric fever cases (263 Typhi and 48 Paratyphi A); 9% (28/311) were 2-59 m and 91% (283/311) >59 m. Altogether, 754 (94+349+311) culture-confirmed enteric fever cases were found, of which 471 were 2-59 m. Of these 471 cases, 94% (443/471) were identified through the hospital surveillances and 6% (28/471) through laboratory results. Twenty-three percent (170/754) of all cases were children <2 years. Additional cost for the integration was USD 44,974/year, a 27% increase to the IB-VPD annual expenditure. CONCLUSION: In a setting where enteric disease is a substantial public health problem, we could integrate enteric fever surveillance into the standard IB-VPD surveillance platform at a modest cost.
[Mh] Termos MeSH primário: Vigilância em Saúde Pública/métodos
Febre Tifoide/epidemiologia
[Mh] Termos MeSH secundário: Bangladesh/epidemiologia
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Febre Paratifoide/economia
Febre Paratifoide/epidemiologia
Febre Paratifoide/prevenção & controle
Salmonella paratyphi A/isolamento & purificação
Salmonella typhi/isolamento & purificação
Febre Tifoide/economia
Febre Tifoide/prevenção & controle
Vacinas Tíficas-Paratíficas/administração & dosagem
Vacinação
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Typhoid-Paratyphoid Vaccines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005999


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[PMID]:29064363
[Au] Autor:Wallace R; Etheart M; Ludder F; Augustin P; Fenelon N; Franka R; Crowdis K; Dely P; Adrien P; Pierre-Louis J; Osinubi M; Orciari L; Vigilato M; Blanton J; Patel R; Lowrance D; Liverdieu A; Coetzer A; Boone J; Lindenmayer J; Millien M
[Ad] Endereço:U.S. Centers for Disease Control and Prevention, Poxvirus and Rabies Branch, Atlanta, Georgia.
[Ti] Título:The Health Impact of Rabies in Haiti and Recent Developments on the Path Toward Elimination, 2010-2015.
[So] Source:Am J Trop Med Hyg;97(4_Suppl):76-83, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Haiti, a Caribbean country of 10.5 million people, is estimated to have the highest burden of canine-mediated human rabies deaths in the Western Hemisphere, and one of the highest rates of human rabies deaths in the world. Haiti is also the poorest country in the Western Hemisphere and has numerous economic and health priorities that compete for rabies-control resources. As a result, primary rabies-control actions, including canine vaccination programs, surveillance systems for human and animal rabies, and appropriate postbite treatment, have not been fully implemented at a national scale. After the 2010 earthquake that further hindered the development of public health program infrastructure and services, the U.S. Centers for Disease Control and Prevention worked with the Ministry of Public Health and Population and key health development partners (including the Pan-American Health Organization) to provide technical expertise and funding for general disease surveillance systems, laboratory capacity, and selected disease control programs; including rabies. In 2011, a cross-ministerial rabies consortium was convened with participation from multiple international rabies experts to develop a strategy for successful rabies control in Haiti. The consortium focused on seven pillars: 1) enhancement of laboratory diagnostic capacity, 2) development of comprehensive animal surveillance system, 3) development of comprehensive human rabies surveillance system, 4) educational outreach, 5) sustainable human rabies biologics supply, 6) achievement of sustained canine vaccination rates of ≥ 70%, and 7) finalization of a national rabies control strategy. From 2010 until 2015, Haiti has seen improvements in the program infrastructure for canine rabies control. The greatest improvements were seen in the area of animal rabies surveillance, in support of which an internationally recognized rabies laboratory was developed thereby leading to an 18-fold increase in the detection of rabid animals. Canine rabies vaccination practices also improved, from a 2010 level of approximately 12% to a 2015 dog population coverage level estimated to be 45%. Rabies vaccine coverage is still below the goal of 70%, however, the positive trend is encouraging. Gaps exist in the capacity to conduct national surveillance for human rabies cases and access to human rabies vaccine is lacking in many parts of the country. However, control has improved over the past 5 years as a result of the efforts of Haiti's health and agriculture sectors with assistance from multiple international organizations. Haiti is well situated to eliminate canine-mediated human rabies deaths in the near future and should serve as a great example to many developing countries struggling with similar barriers and limitations.
[Mh] Termos MeSH primário: Erradicação de Doenças
Doenças do Cão/prevenção & controle
Vacinas Antirrábicas/uso terapêutico
Raiva/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Países em Desenvolvimento
Vetores de Doenças
Doenças do Cão/transmissão
Cães
Haiti
Seres Humanos
Cooperação Internacional
Vigilância em Saúde Pública
Raiva/diagnóstico
Raiva/transmissão
Raiva/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Rabies Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0647



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