Base de dados : MEDLINE
Pesquisa : E05.318.308.985.525 [Categoria DeCS]
Referências encontradas : 24937 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2494 ir para página                         

  1 / 24937 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29430913
[Au] Autor:Prusakova AV; Prusakov VM
[Ti] Título:[Methodical complex for the assessment of mass noninfectious prevalence rate and the medico-ecological situation in the territory].
[So] Source:Gig Sanit;95(9):811-17, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose of this article - the narration of main provisions of the algorithm of the system use of techniques and methods for the determination of the epidemiological risk for the morbidity of the population for the identification and assessment of mass noninfectious diseases, local variants ofpopulation health and the degree of stringency of medical and environmental conditions (or ecological trouble), in areas of industrial and non-administrative units of the area (region). Control-flow chartfor the evaluation of mass non-communicable diseases and medical-ecological situation in the territory on the basis of techniques and methods of risk assessment for decision-making control includes the following steps: 1) determination of the conditional regional level of the background prevalence rate as the unit of regional type of population health, shaped by regional climatic and geographic and other features of the environmental conditions; 2) detection of the epidemiological relative risk of the morbidity rate and mass non-infectious diseases; 3) determination of the wave-like character of the dynamics of the riskfor mass non-infectious morbidity rate of the population and the adaptation process shaping it in the territories; 4) separating the leading mass non-communicable diseases, especially shaping peculiarities of local variants of population health in the special industrial and non-industrial areas; 5) determination of the degree of stringency of medical and environmental situation (or ecological trouble) in the studied area, with local variants ofpopulation health; 6) a forecast of the expected trends in the dynamics of the risk for mass non-infectious prevalence rate; 7) justification of the main directions of the development of medical and environmental preventive measures on the reduction of mass non-infectious diseases and the improvement of the quality of health of the population in the studied areas. The given methodical complex will allow to more effectively solve problems ofprevention of mass non-infectious prevalence of the population and improve health and environmental conditions in the study area based on public health monitoring data.
[Mh] Termos MeSH primário: Estudos Transversais/métodos
Doença Ambiental/epidemiologia
Monitoramento Ambiental
Medição de Risco/métodos
[Mh] Termos MeSH secundário: Monitoramento Ambiental/métodos
Monitoramento Ambiental/normas
Previsões
Seres Humanos
Morbidade/tendências
Saúde da População/estatística & dados numéricos
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28453802
[Au] Autor:Kostron A; Friess M; Inci I; Hillinger S; Schneiter D; Gelpke H; Stahel R; Seifert B; Weder W; Opitz I
[Ad] Endereço:Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
[Ti] Título:Propensity matched comparison of extrapleural pneumonectomy and pleurectomy/decortication for mesothelioma patients.
[So] Source:Interact Cardiovasc Thorac Surg;24(5):740-746, 2017 05 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this retrospective study was to assess perioperative outcomes, overall survival and freedom from recurrence after induction chemotherapy followed by extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D) in patients with mesothelioma in a propensity score matched analysis. METHODS: Between September 1999 and August 2015, 167 patients received multimodality treatment (platinum-based chemotherapy followed by EPP [ n = 141] or P/D [ n = 26]). We performed 2:1 propensity score matching for gender, laterality, epithelioid histological subtype and International Mesothelioma Interest Group (iMig) stage (52 EPP and 26 P/D). RESULTS: Postoperative major morbidity (48% vs 58%, P = 0.5) was similar in both groups; however, the complication profile and severity were different and favoured P/D; the 90-day mortality (8% vs 0%, P = 0.3) rate was lower in P/D although not statistically significant. Prolonged air leak (≥10 days) occurred in 15 patients (58%) undergoing P/D. The intensive care unit stay was significantly longer after EPP ( P = 0.001). Freedom from recurrence was similar for both groups (EPP: median 15 months, 95% confidence interval [CI]: 10-21; P/D: 13 months, 95% CI: 11-17) ( P = 0.2). Overall survival was significantly longer for patients undergoing P/D (median 32 months, 95% CI: 29-35) compared to EPP (23 months, 95% CI: 21-25) ( P = 0.031), but in the P/D group many cases were censored (73%) and the follow-up time was relatively short. CONCLUSIONS: P/D and EPP seem to have similar rates of major morbidity, although the profile of complications is different and more severe after EPP. Freedom from recurrence is comparable in both groups whereas improved overall survival needs to be confirmed in a large patient group with longer follow-up.
[Mh] Termos MeSH primário: Mesotelioma/cirurgia
Pleura/cirurgia
Neoplasias Pleurais/cirurgia
Pneumonectomia/métodos
Complicações Pós-Operatórias/epidemiologia
Pontuação de Propensão
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Mesotelioma/diagnóstico
Meia-Idade
Morbidade/tendências
Recidiva Local de Neoplasia/epidemiologia
Neoplasias Pleurais/diagnóstico
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Suíça/epidemiologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivw422


  3 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28453639
[Au] Autor:Abe T; Takada N; Kikuchi H; Matsumoto R; Osawa T; Murai S; Miyajima N; Maruyama S; Shinohara N
[Ad] Endereço:For reprints and all correspondence: Takashige Abe, Department of Urology, Hokkaido University Graduate School of Medicine, North-15, West-7, North Ward, Sapporo 060-8638, Japan. E-mail: takataka@rf6.so-net.ne.jp
[Ti] Título:Perioperative morbidity and mortality of octogenarians treated by radical cystectomy-a multi-institutional retrospective study in Japan.
[So] Source:Jpn J Clin Oncol;47(8):755-761, 2017 08 01.
[Is] ISSN:1465-3621
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: To determine the characteristics of 90-day morbidity and mortality after radical cystectomy in Japanese octogenarians. Methods: A retrospective multi-institutional study. We reviewed the records of 834 patients treated by open radical cystectomy between 1997 and 2010. All complications within 90 days after surgery were sorted into the 11 categories proposed by the Memorial Sloan-Kettering Cancer Center and graded according to the modified Clavien-Dindo system. We compared the characteristics of complications between ≥80-year (n = 86) and <80-year (n = 748) groups. Multivariate regression models were used to determine the predictors of complications. Results: American Society of Anesthesiologists score III-IV was more frequent (14% vs. 6%, respectively, P < 0.0001), and ureterocutaneostomy was more frequently performed (30% vs. 21%, respectively, P = 0.0148) in the ≥80-year group compared with <80-year group. There were no significant differences in the rates of any complication, major (Grade 3-5) complication, or 90-day mortality between the two groups (≥80-year group: 70%, 21%, 3.5%, respectively, <80-year group: 68%, 22%, 2%, respectively). The ≥80-year group had fewer genitourinary complications (7% vs. 16%, respectively, P = 0.0131). Multivariate regression analyses revealed that bowel-using urinary diversion (P = 0.0031) and the operative time (P = 0.0269) were significant predictors of any grade of complications, and a male sex (P = 0.0167), annual cystectomy volume (P = 0.0284) and prior cardiovascular comorbidity (P = 0.0034) were significant predictors of major complications. Conclusions: In our experience, radical cystectomy in Japanese octogenarians caused similar perioperative comorbidities. Old age as a single criterion should not be used to abandon radical cystectomy; careful preoperative assessment is mandatory.
[Mh] Termos MeSH primário: Cistectomia/efeitos adversos
Período Perioperatório/mortalidade
Neoplasias da Bexiga Urinária/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Comorbidade
Cistectomia/métodos
Feminino
Seres Humanos
Japão
Masculino
Meia-Idade
Morbidade
Estudos Retrospectivos
Resultado do Tratamento
Neoplasias da Bexiga Urinária/mortalidade
Neoplasias da Bexiga Urinária/patologia
Derivação Urinária/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/jjco/hyx062


  4 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28449795
[Au] Autor:Packer M; McMurray JJV; Krum H; Kiowski W; Massie BM; Caspi A; Pratt CM; Petrie MC; DeMets D; Kobrin I; Roux S; Swedberg K; ENABLE Investigators and Committees
[Ad] Endereço:Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas. Electronic address: milton.packer1526@baylorhealth.edu.
[Ti] Título:Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials.
[So] Source:JACC Heart Fail;5(5):317-326, 2017 May.
[Is] ISSN:2213-1787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this clinical trial was to evaluate the long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure. BACKGROUND: Endothelin may play a role in heart failure, but short-term clinical trials with endothelin receptor antagonists have reported disappointing results. Long-term trials are lacking. METHODS: In 2 identical double-blind trials, we randomly assigned 1,613 patients with New York Heart Association functional class IIIb to IV heart failure and an ejection fraction <35% to receive placebo or bosentan (target dose 125 mg twice daily) for a median of 1.5 years. The primary outcome for each trial was clinical status at 9 months (assessed by the hierarchical clinical composite); the primary outcome across the 2 trials was death from any cause or hospitalization for heart failure. RESULTS: Bosentan did not influence clinical status at 9 months in either trial (p = 0.928 and p = 0.263). In addition, 321 patients in the placebo group and 312 patients in the bosentan group died or were hospitalized for heart failure (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.86 to 1.18; p = 0.90). The bosentan group experienced fluid retention within the first 2 to 4 weeks, as evidenced by increased peripheral edema, weight gain, decreases in hemoglobin, and an increased risk of hospitalization for heart failure, despite intensification of background diuretics. During follow-up, 173 patients died in the placebo group and 160 patients died in the bosentan group (HR: 0.94; 95% CI: 0.75 to 1.16). About 10% of the bosentan group showed meaningful increases in hepatic transaminases, but none had acute or chronic liver failure. CONCLUSIONS: Bosentan did not improve the clinical course or natural history of patients with severe chronic heart failure and but caused early and important fluid retention.
[Mh] Termos MeSH primário: Causas de Morte
Antagonistas dos Receptores de Endotelina/administração & dosagem
Insuficiência Cardíaca/tratamento farmacológico
Sulfonamidas/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Austrália
Doença Crônica
Relação Dose-Resposta a Droga
Método Duplo-Cego
Esquema de Medicação
Antagonistas dos Receptores de Endotelina/efeitos adversos
Europa (Continente)
Feminino
Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/mortalidade
Seres Humanos
Internacionalidade
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Morbidade
América do Norte
Prognóstico
Modelos de Riscos Proporcionais
Ensaios Clínicos Controlados Aleatórios como Assunto
Medição de Risco
Índice de Gravidade de Doença
Sulfonamidas/efeitos adversos
Análise de Sobrevida
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Endothelin Receptor Antagonists); 0 (Sulfonamides); Q326023R30 (bosentan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  5 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27778348
[Au] Autor:Barrington-Trimis JL; Cockburn M; Metayer C; Gauderman WJ; Wiemels J; McKean-Cowdin R
[Ad] Endereço:Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
[Ti] Título:Trends in childhood leukemia incidence over two decades from 1992 to 2013.
[So] Source:Int J Cancer;140(5):1000-1008, 2017 Mar 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Incidence rates of childhood leukemia in the United States have steadily increased over the last several decades, but only recently have disparities in the increase in incidence been recognized. In the current analysis, Surveillance, Epidemiology and End Results (SEER) data were used to evaluate recent trends in the incidence of childhood leukemia diagnosed at age 0-19 years from 1992 to 2013, overall and by age, race/ethnicity, gender and histologic subtype. Hispanic White children were more likely than non-Hispanic White, non-Hispanic Black or non-Hispanic Asian children to be diagnosed with acute lymphocytic leukemia (ALL) from 2009 to 2013. From 1992 to 2013, a significant increase in ALL incidence was observed for Hispanic White children [annual percent change (APC) = 1.08, 95% CI: 0.59, 1.58]; no significant increase was observed for non-Hispanic White, Black or Asian children. ALL incidence increased by about 3% per year from 1992 to 2013 for Hispanic White children diagnosed from 15 to 19 years (APC = 2.67; 95% CI: 0.88, 4.49) and by 2% for those 10-14 years (APC = 2.09; 95% CI: 0.57, 3.63), while no significant increases in incidence were observed in non-Hispanic White, Black, or Asian children of the same age. Acute myeloid leukemia (AML) incidence increased among non-Hispanic White children under 1 year at diagnosis, and among Hispanic White children diagnosed at age 1-4. The increase in incidence rates of childhood ALL appears to be driven by rising rates in older Hispanic children (10-14, and 15-19 years). Future studies are needed to evaluate reasons for the increase in ALL among older Hispanic children.
[Mh] Termos MeSH primário: Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Criança
Pré-Escolar
Grupos Étnicos/estatística & dados numéricos
Feminino
Seres Humanos
Incidência
Lactente
Recém-Nascido
Masculino
Morbidade/tendências
Leucemia-Linfoma Linfoblástico de Células Precursoras/etnologia
Estudos Retrospectivos
Programa de SEER
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30487


  6 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29314041
[Au] Autor:MacNeill AJ; Fiore M
[Ad] Endereço:Division of Surgical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
[Ti] Título:Surgical morbidity in retroperitoneal sarcoma resection.
[So] Source:J Surg Oncol;117(1):56-61, 2018 Jan.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Resection of retroperitoneal sarcoma (RPS) typically involves multivisceral resection. The morbidity of RPS resection has decreased over time despite widespread adoption of radical resection. Certain patterns of resection are associated with higher complication rates and elderly patients are at increased risk of morbidity. Administration of preoperative radiotherapy does not increase morbidity, but intraoperative and brachytherapy techniques are associated with heightened toxicities. Long-term functional outcomes and quality of life scores after RPS resection are acceptable.
[Mh] Termos MeSH primário: Qualidade de Vida
Neoplasias Retroperitoneais/epidemiologia
Neoplasias Retroperitoneais/cirurgia
Sarcoma/epidemiologia
Sarcoma/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Morbidade
Neoplasias Retroperitoneais/patologia
Sarcoma/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24902


  7 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460772
[Au] Autor:Vora A; Naik A; Lokhandwala Y; Chopra A; Varma J; Wander GS; Jaswal A; Srikanthan V; Singh B; Kahali D; Gupta A; Mantri RR; Mishra A; Pandurangi U; Ghosh D; Makkar JS; Sahu S; Radhakrishnan R
[Ad] Endereço:Glenmark Cardiac Centre, Mumbai, India.
[Ti] Título:Profiling cardiac arrhythmia and heart failure patients in India: The Pan-arrhythmia and Heart Failure Observational Study.
[So] Source:Indian Heart J;69(2):226-239, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The PANARrhythMia and Heart Failure Registry (PANARM HF) characterized demographic, clinical and interventional therapy indication profiles of cardiac arrhythmia (CA) and heart failure (HF) patients in India. METHODS: Consulting Physicians (CP) who medically manage CA and HF patients enrolled patients with one or more of the following: syncope, pre-syncope, dyspnea, palpitation, fatigue and LV dysfunction. The CPs were trained by interventional cardiologists (IC) to identify CA/HF patients indicated for implantable device/radiofrequency ablation (RFA). 59 CP's, 16 IC's & 2205 patients from 12 cities participated. Demographic, clinical, device/RFA indication and referral-consultation profiles were created. IC's provided device/RFA recommendations based on these profiles. RESULTS: The CA/HF distribution of patients was: HF - 58%, bradyarrhythmia - 15%, atrial fibrillation - 15%, other supraventricular tachyarrhythmia - 10% and ventricular tachycardia/fibrillation - 4.5%. 62% of the CA/HF population was male and 45% were below age 60. Coronary artery disease (52%), hypertension (44%), diabetes (30%) & myocardial infarction (20%) were prominent. 1011 (46%) of the CA/HF population were potential device/RFA candidates according to the IC's. However, only 700 (69%) of these patients were referred to the IC by the CP. Of referred patients, only 177 (25%) consulted the IC and were recommended therapy. Thus, 824 (83%) of patients indicated for interventional therapy were not advised therapy or did not opt for it. CONCLUSION: The India PANARM HF study provides new information and insights into the demographic, clinical, interventional therapy, referral and consultation pattern profiles of CA/HF patients in India.
[Mh] Termos MeSH primário: Arritmias Cardíacas/epidemiologia
Insuficiência Cardíaca/epidemiologia
Medição de Risco
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Índia/epidemiologia
Masculino
Meia-Idade
Morbidade/tendências
Sistema de Registros
Estudos Retrospectivos
Taxa de Sobrevida/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  8 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460766
[Au] Autor:Feinberg L; Menon J; Smith R; Rajeev JG; Kumar RK; Banerjee A
[Ad] Endereço:University of Birmingham, Medical School, Birmingham, United Kingdom. Electronic address: XF132@student.bham.ac.uk.
[Ti] Título:Potential for mobile health (mHealth) prevention of cardiovascular diseases in Kerala: A population-based survey.
[So] Source:Indian Heart J;69(2):182-199, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: India's southern state of Kerala stands at the forefront of India's epidemic of cardiovascular disease (CVD), among other non-communicable diseases (NCDs). Mobile phone use in healthcare (mHealth) has shown promise in India, including NCDs. However, suitability and acceptability of m-Health interventions is poorly researched, particularly in rural settings. OBJECTIVES: METHODS: A questionnaire regarding mobile phone usage and possible use in healthcare was verbally administered in five primary health centres and by home visits in five village councils ("panchayats") of Ernakulam, Kerala. Adults who spoke Malayalam or English, with access to a mobile phone were recruited by convenience sampling in partnership with accredited social health activists (ASHAs). Quantitative data analysis was conducted using SPSS software. RESULTS: 262 participants were recruited. 87% routinely used and 88% owned a mobile phone. 92% were willing to receive mHealth advice, and 94% favoured mobile medication reminders. 70.3% and 73% preferred voice calls over short messaging service (SMS) for delivering health information and medication reminders, respectively. 85.9% would send home recorded information on their blood pressure, weight, medication use and lifestyle to a doctor or ASHA. 75.2% trusted the confidentiality of mHealth data, while 77.1% had no concerns about the privacy of their information. CONCLUSIONS: The majority of this population approve mHealth interventions. While further investigation of mHealth as a health education tool is warranted, SMS interventions may fail to maximise equity and penetration across all patient groups.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/prevenção & controle
Vigilância da População/métodos
Saúde da População Rural
População Rural
Telemedicina
[Mh] Termos MeSH secundário: Adulto
Doenças Cardiovasculares/epidemiologia
Feminino
Seres Humanos
Índia/epidemiologia
Masculino
Meia-Idade
Morbidade/tendências
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  9 / 24937 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29363738
[Au] Autor:Willen SM; Rodeghier M; Strunk RC; Bacharier LB; Rosen CL; Kirkham FJ; DeBaun MR; Cohen RT
[Ad] Endereço:Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
[Ti] Título:Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.
[So] Source:Br J Haematol;180(4):571-577, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Asthma is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive pain episodes among children with sickle cell anaemia (SCA). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for ACS and pain. Participants in a multicentre, longitudinal cohort study, aged 4-18 years with SCA, underwent skin prick testing to ten aeroallergens. ACS and pain episodes were collected from birth until the end of the follow-up period. The number of positive skin tests were tested for associations with prospective rates of ACS and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of ACS (incidence rate ratio (IRR) for each positive test 1·23, 95% confidence interval [CI] 1·11-1·36, P < 0·001). Aeroallergen sensitization was not associated with future pain (IRR 1·14, 95%CI 0·97-1·33, P = 0·11). Our study demonstrated that children with SCA and aeroallergen sensitization are at increased risk for future ACS. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of ACS for children with SCA.
[Mh] Termos MeSH primário: Síndrome Torácica Aguda/diagnóstico
Síndrome Torácica Aguda/etiologia
Alérgenos/imunologia
Anemia Falciforme/complicações
[Mh] Termos MeSH secundário: Adolescente
Aerossóis
Biomarcadores
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Hipersensibilidade/complicações
Hipersensibilidade/imunologia
Imunização
Masculino
Morbidade
Medição da Dor
Prognóstico
Estudos Prospectivos
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aerosols); 0 (Allergens); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15076


  10 / 24937 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29232564
[Au] Autor:Schmidt S; Bounnack S; Hoehn T
[Ad] Endereço:Department of Neonatology and Pediatric Intensive Care, Children's University Hospital, Heinrich-Heine University Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany. Electronic address: simone@email-schmidt.de.
[Ti] Título:Neonatal mortality and morbidity in the post-implementation period of a neonatal teaching program in provincial hospitals in Laos.
[So] Source:Public Health;154:123-129, 2018 Jan.
[Is] ISSN:1476-5616
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Aim of this study was to analyze neonatal mortality and morbidity in the post-implementation period of a neonatal teaching program to examine a possible impact on neonatal outcomes. STUDY DESIGN: This study is a retrospective data analysis of all neonatal patients treated in five provincial hospitals in Laos after implementation of a neonatal teaching program. METHODS: A simulation-based teaching program aims to have positive impact on the theoretical and practical skill of hospital staff in the field of newborn care. A comparison between pre-implementation and post-implementation data of newborns admitted to provincial hospitals in Laos was used to quantify the effect of repetitive teaching on neonatal outcomes. RESULTS: Neonatal mortality and morbidity as well as case fatality rates of infections and asphyxia decreased in the post-implementation period. In contrast, neonatal mortality rate as well as case fatality rate of prematurity increased. The total neonatal mortality rate increased in the post-implementation period. CONCLUSIONS: The pre-implementation and post-implementation data enable longitudinal comparisons between hospitals and highlight the differences between hospitals concerning neonatal mortality and morbidity in provincial hospitals in Laos. These data can serve as a basis for an individual adaption of the teaching program to the unique requirements of each single hospital.
[Mh] Termos MeSH primário: Mortalidade Hospitalar/tendências
Mortalidade Infantil/tendências
Corpo Clínico Hospitalar/educação
Morbidade/tendências
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Recém-Nascido
Laos/epidemiologia
Masculino
Avaliação de Programas e Projetos de Saúde
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE



página 1 de 2494 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde