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[PMID]:29424221
[Au] Autor:Sakiev KZ; Mamyrbaev AA
[Ti] Título:[State of health of the population of the one out of oil and gas extraction regions of Kazakhstan].
[So] Source:Gig Sanit;95(6):528-32, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Research is conducted in the city of Aktau ofMangystau area in 2009-2011. The state of health of adult population of the city of Aktau and quality of atmospheric air were studied. Results of works revealed positive dynamics of a natural increase of the population. There is noted a high rate of birth rate, however infantile mortality has tendency to the gain. There were established the structure and leading indices of the incidence among the male andfemale population. The impurity of atmospheric air by chemicals was shown to have the direct impact on health of urban population.
[Mh] Termos MeSH primário: Poluentes Atmosféricos
Exposição Ambiental
Indústria de Petróleo e Gás
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/efeitos adversos
Poluentes Atmosféricos/análise
Poluentes Atmosféricos/normas
Coeficiente de Natalidade
Exposição Ambiental/efeitos adversos
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Monitoramento Ambiental/métodos
Nível de Saúde
Seres Humanos
Lactente
Mortalidade Infantil
Cazaquistão/epidemiologia
Determinação de Necessidades de Cuidados de Saúde
Indústria de Petróleo e Gás/normas
Indústria de Petróleo e Gás/estatística & dados numéricos
Saúde da População/estatística & dados numéricos
Saúde Pública/métodos
Saúde Pública/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:29377899
[Au] Autor:Pantazis A; Clark SJ
[Ad] Endereço:Department of Sociology, The University of Washington, Seattle, United States of America.
[Ti] Título:A parsimonious characterization of change in global age-specific and total fertility rates.
[So] Source:PLoS One;13(1):e0190574, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to understand trends in global fertility from 1950-2010 though the analysis of age-specific fertility rates. This approach incorporates both the overall level, as when the total fertility rate is modeled, and different patterns of age-specific fertility to examine the relationship between changes in age-specific fertility and fertility decline. Singular value decomposition is used to capture the variation in age-specific fertility curves while reducing the number of dimensions, allowing curves to be described nearly fully with three parameters. Regional patterns and trends over time are evident in parameter values, suggesting this method provides a useful tool for considering fertility decline globally. The second and third parameters were analyzed using model-based clustering to examine patterns of age-specific fertility over time and place; four clusters were obtained. A country's demographic transition can be traced through time by membership in the different clusters, and regional patterns in the trajectories through time and with fertility decline are identified.
[Mh] Termos MeSH primário: Coeficiente de Natalidade/tendências
Demografia/métodos
[Mh] Termos MeSH secundário: Demografia/estatística & dados numéricos
Fertilidade
Seres Humanos
Dinâmica Populacional/tendências
População Rural
Fatores Socioeconômicos
População Urbana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190574


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[PMID]:28448483
[Au] Autor:Dee DL; Pazol K; Cox S; Smith RA; Bower K; Kapaya M; Fasula A; Harrison A; Kroelinger CD; D'Angelo D; Harrison L; Koumans EH; Mayes N; Barfield WD; Warner L
[Ti] Título:Trends in Repeat Births and Use of Postpartum Contraception Among Teens - United States, 2004-2015.
[So] Source:MMWR Morb Mortal Wkly Rep;66(16):422-426, 2017 Apr 28.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Teen* childbearing (one or more live births before age 20 years) can have negative health, social, and economic consequences for mothers and their children (1). Repeat teen births (two or more live births before age 20 years) can constrain the mother's ability to take advantage of educational and workforce opportunities (2), and are more likely to be preterm or of low birthweight than first teen births (3). Despite the historic decline in the U.S. teen birth rate during 1991-2015, from 61.8 to 22.3 births per 1,000 females aged 15-19 years (4), many teens continue to have repeat births (3). The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics both recommend that clinicians counsel women (including teens) during prenatal care about birth spacing and postpartum contraceptive use (5), including the safety and effectiveness of long-acting reversible methods that can be initiated immediately postpartum. To expand upon prior research assessing patterns and trends in repeat childbearing and postpartum contraceptive use among teens with a recent live birth (i.e., 2-6 months after delivery) (3), CDC analyzed data from the National Vital Statistics System natality files (2004 and 2015) and the Pregnancy Risk Assessment Monitoring System (PRAMS; 2004-2013). The number and proportion of teen births that were repeat births decreased from 2004 (82,997; 20.1%) to 2015 (38,324; 16.7%); in 2015, the percentage of teen births that were repeat births varied by state from 10.6% to 21.4%. Among sexually active teens with a recent live birth, postpartum use of the most effective contraceptive methods (intrauterine devices and contraceptive implants) increased from 5.3% in 2004 to 25.3% in 2013; however, in 2013, approximately one in three reported using either a least effective method (15.7%) or no method (17.2%). Strategies that comprehensively address the social and health care needs of teen parents can facilitate access to and use of effective methods of contraception and help prevent repeat teen births.
[Mh] Termos MeSH primário: Coeficiente de Natalidade/tendências
Anticoncepção/utilização
Gravidez na Adolescência/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Afroamericanos/estatística & dados numéricos
Coeficiente de Natalidade/etnologia
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Feminino
Hispano-Americanos/estatística & dados numéricos
Seres Humanos
Período Pós-Parto
Gravidez
Gravidez na Adolescência/etnologia
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6616a3


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[PMID]:27776569
[Au] Autor:Otta E; Fernandes ES; Acquaviva TG; Lucci TK; Kiehl LC; Varella MA; Segal NL; Valentova JV
[Ad] Endereço:Department of Experimental Psychology,Institute of Psychology,University of São Paulo,São Paulo,Brazil.
[Ti] Título:Twinning and Multiple Birth Rates According to Maternal Age in the City of São Paulo, Brazil: 2003-2014.
[So] Source:Twin Res Hum Genet;19(6):679-686, 2016 12.
[Is] ISSN:1832-4274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study investigates the twinning rates in the city of São Paulo, Brazil, during the years 2003-2014. The data were drawn from the Brazilian Health Department database of Sistema de Informações de Nascidos Vivos de São Paulo-SINASC (Live Births Information System of São Paulo). In general, more information is available on the incidence of twinning in developed countries than in developing ones. A total of 24,589 twin deliveries and 736 multiple deliveries were registered in 140 hospitals of São Paulo out of a total of 2,056,016 deliveries during the studied time period. The overall average rates of singleton, twin, and multiple births per 1,000 maternities (‰) were 987.43, 11.96 (dizygotic (DZ) rate was 7.15 and monozygotic (MZ) 4.42), and 0.36, respectively. We further regressed maternal age and historical time period on percentage of singleton, twin, and multiple birth rates. Our results indicated that maternal age strongly positively predicted twin and multiple birth rates, and negatively predicted singleton birth rates. The historical time period also positively, although weakly, predicted twin birth rates, and had no effect on singleton or multiple birth rates. Further, after applying Weinberg's differential method, we computed regressions separately for the estimated frequencies of DZ and MZ twin rates. DZ twinning was strongly positively predicted by maternal age and, to a smaller degree, by time period, while MZ twinning increased marginally only with higher maternal age. Factors such as increasing body mass index or air pollution can lead to the slight historical increase in DZ twinning rates. Importantly, consistent with previous cross-cultural and historical research, our results support the existence of an age-dependent physiological mechanism that leads to a strong increase in twinning and multiple births, but not singleton births, among mothers of higher age categories. From the ultimate perspective, twinning and multiple births in later age can lead to higher individual reproductive success near the end of the reproductive career of the mother.
[Mh] Termos MeSH primário: Coeficiente de Natalidade
Gravidez Múltipla
Gêmeos Dizigóticos
Gêmeos Monozigóticos
[Mh] Termos MeSH secundário: Adulto
Brasil
Feminino
Seres Humanos
Idade Materna
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29215527
[Au] Autor:Verburg PE; Dekker GA; Venugopal K; Scheil W; Erwich JJHM; Mol BW; Roberts CT
[Ad] Endereço:Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, Australia; the Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; and Adelaide Medical School, University of Adelaide, Adelaide, Lyell McEwin Hospital, Elizabeth Vale, and the Epidemiology Branch, SA Health, Adelaide, Australia.
[Ti] Título:Long-term Trends in Singleton Preterm Birth in South Australia From 1986 to 2014.
[So] Source:Obstet Gynecol;131(1):79-89, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe long-term trends in the prevalence of preterm birth and rates of preterm birth in singleton pregnancies complicated by hypertensive disorders of pregnancy, small for gestational age (SGA), and preterm prelabor rupture of membranes (PROM) in South Australia. METHODS: We conducted a retrospective population study including all singleton live births in the state of South Australia from 1986 to 2014. Long-term trends for preterm birth, hypertensive disorders of pregnancy, SGA, preterm PROM as well as stillbirth were assessed using joinpoint regression analyses. Trends in maternal age, body mass index (BMI), ethnic diversity, parity, and smoking over time were also assessed. RESULTS: From 1986 to 2014, with a total of 539,234 singleton births, the overall preterm birth rates increased from 5.1% to 7.1% (P<.001) and for iatrogenic preterm birth increased from 1.6% to 3.2% (P<.001). The incidence of hypertensive disorders of pregnancy decreased from 8.7% to 7.2%. Among pregnancies complicated by hypertensive disorders of pregnancy, the proportion of preterm birth increased (10.4-17.5%, P<.001). The incidence of SGA decreased from 11.1% to 8.0%. Among pregnancies complicated by SGA, the proportion of preterm birth increased (2.9-5.4%, P<.001). The incidence of preterm PROM increased from 1.4% to 2.2%. Among pregnancies complicated by preterm PROM, the proportion of preterm birth remained stable. Preterm stillbirth rates declined (4.23-2.32%, P<.001). Maternal age, BMI, and ethnic diversity have all increased since 1986, whereas maternal smoking has decreased. CONCLUSION: In South Australia, the preterm birth rate among singletons increased from 1986 to 2014 by 40%, with iatrogenic preterm birth being responsible for 80% of this increase. Incidence of hypertensive disorders of pregnancy and SGA declined. Among pregnancies complicated by hypertensive disorders of pregnancy and SGA, the proportions of preterm birth increased, indicating earlier interventions in these women. The diagnosis of preterm PROM increased from 1% to 2%, and greater than 80% of preterm PROM was associated with preterm birth after 1990. Increasing iatrogenic delivery may be attributable, in part, to changing maternal phenotype and to altered clinicians' behavior. However, improvements in fetal surveillance, particularly ultrasonography, and advanced neonatal care may underpin perinatal clinical decision-making and the likelihood of iatrogenic birth.
[Mh] Termos MeSH primário: Ruptura Prematura de Membranas Fetais/epidemiologia
Hipertensão Induzida pela Gravidez/epidemiologia
Idade Materna
Resultado da Gravidez
Nascimento Prematuro/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Coeficiente de Natalidade/tendências
Estudos de Coortes
Feminino
Seres Humanos
Hipertensão Induzida pela Gravidez/diagnóstico
Incidência
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Nascimento Vivo/epidemiologia
Paridade
Vigilância da População
Gravidez
Nascimento Prematuro/etiologia
Estudos Retrospectivos
Medição de Risco
Austrália do Sul/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002419


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[PMID]:29016505
[Au] Autor:Bell AD; Joy S; Gullo S; Higgins R; Stevenson E
[Ad] Endereço:Carolinas HealthCare System, Charlotte, North Carolina; the Institute for Healthcare Improvement, Cambridge, Massachusetts; and Duke University School of Nursing, Durham, North Carolina.
[Ti] Título:Implementing a Systematic Approach to Reduce Cesarean Birth Rates in Nulliparous Women.
[So] Source:Obstet Gynecol;130(5):1082-1089, 2017 Nov.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To implement a systematic approach to safely reduce nulliparous cesarean birth rates. METHODS: This is a quality improvement project at two rural community hospitals and one urban community hospital in North Carolina. These facilities implemented a systematic approach to reduce nulliparous cesarean birth rates, aligning with recommendations developed by the Council on Patient Safety in Women's Health Care: Patient Safety Bundle on the Safe Reduction of Primary Cesarean Births. Health care providers and nurses received education on contemporary labor management guidelines developed by the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine Obstetric Care Consensus regarding safe prevention of primary cesarean deliveries and nurses were instructed on labor support techniques. The preguideline implementation period was January 1, 2015, to June 30, 2015. The postguideline implementation period was July 1, 2016, to December 31, 2016. The primary outcome measured was the nulliparous, term, singleton, vertex cesarean birth rate. Secondary outcomes included maternal and neonatal outcomes. Standard statistical analysis was used and a P value of <.05 was considered significant. RESULTS: There were 434 women identified in the preguideline period and 401 women in the postguideline period. The nulliparous, term, singleton, vertex cesarean birth rate decreased from 27.9% to 19.7% [odds ratio (OR) 0.63, CI 0.46-0.88]. There were improvements in health care provider compliance with following the labor management guidelines from 86.2% to 91.5% (OR 1.73, 95% CI 1.11-2.70), the use of maternal position changes from 78.7% to 87.5% (OR 1.86, 95% CI 1.29-2.68), and use of the peanut birthing ball from 16.8% to 45.2% (OR 3.83, 95% CI 2.84-5.16) as provisions for labor support. DISCUSSION: Implementing a systematic approach for care of nulliparous women is associated with a decrease in term, singleton, vertex cesarean birth rates.
[Mh] Termos MeSH primário: Cesárea/normas
Parto Obstétrico/normas
Implementação de Plano de Saúde
Hospitais Comunitários/normas
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Adulto
Coeficiente de Natalidade
Feminino
Fidelidade a Diretrizes
Seres Humanos
North Carolina
Razão de Chances
Paridade
Gravidez
Nascimento a Termo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002263


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[PMID]:28916332
[Au] Autor:Levine AD; Boulet SL; Berry RM; Jamieson DJ; Alberta-Sherer HB; Kissin DM
[Ad] Endereço:School of Public Policy, Georgia Institute of Technology, Atlanta, Georgia; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia. Electronic address: aaron.levine@pubpolicy.gatech.edu.
[Ti] Título:Assessing the use of assisted reproductive technology in the United States by non-United States residents.
[So] Source:Fertil Steril;108(5):815-821, 2017 Nov.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study cross-border reproductive care (CBRC) by assessing the frequency and nature of assisted reproductive technology (ART) care that non-U.S. residents receive in the United States. DESIGN: Retrospective study of ART cycles reported to the Centers for Disease Control and Prevention's National ART Surveillance System (NASS) from 2006 to 2013. SETTING: Private and academic ART clinics. PATIENT(S): Patients who participated in ART cycles in the United States from 2006 to 2013. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Frequency and trend of ART use in the U.S. by non-U.S. residents, countries of residence for non-U.S. residents, differences by residence status for specific ART treatments received, and the outcomes of these ART cycles. RESULT(S): A total of 1,271,775 ART cycles were reported to NASS from 2006 to 2013. The percentage of ART cycles performed for non-U.S. residents increased from 1.2% (n = 1,683) in 2006 to 2.8% (n = 5,381) in 2013 (P<.001), with treatment delivered to residents of 147 countries. Compared with resident cycles, non-U.S. resident cycles had higher use of oocyte donation (10.6% vs. 42.6%), gestational carriers (1.6% vs. 12.4%), and preimplantation genetic diagnosis or screening (5.3% vs. 19.1%). U.S. resident and non-U.S. resident cycles had similar embryo transfer and multiple birth rates. CONCLUSION(S): This analysis showed that non-U.S. resident cycles accounted for a growing share of all U.S. ART cycles and made higher use of specialized treatment techniques. This study provides important baseline data on CBRC in the U.S. and may also prove to be useful to organizations interested in improving access to fertility treatments.
[Mh] Termos MeSH primário: Turismo Médico
Aceitação pelo Paciente de Cuidados de Saúde
Técnicas de Reprodução Assistida/utilização
[Mh] Termos MeSH secundário: Adulto
Coeficiente de Natalidade
Centers for Disease Control and Prevention (U.S.)
Bases de Dados Factuais
Feminino
Seres Humanos
Turismo Médico/tendências
Vigilância da População
Gravidez
Taxa de Gravidez
Técnicas de Reprodução Assistida/tendências
Fatores de Tempo
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


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[PMID]:28914520
[Au] Autor:Berlin O
[Ti] Título:Where Have All the Babies Gone?
[So] Source:State Legis;43(8):9, 2017 Sep.
[Is] ISSN:0147-6041
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Coeficiente de Natalidade/tendências
[Mh] Termos MeSH secundário: Adolescente
Adulto
Recessão Econômica/estatística & dados numéricos
Feminino
Seres Humanos
Gravidez
Gravidez na Adolescência/estatística & dados numéricos
Gravidez não Planejada
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


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[PMID]:28791691
[Au] Autor:Anderson C; Engel SM; Weaver MA; Zevallos JP; Nichols HB
[Ad] Endereço:Department of Epidemiology, University of North Carolina, Chapel Hill, NC.
[Ti] Título:Birth rates after radioactive iodine treatment for differentiated thyroid cancer.
[So] Source:Int J Cancer;141(11):2291-2295, 2017 Dec 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Treatment with radioactive iodine (RAI) for differentiated thyroid cancer has been associated with alterations in gonadal function in women, including changes in menstrual function and an earlier age at menopause. Our objective was to evaluate associations between RAI and postdiagnosis live birth rates among thyroid cancer survivors diagnosed at ages 15-39 years. We identified women diagnosed with differentiated thyroid cancer between January 2000 and December 2013 in the North Carolina Central Cancer Registry (CCR). CCR records were linked to state birth certificate files to identify livebirths to thyroid cancer survivors through December 2014. Person-years of follow-up were accrued from 6 months after diagnosis to first birth, 46th birthday, death, or December 31, 2014, whichever came first. Cox proportional hazards regression was used to estimate hazards ratios (HR) and 95% confidence intervals (CI) for first livebirth. Among 2,360 women with a differentiated thyroid cancer diagnosis, 53% received RAI. The cumulative incidence of birth at the end of follow-up (maximum 14.5 years) was 30.0 and 29.3% among those who were and were not treated with RAI, respectively. Overall, first birth rates did not significantly differ between groups (HR = 1.00; 95% CI: 0.82, 1.23). In our observational cohort, treatment with RAI was not associated with a reduced birth rate. Our findings add to the evidence available for counseling thyroid cancer patients with concerns about future fertility.
[Mh] Termos MeSH primário: Adenocarcinoma/radioterapia
Antineoplásicos/efeitos adversos
Fertilidade/efeitos dos fármacos
Radioisótopos do Iodo/efeitos adversos
Neoplasias da Glândula Tireoide/radioterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Coeficiente de Natalidade
Feminino
Seres Humanos
Modelos de Riscos Proporcionais
Sistema de Registros
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Iodine Radioisotopes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30917


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[PMID]:28732531
[Au] Autor:van Hoogenhuijze NE; Torrance HL; Mol F; Laven JSE; Scheenjes E; Traas MAF; Janssen C; Cohlen B; Teklenburg G; de Bruin JP; van Oppenraaij R; Maas JWM; Moll E; Fleischer K; van Hooff MH; de Koning C; Cantineau A; Lambalk CB; Verberg M; Nijs M; Manger AP; van Rumste M; van der Voet LF; Preys-Bosman A; Visser J; Brinkhuis E; den Hartog JE; Sluijmer A; Jansen FW; Hermes W; Bandell ML; Pelinck MJ; van Disseldorp J; van Wely M; Smeenk J; Pieterse QD; Boxmeer JC; Groenewoud ER; Eijkemans MJC; Kasius JC; Broekmans FJM
[Ad] Endereço:University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. n.e.vanhoogenhuijze@umcutrecht.nl.
[Ti] Título:Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342).
[So] Source:BMC Womens Health;17(1):47, 2017 Jul 21.
[Is] ISSN:1472-6874
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. METHOD: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2 fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2 IVF/ICSI cycle and over 12 months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. DISCUSSION: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. TRIAL REGISTRATION: NTR 5342 , registered July 31 , 2015. PROTOCOL VERSION: Version 4.10, January 4th, 2017.
[Mh] Termos MeSH primário: Transferência Embrionária/métodos
Endométrio/cirurgia
Fertilização In Vitro/métodos
Nascimento Vivo
Injeções de Esperma Intracitoplásmicas/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Coeficiente de Natalidade
Implantação do Embrião
Endométrio/lesões
Feminino
Seres Humanos
Países Baixos
Gravidez
Taxa de Gravidez
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE
[do] DOI:10.1186/s12905-017-0378-y



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