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  1 / 1396 MEDLINE  
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[PMID]:27775369
[Au] Autor:Kashdan E; Duncan D; Parnell A; Schattler H
[Ad] Endereço:School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4, Ireland. email: eugene.kashdan@ucd.ie.
[Ti] Título:Mathematical methods in systems biology.
[So] Source:Math Biosci Eng;13(6):i-ii, 2016 Dec 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The editors of this Special Issue of Mathematical Biosciences and Engineering were the organizers for the Third International Workshop "Mathematical Methods in System Biology" that took place on June 15-18, 2015 at the University College Dublin in Ireland. As stated in the workshop goals, we managed to attract a good mix of mathematicians and statisticians working on biological and medical applications with biologists and clinicians interested in presenting their challenging problems and looking to find mathematical and statistical tools for their solutions.
[Mh] Termos MeSH primário: Matemática
Biologia de Sistemas
[Mh] Termos MeSH secundário: Bioestatística
Biologia de Sistemas/tendências
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.201606i


  2 / 1396 MEDLINE  
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[PMID]:28739999
[Au] Autor:Yamamoto K
[Ad] Endereço:Department of Medical Statistics, Osaka City University Graduate School of Medicine.
[Ti] Título:[Clinical Research and Biostatistics].
[So] Source:Brain Nerve;69(7):843-847, 2017 Jul.
[Is] ISSN:1881-6096
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We discuss the important role of biostatisticians in clinical research. In addition, the biases that occur in a study, especially "confounding" in an observational study, are discussed using a real example. Finally, the manuscript provides an overview of propensity score matching, a method to eliminate confounding.
[Mh] Termos MeSH primário: Bioestatística
[Mh] Termos MeSH secundário: Pesquisa Biomédica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.11477/mf.1416200829


  3 / 1396 MEDLINE  
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[PMID]:28942963
[Au] Autor:Benner C; Havulinna AS; Järvelin MR; Salomaa V; Ripatti S; Pirinen M
[Ad] Endereço:Institute for Molecular Medicine Finland, University of Helsinki, 00014 Helsinki, Finland; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. Electronic address: christian.benner@helsinki.fi.
[Ti] Título:Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies.
[So] Source:Am J Hum Genet;101(4):539-551, 2017 Oct 05.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide association studies (GWASs). Although these approaches require information about the linkage disequilibrium (LD) between variants, there has not been a comprehensive evaluation of how estimation of the LD structure from reference genotype panels performs in comparison with that from the original individual-level GWAS data. Using population genotype data from Finland and the UK Biobank, we show here that a reference panel of 1,000 individuals from the target population is adequate for a GWAS cohort of up to 10,000 individuals, whereas smaller panels, such as those from the 1000 Genomes Project, should be avoided. We also show, both theoretically and empirically, that the size of the reference panel needs to scale with the GWAS sample size; this has important consequences for the application of these methods in ongoing GWAS meta-analyses and large biobank studies. We conclude by providing software tools and by recommending practices for sharing LD information to more efficiently exploit summary statistics in genetics research.
[Mh] Termos MeSH primário: Bioestatística/métodos
Mapeamento Cromossômico/métodos
Estudo de Associação Genômica Ampla/métodos
Desequilíbrio de Ligação
Locos de Características Quantitativas
Software
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Coortes
Feminino
Finlândia
Genoma Humano
Genótipo
Seres Humanos
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  4 / 1396 MEDLINE  
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[PMID]:28934206
[Au] Autor:Bakuza JS; Denwood MJ; Nkwengulila G; Mable BK
[Ad] Endereço:Institute of Biodiversity Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
[Ti] Título:Estimating the prevalence and intensity of Schistosoma mansoni infection among rural communities in Western Tanzania: The influence of sampling strategy and statistical approach.
[So] Source:PLoS Negl Trop Dis;11(9):e0005937, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schistosoma mansoni is a parasite of major public health importance in developing countries, where it causes a neglected tropical disease known as intestinal schistosomiasis. However, the distribution of the parasite within many endemic regions is currently unknown, which hinders effective control. The purpose of this study was to characterize the prevalence and intensity of infection of S. mansoni in a remote area of western Tanzania. METHODOLOGY/PRINCIPAL FINDINGS: Stool samples were collected from 192 children and 147 adults residing in Gombe National Park and four nearby villages. Children were actively sampled in local schools, and adults were sampled passively by voluntary presentation at the local health clinics. The two datasets were therefore analysed separately. Faecal worm egg count (FWEC) data were analysed using negative binomial and zero-inflated negative binomial (ZINB) models with explanatory variables of site, sex, and age. The ZINB models indicated that a substantial proportion of the observed zero FWEC reflected a failure to detect eggs in truly infected individuals, meaning that the estimated true prevalence was much higher than the apparent prevalence as calculated based on the simple proportion of non-zero FWEC. For the passively sampled data from adults, the data were consistent with close to 100% true prevalence of infection. Both the prevalence and intensity of infection differed significantly between sites, but there were no significant associations with sex or age. CONCLUSIONS/SIGNIFICANCE: Overall, our data suggest a more widespread distribution of S. mansoni in this part of Tanzania than was previously thought. The apparent prevalence estimates substantially under-estimated the true prevalence as determined by the ZINB models, and the two types of sampling strategies also resulted in differing conclusions regarding prevalence of infection. We therefore recommend that future surveillance programmes designed to assess risk factors should use active sampling whenever possible, in order to avoid the self-selection bias associated with passive sampling.
[Mh] Termos MeSH primário: Bioestatística/métodos
Esquistossomose mansoni/epidemiologia
Esquistossomose mansoni/patologia
[Mh] Termos MeSH secundário: Fezes/parasitologia
Seres Humanos
Contagem de Ovos de Parasitas
Prevalência
População Rural
Viés de Seleção
Tanzânia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005937


  5 / 1396 MEDLINE  
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[PMID]:28652472
[Au] Autor:Gajjala PR; Jankowski V; Heinze G; Bilo G; Zanchetti A; Noels H; Liehn E; Perco P; Schulz A; Delles C; Kork F; Biessen E; Narkiewicz K; Kawecka-Jaszcz K; Floege J; Soranna D; Zidek W; Jankowski J
[Ad] Endereço:From the Universitätsklinikum RWTH Aachen, Institute for Molecular Cardiovascular Research, Germany (P.R.G., V.J., H.N., E.L., F.K., E.B., J.J.); Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands (P.R.G., E.B., J.J.); Section for
[Ti] Título:Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma.
[So] Source:Hypertension;70(2):412-419, 2017 Aug.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite advancements in lowering blood pressure, the best approach to lower it remains controversial because of the lack of information on the molecular basis of hypertension. We, therefore, performed plasma proteomics of plasma from patients with hypertension to identify molecular determinants detectable in these subjects but not in controls and vice versa. Plasma samples from hypertensive subjects (cases; n=118) and controls (n=85) from the InGenious HyperCare cohort were used for this study and performed mass spectrometric analysis. Using biostatistical methods, plasma peptides specific for hypertension were identified, and a model was developed using least absolute shrinkage and selection operator logistic regression. The underlying peptides were identified and sequenced off-line using matrix-assisted laser desorption ionization orbitrap mass spectrometry. By comparison of the molecular composition of the plasma samples, 27 molecular determinants were identified differently expressed in cases from controls. Seventy percent of the molecular determinants selected were found to occur less likely in hypertensive patients. In cross-validation, the overall was 0.434, and the area under the curve was 0.891 with 95% confidence interval 0.8482 to 0.9349, <0.0001. The mean values of the cross-validated proteomic score of normotensive and hypertensive patients were found to be -2.007±0.3568 and 3.383±0.2643, respectively, <0.0001. The molecular determinants were successfully identified, and the proteomic model developed shows an excellent discriminatory ability between hypertensives and normotensives. The identified molecular determinants may be the starting point for further studies to clarify the molecular causes of hypertension.
[Mh] Termos MeSH primário: Bioestatística/métodos
Pressão Sanguínea/fisiologia
Hipertensão
Proteômica/métodos
[Mh] Termos MeSH secundário: Adulto
Anti-Hipertensivos/uso terapêutico
Estudos de Casos e Controles
Intervalos de Confiança
Europa (Continente)
Feminino
Seres Humanos
Hipertensão/diagnóstico
Hipertensão/tratamento farmacológico
Hipertensão/metabolismo
Hipertensão/fisiopatologia
Masculino
Meia-Idade
Modelos Biológicos
Técnicas de Diagnóstico Molecular
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.116.08906


  6 / 1396 MEDLINE  
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[PMID]:28651023
[Au] Autor:Hlavin G; Hampson LV; Koenig F
[Ad] Endereço:Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
[Ti] Título:Many-to-one comparisons after safety selection in multi-arm clinical trials.
[So] Source:PLoS One;12(6):e0180131, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In phase II platform trials, 'many-to-one' comparisons are performed when K experimental treatments are compared with a common control to identify the most promising treatment(s) to be selected for Phase III trials. However, when sample sizes are limited, such as when the disease of interest is rare, only a single Phase II/III trial addressing both treatment selection and confirmatory efficacy testing may be feasible. In this paper, we suggest a two-step safety selection and testing procedure for such seamless trials. At the end of the study, treatments are first screened on the basis of safety, and those deemed to be sufficiently safe are then taken forwards for efficacy testing against a common control. All safety and efficacy evaluations are therefore performed at the end of the study, when for each patient all safety and efficacy data are available. If confirmatory conclusions are to be drawn from the trial, strict control of the family-wise error rate (FWER) is essential. However, to avoid unnecessary losses in power, no type I error rate should be "wasted" on comparisons which are no longer of interest because treatments have been dropped due to safety concerns. We investigate the impact on power and FWER control of multiplicity adjustments which correct efficacy tests only for the number of safe selected treatments instead of adjusting for all K null hypotheses the trial begins testing. We derive conditions under which strict control of the FWER can be achieved. Procedures using the estimated association between safety and efficacy outcomes are developed for the case when the correlation between endpoints is unknown. The operating characteristics of the proposed procedures are assessed via simulation.
[Mh] Termos MeSH primário: Ensaios Clínicos Fase II como Assunto/métodos
Ensaios Clínicos Fase III como Assunto/métodos
[Mh] Termos MeSH secundário: Bioestatística
Ensaios Clínicos Fase II como Assunto/estatística & dados numéricos
Ensaios Clínicos Fase III como Assunto/estatística & dados numéricos
Simulação por Computador
Ensaios Clínicos Controlados como Assunto/métodos
Ensaios Clínicos Controlados como Assunto/estatística & dados numéricos
Seres Humanos
Modelos Estatísticos
Ensaios Clínicos Controlados Aleatórios como Assunto/métodos
Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos
Segurança
Tamanho da Amostra
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180131


  7 / 1396 MEDLINE  
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[PMID]:28650962
[Au] Autor:Villela DAM; Garcia GA; Maciel-de-Freitas R
[Ad] Endereço:Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
[Ti] Título:Novel inference models for estimation of abundance, survivorship and recruitment in mosquito populations using mark-release-recapture data.
[So] Source:PLoS Negl Trop Dis;11(6):e0005682, 2017 Jun.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Experiments involving mosquito mark-release-recapture (MRR) design are helpful to determine abundance, survival and even recruitment of mosquito populations in the field. Obstacles in mosquito MRR protocols include marking limitations due to small individual size, short lifespan, low efficiency in capturing devices such as traps, and individual removal upon capture. These limitations usually make MRR analysis restricted to only abundance estimation or a combination of abundance and survivorship, and often generate a great degree of uncertainty about the estimations. METHODOLOGY/PRINCIPAL FINDINGS: We present a set of Bayesian biodemographic models designed to fit data from most common mosquito recapture experiments. Using both field data and simulations, we consider model features such as capture efficiency, survival rates, removal of individuals due to capturing, and collection of pupae. These models permit estimation of abundance, survivorship of both marked and unmarked mosquitoes, if different, and recruitment rate. We analyze the accuracy of estimates by varying the number of released individuals, abundance, survivorship, and capture efficiency in multiple simulations. These methods can stand capture efficiencies as low as usually reported but their accuracy depends on the number of released mosquitoes, abundance and survivorship. We also show that gathering pupal counts allows estimating differences in survivorship between released mosquitoes and the unmarked population. CONCLUSION/SIGNIFICANCE: These models are important both to reduce uncertainty in evaluating MMR experiments and also to help planning future MRR studies.
[Mh] Termos MeSH primário: Bioestatística/métodos
Culicidae/crescimento & desenvolvimento
Entomologia/métodos
Densidade Demográfica
Taxa de Sobrevida
[Mh] Termos MeSH secundário: Animais
Pupa/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005682


  8 / 1396 MEDLINE  
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[PMID]:28422593
[Au] Autor:Pozos-Guillén A; Ruiz-Rodríguez S; Garrocho-Rangel A
[Ti] Título:Fundamentals in Biostatistics for Investigation in Pediatric Dentistry: Part II -Biostatistical Methods.
[So] Source:J Clin Pediatr Dent;41(3):173-178, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The main purpose of the second part of this series was to provide the reader with some basic aspects of the most common biostatistical methods employed in health sciences, in order to better understand the validity, significance and reliability of the results from any article on Pediatric Dentistry. Currently, as mentioned in the first paper, Pediatric Dentists need basic biostatistical knowledge to be able to apply it when critically appraise a dental article during the Evidence-based Dentistry (EBD) process, or when participating in the development of a clinical study with dental pediatric patients. The EBD process provides a systematic approach of collecting, review and analyze current and relevant published evidence about oral health care in order to answer a particular clinical question; then this evidence should be applied in everyday practice. This second report describes the most commonly used statistical methods for analyzing and interpret collected data, and the methodological criteria to be considered when choosing the most appropriate tests for a specific study. These are available to Pediatric Dentistry practicants interested in reading or designing original clinical or epidemiological studies.
[Mh] Termos MeSH primário: Bioestatística
Odontopediatria
[Mh] Termos MeSH secundário: Odontologia Baseada em Evidências
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.3.173


  9 / 1396 MEDLINE  
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[PMID]:28356102
[Au] Autor:Lim LS; Pullenayegum E; Moineddin R; Gladman DD; Silverman ED; Feldman BM
[Ad] Endereço:Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada. llim@chrim.ca.
[Ti] Título:Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients.
[So] Source:Pediatr Rheumatol Online J;15(1):18, 2017 Mar 29.
[Is] ISSN:1546-0096
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution.Longitudinal studies require special analytic methods. Newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. In recent years, an increasing number of studies have used longitudinal design. This review aims to help readers understand and apply the findings from longitudinal studies. Using a cohort of children with juvenile dermatomyositis (JDM), we illustrate how to study evolution of disease activity in JDM using longitudinal methods.
[Mh] Termos MeSH primário: Dermatomiosite/epidemiologia
Estudos Observacionais como Assunto/métodos
Doenças Reumáticas/epidemiologia
[Mh] Termos MeSH secundário: Análise de Variância
Bioestatística
Criança
Seres Humanos
Estudos Longitudinais
Modelos Biológicos
Estudos Observacionais como Assunto/estatística & dados numéricos
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1186/s12969-017-0148-2


  10 / 1396 MEDLINE  
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[PMID]:28288291
[Au] Autor:Garrocho-Rangel JA; Ruiz-Rodríguez MS; Pozos-Guillén AJ
[Ti] Título:Fundamentals in Biostatistics for Research in Pediatric Dentistry: Part I - Basic Concepts.
[So] Source:J Clin Pediatr Dent;41(2):87-94, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this report was to provide the reader with some basic concepts in order to better understand the significance and reliability of the results of any article on Pediatric Dentistry. Currently, Pediatric Dentists need the best evidence available in the literature on which to base their diagnoses and treatment decisions for the children's oral care. Basic understanding of Biostatistics plays an important role during the entire Evidence-Based Dentistry (EBD) process. This report describes Biostatistics fundamentals in order to introduce the basic concepts used in statistics, such as summary measures, estimation, hypothesis testing, effect size, level of significance, p value, confidence intervals, etc., which are available to Pediatric Dentists interested in reading or designing original clinical or epidemiological studies.
[Mh] Termos MeSH primário: Bioestatística
Odontopediatria
[Mh] Termos MeSH secundário: Odontologia Baseada em Evidências
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.2.87



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