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  1 / 54503 MEDLINE  
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[PMID]:29381719
[Au] Autor:Vierimaa M; Bruner MW; Côté J
[Ad] Endereço:Department of Kinesiology and Health Science, Utah State University, Logan, Utah, United States of America.
[Ti] Título:Positive youth development and observed athlete behavior in recreational sport.
[So] Source:PLoS One;13(1):e0191936, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Competence, confidence, connection, and character are regarded as outcomes of positive youth development (PYD) in sport. However, the specific athlete behaviors associated with different PYD profiles are not well understood. Thus, the purpose of this study was to investigate the relationship between athletes' observed behavior during sport competitions and their perceptions of PYD outcomes. DESIGN: Cross-sectional study with systematic behavioral observation. METHOD: Sixty-seven youth athletes were observed during basketball games near the end of their season, and the content of their behavior was systematically coded. Athletes also completed measures of the 4 Cs (competence, confidence connection, and character). A person-centered analysis approach was used to examine the relationship between PYD profiles and observed behavior. RESULTS: A cluster analysis identified two homogenous groups of athletes characterized by relatively high and low perceptions of confidence, connection, and character. A MANCOVA revealed that after controlling for gender and years of playing experience, the high Cs group engaged in more frequent sport communication with their coaches. CONCLUSIONS: Results re-affirm the critical role that coaches play in the developmental experiences of young athletes, and highlight the importance of contextual factors of the youth sport environment.
[Mh] Termos MeSH primário: Recreação
[Mh] Termos MeSH secundário: Adolescente
Criança
Análise por Conglomerados
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191936


  2 / 54503 MEDLINE  
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[PMID]:29265788
[Au] Autor:Jezewska-Zychowicz M; Guzek D
[Ad] Endereço:Warsaw University of Life Sciences, Faculty of Human Nutrition and Consumer Sciences, Department of Organization and Consumption Economics, Warsaw, Poland
[Ti] Título:Associations between adult perception of body weight, diet, preparing meals and dietary patterns
[So] Source:Rocz Panstw Zakl Hig;68(4):381-387, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: The links between dietary patterns, the perception of one's body weight and diet as well preparing meals are poorly recognised in the literature. In order to develop effective nutritional education and focused interventions, more of such information is thereby required to improve the nation's health Objective: To identify dietary patterns based on declared food consumption rates and subject responses on whether dieting, perception of body weight and diet and preparing meals are linked to such dietary patterns Material and methods: The survey was conducted in 2016 on 344 consumers chosen for age (20-65 years) and their consent for study participation. Rates of eating the foods selected were measured using a 7-point scale. Cluster analysis was used to identify three dietary patterns of behaviour: 'potentially beneficial to health', 'potentially unfavourable for health; deficient' and 'potentially unfavourable for health; excessive'. The analysis was performed using IBM SPSS Statistics version 23.0 Results: There were significantly more subjects showing 'potentially beneficial for health' behaviour, normal body weight, those dieting (whether now or in the past) and those who evaluated their diet as being very good or good compared to other groups. They were also more involved in preparing their meals at home. Differences were found between the 'unfavourable for health' dietary patterns concerning subject's involvement in meal preparation. The dietary pattern for 'deficient' behaviour found lower rates of those preparing their meals at home Conclusions: The pattern of potentially beneficial dietary habits was linked to weight control through a slimming diet and greater involvement in the preparation of food for consumption. The results show the need to develop food choice skills rather than just transferring knowledge in the nutrition education process
[Mh] Termos MeSH primário: Dieta/psicologia
Comportamento Alimentar/psicologia
Preferências Alimentares/psicologia
Conhecimentos, Atitudes e Prática em Saúde
Peso Corporal Ideal
Refeições/psicologia
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Análise por Conglomerados
Ingestão de Alimentos/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Percepção
Fatores Sexuais
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  3 / 54503 MEDLINE  
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[PMID]:29244007
[Au] Autor:Haspel N; Luo D; González E
[Ad] Endereço:Department of Computer Science, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, 02125, MA, USA. nurit.haspel@umb.edu.
[Ti] Título:Detecting intermediate protein conformations using algebraic topology.
[So] Source:BMC Bioinformatics;18(Suppl 15):502, 2017 Dec 06.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Understanding protein structure and dynamics is essential for understanding their function. This is a challenging task due to the high complexity of the conformational landscapes of proteins and their rugged energy levels. In particular, it is important to detect highly populated regions which could correspond to intermediate structures or local minima. RESULTS: We present a hierarchical clustering and algebraic topology based method that detects regions of interest in protein conformational space. The method is based on several techniques. We use coarse grained protein conformational search, efficient robust dimensionality reduction and topological analysis via persistent homology as the main tools. We use two dimensionality reduction methods as well, robust Principal Component Analysis (PCA) and Isomap, to generate a reduced representation of the data while preserving most of the variance in the data. CONCLUSIONS: Our hierarchical clustering method was able to produce compact, well separated clusters for all the tested examples.
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Conformação Proteica
Proteínas
[Mh] Termos MeSH secundário: Análise por Conglomerados
Análise de Componente Principal
Proteínas/química
Proteínas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1918-z


  4 / 54503 MEDLINE  
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[PMID]:29187152
[Au] Autor:Spadafore M; Najarian K; Boyle AP
[Ad] Endereço:University of Michigan Medical School, 1301 Catherine, Ann Arbor, 48109-5624, USA. maxspad@umich.edu.
[Ti] Título:A proximity-based graph clustering method for the identification and application of transcription factor clusters.
[So] Source:BMC Bioinformatics;18(1):530, 2017 Nov 29.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transcription factors (TFs) form a complex regulatory network within the cell that is crucial to cell functioning and human health. While methods to establish where a TF binds to DNA are well established, these methods provide no information describing how TFs interact with one another when they do bind. TFs tend to bind the genome in clusters, and current methods to identify these clusters are either limited in scope, unable to detect relationships beyond motif similarity, or not applied to TF-TF interactions. METHODS: Here, we present a proximity-based graph clustering approach to identify TF clusters using either ChIP-seq or motif search data. We use TF co-occurrence to construct a filtered, normalized adjacency matrix and use the Markov Clustering Algorithm to partition the graph while maintaining TF-cluster and cluster-cluster interactions. We then apply our graph structure beyond clustering, using it to increase the accuracy of motif-based TFBS searching for an example TF. RESULTS: We show that our method produces small, manageable clusters that encapsulate many known, experimentally validated transcription factor interactions and that our method is capable of capturing interactions that motif similarity methods might miss. Our graph structure is able to significantly increase the accuracy of motif TFBS searching, demonstrating that the TF-TF connections within the graph correlate with biological TF-TF interactions. CONCLUSION: The interactions identified by our method correspond to biological reality and allow for fast exploration of TF clustering and regulatory dynamics.
[Mh] Termos MeSH primário: Algoritmos
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Imunoprecipitação da Cromatina
Análise por Conglomerados
DNA/química
DNA/isolamento & purificação
DNA/metabolismo
Redes Reguladoras de Genes
Seres Humanos
Células K562
Cadeias de Markov
Mapas de Interação de Proteínas/genética
Análise de Sequência de DNA
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transcription Factors); 9007-49-2 (DNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1935-y


  5 / 54503 MEDLINE  
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[PMID]:29187143
[Au] Autor:Gaspar JM; Hart RP
[Ad] Endereço:Department of Pharmaceutics, Rutgers University, Piscataway, NJ, USA. jsh58@wildcats.unh.edu.
[Ti] Título:DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data.
[So] Source:BMC Bioinformatics;18(1):528, 2017 Nov 29.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: DNA methylation is an epigenetic modification that is studied at a single-base resolution with bisulfite treatment followed by high-throughput sequencing. After alignment of the sequence reads to a reference genome, methylation counts are analyzed to determine genomic regions that are differentially methylated between two or more biological conditions. Even though a variety of software packages is available for different aspects of the bioinformatics analysis, they often produce results that are biased or require excessive computational requirements. RESULTS: DMRfinder is a novel computational pipeline that identifies differentially methylated regions efficiently. Following alignment, DMRfinder extracts methylation counts and performs a modified single-linkage clustering of methylation sites into genomic regions. It then compares methylation levels using beta-binomial hierarchical modeling and Wald tests. Among its innovative attributes are the analyses of novel methylation sites and methylation linkage, as well as the simultaneous statistical analysis of multiple sample groups. To demonstrate its efficiency, DMRfinder is benchmarked against other computational approaches using a large published dataset. Contrasting two replicates of the same sample yielded minimal genomic regions with DMRfinder, whereas two alternative software packages reported a substantial number of false positives. Further analyses of biological samples revealed fundamental differences between DMRfinder and another software package, despite the fact that they utilize the same underlying statistical basis. For each step, DMRfinder completed the analysis in a fraction of the time required by other software. CONCLUSIONS: Among the computational approaches for identifying differentially methylated regions from high-throughput bisulfite sequencing datasets, DMRfinder is the first that integrates all the post-alignment steps in a single package. Compared to other software, DMRfinder is extremely efficient and unbiased in this process. DMRfinder is free and open-source software, available on GitHub ( github.com/jsh58/DMRfinder ); it is written in Python and R, and is supported on Linux.
[Mh] Termos MeSH primário: Metilação de DNA
Software
[Mh] Termos MeSH secundário: Linhagem Celular
Análise por Conglomerados
Ilhas de CpG
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Análise de Sequência de DNA/métodos
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1909-0


  6 / 54503 MEDLINE  
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[PMID]:28452690
[Au] Autor:Prior KN; Bond MJ
[Ad] Endereço:School of Medicine, Flinders University, Adelaide, Australia.
[Ti] Título:Patterns of 'Abnormal' Illness Behavior among Healthy Individuals.
[So] Source:Am J Health Behav;41(2):139-146, 2017 Mar 01.
[Is] ISSN:1945-7359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We extend the seminal work of Professor Issy Pilowsky by presenting a contemporary re-conceptualization of abnormal illness behavior (AIB) as a general psychological phenomenon evident among healthy community members. METHODS: Participants (N = 344) completed a self- report questionnaire comprising health information and well-validated psychological measures from the field of somatization (eg, AIB, attributional style for physical symptoms, cognitive distortion of somatic information, illness likelihood, maladaptive coping). RESULTS: Cluster analysis of illness behavior responses resulted in 3 unique groupings distinguished by key health and psychological variables. Cluster 1 reflected 'normal' responses, Cluster 2 'atypical' and Cluster 3 'maladaptive'. Cluster 3 may represent a personality attribute indicative of a general style of interpreting illness in a more extreme way (trait AIB) whereas Cluster 2 may reflect a transient response to a specific illness event (state AIB). CONCLUSIONS: The construct of 'abnormal' illness behavior may usefully be extended to include individual differences in responses regardless of current health status. Furthermore, the potential to further characterize illness behavior as either dispositional (trait) or situational (state) emerges as a fruitful area for future analyses. Specifically, longitudinal studies are recommended to determine the causal links between health events and illness behavior profiles.
[Mh] Termos MeSH primário: Comportamento de Doença/classificação
Personalidade/classificação
Transtornos Somatoformes/classificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise por Conglomerados
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Somatoformes/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5993/AJHB.41.2.4


  7 / 54503 MEDLINE  
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[PMID]:29413580
[Au] Autor:Jiang G; Shen X; Kang H; Li K; Zheng J; Yu Y
[Ad] Endereço:School of Pharmacy, Fudan University, Shanghai 201203, PR China.
[Ti] Título:Serum metabolite profiling of cutaneous T-cell lymphoma based on a multiplatform approach.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:71-76, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma with a difficult early diagnosis. The overall annual age-adjusted incidence of CTCL had consistently increased to around 10.2 cases per million persons. However, our knowledge regarding its mechanism of disease origin and progression remains unclear. In this study, serum samples from 31 CTCL patients and 31 matched healthy volunteers were analyzed in depth to screen metabolites capable of differentiating CTCL from controls. To obtain a higher coverage of metabolome with various hydrophilicity, a multiplatform approach with GC-MS and UHPLC-QTOF-MS has been employed. Data were analyzed by multivariate statistical analysis and CTCL group was separated from control group successfully using supervised OPLS-DA model. A total of 51 CTCL-regulated metabolites were identified, among which 15 differential metabolites have an AUC > 0.9 in receiver operating characteristic (ROC) curve analysis. Glycerophospholipid metabolism, tryptophan metabolism and purine metabolism were highlighted as 3 major altered pathways in CTCL serum. These alterations revealed impacts to membrane stability and weakened immune as well as ATP depletion associated with CTCL. Overall, these results aid in improving understanding of the mechanism related to CTCL, and demonstrate this multiplatform approach is suitable for serum metabolomics researches.
[Mh] Termos MeSH primário: Linfoma Cutâneo de Células T/sangue
Linfoma Cutâneo de Células T/metabolismo
Metaboloma/fisiologia
Metabolômica/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Cromatografia Líquida de Alta Pressão
Análise por Conglomerados
Feminino
Seres Humanos
Masculino
Meia-Idade
Curva ROC
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:28460430
[Au] Autor:Lin D; Ettinger SL; Qu S; Xue H; Nabavi N; Choi SYC; Bell RH; Mo F; Haegert AM; Gout PW; Fleshner N; Gleave ME; Pollak M; Collins CC; Wang Y
[Ad] Endereço:The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
[Ti] Título:Metabolic heterogeneity signature of primary treatment-naïve prostate cancer.
[So] Source:Oncotarget;8(16):25928-25941, 2017 Apr 18.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To avoid over- or under-treatment of primary prostate tumours, there is a critical need for molecular signatures to discriminate indolent from aggressive, lethal disease. Reprogrammed energy metabolism is an important hallmark of cancer, and abnormal metabolic characteristics of cancers have been implicated as potential diagnostic/prognostic signatures. While genomic and transcriptomic heterogeneity of prostate cancer is well documented and associated with tumour progression, less is known about metabolic heterogeneity of the disease. Using a panel of high fidelity patient-derived xenograft (PDX) models derived from hormone-naïve prostate cancer, we demonstrated heterogeneity of expression of genes involved in cellular energetics and macromolecular biosynthesis. Such heterogeneity was also observed in clinical, treatment-naïve prostate cancers by analyzing the transcriptome sequencing data. Importantly, a metabolic gene signature of increased one-carbon metabolism or decreased proline degradation was identified to be associated with significantly decreased biochemical disease-free patient survival. These results suggest that metabolic heterogeneity of hormone-naïve prostate cancer is of biological and clinical importance and motivate further studies to determine the heterogeneity in metabolic flux in the disease that may lead to identification of new signatures for tumour/patient stratification and the development of new strategies and targets for therapy of prostate cancer.
[Mh] Termos MeSH primário: Metabolismo Energético/genética
Neoplasias da Próstata/genética
Neoplasias da Próstata/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Análise por Conglomerados
Modelos Animais de Doenças
Perfilação da Expressão Gênica
Xenoenxertos
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Redes e Vias Metabólicas
Camundongos
Prognóstico
Neoplasias da Próstata/mortalidade
Neoplasias da Próstata/patologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15237


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[PMID]:27776836
[Au] Autor:Barsevick A
[Ad] Endereço:Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA Guest Editor.
[Ti] Título:Symptom Clusters.
[So] Source:Semin Oncol Nurs;32(4):333, 2016 11.
[Is] ISSN:1878-3449
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias/diagnóstico
Neoplasias/patologia
Enfermagem Oncológica/métodos
[Mh] Termos MeSH secundário: Análise por Conglomerados
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  10 / 54503 MEDLINE  
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[PMID]:29465556
[Au] Autor:Ni Y; Jiang C
[Ad] Endereço:Department of Spine Surgery.
[Ti] Título:Identification of potential target genes for ankylosing spondylitis treatment.
[So] Source:Medicine (Baltimore);97(8):e9760, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to identify the potential target genes for the treatment of ankylosing spondylitis (AS).Dataset GSE25101 was downloaded from Gene Expression Omnibus, including 16 AS and 16 normal control blood samples. Differentially expressed genes (DEGs) were identified using unmatched t-test in limma package with adjusted P < .05. Gene ontology-biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using multifaceted analysis tool for human transcriptome. Protein-protein interaction (PPI) network was constructed using STRING and Cytoscape, and module analysis was performed using MCODE plug-in. Webgestal was utilized to predict transcriptional factor (TF)-microRNA-target network and Comparative Toxicogenomics Database (CTD) was applied to predict chemical-target network.A total of 334 DEGs were identified, including 136 upregulated genes and 198 downregulated genes. According to STRING, a PPI network was constructed and 1 significant clustered module was screen out with score = 6.33. MAPK7 (degree = 11) and NDUFS4 (degree = 10) were 2 important nodes in PPI network, and both of them were significantly enriched in cAMP mediated signaling pathway (P = 2.02E-02). MAPK7 could be regulated by NFY. Both MAPK7 and NDUFS4 were 2 potential targets for Indomethacin.MAPK7 and NDUFS4 played important roles in the pathogenesis of AS via cAMP mediated signaling pathway. Both of them could be targeted by Indomethacin.
[Mh] Termos MeSH primário: Proteína Quinase 7 Ativada por Mitógeno/sangue
NADH Desidrogenase/sangue
Mapeamento de Interação de Proteínas/métodos
Mapas de Interação de Proteínas/genética
Espondilite Anquilosante/genética
[Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/farmacologia
Estudos de Casos e Controles
Análise por Conglomerados
Biologia Computacional
Redes Reguladoras de Genes
Seres Humanos
Indometacina/farmacologia
Transdução de Sinais/genética
Espondilite Anquilosante/sangue
Espondilite Anquilosante/tratamento farmacológico
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); EC 1.6.5.3 (NDUFS4 protein, human); EC 1.6.99.3 (NADH Dehydrogenase); EC 2.7.11.24 (MAPK7 protein, human); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 7); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009760



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