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[PMID]:29362788
[Au] Autor:Serghiou S; Ioannidis JPA
[Ad] Endereço:Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
[Ti] Título:Altmetric Scores, Citations, and Publication of Studies Posted as Preprints.
[So] Source:JAMA;319(4):402-404, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bibliometria
Publicações Periódicas como Assunto
Editoração
[Mh] Termos MeSH secundário: Internet
Modelos Estatísticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.21168


  2 / 81218 MEDLINE  
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[PMID]:29318276
[Au] Autor:Plevritis SK; Munoz D; Kurian AW; Stout NK; Alagoz O; Near AM; Lee SJ; van den Broek JJ; Huang X; Schechter CB; Sprague BL; Song J; de Koning HJ; Trentham-Dietz A; van Ravesteyn NT; Gangnon R; Chandler Y; Li Y; Xu C; Ergun MA; Huang H; Berry DA; Mandelblatt JS
[Ad] Endereço:Departments of Radiology and Biomedical Data Science, School of Medicine, Stanford University, Stanford, California.
[Ti] Título:Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012.
[So] Source:JAMA;319(2):154-164, 2018 01 09.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Given recent advances in screening mammography and adjuvant therapy (treatment), quantifying their separate and combined effects on US breast cancer mortality reductions by molecular subtype could guide future decisions to reduce disease burden. Objective: To evaluate the contributions associated with screening and treatment to breast cancer mortality reductions by molecular subtype based on estrogen-receptor (ER) and human epidermal growth factor receptor 2 (ERBB2, formerly HER2 or HER2/neu). Design, Setting, and Participants: Six Cancer Intervention and Surveillance Network (CISNET) models simulated US breast cancer mortality from 2000 to 2012 using national data on plain-film and digital mammography patterns and performance, dissemination and efficacy of ER/ERBB2-specific treatment, and competing mortality. Multiple US birth cohorts were simulated. Exposures: Screening mammography and treatment. Main Outcomes and Measures: The models compared age-adjusted, overall, and ER/ERBB2-specific breast cancer mortality rates from 2000 to 2012 for women aged 30 to 79 years relative to the estimated mortality rate in the absence of screening and treatment (baseline rate); mortality reductions were apportioned to screening and treatment. Results: In 2000, the estimated reduction in overall breast cancer mortality rate was 37% (model range, 27%-42%) relative to the estimated baseline rate in 2000 of 64 deaths (model range, 56-73) per 100 000 women: 44% (model range, 35%-60%) of this reduction was associated with screening and 56% (model range, 40%-65%) with treatment. In 2012, the estimated reduction in overall breast cancer mortality rate was 49% (model range, 39%-58%) relative to the estimated baseline rate in 2012 of 63 deaths (model range, 54-73) per 100 000 women: 37% (model range, 26%-51%) of this reduction was associated with screening and 63% (model range, 49%-74%) with treatment. Of the 63% associated with treatment, 31% (model range, 22%-37%) was associated with chemotherapy, 27% (model range, 18%-36%) with hormone therapy, and 4% (model range, 1%-6%) with trastuzumab. The estimated relative contributions associated with screening vs treatment varied by molecular subtype: for ER+/ERBB2-, 36% (model range, 24%-50%) vs 64% (model range, 50%-76%); for ER+/ERBB2+, 31% (model range, 23%-41%) vs 69% (model range, 59%-77%); for ER-/ERBB2+, 40% (model range, 34%-47%) vs 60% (model range, 53%-66%); and for ER-/ERBB2-, 48% (model range, 38%-57%) vs 52% (model range, 44%-62%). Conclusions and Relevance: In this simulation modeling study that projected trends in breast cancer mortality rates among US women, decreases in overall breast cancer mortality from 2000 to 2012 were associated with advances in screening and in adjuvant therapy, although the associations varied by breast cancer molecular subtype.
[Mh] Termos MeSH primário: Neoplasias da Mama/mortalidade
Detecção Precoce de Câncer
Mamografia
Modelos Estatísticos
[Mh] Termos MeSH secundário: Neoplasias da Mama/diagnóstico por imagem
Neoplasias da Mama/terapia
Feminino
Seres Humanos
Mamografia/métodos
Mortalidade/tendências
Receptor ErbB-2
Receptores Estrogênicos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Estrogen); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19130


  3 / 81218 MEDLINE  
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[PMID]:28461122
[Au] Autor:Werisch M; Berger U; Berendonk TU
[Ad] Endereço:Technische Universität Dresden, Department of Forest Sciences, Institute of Forest Growth and Forest Computer Sciences, Tharandt 01735, Germany. Electronic address: martin.werisch@tu-dresden.de.
[Ti] Título:Conjugative plasmids enable the maintenance of low cost non-transmissible plasmids.
[So] Source:Plasmid;91:96-104, 2017 May.
[Is] ISSN:1095-9890
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some plasmids can be transferred by conjugation to other bacterial hosts. But almost half of the plasmids are non-transmissible. These plasmid types can only be transmitted to the daughter cells of their host after bacterial fission. Previous studies suggest that non-transmissible plasmids become extinct in the absence of selection of their encoded traits, as plasmid-free bacteria are more competitive. Here, we aim to identify mechanisms that enable non-transmissible plasmids to persist, even if they are not beneficial. For this purpose, an individual-based model for plasmid population dynamics was set up and carefully tested for structural consistency and plausibility. Our results demonstrate that non-transmissible plasmids can be stably maintained in a population, even if they impose a substantial burden on their host cells growth. A prerequisite is the co-occurrence of an incompatible and costly conjugative plasmid type, which indirectly facilitates the preservation of the non-transmissible type. We suggest that this constellation might be considered as a potential mechanism maintaining plasmids and associated antibiotic resistances. It should be investigated in upcoming laboratory experiments.
[Mh] Termos MeSH primário: Bactérias/genética
Conjugação Genética
Regulação Bacteriana da Expressão Gênica
Transferência Genética Horizontal
Modelos Estatísticos
Plasmídeos/química
[Mh] Termos MeSH secundário: Bactérias/metabolismo
Simulação por Computador
Aptidão Genética
Plasmídeos/metabolismo
Seleção Genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  4 / 81218 MEDLINE  
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[PMID]:28461121
[Au] Autor:Hall JPJ; Brockhurst MA; Dytham C; Harrison E
[Ad] Endereço:Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK.
[Ti] Título:The evolution of plasmid stability: Are infectious transmission and compensatory evolution competing evolutionary trajectories?
[So] Source:Plasmid;91:90-95, 2017 May.
[Is] ISSN:1095-9890
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Conjugative plasmids are widespread and play an important role in bacterial evolution by accelerating adaptation through horizontal gene transfer. However, explaining the long-term stability of plasmids remains challenging because segregational loss and the costs of plasmid carriage should drive the loss of plasmids though purifying selection. Theoretical and experimental studies suggest two key evolutionary routes to plasmid stability: First, the evolution of high conjugation rates would allow plasmids to survive through horizontal transmission as infectious agents, and second, compensatory evolution to ameliorate the cost of plasmid carriage can weaken purifying selection against plasmids. How these two evolutionary strategies for plasmid stability interact is unclear. Here, we summarise the literature on the evolution of plasmid stability and then use individual based modelling to investigate the evolutionary interplay between the evolution of plasmid conjugation rate and cost amelioration. We find that, individually, both strategies promote plasmid stability, and that they act together to increase the likelihood of plasmid survival. However, due to the inherent costs of increasing conjugation rate, particularly where conjugation is unlikely to be successful, our model predicts that amelioration is the more likely long-term solution to evolving stable bacteria-plasmid associations. Our model therefore suggests that bacteria-plasmid relationships should evolve towards lower plasmid costs that may forestall the evolution of highly conjugative, 'infectious' plasmids.
[Mh] Termos MeSH primário: Bactérias/genética
Conjugação Genética
Regulação Bacteriana da Expressão Gênica
Transferência Genética Horizontal
Modelos Estatísticos
Plasmídeos/química
[Mh] Termos MeSH secundário: Bactérias/metabolismo
Evolução Biológica
Cromossomos Bacterianos/química
Cromossomos Bacterianos/metabolismo
Aptidão Genética
Loci Gênicos
Mutagênese Insercional
Plasmídeos/metabolismo
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  5 / 81218 MEDLINE  
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[PMID]:28454568
[Au] Autor:Nguyen TL; Collins GS; Spence J; Daurès JP; Devereaux PJ; Landais P; Le Manach Y
[Ad] Endereço:Laboratory of Biostatistics, Epidemiology, Clinical Research and Health Economics, UPRES EA2415, Montpellier University, Montpellier, France.
[Ti] Título:Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance.
[So] Source:BMC Med Res Methodol;17(1):78, 2017 Apr 28.
[Is] ISSN:1471-2288
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the optimal imbalance threshold for entering covariates into regression. METHODS: We conducted a series of Monte Carlo simulations on virtual populations of 5,000 subjects. We performed PS 1:1 nearest-neighbor matching on each sample. We calculated standardized mean differences across groups to detect any remaining imbalance in the matched samples. We examined 25 thresholds (from 0.01 to 0.25, stepwise 0.01) for considering residual imbalance. The treatment effect was estimated using logistic regression that contained only those covariates considered to be unbalanced by these thresholds. RESULTS: We showed that regression adjustment could dramatically remove residual confounding bias when it included all of the covariates with a standardized difference greater than 0.10. The additional benefit was negligible when we also adjusted for covariates with less imbalance. We found that the mean squared error of the estimates was minimized under the same conditions. CONCLUSION: If covariate balance is not achieved, we recommend reiterating PS modeling until standardized differences below 0.10 are achieved on most covariates. In case of remaining imbalance, a double adjustment might be worth considering.
[Mh] Termos MeSH primário: Algoritmos
Modelos Estatísticos
Pontuação de Propensão
[Mh] Termos MeSH secundário: Viés
Simulação por Computador
Seres Humanos
Modelos Logísticos
Método de Monte Carlo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s12874-017-0338-0


  6 / 81218 MEDLINE  
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[PMID]:29252212
[Au] Autor:Khairani AZ; Ahmad NS; Khairani MZ
[Ad] Endereço:Ahmad Zamri Khairani, School of Educational Studies, 11800 Universiti Sains Malaysia, Penang, Malaysia, Ahmadzamri@usm.my.
[Ti] Título:Measuring Anger Types among Malaysian Adolescents using the Rasch Model.
[So] Source:J Appl Meas;18(4):449-458, 2017.
[Is] ISSN:1529-7713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adolescences is an important transitional phase in human development where they experience physiological as well as psychological changes. Nevertheless, these changes are often understood by teachers, parents, and even the adolescents themselves. Thus, conflicts exist and adolescents are affected from the conflict physically and emotionally. An important state of emotions that result from this conflict is anger. This article describes the development and validation of the 34-item Adolescent Anger Inventory (AAI) to measure types of anger among Malaysian adolescents. A sample of 2,834 adolescents in secondary school who provide responses that were analyzed using Rasch model measurement framework. The 4 response category worked satisfactorily for the scale developed. A total of 11 items did not fit to the model's expectations, and thus dropped from the final scale. The scale also demonstrated satisfactory reliability and separation evidence. Also, items in the AAI depicted no evidence of DIF between 14- and 16-year-old adolescents. Nevertheless, the AAI did not have sufficient items to target adolescents with a high level of physical aggressive anger.
[Mh] Termos MeSH primário: Ira
Interpretação Estatística de Dados
Avaliação Educacional/métodos
Modelos Estatísticos
Psicometria/métodos
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adolescente
Algoritmos
Simulação por Computador
Seres Humanos
Malásia/epidemiologia
Masculino
Prevalência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  7 / 81218 MEDLINE  
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[PMID]:29252211
[Au] Autor:Slantcheva-Durst S; Liu M
[Ad] Endereço:Snejana Slantcheva-Durst, Judith Herb College of Education, University of Toledo, 2801 W. Bancroft St., M.S. 954, Toledo, Ohio 43606-3390, USA, snejana.slantchevadurst@utoledo.edu.
[Ti] Título:Confidence to Perform in the Global Marketplace: Constructing and Validating a Survey Instrument for Community College Students.
[So] Source:J Appl Meas;18(4):434-448, 2017.
[Is] ISSN:1529-7713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article discusses the construction and validation of an instrument to gauge community college students' confidence to perform in the global marketplace. The instrument was designed to capture students' beliefs in their own abilities to successfully carry out job-related tasks in cross-cultural work environments that are globally-interconnected and constantly at flux. The instrument items emerged from a comprehensive review of literature, nationwide workforce skills initiatives, rounds of expert panel analyses, and focus groups. Items were formulated within Bandura's framework of self-efficacy, and the instrument was analyzed with Rasch measurement. The Rasch analysis, conducted on a sample of 741 students, provided evidence of the content validity of the items, the generalizability of the measure, and its external validity. The instrument can offer useful feedback to community college internationalization-focused staff in their efforts to assess outcomes of international initiatives for community college students, thus supporting program assessment, evaluation of student growth, and institutional decision-making.
[Mh] Termos MeSH primário: Modelos Estatísticos
Autoeficácia
Estudantes/estatística & dados numéricos
Inquéritos e Questionários
Universidades/estatística & dados numéricos
[Mh] Termos MeSH secundário: Avaliação Educacional/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  8 / 81218 MEDLINE  
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[PMID]:29252210
[Au] Autor:Lange R; Martinez-Garrido C; Ventura A
[Ad] Endereço:Rense Lange, 107 Carefree Dr., Chatham, IL 62629, USA, Rense.Lange@gmail.com.
[Ti] Título:I'm scared to go to School! Capturing the Effects of Chronic Daily Fears on Students' Concept of Self.
[So] Source:J Appl Meas;18(4):420-433, 2017.
[Is] ISSN:1529-7713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Students may experience considerable fear and stress in school settings, and based on Dweck's (2006) notion of "mindset" we hypothesized that fear introduces qualitative changes in students' self-concepts. Hypotheses were tested on 3847 third-grade students from nine Iberoamerican countries (Bolivia, Chile, Colombia, Cuba, Ecuador, Panama, Peru, Spain, and Venezuela), who completed Murillo's (2007) adaptation of Marsh' (1988) SDQ-I. Rasch scaling indicated that the information-content of High-Fear students' ratings was more localized across the latent dimension than was that of Low-Fear students, and their ratings also showed less cognitive variety. The resulting measurement distortions could be captured via logistic regression over the ratings' residuals. Also, using training and validation samples (with respectively 60 and 40% of all cases), it proved possible to predict students' fear levels and their gender. We see the present findings as a first step towards implementing an online warning and detection system for signs of bullying among students.
[Mh] Termos MeSH primário: Ansiedade/epidemiologia
Ansiedade/psicologia
Interpretação Estatística de Dados
Psicometria/métodos
Estudantes/psicologia
Estudantes/estatística & dados numéricos
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adolescente
Algoritmos
Ansiedade/diagnóstico
Criança
Medo/psicologia
Feminino
Seres Humanos
Masculino
Modelos Estatísticos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
América do Sul/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  9 / 81218 MEDLINE  
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[PMID]:29252209
[Au] Autor:Schumacker RE; Hoi CKW
[Ad] Endereço:Randall Schumacker, Educational Research Hall, University of Alabama, 316 Carmichael, Box 807231, Tuscaloosa, AL 35487-0231, USA, rschumacker@ua.edu.
[Ti] Título:Social Desirability Amongst Chinese Teachers.
[So] Source:J Appl Meas;18(4):408-419, 2017.
[Is] ISSN:1529-7713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research has suggested that self-reported responses on surveys can be affected by a participant's tendency toward social desirability, which would prevent them from revealing their true feelings or behaviors. Researchers should provide evidence that their results have not been affected by socially desirable responses using the Marlowe-Crowne Social Desirability Scale (MC-SDS). Past research has used the 33-item original form and 13-item short form of the MC-SDS, although a few researchers have found questionable validation of the 13 item MC-SDS in several populations. Traditional factor analysis failed to converge on a factor structure. Therefore, the current research was conducted using a Rasch dichotomous model analysis on the original 33-item MC-SDS, a 20-item MC-SDS, and the 13-item MC-SDS. Findings indicated that the 33-item MC-SDS had several overlapping items, the 20-item MC-SDS provided a somewhat meaningful measure of social desirability, and the 13-item MC-SDS did not provide sufficient item distribution or separation to produce a meaningful measure. A researcher should check on the factor structure of the MC-SDS when using it in their research, especially with different cultural populations.
[Mh] Termos MeSH primário: Interpretação Estatística de Dados
Modelos Estatísticos
Psicometria/métodos
Professores Escolares/classificação
Professores Escolares/estatística & dados numéricos
Desejabilidade Social
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adulto
Algoritmos
China
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  10 / 81218 MEDLINE  
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[PMID]:29252208
[Au] Autor:Kulas JT; Smith JA; Xu H
[Ad] Endereço:John T. Kulas, 1046 Voyageur St., St. Cloud, MN 56303, USA, jtkulas@stcloudstate.edu.
[Ti] Título:Approximate Functional Relationship between IRT and CTT Item Discrimination Indices: A Simulation, Validation, and Practical Extension of Lord's (1980) Formula.
[So] Source:J Appl Meas;18(4):393-407, 2017.
[Is] ISSN:1529-7713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lord (1980) presented a purely conceptual equation to approximate the nonlinear functional relationship between classical test theory (CTT; aka true score theory) and item response theory (IRT) item discrimination indices. The current project proposes a modification to his equation that makes it useful in practice. The suggested modification acknowledges the more common contemporary CTT discrimination index of a corrected item-total correlation and incorporates item difficulty. We simulated slightly over 768 trillion individual item responses to uncover a best-fitting empirical function relating the IRT and CTT discrimination indices. To evaluate the effectiveness of the function, we applied it to real-world test data from 16 workforce and educational tests. Our modification results in shifted functional asymptotes, slopes, and points of inflection across item difficulties. Validation with the workforce and educational tests suggests good prediction under common assumption testing conditions (approximately normal distribution of abilities and moderate item difficulties) and greater precision than Lord's (1980) formula.
[Mh] Termos MeSH primário: Algoritmos
Interpretação Estatística de Dados
Avaliação Educacional/métodos
Modelos Estatísticos
Psicometria/métodos
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Avaliação Educacional/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE



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