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[PMID]: 28922778 [Au] Autor: Fanidi A; Muller DC; Yuan JM; Stevens VL; Weinstein SJ; Albanes D; Prentice R; Thomsen CA; Pettinger M; Cai Q; Blot WJ; Wu J; Arslan AA; Zeleniuch-Jacquotte A; McCullough ML; Le Marchand L; Wilkens LR; Haiman CA; Zhang X; Han J; Stampfer MJ; Smith-Warner SA; Giovannucci E; Giles GG; Hodge AM; Severi G; Johansson M; Grankvist K; Langhammer A; Krokstad S; Næss M; Wang R; Gao YT; Butler LM; Koh WP; Shu XO; Xiang YB; Li H; Zheng W; Lan Q; Visvanathan K; Bolton JH; Ueland PM; Midttun Ø; Ulvik A; Caporaso NE; Purdue M; Ziegler RG; Freedman ND; Buring JE [Ad] Endereço: Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, London, UK; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA; Department of Epide [Ti] Título: Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3). [So] Source: J Natl Cancer Inst;110(1), 2018 Jan 01. [Is] ISSN: 1460-2105 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups. Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6. [Mh] Termos MeSH primário: Ácido Fólico/sangue Neoplasias Pulmonares/epidemiologia Metionina/sangue Vitamina B 6/sangue [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Ásia/epidemiologia Austrália/epidemiologia Estudos de Casos e Controles Cotinina/sangue Europa (Continente)/epidemiologia Feminino Seres Humanos Incidência Neoplasias Pulmonares/sangue Masculino Meia-Idade Estudos Prospectivos Fatores de Proteção Fatores de Risco Fatores Sexuais Fumar/sangue Fumar/epidemiologia Estados Unidos/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 8059-24-3 (Vitamin B 6); 935E97BOY8 (Folic Acid); AE28F7PNPL (Methionine); K5161X06LL (Cotinine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170920 [St] Status: MEDLINE [do] DOI: 10.1093/jnci/djx119

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[PMID]: 28922784 [Au] Autor: Jiao L; Chen L; White DL; Tinker L; Chlebowski RT; Van Horn LV; Richardson P; Lane D; Sangi-Haghpeykar H; El-Serag HB [Ad] Endereço: Department of Medicine, Department of Obstetrics and Gynecology, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX; Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX; Division of Public Health Sciences, Fred [Ti] Título: Low-fat Dietary Pattern and Pancreatic Cancer Risk in the Women's Health Initiative Dietary Modification Randomized Controlled Trial. [So] Source: J Natl Cancer Inst;110(1), 2018 Jan 01. [Is] ISSN: 1460-2105 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Observational studies suggest that diet may influence pancreatic cancer risk. We investigated the effect of a low-fat dietary intervention on pancreatic cancer incidence. Methods: The Women's Health Initiative Dietary Modification (WHI-DM) trial is a randomized controlled trial conducted in 48 835 postmenopausal women age 50 to 79 years in the United States between 1993 and 1998. Women were randomly assigned to the intervention group (n = 19 541), with the goal of reducing total fat intake and increasing intake of vegetables, fruits, and grains, or to the usual diet comparison group (n = 29 294). The intervention concluded in March 2005. We evaluated the effect of the intervention on pancreatic cancer incidence with the follow-up through 2014 using the log-rank test and multivariable Cox proportional hazards regression model. All statistical tests were two-sided. Results: In intention-to-treat analyses including 46 200 women, 92 vs 165 pancreatic cancer cases were ascertained in the intervention vs the comparison group (P = .23). The multivariable hazard ratio (HR) of pancreatic cancer was 0.86 (95% confidence interval [CI] = 0.67 to 1.11). Risk was statistically significantly reduced among women with baseline body mass indexes (BMIs) of 25 kg/m2 or higher (HR = 0.71, 95% CI = 0.53 to 0.96), but not among women with BMIs of less than 25 kg/m2 (HR = 1.62, 95% CI = 0.97 to 2.71, Pinteraction = .01). Conclusions: A low-fat dietary intervention was associated with reduced pancreatic cancer incidence in women who were overweight or obese in the WHI-DM trial. Caution needs to be taken in interpreting the findings based on subgroup analyses. [Mh] Termos MeSH primário: Índice de Massa Corporal Dieta com Restrição de Gorduras Neoplasias Pancreáticas/epidemiologia Neoplasias Pancreáticas/prevenção & controle [Mh] Termos MeSH secundário: Idoso Grãos Comestíveis Feminino Seguimentos Frutas Seres Humanos Análise de Intenção de Tratamento Meia-Idade Obesidade/epidemiologia Modelos de Riscos Proporcionais Fatores de Proteção Estados Unidos Verduras [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170920 [St] Status: MEDLINE [do] DOI: 10.1093/jnci/djx117

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[PMID]: 28468786 [Au] Autor: Chang WT; Chang CL; Ho CH; Hong CS; Wang JJ; Chen ZC [Ad] Endereço: Department of Cardiology, Chi Mei Medical Center, Tainan, Taiwan. [Ti] Título: Long-Term Effects of Unprovoked Venous Thromboembolism on Mortality and Major Cardiovascular Events. [So] Source: J Am Heart Assoc;6(5), 2017 May 03. [Is] ISSN: 2047-9980 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Patients with unprovoked venous thromboembolism (VTE) are at an increased risk of mortality, but whether their cardiovascular risks also increase remains to be determined. We aimed to investigate the factors associated with overall mortality and major adverse cardiovascular events in patients with unprovoked VTE. METHODS AND RESULTS: We identified 2154 patients newly diagnosed with unprovoked VTE from Taiwan's National Health Insurance Database between 2000 and 2013, excluding those with reversible etiologies, underlying cancer, or autoimmune diseases. These patients with VTE were compared with an age-, sex-, and cardiovascular risk-matched cohort of 4308 controls. The risk of mortality and major adverse cardiovascular events in patients with VTE was 2.23 (CI, 1.93-2.57; <0.0001) and 1.86 (CI, 1.65-2.09; <0.0001) times, respectively, higher than that of the conditions in controls. These events mostly occurred during the first year after the diagnosis of unprovoked VTE. Among patients with VTE, advanced age, male sex, and comorbid diabetes mellitus indicated a higher incidence of mortality and major adverse cardiovascular events. Conversely, comorbid hyperlipidemia attenuated these risks. CONCLUSIONS: This nation-wide cohort study revealed that patients with unprovoked VTE, particularly older males with diabetes mellitus, had an elevated risk of both mortality and cardiovascular events. Risk of mortality and major adverse cardiovascular events were highest within the first year after diagnosis and persisted during the 10 years of follow-up. [Mh] Termos MeSH primário: Tromboembolia Venosa/mortalidade [Mh] Termos MeSH secundário: Adulto Fatores Etários Idoso Comorbidade Bases de Dados Factuais Diabetes Mellitus/diagnóstico Diabetes Mellitus/mortalidade Feminino Seres Humanos Hiperlipidemias/diagnóstico Hiperlipidemias/mortalidade Incidência Estimativa de Kaplan-Meier Masculino Meia-Idade Prognóstico Modelos de Riscos Proporcionais Fatores de Proteção Estudos Retrospectivos Medição de Risco Fatores de Risco Fatores Sexuais Taiwan/epidemiologia Fatores de Tempo Tromboembolia Venosa/diagnóstico Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28468783 [Au] Autor: Ramirez FD; Chen Y; Di Santo P; Simard T; Motazedian P; Hibbert B [Ad] Endereço: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. [Ti] Título: Association Between Self-Reported Potentially Modifiable Cardiac Risk Factors and Perceived Need to Improve Physical Health: A Population-Based Study. [So] Source: J Am Heart Assoc;6(5), 2017 May 03. [Is] ISSN: 2047-9980 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: An individual's perceived need to improve their physical health (PNIPH) is an essential precursor to adopting healthy behaviors. Nine potentially modifiable risk factors (PMRFs) for myocardial infarction collectively account for ≥90% of the population attributable risk. Though widely recognized, their impact on individuals' health perceptions is unclear. METHODS AND RESULTS: Residents from 6 provinces were administered a module on changes to improve health as part of the 2011-2012 Canadian Community Health Survey, yielding relevant data for 8 of the 9 PMRFs sought. The potential effects of PMRFs individually and cumulatively on PNIPH were examined using modified Poisson regression. In total, 45 443 respondents were included, representing 11 006 123 individuals and corresponding to 96.8% of the adult population of the sampled provinces. The sum of PMRFs was positively associated with PNIPH (adjusted prevalence ratio, 1.08; 95% CI, 1.07-1.09 per additional PMRF) with 82.3% of individuals with ≥5 PMRFs reporting this perception. Smoking, obesity, and low physical activity were most strongly associated with PNIPH, whereas hypertension and diabetes mellitus exhibited no association with this outcome after adjusting for potential confounders. Barriers to adopting healthy behaviors were reported by 55.9% of individuals endorsing PNIPH. CONCLUSIONS: The cumulative burden of PMRFs is positively associated with PNIPH; however, individual PMRFs differentially contribute to this perception. Among those at highest cardiac risk, ≈1 in 5 denied PNIPH. A better understanding of factors underlying health perceptions and behaviors is needed to capitalize on cardiovascular preventive efforts. [Mh] Termos MeSH primário: Comportamentos Relacionados com a Saúde Conhecimentos, Atitudes e Prática em Saúde Estilo de Vida Saudável Infarto do Miocárdio/prevenção & controle Percepção Comportamento de Redução do Risco Autorrelato [Mh] Termos MeSH secundário: Adolescente Adulto Canadá/epidemiologia Comorbidade Estudos Transversais Exercício Feminino Nível de Saúde Inquéritos Epidemiológicos Dieta Saudável Seres Humanos Masculino Meia-Idade Infarto do Miocárdio/diagnóstico Infarto do Miocárdio/epidemiologia Infarto do Miocárdio/psicologia Valor Preditivo dos Testes Prevalência Fatores de Proteção Medição de Risco Fatores de Risco Estilo de Vida Sedentário Fumar/efeitos adversos Fumar/epidemiologia Abandono do Hábito de Fumar Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28465301 [Au] Autor: Ritchey MD; Loustalot F; Wall HK; Steiner CA; Gillespie C; George MG; Wright JS [Ad] Endereço: Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA hha7@cdc.gov. [Ti] Título: Million Hearts: Description of the National Surveillance and Modeling Methodology Used to Monitor the Number of Cardiovascular Events Prevented During 2012-2016. [So] Source: J Am Heart Assoc;6(5), 2017 May 02. [Is] ISSN: 2047-9980 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: This study describes the national surveillance and modeling methodology developed to monitor achievement of the Million Hearts initiative's aim of preventing 1 million acute myocardial infarctions, strokes, and other related cardiovascular events during 2012-2016. METHODS AND RESULTS: We calculate sex- and age-specific cardiovascular event rates (combination of emergency department, hospitalization, and death events) among US adults aged ≥18 from 2006 to 2011 and, based on log-linear models fitted to the rates, calculate their annual percent change. We describe 2 baseline strategies to be used to compare observed versus expected event totals during 2012-2016: (1) assume no rate changes, with modeled 2011 rates held constant through 2016; and (2) assume 2006-2011 rate trends will continue, with the annual percent changes applied to the modeled 2011 rates to calculate expected 2012-2016 rates. Events prevented estimates during 2012-2013 were calculated using available data: 115 210 (95% CI, 60 858, 169 562) events were prevented using stable baselines and an excess of 43 934 (95% CI, -14 264, 102 132) events occurred using trend baselines. Women aged ≥75 had the most events prevented (stable, 76 242 [42 067, 110 417]; trend, 39 049 [1901, 76 197]). Men aged 45 to 64 had the greatest number of excess events (stable, 22 912 [95% CI, 855, 44 969]; trend, 38 810 [95% CI, 15 567, 62 053]). CONCLUSIONS: Around 115 000 events were prevented during the initiative's first 2 years compared with what would have occurred had 2011 rates remained stable. Recent flattening or reversals in some event rate trends were observed supporting intensifying national action to prevent cardiovascular events. [Mh] Termos MeSH primário: Doenças Cardiovasculares/prevenção & controle Serviços Preventivos de Saúde/tendências [Mh] Termos MeSH secundário: Adolescente Adulto Distribuição por Idade Idoso Idoso de 80 Anos ou mais Doenças Cardiovasculares/diagnóstico Doenças Cardiovasculares/mortalidade Bases de Dados Factuais Feminino Pesquisas sobre Serviços de Saúde Mortalidade Hospitalar/tendências Seres Humanos Masculino Meia-Idade Prognóstico Fatores de Proteção Fatores de Risco Distribuição por Sexo Fatores de Tempo Estados Unidos/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE

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[PMID]: 28453734 [Au] Autor: Hausenloy DJ; Garcia-Dorado D; Bøtker HE; Davidson SM; Downey J; Engel FB; Jennings R; Lecour S; Leor J; Madonna R; Ovize M; Perrino C; Prunier F; Schulz R; Sluijter JPG; Van Laake LW; Vinten-Johansen J; Yellon DM; Ytrehus K; Heusch G; Ferdinandy P [Ad] Endereço: The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road London, W1T 7DN, UK; Cardiovascular and Metabolic Disorders Program [Ti] Título: Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. [So] Source: Cardiovasc Res;113(6):564-585, 2017 May 01. [Is] ISSN: 1755-3245 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Ischaemic heart disease and the heart failure that often results, remain the leading causes of death and disability in Europe and worldwide. As such, in order to prevent heart failure and improve clinical outcomes in patients presenting with an acute ST-segment elevation myocardial infarction and patients undergoing coronary artery bypass graft surgery, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinic-however, their translation from experimental to clinical studies for improving patient outcomes has been both challenging and disappointing. Therefore, in this Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart, we critically analyse the current state of ischaemic conditioning in both the experimental and clinical settings, provide recommendations for improving its translation into the clinical setting, and highlight novel therapeutic targets and new treatment strategies for reducing acute myocardial IRI. [Mh] Termos MeSH primário: Cardiologia/métodos Fármacos Cardiovasculares/uso terapêutico Ponte de Artéria Coronária/efeitos adversos Insuficiência Cardíaca/prevenção & controle Precondicionamento Isquêmico/métodos Traumatismo por Reperfusão Miocárdica/prevenção & controle Intervenção Coronária Percutânea/efeitos adversos Infarto do Miocárdio com Supradesnível do Segmento ST/terapia Pesquisa Médica Translacional/métodos [Mh] Termos MeSH secundário: Animais Cardiologia/normas Fármacos Cardiovasculares/efeitos adversos Ponte de Artéria Coronária/normas Modelos Animais de Doenças Insuficiência Cardíaca/etiologia Insuficiência Cardíaca/patologia Insuficiência Cardíaca/fisiopatologia Seres Humanos Pós-Condicionamento Isquêmico/métodos Precondicionamento Isquêmico/efeitos adversos Precondicionamento Isquêmico/normas Precondicionamento Isquêmico Miocárdico/métodos Traumatismo por Reperfusão Miocárdica/etiologia Traumatismo por Reperfusão Miocárdica/patologia Traumatismo por Reperfusão Miocárdica/fisiopatologia Intervenção Coronária Percutânea/normas Fatores de Proteção Fatores de Risco Infarto do Miocárdio com Supradesnível do Segmento ST/complicações Infarto do Miocárdio com Supradesnível do Segmento ST/patologia Infarto do Miocárdio com Supradesnível do Segmento ST/fisiopatologia Pesquisa Médica Translacional/normas Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW [Nm] Nome de substância: 0 (Cardiovascular Agents) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/cvr/cvx049

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[PMID]: 29443768 [Au] Autor: Liu B; Deng T; Zhu L; Zhong J [Ad] Endereço: Department of Ophthalmology, the First Affiliated Hospital of Jinan University. [Ti] Título: Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. [So] Source: Medicine (Baltimore);97(7):e9914, 2018 Feb. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease. METHODS: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated from extracted data to access the strength of the association between a genotype and VKH. RESULTS: HLA-DQ4 was confirmed to increase the risk of VKH significantly (OR = 4.63, 95% CI: 1.74-12.31, P = .002), while HLA-DQ1 seemed to reduce VKH occurrence with OR = 0.32 (95% CI: 0.22-0.47, P < .00001). HLA-DQA1*0301-(OR = 4.52, 95% CI: 1.42-14.35, P = .01) and HLA-DQB1*0401-(OR = 23.12, 95% CI: 11.54-46.31, P < .00001) positive patients probably had a rising tendency to suffer from VKH. Alleles including HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 were significant protective genetic factors. CONCLUSION: We concluded that HLA-DQ4 carriers had a higher risk of VKH and HLA-DQ1 seemed to be protective. People with positive HLA-DQA1*0301 and HLA-DQB1*0401 demonstrated to be more susceptible to VKH. HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 could be potential protectors. [Mh] Termos MeSH primário: Antígenos HLA-DQ/genética Cadeias alfa de HLA-DQ/genética Cadeias beta de HLA-DQ/genética Síndrome Uveomeningoencefálica/genética [Mh] Termos MeSH secundário: Predisposição Genética para Doença Seres Humanos Fatores de Proteção [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (HLA-DQ Antigens); 0 (HLA-DQ alpha-Chains); 0 (HLA-DQ beta-Chains); 0 (HLA-DQ4 antigen); 0 (HLA-DQA1 antigen); 0 (HLA-DQB1 antigen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009914

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[PMID]: 27779104 [Au] Autor: Wang MJ; Yang HY; Zhang H; Zhou X; Liu RP; Mi YY [Ad] Endereço: Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China. [Ti] Título: TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis. [So] Source: Oncotarget;7(50):82933-82942, 2016 Dec 13. [Is] ISSN: 1949-2553 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 13 case-control studies for rs10499194 polymorphism and 6 studies for rs13207033 polymorphism were included. Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA. Stratification analyses of ethnicity indicated rs10499194, rs13207033 polymorphisms decreased the risk of RA among Caucasian populations, but not among Asian populations. In conclusion, this meta-analysis indicates that TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of RA, especially among Caucasian populations. [Mh] Termos MeSH primário: Artrite Reumatoide/genética Polimorfismo de Nucleotídeo Único Proteína 3 Induzida por Fator de Necrose Tumoral alfa/genética [Mh] Termos MeSH secundário: Artrite Reumatoide/diagnóstico Artrite Reumatoide/etnologia Artrite Reumatoide/prevenção & controle Grupo com Ancestrais do Continente Asiático/genética Estudos de Casos e Controles Distribuição de Qui-Quadrado Grupo com Ancestrais do Continente Europeu/genética Estudos de Associação Genética Predisposição Genética para Doença Seres Humanos Modelos Lineares Razão de Chances Fenótipo Fatores de Proteção Medição de Risco Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Nm] Nome de substância: EC 3.4.19.12 (TNFAIP3 protein, human); EC 3.4.19.12 (Tumor Necrosis Factor alpha-Induced Protein 3) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.18632/oncotarget.12638

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[PMID]: 29308836 [Au] Autor: Borovkova EI; Antipova NV; Komeenko TV; Shakhparonov MI; Borovkov IM [Ti] Título: Paraoxonase: The Universal Factor of Antioxidant Defense in Human Body. [So] Source: Vestn Ross Akad Med Nauk;72(1):5-10, 2017. [Is] ISSN: 0869-6047 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: The paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3 aligned in tandem on chromosome 7 in humans. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. Increased production of reactive oxygen species as a result of decreased activities of mitochondrial electron transport chain complexes plays a role in the development of many inflammatory diseases, including atherosclerosis. PON1 and PON3 proteins can be detected in plasma and reside in the high-density lipoprotein fraction and protect against oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages, and atherosclerotic lesions. Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower ROS levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells. In contrast to PON1 and PON3, PON2 is cell-associated and is not found in plasma. It is widely expressed in a variety of tissues, including the kidney, and protects against cellular oxidative stress. Overexpression of PON2 reduces oxidative status, prevents apoptosis in vascular endothelial cells, and inhibits cell-mediated low density lipoprotein oxidation. PON2 also inhibits the development of atherosclerosis, via mechanisms involving the reduction of oxidative stress. In this review we explore the physiological roles of PON in disease development and modulation of PONs by infective (bacterial, viral) agents. [Mh] Termos MeSH primário: Arildialquilfosfatase/fisiologia Aterosclerose/metabolismo Expressão Gênica Estresse Oxidativo/genética [Mh] Termos MeSH secundário: Seres Humanos Fatores de Proteção [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: EC 3.1.8.1 (Aryldialkylphosphatase) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180109 [St] Status: MEDLINE [do] DOI: 10.15690/vramn764

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[PMID]: 27776683 [Au] Autor: Davis JP; Dumas TM; Wagner EF; Merrin GJ [Ad] Endereço: University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address: jdavis37@illinois.edu. [Ti] Título: Social Ecological Determinants of Substance Use Treatment Entry Among Serious Juvenile Offenders From Adolescence Through Emerging Adulthood. [So] Source: J Subst Abuse Treat;71:8-15, 2016 12. [Is] ISSN: 1873-6483 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To examine the social-ecological determinants of substance use treatment entry among serious juvenile offenders over a 7 year period. Using the social-ecological framework, relevant predictors of substance use from the literature were used to assess risk (and protective) factors at the individual, parental, peer and neighborhood level. METHOD: Serious juvenile offenders (N=1354, M =16.0 years, SD=1.14) were prospectively followed over 7 years (M =23.0 years, SD=1.15). Cox regression with time invariant and time varying predictors was used to predict time to first substance use treatment entry. RESULTS: Results for each dimension, separately, varied slightly from the full model. In the full model peer delinquency, peer arrests, post-traumatic stress disorder (PTSD), impulse control, temperament, and emotional regulation remained salient risk (and protective) factors for treatment entry. CONCLUSION: Associating with more deviant peers and having more of your peers arrested over the 7 year study period was associated with substantial increase in time to treatment entry. Furthermore, one of the strongest risk factors for treatment entry was a PTSD diagnosis. Treatment implications are discussed regarding peer affiliation and PTSD symptomology as well as potential neurological and biological contributors to increased risk for treatment entry. [Mh] Termos MeSH primário: Criminosos/estatística & dados numéricos Delinquência Juvenil/estatística & dados numéricos Meio Social Transtornos de Estresse Pós-Traumáticos/epidemiologia Transtornos Relacionados ao Uso de Substâncias/epidemiologia Transtornos Relacionados ao Uso de Substâncias/terapia [Mh] Termos MeSH secundário: Adolescente Adulto Feminino Seres Humanos Estudos Longitudinais Masculino Pais Grupo Associado Fatores de Proteção Fatores de Risco Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 180215 [Lr] Data última revisão: 180215 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE

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