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Pesquisa : E05.325.192 [Categoria DeCS]
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[PMID]:28460835
[Au] Autor:Madularu D; Kumaragamage C; Mathieu AP; Kulkarni P; Rajah MN; Gratton AP; Near J
[Ad] Endereço:Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; Brain Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. Electronic address: dan.madularu@gmail.com.
[Ti] Título:A chronic in situ coil system adapted for intracerebral stimulation during MRI in rats.
[So] Source:J Neurosci Methods;284:85-95, 2017 Jun 01.
[Is] ISSN:1872-678X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We describe the fabrication and performance of a chronic in situ coil system designed to allow focal brain stimulation in rats while acquiring functional MRI data. NEW METHOD: An implantable receive-only surface radiofrequency coil (iCoil) was designed to be fitted subcutaneously, directly onto to the rat skull surface during the intracerebral cannulation procedure. The coil is fixed in place using acrylic dental cement anchored to four screws threaded into the skull. To demonstrate the use of this coil system in situ, whole-brain functional MRI scans were acquired during various stimuli, including intracranial microinfusions of bicuculline and morphine in the prefrontal cortex and ventral tegmental area, respectively. RESULTS/COMPARISON TO OTHER METHODS: SNR performance of the iCoil was superior to three commercially-available coils, in some instances by a factor of two. Widespread BOLD activation was observed in response to bicuculline and morphine microinfusions. CONCLUSION: A new approach was demonstrated for high-SNR MR imaging of the brain in rats with intracranial implants using an implantable surface coil. This approach enables mapping the functional response to highly targeted stimuli such as intracranial microinfusions.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Estimulação Encefálica Profunda/instrumentação
Estimulação Encefálica Profunda/veterinária
Bombas de Infusão Implantáveis
Imagem por Ressonância Magnética/instrumentação
Imagem por Ressonância Magnética/veterinária
Microinjeções/veterinária
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
Análise de Falha de Equipamento
Masculino
Microinjeções/instrumentação
Próteses e Implantes
Ratos
Ratos Long-Evans
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Transdutores/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:27775510
[Au] Autor:Lucisano JY; Routh TL; Lin JT; Gough DA
[Ti] Título:Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model.
[So] Source:IEEE Trans Biomed Eng;64(9):1982-1993, 2017 09.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The use of a fully implanted first-generation prototype sensor/telemetry system is described for long-term monitoring of subcutaneous tissue glucose in a small cohort of people with diabetes. METHODS: Sensors are based on a membrane containing immobilized glucose oxidase and catalase coupled to oxygen electrodes and a telemetry system, integrated as an implant. The devices remained implanted for up to 180 days, with signals transmitted every 2 min to external receivers. RESULTS: The data include signal recordings from glucose clamps and spontaneous glucose excursions, matched, respectively, to reference blood glucose and finger-stick values. The sensor signals indicate dynamic tissue glucose, for which there is no independent standard, and a model describing the relationship between blood glucose and the signal is, therefore, included. The values of all model parameters have been estimated, including the permeability of adjacent tissues to glucose, and equated to conventional mass transfer parameters. As a group, the sensor calibration varied randomly at an average rate of -2.6%/week. Statistical correlation indicated strong association between the sensor signals and reference glucose values. CONCLUSION: Continuous long-term glucose monitoring in individuals with diabetes is feasible with this system. SIGNIFICANCE: All therapies for diabetes are based on glucose control, and therefore, require glucose monitoring. This fully implanted long-term sensor/telemetry system may facilitate a new era of management of the disease.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Glicemia/análise
Diabetes Mellitus/sangue
Monitorização Ambulatorial/instrumentação
Monitorização Ambulatorial/métodos
Próteses e Implantes
Telemetria/instrumentação
[Mh] Termos MeSH secundário: Glicemia/química
Condutometria/instrumentação
Diabetes Mellitus/diagnóstico
Fontes de Energia Elétrica
Desenho de Equipamento
Análise de Falha de Equipamento
Estudos de Viabilidade
Glucose Oxidase/química
Seres Humanos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Integração de Sistemas
Transdutores
Tecnologia sem Fio/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Blood Glucose); EC 1.1.3.4 (Glucose Oxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2619333


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[PMID]:29381289
[Au] Autor:Ling Q; Wang T; Yu X; Wang SG; Ye ZQ; Liu JH; Yang SW; Zhu XB; Yu J
[Ti] Título:UC-VEGF-SMC Three Dimensional (3D) Nano Scaffolds Exhibits Good Repair Function in Bladder Damage.
[So] Source:J Biomed Nanotechnol;13(3):313-23, 2017 Mar.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We constructed a UC-VEGF-SMC three dimensional (3D) scaffold to explore its effect on blood vessel regeneration and bladder repair function in a rabbit model with bladder injury. Rabbit adipose tissue-derived stem cells (ADSCs) were cultured to construct pluripotent stem cell systems that can be induced to differentiate into urothelial cells (UCs) and smooth muscle cells (SMCs). Reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), immunofluorescence, MTT assay and HE staining were used in our study. Rabbit models were divided into an experimental group, control group and sham group. The bladder histology, urodynamics, smooth muscle function, stent degradation rate, urothelial permeability and biomechanical determination of rabbits were detected after grafting the scaffold. Correct stem cells based on the ADSC surface marker and found that CD90 and CD105 were positive and that CD34 and CD45 were negative. RT-PCR showed that ADSC-iPS cells expressed the marker gene of embryonic stem cells (ESCs), which indicated that Sox2, Klf4, Oct4 and c-Myc were inserted into the iPS nucleus and that the ADSC-iPS system was constructed successfully. Immunofluorescence and MTT assays indicated that iPS differentiated into mature SMCs and UCs. ELISA and HEMC culturing methods revealed that vascular endothelia growth factor (VEGF) could promote the growth of HMECs. Rabbit bladder repair function (urodynamics, smooth muscle function, urothelial permeability and biomechanical determination) was stronger in the experimental group than in the control group. UC-VEGF-SMC 3D nano scaffold exhibits good repair function for bladder damage, which may helpful for treatment of damaged bladders.
[Mh] Termos MeSH primário: Regeneração Tecidual Guiada/instrumentação
Nanoestruturas/química
Transplante de Células-Tronco/instrumentação
Tecidos Suporte
Doenças da Bexiga Urinária/patologia
Doenças da Bexiga Urinária/terapia
Fator A de Crescimento do Endotélio Vascular/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Regeneração Tecidual Guiada/métodos
Masculino
Nanocápsulas/administração & dosagem
Nanocápsulas/química
Nanocápsulas/ultraestrutura
Nanoestruturas/ultraestrutura
Impressão Tridimensional
Coelhos
Recuperação de Função Fisiológica
Transplante de Células-Tronco/métodos
Células-Tronco/citologia
Células-Tronco/fisiologia
Engenharia Tecidual/instrumentação
Engenharia Tecidual/métodos
Resultado do Tratamento
Doenças da Bexiga Urinária/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanocapsules); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:29381285
[Au] Autor:Wu T; Zhang J; Wang Y; Sun B; Guo X; Morsi Y; El-Hamshary H; El-Newehy M; Mo X
[Ti] Título:Development of Dynamic Liquid and Conjugated Electrospun Poly(L-lactide-co-caprolactone)/Collagen Nanoyarns for Regulating Vascular Smooth Muscle Cells Growth.
[So] Source:J Biomed Nanotechnol;13(3):303-12, 2017 Mar.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Simulating the modeling of smooth muscle layer in the vascular structure makes a great difference for vascular tissue regeneration. A functional tissue engineered vascular media shall promote the aligned organization and three-dimensional penetration of smooth muscle cells (SMCs) into the scaffold. To this aim, dynamic liquid and conjugated nanoyarns based on poly(L-lactide-co-caprolactone) (P(LLA-CL)) and collagen (COL) with a weight ratio at 3:1 were fabricated by electrospinning methods, with random and aligned nanofibers as control groups. The Fourier transform infrared spectroscopy and X-ray diffraction analyses confirmed the preservation of P(LLA-CL)/COL components and structure. Scanning electron microscope (SEM) results indicated a significant increase of yarn diameters at 19.27 ± 6.16 µm (dynamic liquid) and 10.24 ± 3.09 µm (conjugated), and both of the nanoyarns had improved mechanical tensile properties than the random nanofibers. Compared with random and aligned nanofibers, the nanoyarns presented significant higher porosity and larger pore diameter, leading to a decrease of water contact angle and a promotion of SMCs proliferation and migration. Better SMCs orientation was observed on the conjugated nanoyarns, while superior SMCs penetration was achieved on the dynamic liquid nanoyarns, owing to the differences in yarns microstructure. Herein, this study demonstrated that the aligned and porous P(LLA-CL)/COL nanoyarns fabricated by dynamic liquid and conjugated electrospinning were beneficial to regulating vascular SMCs outgrowth, which had important implications for functional reconstruction of vascular media.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/síntese química
Colágeno/química
Músculo Liso Vascular/citologia
Miócitos de Músculo Liso/citologia
Nanoconjugados/química
Poliésteres/química
Tecidos Suporte
[Mh] Termos MeSH secundário: Proliferação Celular/fisiologia
Células Cultivadas
Galvanoplastia/métodos
Desenho de Equipamento
Análise de Falha de Equipamento
Seres Humanos
Músculo Liso Vascular/fisiologia
Miócitos de Músculo Liso/fisiologia
Nanoconjugados/ultraestrutura
Rotação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Nanoconjugates); 0 (Polyesters); 0 (poly(lactic acid-co-epsilon-caprolactone)); 9007-34-5 (Collagen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:29381284
[Au] Autor:Sun F; Shi T; Zhou T; Dong D; Xie J; Wang R; An X; Chen M; Cai J
[Ti] Título:3D Poly(Lactic-co-glycolic acid) Scaffolds for Treating Spinal Cord Injury.
[So] Source:J Biomed Nanotechnol;13(3):290-302, 2017 Mar.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, poly(lactic-co-glycolic acid) (PLGA) was used to fabricate spinal cord scaffolds using low temperature deposition manufacturing (LDM) technology. The PLGA scaffolds were characterized as having good porosity, hydrophilicity and considerable biodegradability. The effects of the PLGA scaffolds on cell proliferation and cytotoxicity were evaluated by culturing Schwann cells (SCs) on the surfaces of the scaffolds. The results showed that the SCs spread and proliferated well on the PLGA scaffolds. Histological assessment including Glia fibrillary acidic protein (GFAP) staining, Nissl staining, Luxol fast blue (LFB) staining and Bielschowsky silver staining showed that the spinal cord recoveries considerably improved with the PLGA scaffolds, indicating that the PLGA scaffolds exhibited potential for applications in the management of spinal cord injuries.
[Mh] Termos MeSH primário: Regeneração Tecidual Guiada/instrumentação
Ácido Láctico/química
Ácido Poliglicólico/química
Células de Schwann/transplante
Traumatismos da Medula Espinal/terapia
Regeneração da Medula Espinal/fisiologia
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Masculino
Impressão Tridimensional
Ratos
Ratos Sprague-Dawley
Células de Schwann/citologia
Traumatismos da Medula Espinal/patologia
Engenharia Tecidual/instrumentação
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (polylactic acid-polyglycolic acid copolymer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:29395078
[Au] Autor:Han S; Lee JY; Heo EY; Kwon IK; Yune TY; Youn I
[Ad] Endereço:Biomedical Research Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02791, Republic of Korea.
[Ti] Título:Implantation of a Matrigel-loaded agarose scaffold promotes functional regeneration of axons after spinal cord injury in rat.
[So] Source:Biochem Biophys Res Commun;496(3):785-791, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An agarose scaffold can be useful for supporting and guiding injured axons after spinal cord injury (SCI), but the electrophysiological signal of regenerated axon in scaffolds has not yet been determined. The current study investigated whether a Matrigel-loaded agarose scaffold would enhance the regeneration of axons after SCI. Moreover, the functional connectivity of regenerated axons within the channels of the scaffold was evaluated by directly recording motor evoked potentials. Our data showed that the agarose scaffold containing Matrigel can support and enhance linearly organized axon regeneration after SCI. Additionally, motor evoked potentials were successfully recorded from regenerated axons. These results demonstrate that an agarose scaffold loaded with Matrigel could promote the regeneration of axons and guide the reconnection of functional axons after SCI.
[Mh] Termos MeSH primário: Axônios/patologia
Colágeno/química
Regeneração Tecidual Guiada/instrumentação
Laminina/química
Regeneração Nervosa/fisiologia
Proteoglicanas/química
Traumatismos da Medula Espinal/patologia
Traumatismos da Medula Espinal/terapia
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Materiais Biomiméticos/síntese química
Combinação de Medicamentos
Desenho de Equipamento
Análise de Falha de Equipamento
Masculino
Crescimento Neuronal
Próteses e Implantes
Ratos
Ratos Sprague-Dawley
Recuperação de Função Fisiológica
Sefarose/química
Traumatismos da Medula Espinal/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Laminin); 0 (Proteoglycans); 119978-18-6 (matrigel); 9007-34-5 (Collagen); 9012-36-6 (Sepharose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


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[PMID]:25816782
[Au] Autor:Jimenez-Palomar I; Shipov A; Shahar R; Barber AH
[Ad] Endereço:Department of Materials, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK.
[Ti] Título:Structural orientation dependent sub-lamellar bone mechanics.
[So] Source:J Mech Behav Biomed Mater;52:63-71, 2015 Dec.
[Is] ISSN:1878-0180
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The lamellar unit is a critical component in defining the overall mechanical properties of bone. In this paper, micro-beams of bone with dimensions comparable to the lamellar unit were fabricated using focused ion beam (FIB) microscopy and mechanically tested in bending to failure using atomic force microscopy (AFM). A variation in the mechanical properties, including elastic modulus, strength and work to fracture of the micro-beams was observed and related to the collagen fibril orientation inferred from back-scattered scanning electron microscopy (SEM) imaging. Established mechanical models were further applied to describe the relationship between collagen fibril orientation and mechanical behaviour of the lamellar unit. Our results highlight the ability to measure mechanical properties of discrete bone volumes directly and correlate with structural orientation of collagen fibrils.
[Mh] Termos MeSH primário: Fêmur
Fenômenos Mecânicos
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Análise de Falha de Equipamento
Ratos
Ratos Sprague-Dawley
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150331
[St] Status:MEDLINE


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[PMID]:29309789
[Au] Autor:Ke M; Cai S; Zou M; Zhao Y; Li B; Chen S; Chen L
[Ad] Endereço:College of Bioengineering, Chongqing University, Chongqing, 400044, China.
[Ti] Título:A microfluidic device for study of the effect of tumor vascular structures on the flow field and HepG2 cellular flow behaviors.
[So] Source:Biochem Biophys Res Commun;496(1):238-243, 2018 01 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To build a microfluidic device with various morphological features of the tumor vasculature for study of the effects of tumor vascular structures on the flow field and tumor cellular flow behaviors. The designed microfluidic device was able to approximatively simulate the in vivo structures of tumor vessels and the flow within it. In this models, the influences of the angle of bifurcation, the number of branches, and the narrow channels on the flow field and the influence of vorticity on the retention of HepG2 cells were significant. Additionally, shear stress below physiological conditions of blood circulation has considerable effect on the formation of the lumen-like structures (LLSs) of HepG2 cells. These results can provide some data and reference in the understanding of the interaction between hemorheological properties and tumor vascular structures in solid tumors.
[Mh] Termos MeSH primário: Reatores Biológicos
Técnicas de Cultura de Células/instrumentação
Separação Celular/instrumentação
Células Hep G2/fisiologia
Dispositivos Lab-On-A-Chip
Neovascularização Patológica/fisiopatologia
[Mh] Termos MeSH secundário: Desenho de Equipamento
Análise de Falha de Equipamento
Células Hep G2/patologia
Seres Humanos
Neovascularização Patológica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


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[PMID]:28462479
[Au] Autor:DeMarco AL; Good CA; Chimich DD; Bakal JA; Siegmund GP
[Ad] Endereço:MEA Forensic Engineers & Scientists, 11-11151 Horseshoe Way, Richmond, BC, V7A 4S5, Canada.
[Ti] Título:Age has a Minimal Effect on the Impact Performance of Field-Used Bicycle Helmets.
[So] Source:Ann Biomed Eng;45(8):1974-1984, 2017 08.
[Is] ISSN:1573-9686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helmet manufacturers recommend replacing a bicycle helmet after an impact or after anywhere from 2 to 10 years of use. The goal of this study was to quantify the effect of helmet age on peak headform acceleration during impact attenuation testing of field-used bicycle helmets. Helmets were acquired by donation from consumers and retail stores, and were included in the study if they were free of impact-related damage, had a legible manufacture date label, and were certified to at least one helmet standard. Helmets (n = 770) spanning 0-26 years old were drop tested to measure peak linear headform acceleration during impacts to the right and left front regions of the helmets at two impact speeds (3.0 and 6.2 m/s). General linear mixed models were used to assess the effect of age and three covariates (helmet style, size and certification impact speed) on peak acceleration. Overall, age was related to either no difference or a statistically significant but small increase (≤0.76 g/year of helmet age) in peak headform acceleration. Extrapolated across 20 years, age-related differences were less than both style- (traditional vs. BMX) and size-related differences. The age-related differences were also less than the variability observed between different helmets after accounting for style, size and certification effects. These findings mean that bicycle helmets (up to 26-year-old traditional helmets and 13-year-old BMX helmets) do not lose their ability to attenuate impacts with age; however, other helmet features that may change with age were not evaluated in this study.
[Mh] Termos MeSH primário: Aceleração
Ciclismo
Dispositivos de Proteção da Cabeça
Estimulação Física/métodos
Equipamentos Esportivos
[Mh] Termos MeSH secundário: Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1007/s10439-017-1842-4


  10 / 36080 MEDLINE  
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[PMID]:28463204
[Au] Autor:Lee JD; Mooney LM; Rouse EJ
[Ti] Título:Design and Characterization of a Quasi-Passive Pneumatic Foot-Ankle Prosthesis.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(7):823-831, 2017 07.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The majority of commercially available passive prosthetic feet are not capable of providing joint mechanics that match that of the intact human ankle. Due to their cantilever design, their stiffness characteristics contrast with what has been observed in the biological ankle, namely, an increase in stiffness during the stance phase of walking. In this paper, we introduce the design and control of a pneumatic foot-ankle prosthesis that attempts to provide biomimetic mechanics. The prosthesis is comprised of a pneumatic cylinder in series with a fiberglass leaf spring, and a solenoid valve to control the flow of air between the two sides of the cylinder. The solenoid valve acts as a mechanical clutch, enabling resetting of the ankle's equilibrium position. By adjusting the pressure inside the cylinder, the prosthesis can be customized to provide a range of ankle mechanics. A mechanical testing machine is used to compare the torque-angle curve of the pneumatic prosthesis with a low-profile passive prosthetic foot. Finally, data are presented of one transtibial amputee walking with the prosthesis at 1.2 m/s. The testing shows that the pneumatic prosthesis is capable of providing an appropriate range of motion as well a maximum torque of 94 Nm, while returning approximately 11.5 J of energy.
[Mh] Termos MeSH primário: Amputados/reabilitação
Articulação do Tornozelo/fisiopatologia
Membros Artificiais
Biomimética/instrumentação
Exoesqueleto Energizado
Prótese Articular
Robótica/métodos
[Mh] Termos MeSH secundário: Pressão do Ar
Projeto Auxiliado por Computador
Desenho de Equipamento
Análise de Falha de Equipamento
Seres Humanos
Meia-Idade
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2017.2699867



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