[PMID]: | 29377921 |
[Au] Autor: | Caixeta DC; Teixeira RR; Peixoto LG; Machado HL; Baptista NB; de Souza AV; Vilela DD; Franci CR; Salmen Espindola F |
[Ad] Endereço: | Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil. |
[Ti] Título: | Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress. |
[So] Source: | PLoS One;13(1):e0191889, 2018. |
[Is] ISSN: | 1932-6203 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ. |
[Mh] Termos MeSH primário: |
Ácidos Graxos Fígado/fisiopatologia Estresse Fisiológico
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[Mh] Termos MeSH secundário: |
Animais Glicemia/metabolismo Peso Corporal Doença Crônica Temperatura Baixa Corticosterona/sangue Imobilização Fígado/enzimologia Fígado/metabolismo Masculino Ratos Ratos Wistar
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Blood Glucose); 0 (Fatty Acids); L497I37F0C (royal jelly); W980KJ009P (Corticosterone) |
[Em] Mês de entrada: | 1803 |
[Cu] Atualização por classe: | 180309 |
[Lr] Data última revisão:
| 180309 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 180130 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pone.0191889 |
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