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  1 / 60669 MEDLINE  
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[PMID]:29346451
[Au] Autor:Chen H; Qian C; Liang C; Kang W
[Ad] Endereço:School of Materials Science and Engineering, Southeast University, Nanjing, Jiangsu province, China.
[Ti] Título:An approach for predicting the compressive strength of cement-based materials exposed to sulfate attack.
[So] Source:PLoS One;13(1):e0191370, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, a support vector machine (SVM) model which can be used to predict the compressive strength of mortars exposed to sulfate attack was established. An accelerated corrosion test was applied to collect compressive strength data. For predicting the compressive strength of mortars, a total of 638 data samples obtained from experiment was chosen as a dataset to establish a SVM model. The values of the coefficient of determination, the mean absolute error, the mean absolute percentage error and the root mean square error were used for evaluating the predictive accuracy. The main factors affecting the predicted compressive strength were obtained by sensitivity analysis. A SVM model was calibrated, validated, and finally established. Moreover, the performance of the SVM model was compared to an artificial neural network (ANN) model. Results show that the prediction values from the SVM model were close to the experimental values; the main factors sensitive to concrete compressive strength were exposure time, water-cement ratio and sulfate ions; the performance of the SVM model was better than the ANN model. The SVM model developed in this study can be potentially used for predicting the compressive strength of cement-based materials servicing in harsh environments.
[Mh] Termos MeSH primário: Força Compressiva
Materiais de Construção
Teste de Materiais
Sulfatos
[Mh] Termos MeSH secundário: Redes Neurais (Computação)
Máquina de Vetores de Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Sulfates)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191370


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[PMID]:29238193
[Au] Autor:Mahmood SK; Razak IA; Ghaji MS; Yusof LM; Mahmood ZK; Rameli MABP; Zakaria ZAB
[Ad] Endereço:Department of Veterinary Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, Malaysia.
[Ti] Título:In vivo evaluation of a novel nanocomposite porous 3D scaffold in a rabbit model: histological analysis.
[So] Source:Int J Nanomedicine;12:8587-8598, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The healing of load-bearing segmental defects in long bones is a challenge due to the complex nature of the weight that affects the bone part and due to bending, shearing, axial, and torsional forces. An innovative porous 3D scaffolds implant of CaCO aragonite nanocomposite derived from cockle shell was advanced for substitute bone solely for load-bearing cases. The biomechanical characteristics of such materials were designed to withstand cortical bone strength. In promoting bone growth to the implant material, an ideal surface permeability was formed by means of freeze drying and by adding copolymers to the materials. The properties of coating and copolymers supplement were also assessed for bone-implant connection resolutions. To examine the properties of the material in advanced biological system, an experimental trial in an animal model was carried out. Critical sized defect of bone was created in rabbit's radial bone to assess the material for a load-bearing application with a short and extended period assessment with histological evaluation of the incorporated implanted material to the bone of the host. Trials in animal models proved that the material has the capability of enduring load-bearing conditions for long-term use devoid of breaking or generating stress that affects the host bone. Histological examination further confirmed the improved integration of the implanted materials to the host bone with profound bone development into and also above the implanted scaffold, which was attained with negligible reaction of the tissues to a foreign implanted material.
[Mh] Termos MeSH primário: Regeneração Óssea
Substitutos Ósseos
Nanocompostos/química
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Osso e Ossos/fisiologia
Osso e Ossos/cirurgia
Masculino
Teste de Materiais
Porosidade
Coelhos
Tecidos Suporte
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S145663


  3 / 60669 MEDLINE  
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[PMID]:28470446
[Au] Autor:Sundaran PS; Bhaskaran A; Alex ST; Prasad T; Haritha VH; Anie Y; Kumary TV; Anil Kumar PR
[Ad] Endereço:Division of Tissue Culture, Department of Applied Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, 695 012, India.
[Ti] Título:Drug loaded microbeads entrapped electrospun mat for wound dressing application.
[So] Source:J Mater Sci Mater Med;28(6):88, 2017 Jun.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new design of antibiotic loaded wound dressing and its initial in vitro evaluation is described. Chitosan microbeads loaded with ampicillin were sandwiched within polycaprolactone electrospun mat (MbAPPCL). The morphology was analyzed by scanning electron microscopy and surface chemistry was characterized by Fourier Transform Infrared Spectroscopy. In vitro cytotoxicity using L-929 fibroblast cells by direct contact test and elution assay revealed non-cytotoxic nature of MbAPPCL. The cell adhesion and viability analysis further confirmed the cytocompatibility of MbAPPCL as a wound dressing material. Percentage hemolysis and platelet adhesion on the mat exposed to blood substantiated the hemocompatibility. The antibiotic susceptibility test analyzed on Staphylococcus aureus by agar plate method confirmed the drug release and antimicrobial property. The proposed wound dressing model explained with ampicillin as a candidate drug has the potential to include microbeads with different antibiotics for multi drug treatment.
[Mh] Termos MeSH primário: Bandagens
Portadores de Fármacos
Microesferas
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Materiais Biocompatíveis
Plaquetas
Linhagem Celular
Quitosana
Técnicas Eletroquímicas
Fibroblastos/fisiologia
Teste de Materiais
Camundongos
Penicilinas/química
Penicilinas/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Estreptomicina/química
Estreptomicina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biocompatible Materials); 0 (Drug Carriers); 0 (Penicillins); 9012-76-4 (Chitosan); Y45QSO73OB (Streptomycin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5893-8


  4 / 60669 MEDLINE  
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[PMID]:28470444
[Au] Autor:Lim PN; Feng J; Wang Z; Chong M; Konishi T; Tan LG; Chan J; Thian ES
[Ad] Endereço:Department of Mechanical Engineering, National University of Singapore, Singapore, 117 576, Singapore.
[Ti] Título:In-vivo evaluation of subcutaneously implanted cell-loaded apatite microcarriers for osteogenic potency.
[So] Source:J Mater Sci Mater Med;28(6):86, 2017 Jun.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell-loaded apatite microcarriers present as potential scaffolds for direct in-vivo delivery of cells post-expansion to promote bone regeneration. The objective of this study was to evaluate the osteogenic potency of human foetal mesenchymal stem cells (hfMSC)-loaded apatite microcarriers when implanted subcutaneously in a mouse model. This was done by examining for ectopic bone formation at 2 weeks, 1 month and 2 months, which were intended to coincide with the inflammation, healing and remodelling phases, respectively. Three histological examinations including haematoxylin and eosin staining to examine general tissue morphology, Masson's trichrome staining to identify tissue type, and Von Kossa staining to examine extent of tissue mineralisation were performed. In addition, immunohistochemistry assay of osteopontin was conducted to confirm active bone formation by the seeded hfMSCs. Results showed a high level of tissue organisation and new bone formation, with active bone remodelling being observed at the end of 2 months, and an increase in tissue density, organisation, and mineralisation could also be observed for hfMSC-loaded apatite microcarriers. Various cell morphology resembling that of osteoblasts and osteoclasts could be seen on the surfaces of the hfMSC-loaded apatite microcarriers, with presence of woven bone tissue formation being observed at the intergranular space. These observations were consistent with evidence of ectopic bone formation, which were absent in group containing apatite microcarriers only. Overall, results suggested that hfMSC-loaded apatite microcarriers retained their osteogenic potency after implantation, and provided an effective platform for bone tissue regeneration.
[Mh] Termos MeSH primário: Apatitas/química
Transplante de Células-Tronco Mesenquimais/métodos
Células Mesenquimais Estromais/fisiologia
Osteogênese/fisiologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Seres Humanos
Teste de Materiais
Camundongos
Engenharia Tecidual/métodos
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apatites)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5897-4


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[PMID]:28462910
[Au] Autor:Mihailescu IN; Bociaga D; Popescu-Pelin G; Stan GE; Duta L; Socol G; Chifiriuc MC; Bleotu C; Lazar V; Husanu MA; Zgura I; Miculescu F; Negut I; Hapenciuc C
[Ad] Endereço:National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania.
[Ti] Título:Optimized silicon reinforcement of carbon coatings by pulsed laser technique for superior functional biomedical surfaces fabrication.
[So] Source:Biofabrication;9(2):025029, 2017 Jun 01.
[Is] ISSN:1758-5090
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbiological points of view. Scanning electron microscopy revealed the presence, on top of the deposited layers, of spheroid particulates with sizes in the micron range. No micro-cracks or delaminations were observed. Energy dispersive x-ray spectroscopy and grazing incidence x-ray diffraction pointed to the existence of a C to Si compositional gradient from one end of the film to the other. Raman investigation revealed a relatively high sp hybridization of up to 80% at 40-48 mm apart from the edge with higher C content. Si addition was demonstrated to significantly increase C:Si film bonding to the substrate, with values above the ISO threshold for coatings to be used in high-loading biomedical applications. Surface energy studies pointed to an increase in the hydrophilic character of the deposited structures along with Si content up to 52 mN m . In certain cases, the Si-reinforced C coatings elicited an antimicrobial biofilm action. The presence of Si was proven to be benign to HEp-2 cells of human origin, without interfering with their cellular cycle. On this basis, reliable C:Si structures with good adherence to the substrate and high efficiency against microbial biofilms can be developed for implant coatings and other advanced medical devices.
[Mh] Termos MeSH primário: Tecnologia Biomédica/métodos
Carbono/química
Materiais Revestidos Biocompatíveis/química
Lasers
Silício/química
[Mh] Termos MeSH secundário: Ciclo Celular
Forma Celular
Seres Humanos
Teste de Materiais
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Espectrometria por Raios X
Análise Espectral Raman
Propriedades de Superfície
Água/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 059QF0KO0R (Water); 7440-44-0 (Carbon); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1088/1758-5090/aa7076


  6 / 60669 MEDLINE  
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[PMID]:29267675
[Au] Autor:Oliveira KV; Silva BMD; Leonardi DP; Crozeta BM; Sousa-Neto MD; Baratto-Filho F; Gabardo MCL
[Ad] Endereço:Universidade Positivo, Department of Dentistry, Curitiba, PR, Brazil.
[Ti] Título:Effectiveness of different final irrigation techniques and placement of endodontic sealer into dentinal tubules.
[So] Source:Braz Oral Res;31:e114, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare two irrigation techniques and four devices for endodontic sealer placement into the dentinal tubules. Ninety-nine single-rooted human teeth were instrumented and allocated to either the control (CO) (n=11) or experimental groups according to the irrigation method: syringe and NaveTip needle (NT) (n=44), and EndoActivator (EA) (n=44). These groups were subdivided according to sealer placement into K-File (KF), lentulo spiral (LS), Easy Clean (EC), and EndoActivator (EA) subgroups. Moreover, the distances of 5 mm and 2 mm from the apex were analyzed. The teeth were obturated with AH Plus and GuttaCore X3. Analyses were performed by scanning electron microscopy associated to cathodoluminescence. The percentage and maximum depth of sealer penetration were measured. Data were evaluated by three-way analysis of variance (ANOVA) and Games-Howell test (p<0.05). EA was superior to NT in percentage of sealer penetration. EC was significantly superior to EA (subgroup) for sealer penetration, and both improved the percentage of sealer penetration when compared to LS. Better sealer penetration was observed at the distance of 5 mm from the apex. Sealer penetration into the dentinal tubules was significantly improved by sonic irrigant activation.
[Mh] Termos MeSH primário: Dentina/efeitos dos fármacos
Materiais Restauradores do Canal Radicular/química
Irrigantes do Canal Radicular/química
Obturação do Canal Radicular/métodos
Preparo de Canal Radicular/métodos
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Cavidade Pulpar/efeitos dos fármacos
Cavidade Pulpar/ultraestrutura
Dentina/ultraestrutura
Resinas Epóxi/química
Resinas Epóxi/uso terapêutico
Seres Humanos
Teste de Materiais
Microscopia Confocal
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Rodaminas
Materiais Restauradores do Canal Radicular/uso terapêutico
Irrigantes do Canal Radicular/uso terapêutico
Obturação do Canal Radicular/instrumentação
Preparo de Canal Radicular/instrumentação
Irrigação Terapêutica/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epoxy Resins); 0 (Rhodamines); 0 (Root Canal Filling Materials); 0 (Root Canal Irrigants); 0 (epoxy resin-based root canal sealer); BA7THR07HH (rhodamine isothiocyanate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  7 / 60669 MEDLINE  
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[PMID]:29267674
[Au] Autor:Rodrigues CT; Duarte MAH; Guimarães BM; Vivan RR; Bernardineli N
[Ad] Endereço:Universidade de São Paulo - USP, Bauru School of Dentistry, Department of Dentistry, Endodontics and Dental Materials, Bauru, SP, Brazil.
[Ti] Título:Comparison of two methods of irrigant agitation in the removal of residual filling material in retreatment.
[So] Source:Braz Oral Res;31:e113, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare the efficacy of passive ultrasonic irrigation and EasyClean for removing residual filling material in retreatment. Twenty-two maxillary lateral incisors with apical curvature were instrumented with ProTaper files and filled with Endofill using the lateral compactation technique. Removal of filling material was performed with Reciproc, Mtwo and ProDesign Logic 50/.01 files. The teeth were inserted in a silicone mould, which was placed in a metal muffle, and split to visualize the residual filling material. The samples were divided into two groups (n = 11) according to the irrigation protocol: Passive ultrasonic irrigation (PUI group) with 3 activations of 20 seconds and EasyClean (Easy Equipamentos Odontológicos, Belo Horizonte, Brazil) (EC group) used in continuous rotation with 3 activations of 20 seconds, both using NaOCl and EDTA. Environmental scanning electron microscopic images of the apical, middle, and cervical thirds were taken before and after the irrigant activation. The Kappa test was used to determine interexaminer agreement. Statistical analysis was performed using Kruskal-Wallis, Mann-Whitney, and Wilcoxon tests (p < 0.05). PUI and EC improved the removal of remnant filling material in all root canal thirds (p < 0.05). PUI and EC presented similar performance in the final step of retreatment (p > 0.05). No significant difference was observed in the removal of filling material in the apical, middle, and cervical thirds in both groups (p > 0.05). EasyClean in continuous rotary motion is useful in retreatment and was shown to be as effective as ultrasonic activation in the removal of remnant filling material.
[Mh] Termos MeSH primário: Materiais Restauradores do Canal Radicular
Irrigantes do Canal Radicular/química
Tratamento do Canal Radicular/instrumentação
Terapia por Ultrassom/instrumentação
[Mh] Termos MeSH secundário: Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Valores de Referência
Reprodutibilidade dos Testes
Retratamento/instrumentação
Irrigantes do Canal Radicular/uso terapêutico
Tratamento do Canal Radicular/métodos
Estatísticas não Paramétricas
Irrigação Terapêutica/instrumentação
Irrigação Terapêutica/métodos
Fatores de Tempo
Terapia por Ultrassom/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Root Canal Filling Materials); 0 (Root Canal Irrigants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  8 / 60669 MEDLINE  
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[PMID]:29267670
[Au] Autor:Bellan MC; Cunha PFJSD; Tavares JG; Spohr AM; Mota EG
[Ad] Endereço:Pontifícia Universidade Católica da Universidade Federal do Rio Grande do Sul - PUC-RS, School of Dentistry, Graduate Program, Porto Alegre, RS, Brazil.
[Ti] Título:Microtensile bond strength of CAD/CAM materials to dentin under different adhesive strategies.
[So] Source:Braz Oral Res;31:e109, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the microtensile bond strength (µTBS) of novel computer-aided design/computer-aided manufacturing (CAD/CAM) restorative materials to dentin using different adhesive strategies. Thirty-two crowns were milled using CAD/CAM materials (Vita Mark II as control, Vita Suprinity, Vita Enamic and Lava Ultimate) and luted to dentin using different resin cements (RelyX ARC, RelyX Unicem 2 and RelyX Ultimate). The specimens were stored in 100% relative humidity at 37°C for 24 h and sectioned. The samples (n = 16) with cross-sectional areas of approximately 0.90 mm2, were submitted to a µTBS test in a universal testing machine with a crosshead speed of 0.5 mm/min. The samples were analyzed with SEM to determinate the failure mode. According to 2-way ANOVA and Tukey's test (α=0.05), the interaction effect (material x luting strategy) was significant (p=0.001). Regardless of the luting strategy, a higher µTBS was obtained with Lava Ultimate and Vita Enamic, which were significantly different from Vita Mark II and Vita Suprinity (p<0.05). For Vita Mark II, Vita Suprinity, Vita Enamic, and Lava Ultimate, the µTBS obtained with RelyX Unicem 2 was not significantly different from that obtained with RelyX ARC or RelyX Ultimate. All groups obtained at least three types of failure. The adhesive strategy with self-adhesive resin cement was comparable to conventional resin cement with total-etch or self-etch adhesive techniques in the bond of novel CAD/CAM materials to dentin.
[Mh] Termos MeSH primário: Cerâmica/química
Projeto Auxiliado por Computador
Colagem Dentária/métodos
Dentina/efeitos dos fármacos
Cimentos de Resina/química
[Mh] Termos MeSH secundário: Análise de Variância
Falha de Restauração Dentária
Dentina/química
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Propriedades de Superfície/efeitos dos fármacos
Resistência à Tração
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  9 / 60669 MEDLINE  
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[PMID]:29267661
[Au] Autor:Almeida LJDS; Penha KJS; Souza AF; Lula ECO; Magalhães FC; Lima DM; Firoozmand LM
[Ad] Endereço:Universidade Federal do Maranhão - UFMA, Department of Dentistry I, São Luís, MA, Brazil.
[Ti] Título:Is there correlation between polymerization shrinkage, gap formation, and void in bulk fill composites? A µCT study.
[So] Source:Braz Oral Res;31:e100, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This in vitro study aimed to evaluate the volume of polymerization shrinkage (VS), gap (VG), and void (VV) using computerized microtomography (µCT) in bulk fill resin composites and conventional class I restorations, and to establish a correlation between these factors. Class I cavities (4 x 5 x 4 mm), C-factor = 4.2, were performed on caries-free human third molars and randomly divided into five groups (n = 6): FSI (Filtek Supreme XTE incremental insertion); FSS [(Filtek Supreme XTE single insertion(SI)]; TBF [(Tetric Bulk Fill: SI and manual filling (MF)]; SFM (Sonic Fill: SI/MF); and SFS (SonicFill: SI and sonic filling). The teeth were scanned and analyzed by µCT at T0, after filling the cavity with resin, and at T1, after polymerization for VG and VV, and for VS (T1-T0). There was statistically significant difference in VS in µCT for the FSI and FSS groups and between SFS and FSS as well as some difference in VV for FSI and bulk fill resin composites and no difference in VG between the conventional technique and bulk fill composites. Bulk fill resin composites presented similar VS and gap formation to those of incrementally inserted conventional resin composites. There is a moderate and weak positive correlation between polymerization shrinkage and gap formation and void, respectively. The final gap formation was more dependent on the initial gap than on polymerization shrinkage or void volume.
[Mh] Termos MeSH primário: Resinas Compostas/química
Restauração Dentária Permanente/métodos
Polimerização
[Mh] Termos MeSH secundário: Análise de Variância
Luzes de Cura Dentária
Cimentos Dentários/química
Seres Humanos
Teste de Materiais
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Fatores de Tempo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Composite Resins); 0 (Dental Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  10 / 60669 MEDLINE  
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[PMID]:29203752
[Au] Autor:Gruber-Bzura BM
[Ad] Endereço:Zaklad Biochemii I Biofarmaceutykow; Narodowy Instytut Lekow, Warszawa Polska.
[Ti] Título:[Cytotoxicity in vitro as the principal parameter for evaluation of biocompatibility of medical devices].
[So] Source:Wiad Lek;70(5):977-981, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:According to the Polish Ministry of Health decree, the medical devices and all raw materials used for their manufacturing are in force to be compatible with biological tissues, cells and body fluids regarding its clinical use. It is defined as biocompatibility. The scope of the methods proposed in the norm PN-EN ISO 10993-1 makes possible to get full preclinical characteristics of the medical device and allows to form the opinion about safety of it to the patients after its marketing. The test directed as the principal to make, independently on characteristics, kind, contact duration and clinical use of the device is cytotoxicity in vitro. This test defines the impact of the device on the cells through microscopic evaluation or through activities of the enzymes specific for living cells. Toxicity of the material to the cells may be reflected in: change of single cells or whole cell culture morphology, change of cellular metabolic activity, DNA damage or disadvantage of cell proliferation. Biocompatibility of the medical devices is one of the main elements considered in a risk management process at the stage of designing and manufacturing as well of the raw materials as the final product and the critical point in this matter is sterilization.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/normas
Equipamentos e Provisões/normas
Teste de Materiais/normas
Testes de Toxicidade/normas
[Mh] Termos MeSH secundário: Seres Humanos
Legislação de Dispositivos Médicos
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biocompatible Materials)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE



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