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[PMID]:29362786
[Au] Autor:Woloshin S; Schwartz LM; Bagley PJ; Blunt HB; White B
[Ad] Endereço:Center for Medicine in the Media, Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire.
[Ti] Título:Characteristics of Interim Publications of Randomized Clinical Trials and Comparison With Final Publications.
[So] Source:JAMA;319(4):404-406, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Editoração
Ensaios Clínicos Controlados Aleatórios como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Publicações
Projetos de Pesquisa
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.20653


  2 / 89159 MEDLINE  
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[PMID]:29437644
[Au] Autor:Sun X; Tan J; Tang L; Guo JJ; Li X
[Ad] Endereço:Chinese Evidence-based Medicine Centre and CREAT Group, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China sunx79@hotmail.com.
[Ti] Título:Real world evidence: experience and lessons from China.
[So] Source:BMJ;360:j5262, 2018 02 05.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Coleta de Dados/métodos
Medicina Baseada em Evidências
Melhoria de Qualidade
[Mh] Termos MeSH secundário: China
Seres Humanos
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5262


  3 / 89159 MEDLINE  
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[PMID]:27772645
[Au] Autor:Jeng BH; Farid M; Patel SV; Schwab IR
[Ad] Endereço:Baltimore, Maryland. Electronic address: bjeng@som.umaryland.edu.
[Ti] Título:Corneal Cross-linking for Keratoconus: A Look at the Data, the Food and Drug Administration, and the Future.
[So] Source:Ophthalmology;123(11):2270-2272, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Reagentes para Ligações Cruzadas
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
United States Food and Drug Administration/tendências
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Colágeno/metabolismo
Substância Própria/metabolismo
Aprovação de Drogas
Previsões
Seres Humanos
Ceratocone/metabolismo
Projetos de Pesquisa
Raios Ultravioleta
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 89159 MEDLINE  
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[PMID]:29231018
[Au] Autor:Li R; Li CT; Zhao SM; Li HX; Li L; Wu RG; Zhang CC; Sun HY
[Ad] Endereço:Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510089, China.
[Ti] Título:[Full Sibling Identification by IBS Scoring Method and Establishment of the Query Table of Its Critical Value].
[So] Source:Fa Yi Xue Za Zhi;33(2):136-140, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To establish a query table of IBS critical value and identification power for the detection systems with different numbers of STR loci under different false judgment standards. METHODS: Samples of 267 pairs of full siblings and 360 pairs of unrelated individuals were collected and 19 autosomal STR loci were genotyped by Golden ye™ 20A system. The full siblings were determined using IBS scoring method according to the 'Regulation for biological full sibling testing'. The critical values and identification power for the detection systems with different numbers of STR loci under different false judgment standards were calculated by theoretical methods. RESULTS: According to the formal IBS scoring criteria, the identification power of full siblings and unrelated individuals was 0.764 0 and the rate of false judgment was 0. The results of theoretical calculation were consistent with that of sample observation. The query table of IBS critical value for identification of full sibling detection systems with different numbers of STR loci was successfully established. CONCLUSIONS: The IBS scoring method defined by the regulation has high detection efficiency and low false judgment rate, which provides a relatively conservative result. The query table of IBS critical value for identification of full sibling detection systems with different numbers of STR loci provides an important reference data for the result judgment of full sibling testing and owns a considerable practical value.
[Mh] Termos MeSH primário: Síndrome do Intestino Irritável/genética
Irmãos
[Mh] Termos MeSH secundário: Alelos
Genótipo
Seres Humanos
Reprodutibilidade dos Testes
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.006


  5 / 89159 MEDLINE  
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[PMID]:29384605
[Au] Autor:Rohde M; van Dam LCJ; Ernst M
[Ti] Título:Statistically Optimal Multisensory Cue Integration: A Practical Tutorial.
[So] Source:Multisens Res;29(4-5):279-317, 2016.
[Is] ISSN:2213-4794
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Humans combine redundant multisensory estimates into a coherent multimodal percept. Experiments in cue integration have shown for many modality pairs and perceptual tasks that multisensory information is fused in a statistically optimal manner: observers take the unimodal sensory reliability into consideration when performing perceptual judgments. They combine the senses according to the rules of Maximum Likelihood Estimation to maximize overall perceptual precision. This tutorial explains in an accessible manner how to design optimal cue integration experiments and how to analyse the results from these experiments to test whether humans follow the predictions of the optimal cue integration model. The tutorial is meant for novices in multisensory integration and requires very little training in formal models and psychophysical methods. For each step in the experimental design and analysis, rules of thumb and practical examples are provided. We also publish Matlab code for an example experiment on cue integration and a Matlab toolbox for data analysis that accompanies the tutorial online. This way, readers can learn about the techniques by trying them out themselves. We hope to provide readers with the tools necessary to design their own experiments on optimal cue integration and enable them to take part in explaining when, why and how humans combine multisensory information optimally.
[Mh] Termos MeSH primário: Teorema de Bayes
Encéfalo/fisiologia
Sinais (Psicologia)
Modelos Neurológicos
Percepção/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Funções Verossimilhança
Teoria Psicológica
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


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[PMID]:29371211
[Au] Autor:Hey SP; Weijer C; Taljaard M; Kesselheim AS
[Ad] Endereço:Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, USA shey@bwh.harvard.edu.
[Ti] Título:Research ethics for emerging trial designs: does equipoise need to adapt?
[So] Source:BMJ;360:k226, 2018 01 25.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto/ética
Projetos de Pesquisa
Equipolência Terapêutica
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto/métodos
Ética em Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k226


  7 / 89159 MEDLINE  
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[PMID]:29489645
[Au] Autor:Xiong J; Li H; Li X; Wang L; Zhao P; Meng D; Wei ZX; Tian T
[Ad] Endereço:The First Affiliated Hospital of Henan University of Traditional Chinese Medicine.
[Ti] Título:Electroacupuncture for postoperative pain management after total knee arthroplasty: Protocol for a systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(9):e0014, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Total knee arthroplasty (TKA) is one of the most common joint replacement surgeries in the United States. Postoperative pain is still a major complication after TKA. Electroacupuncture (EA) has been commonly used in clinical practice for pain after TKA, but its effects and safety remain uncertain. This protocol is described for a systematic review to investigate the beneficial effects and safety of EA for postoperative pain after TKA. METHODS: Randomized controlled trials (RCTs) related to EA treatment of pain after TKA will be collected from 3 databases of English literature, namely PubMed, Embase, and Cochrane Library, and 4 databases of Chinese literatures, namely CBM, CNKI, VIP and Wanfang database. The retrieved trials will be those published from the time when the respective databases were built to January 2018. The therapeutic effects according to the change from baseline in the amount of pain measured by the visual analogue scale (VAS) or numerical rating scale, will be accepted as the primary outcomes. We will use RevMan V.5.3 software as well to compute the data synthesis carefully when a meta-analysis is allowed. RESULTS: This systematic review and meta-analysis will provide a high-quality synthesis of current evidence of EA for pain after TKA. CONCLUSION: The conclusion of our systematic review will provide evidence to judge whether EA is an effective intervention for patient with postoperative pain after TKA. PROSPERO REGISTRATION NUMBER: PROSPERO CRD 42018082407.
[Mh] Termos MeSH primário: Artroplastia do Joelho/efeitos adversos
Eletroacupuntura
Dor Pós-Operatória/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Manejo da Dor/métodos
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010014


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[PMID]:29472181
[Au] Autor:Smith AJ; Clutton RE; Lilley E; Hansen KEA; Brattelid T
[Ad] Endereço:Norecopa, c/o Norwegian Veterinary Institute, PO Box 750, Sentrum, 0106 Oslo, Norway.
[Ti] Título:Improving animal research: PREPARE before you ARRIVE.
[So] Source:BMJ;360:k760, 2018 02 22.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Experimentação Animal
Projetos de Pesquisa
[Mh] Termos MeSH secundário: Animais
Lista de Checagem
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180224
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k760


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[PMID]:29284666
[Au] Autor:Hey SP; London AJ; Weijer C; Rid A; Miller F
[Ad] Endereço:Harvard Center for Bioethics, Boston, MA, USA shey@bwh.harvard.edu annette.rid@kcl.ac.uk.
[Ti] Título:Is the concept of clinical equipoise still relevant to research?
[So] Source:BMJ;359:j5787, 2017 12 28.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Qualidade da Assistência à Saúde/normas
Projetos de Pesquisa/normas
[Mh] Termos MeSH secundário: Ética em Pesquisa
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto/ética
Projetos de Pesquisa/tendências
Valores Sociais
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5787


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[PMID]:28464930
[Au] Autor:Hind D; Reeves BC; Bathers S; Bray C; Corkhill A; Hayward C; Harper L; Napp V; Norrie J; Speed C; Tremain L; Keat N; Bradburn M
[Ad] Endereço:CTRU, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. d.hind@sheffield.ac.uk.
[Ti] Título:Comparative costs and activity from a sample of UK clinical trials units.
[So] Source:Trials;18(1):203, 2017 May 02.
[Is] ISSN:1745-6215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS: Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, and written justification for, costs associated with CTU activities required to implement an identical protocol. The protocol described a 5.5-year, nonpharmacological randomized controlled trial (RCT) conducted at 20 centres. Direct and indirect costs, the number of full time equivalents (FTEs) and the FTEs attracting overheads were compared and qualitative methods (unstructured interviews and thematic analysis) were used to interpret the results. Four members of the group (funding-body representatives or award panel members) reviewed the justification statements for transparency and information content. Separately, 163 activities common to trials were assigned to roles used by nine CTUs; the consistency of role delineation was assessed by Cohen's κ. RESULTS: Median full economic cost of CTU activities was £769,637 (range: £661,112 to £1,383,323). Indirect costs varied considerably, accounting for between 15% and 59% (median 35%) of the full economic cost of the grant. Excluding one CTU, which used external statisticians, the total number of FTEs ranged from 2.0 to 3.0; total FTEs attracting overheads ranged from 0.3 to 2.0. Variation in directly incurred staff costs depended on whether CTUs: supported particular roles from core funding rather than grants; opted not to cost certain activities into the grant; assigned clerical or data management tasks to research or administrative staff; employed extensive on-site monitoring strategies (also the main source of variation in non-staff costs). Funders preferred written justifications of costs that described both FTEs and indicative tasks for funded roles, with itemised non-staff costs. Consistency in role delineation was fair (κ = 0.21-0.40) for statisticians/data managers and poor for other roles (κ < 0.20). CONCLUSIONS: Some variation in costs is due to factors outside the control of CTUs such as access to core funding and levels of indirect costs levied by host institutions. Research is needed on strategies to control costs appropriately, especially the implementation of risk-based monitoring strategies.
[Mh] Termos MeSH primário: Estudos Multicêntricos como Assunto/economia
Ensaios Clínicos Controlados Aleatórios como Assunto/economia
Projetos de Pesquisa
Apoio à Pesquisa como Assunto/economia
[Mh] Termos MeSH secundário: Orçamentos
Controle de Custos
Análise Custo-Benefício
Seres Humanos
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s13063-017-1934-3



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