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Pesquisa : E05.601.043 [Categoria DeCS]
Referências encontradas : 31728 [refinar]
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[PMID]:29348634
[Au] Autor:Wood RJ; Ormsby AR; Radwan M; Cox D; Sharma A; Vöpel T; Ebbinghaus S; Oliveberg M; Reid GE; Dickson A; Hatters DM
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.
[Ti] Título:A biosensor-based framework to measure latent proteostasis capacity.
[So] Source:Nat Commun;9(1):287, 2018 01 18.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The pool of quality control proteins (QC) that maintains protein-folding homeostasis (proteostasis) is dynamic but can become depleted in human disease. A challenge has been in quantitatively defining the depth of the QC pool. With a new biosensor, flow cytometry-based methods and mathematical modeling we measure the QC capacity to act as holdases and suppress biosensor aggregation. The biosensor system comprises a series of barnase kernels with differing folding stability that engage primarily with HSP70 and HSP90 family proteins. Conditions of proteostasis stimulation and stress alter QC holdase activity and aggregation rates. The method reveals the HSP70 chaperone cycle to be rate limited by HSP70 holdase activity under normal conditions, but this is overcome by increasing levels of the BAG1 nucleotide exchange factor to HSPA1A or activation of the heat shock gene cluster by HSF1 overexpression. This scheme opens new paths for biosensors of disease and proteostasis systems.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Citometria de Fluxo/métodos
Modelos Teóricos
Proteostase
[Mh] Termos MeSH secundário: Algoritmos
Western Blotting
Células HEK293
Proteínas de Choque Térmico HSP72/metabolismo
Proteínas de Choque Térmico HSP90/metabolismo
Fatores de Transcrição de Choque Térmico/metabolismo
Seres Humanos
Proteoma/metabolismo
Proteômica/métodos
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HSF1 protein, human); 0 (HSP72 Heat-Shock Proteins); 0 (HSP90 Heat-Shock Proteins); 0 (Heat Shock Transcription Factors); 0 (Proteome)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02562-5


  2 / 31728 MEDLINE  
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[PMID]:28462423
[Au] Autor:Xie W; Lewis WM; Kaser J; Ross Welch C; Li P; Nelson CA; Kothari V; Terry BS
[Ad] Endereço:Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W342 Nebraska Hall, Lincoln, NE 68588-0526.
[Ti] Título:Design and Validation of a Biosensor Implantation Capsule Robot.
[So] Source:J Biomech Eng;139(8), 2017 Aug 01.
[Is] ISSN:1528-8951
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have proposed a long-term, noninvasive, nonrestrictive method of delivering and implanting a biosensor within the body via a swallowable implantation capsule robot (ICR). The design and preliminary validation of the ICR's primary subsystem-the sensor deployment system-is discussed and evidence is provided for major design choices. The purpose of the sensor deployment system is to adhere a small biosensor to the mucosa of the intestine long-term, and the modality was inspired by tapeworms and other organisms that employ a strategy of mechanical adhesion to soft tissue via the combined use of hooks or needles and suckers. Testing was performed to refine the design of the suction and needle attachment as well as the sensor ejection features of the ICR. An experiment was conducted in which needle sharpness, needle length, and vacuum volume were varied, and no statistically significant difference was observed. Finally, preliminary testing, coupled with prior work within a live porcine model, provided evidence that this is a promising approach for implanting a biosensor within the small intestine.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Próteses e Implantes
Robótica/instrumentação
[Mh] Termos MeSH secundário: Animais
Cápsulas
Desenho de Equipamento
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Capsules)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1115/1.4036607


  3 / 31728 MEDLINE  
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[PMID]:28459059
[Au] Autor:Hsieh PC; Lin HT; Chen WY; Tsai JJP; Hu WP
[Ad] Endereço:Department of Bioinformatics and Medical Engineering, Asia University, Taichung City 41354, Taiwan.
[Ti] Título:The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen.
[So] Source:Biomed Res Int;2017:5041683, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herein, we report a method of combining bioinformatics and biosensing technologies to select aptamers against prostate specific antigen (PSA). The main objective of this study is to select DNA aptamers with higher binding affinity for PSA by using the proposed method. Based on the five known sequences of PSA-binding aptamers, we adopted the functions of reproduction and crossover in the genetic algorithm to produce next-generation sequences for the computational and experimental analysis. RNAfold web server was utilized to analyze the secondary structures, and the 3-dimensional molecular models of aptamer sequences were generated by using RNAComposer web server. ZRANK scoring function was used to rerank the docking predictions from ZDOCK. The biosensors, the quartz crystal microbalance (QCM) and a surface plasmon resonance (SPR) instrument, were used to verify the binding ability of selected aptamer for PSA. By carrying out the simulations and experiments after two generations, we obtain one aptamer that can have the highest binding affinity with PSA, which generates almost 2-fold and 3-fold greater measured signals than the responses produced by the best known DNA sequence in the QCM and SPR experiments, respectively.
[Mh] Termos MeSH primário: Aptâmeros de Nucleotídeos/química
Técnicas Biossensoriais/métodos
Biologia Computacional/métodos
Antígeno Prostático Específico/sangue
[Mh] Termos MeSH secundário: Algoritmos
Seres Humanos
Masculino
Técnicas de Microbalança de Cristal de Quartzo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aptamers, Nucleotide); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1155/2017/5041683


  4 / 31728 MEDLINE  
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[PMID]:27775390
[Au] Autor:Dai Z; Rosen IG; Wang C; Barnett N; Luczak SE
[Ad] Endereço:Department of Mathematics, University of Southern California, Los Angeles, CA 90089-2532, United States. email: zhengdai@usc.edu.
[Ti] Título:Using drinking data and pharmacokinetic modeling to calibrate transport model and blind deconvolution based data analysis software for transdermal alcohol biosensors.
[So] Source:Math Biosci Eng;13(5):911-934, 2016 10 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alcohol researchers/clinicians have two ways to collect subject /patient field data, standard-drink self-report and the breath analyzer, neither of which is passive or accurate because active subject participation is required. Transdermal alcohol sensors have been developed to measure transdermal alcohol concentration (TAC), but they are used primarily as abstinence monitors because converting TAC into more meaningful blood/breath alcohol concentration (BAC/BrAC) is difficult. In this paper, BAC/BrAC is estimated from TAC by first calibrating forward distributed parameter-based convolution models for ethanol transport from the blood through the skin using patient-collected drinking data for a single drinking episode and a nonlinear pharmacokinetic metabolic absorption/elimination model to estimate BAC. TAC and estimated BAC are then used to fit the forward convolution filter. Nonlinear least squares with adjoint-based gradient computation are used to fit both models. Calibration results are compared with those obtained using BAC/BrAC from alcohol challenges and from standard, linear, metabolic absorption, and zero order kinetics-based elimination models, by considering peak BAC, time of peak, and area under the BAC curve. Our models (with population parameters) could be included in a smart phone app that makes it convenient for the subject/patient to enter drinking data for a single episode in the field.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas
Técnicas Biossensoriais/métodos
Modelos Biológicos
Monitorização Ambulatorial/métodos
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/instrumentação
Calibragem
Técnicas e Procedimentos Diagnósticos/instrumentação
Etanol/análise
Etanol/farmacocinética
Seres Humanos
Smartphone
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.2016023


  5 / 31728 MEDLINE  
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[PMID]:29371614
[Au] Autor:Sreekanth KV; Sreejith S; Han S; Mishra A; Chen X; Sun H; Lim CT; Singh R
[Ad] Endereço:Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
[Ti] Título:Biosensing with the singular phase of an ultrathin metal-dielectric nanophotonic cavity.
[So] Source:Nat Commun;9(1):369, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The concept of point of darkness has received much attention for biosensing based on phase-sensitive detection and perfect absorption of light. The maximum phase change is possible at the point of darkness where the reflection is almost zero. To date, this has been experimentally realized using different material systems through the concept of topological darkness. However, complex nanopatterning techniques are required to realize topological darkness. Here, we report an approach to realize perfect absorption and extreme phase singularity using a simple metal-dielectric multilayer thin-film stack. The multilayer stack works on the principle of an asymmetric Fabry-Perot cavity and shows an abrupt phase change at the reflectionless point due to the presence of a highly absorbing ultrathin film of germanium in the stack. In the proof-of-concept phase-sensitive biosensing experiments, we functionalize the film surface with an ultrathin layer of biotin-thiol to capture streptavidin at a low concentration of 1 pM.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Metais/química
[Mh] Termos MeSH secundário: Biotina/química
Estreptavidina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Metals); 6SO6U10H04 (Biotin); 9013-20-1 (Streptavidin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-018-02860-6


  6 / 31728 MEDLINE  
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[PMID]:29339793
[Au] Autor:Hua Q; Sun J; Liu H; Bao R; Yu R; Zhai J; Pan C; Wang ZL
[Ad] Endereço:CAS Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
[Ti] Título:Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing.
[So] Source:Nat Commun;9(1):244, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mechanosensation electronics (or Electronic skin, e-skin) consists of mechanically flexible and stretchable sensor networks that can detect and quantify various stimuli to mimic the human somatosensory system, with the sensations of touch, heat/cold, and pain in skin through various sensory receptors and neural pathways. Here we present a skin-inspired highly stretchable and conformable matrix network (SCMN) that successfully expands the e-skin sensing functionality including but not limited to temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity. The actualized specific expandable sensor units integrated on a structured polyimide network, potentially in three-dimensional (3D) integration scheme, can also fulfill simultaneous multi-stimulus sensing and achieve an adjustable sensing range and large-area expandability. We further construct a personalized intelligent prosthesis and demonstrate its use in real-time spatial pressure mapping and temperature estimation. Looking forward, this SCMN has broader applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies.
[Mh] Termos MeSH primário: Fenômenos Mecânicos
Sensação/fisiologia
Fenômenos Fisiológicos da Pele
Pele/metabolismo
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/instrumentação
Técnicas Biossensoriais/métodos
Seres Humanos
Umidade
Campos Magnéticos
Mecanotransdução Celular/fisiologia
Microscopia Eletrônica de Varredura
Pressão
Pele/citologia
Pele/ultraestrutura
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02685-9


  7 / 31728 MEDLINE  
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[PMID]:27775510
[Au] Autor:Lucisano JY; Routh TL; Lin JT; Gough DA
[Ti] Título:Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model.
[So] Source:IEEE Trans Biomed Eng;64(9):1982-1993, 2017 09.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The use of a fully implanted first-generation prototype sensor/telemetry system is described for long-term monitoring of subcutaneous tissue glucose in a small cohort of people with diabetes. METHODS: Sensors are based on a membrane containing immobilized glucose oxidase and catalase coupled to oxygen electrodes and a telemetry system, integrated as an implant. The devices remained implanted for up to 180 days, with signals transmitted every 2 min to external receivers. RESULTS: The data include signal recordings from glucose clamps and spontaneous glucose excursions, matched, respectively, to reference blood glucose and finger-stick values. The sensor signals indicate dynamic tissue glucose, for which there is no independent standard, and a model describing the relationship between blood glucose and the signal is, therefore, included. The values of all model parameters have been estimated, including the permeability of adjacent tissues to glucose, and equated to conventional mass transfer parameters. As a group, the sensor calibration varied randomly at an average rate of -2.6%/week. Statistical correlation indicated strong association between the sensor signals and reference glucose values. CONCLUSION: Continuous long-term glucose monitoring in individuals with diabetes is feasible with this system. SIGNIFICANCE: All therapies for diabetes are based on glucose control, and therefore, require glucose monitoring. This fully implanted long-term sensor/telemetry system may facilitate a new era of management of the disease.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Glicemia/análise
Diabetes Mellitus/sangue
Monitorização Ambulatorial/instrumentação
Monitorização Ambulatorial/métodos
Próteses e Implantes
Telemetria/instrumentação
[Mh] Termos MeSH secundário: Glicemia/química
Condutometria/instrumentação
Diabetes Mellitus/diagnóstico
Fontes de Energia Elétrica
Desenho de Equipamento
Análise de Falha de Equipamento
Estudos de Viabilidade
Glucose Oxidase/química
Seres Humanos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Integração de Sistemas
Transdutores
Tecnologia sem Fio/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Blood Glucose); EC 1.1.3.4 (Glucose Oxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2619333


  8 / 31728 MEDLINE  
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[PMID]:29378185
[Au] Autor:Cook A; Hari-Gupta Y; Toseland CP
[Ad] Endereço:School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.
[Ti] Título:Application of the SSB biosensor to study in vitro transcription.
[So] Source:Biochem Biophys Res Commun;496(3):820-825, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gene expression, catalysed by RNA polymerases (RNAP), is one of the most fundamental processes in living cells. The majority of methods to quantify mRNA are based upon purification of the nucleic acid which leads to experimental inaccuracies and loss of product, or use of high cost dyes and sensitive spectrophotometers. Here, we describe the use of a fluorescent biosensor based upon the single stranded binding (SSB) protein. In this study, the SSB biosensor showed similar binding properties to mRNA, to that of its native substrate, single-stranded DNA (ssDNA). We found the biosensor to be reproducible with no associated loss of product through purification, or the requirement for expensive dyes. Therefore, we propose that the SSB biosensor is a useful tool for comparative measurement of mRNA yield following in vitro transcription.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Proteínas de Ligação a DNA/metabolismo
Corantes Fluorescentes/metabolismo
Técnicas de Sonda Molecular
RNA Mensageiro/metabolismo
Espectrometria de Fluorescência/métodos
Transcrição Genética/fisiologia
[Mh] Termos MeSH secundário: Escherichia coli/metabolismo
Sondas Moleculares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Fluorescent Dyes); 0 (Molecular Probes); 0 (RNA, Messenger)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  9 / 31728 MEDLINE  
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[PMID]:29366791
[Au] Autor:Ganareal TACS; Balbin MM; Monserate JJ; Salazar JR; Mingala CN
[Ad] Endereço:Department of Chemistry, College of Arts and Sciences, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines.
[Ti] Título:Gold nanoparticle-based probes for the colorimetric detection of Mycobacterium avium subspecies paratuberculosis DNA.
[So] Source:Biochem Biophys Res Commun;496(3):988-997, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gold nanoparticle (AuNP) is considered to be the most stable metal nanoparticle having the ability to be functionalized with biomolecules. Recently, AuNP-based DNA detection methods captured the interest of researchers worldwide. Paratuberculosis or Johne's disease, a chronic gastroenteritis in ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), was found to have negative effect in the livestock industry. In this study, AuNP-based probes were evaluated for the specific and sensitive detection of MAP DNA. AuNP-based probe was produced by functionalization of AuNPs with thiol-modified oligonucleotide and was confirmed by Fourier-Transform Infrared (FTIR) spectroscopy. UV-Vis spectroscopy and Scanning Electron Microscopy (SEM) were used to characterize AuNPs. DNA detection was done by hybridization of 10 µL of DNA with 5 µL of probe at 63 °C for 10 min and addition of 3 µL salt solution. The method was specific to MAP with detection limit of 103 ng. UV-Vis and SEM showed dispersion and aggregation of the AuNPs for the positive and negative results, respectively, with no observed particle growth. This study therefore reports an AuNP-based probes which can be used for the specific and sensitive detection of MAP DNA.
[Mh] Termos MeSH primário: Colorimetria/métodos
DNA/genética
DNA/isolamento & purificação
Ouro/química
Nanopartículas Metálicas/química
Mycobacterium avium/genética
Mycobacterium avium/isolamento & purificação
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/métodos
Hibridização In Situ/métodos
Técnicas de Sonda Molecular
Sondas Moleculares/química
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Molecular Probes); 7440-57-5 (Gold); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  10 / 31728 MEDLINE  
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[PMID]:29335403
[Au] Autor:Mignot A; Ferrari R; Claustre H
[Ad] Endereço:Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. mignot@obs-vlfr.fr.
[Ti] Título:Floats with bio-optical sensors reveal what processes trigger the North Atlantic bloom.
[So] Source:Nat Commun;9(1):190, 2018 01 15.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The North Atlantic bloom corresponds to a strong seasonal increase in phytoplankton that produces organic carbon through photosynthesis. It is still debated what physical and biological conditions trigger the bloom, because comprehensive time series of the vertical distribution of phytoplankton biomass are lacking. Vertical profiles from nine floats that sampled the waters of the North Atlantic every few days for a couple of years reveal that phytoplankton populations start growing in early winter at very weak rates. A proper bloom with rapidly accelerating population growth rates instead starts only in spring when atmospheric cooling subsides and the mixed layer rapidly shoals. While the weak accumulation of phytoplankton in winter is crucial to maintaining a viable population, the spring bloom dominates the overall seasonal production of organic carbon.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Monitoramento Ambiental/métodos
Eutrofização/fisiologia
Fotossíntese/fisiologia
Fitoplâncton/fisiologia
[Mh] Termos MeSH secundário: Oceano Atlântico
Biomassa
Clorofila/fisiologia
Monitoramento Ambiental/instrumentação
Estações do Ano
Água do Mar
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
1406-65-1 (Chlorophyll)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02143-6



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