Base de dados : MEDLINE
Pesquisa : E05.723.402.403 [Categoria DeCS]
Referências encontradas : 11632 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1164 ir para página                         

  1 / 11632 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29368462
[Au] Autor:Bertucci P
[Ti] Título:Shocking Subjects: Human Experiments and the Material Culture of Medical Electricity in Eighteenth-Century England.
[So] Source:Clio Med;95:111-38, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Eletricidade/história
Eletrofisiologia/história
Eletrochoque/história
Experimentação Humana/história
[Mh] Termos MeSH secundário: Pesquisa Biomédica/história
Estimulação Elétrica
Inglaterra
História do Século XVIII
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27778062
[Au] Autor:Tutka P; Kondrat-Wróbel MW; Zaluska K; Zólkowska D; Florek-Luszczki M; Luszczki JJ
[Ad] Endereço:Department of Pharmacology, University of Rzeszów, Al. Rejtana 16c, 35-959, Rzeszów, Poland. tutka@umlub.pl.
[Ti] Título:Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
[So] Source:Psychopharmacology (Berl);234(2):281-291, 2017 Jan.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cytisine (CYT) is a partial agonist of brain α4ß2 nicotinic acetylcholine receptors widely used in Central/Eastern Europe for smoking cessation. OBJECTIVES: This study evaluated the effect of CYT on the ability of classical and novel antiepileptic drugs to prevent seizures evoked by the 6-Hz test, a model of psychomotor seizures in mice thought as a model of drug-resistant seizures. RESULTS: CYT administered intraperitoneally (i.p.) in a dose of 2 mg kg significantly inhibited the anticonvulsant activity of lacosamide, levetiracetam, and pregabalin, increasing their median effective doses 50 (ED ) values from 6.88 to 10.52 mg kg (P < 0.05) for lacosamide, from 22.08 to 38.26 mg kg (P < 0.05) for levetiracetam, and from 40.48 to 64.61 mg kg (P < 0.01) for pregabalin, respectively. There were no significant changes in total brain concentrations of lacosamide, levetiracetam, and pregabalin following CYT i.p. administration. CYT administered in a dose of 2 mg kg failed to change the protective action of clobazam, clonazepam, phenobarbital, tiagabine, and valproate in the 6-Hz test. Neither CYT (2 mg kg ) alone nor its combination with the anticonvulsant drugs (at their ED values from the 6-Hz test) affected motor coordination; skeletal muscular strength and long-term memory, as determined in the chimney; and grip strength and passive avoidance tests, respectively. CONCLUSION: CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks.
[Mh] Termos MeSH primário: Alcaloides/toxicidade
Anticonvulsivantes/uso terapêutico
Eletrochoque/efeitos adversos
Agonistas Nicotínicos/toxicidade
Convulsões/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anticonvulsivantes/farmacologia
Azocinas/toxicidade
Relação Dose-Resposta a Droga
Masculino
Memória de Longo Prazo/efeitos dos fármacos
Memória de Longo Prazo/fisiologia
Camundongos
Fenobarbital/antagonistas & inibidores
Fenobarbital/farmacologia
Fenobarbital/uso terapêutico
Piracetam/análogos & derivados
Piracetam/antagonistas & inibidores
Piracetam/farmacologia
Piracetam/uso terapêutico
Quinolizinas/toxicidade
Convulsões/etiologia
Convulsões/psicologia
Ácido Valproico/antagonistas & inibidores
Ácido Valproico/farmacologia
Ácido Valproico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anticonvulsants); 0 (Azocines); 0 (Nicotinic Agonists); 0 (Quinolizines); 230447L0GL (etiracetam); 53S5U404NU (cytisine); 614OI1Z5WI (Valproic Acid); YQE403BP4D (Phenobarbital); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-016-4461-0


  3 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28957678
[Au] Autor:Lee SC; Amir A; Haufler D; Pare D
[Ad] Endereço:Center for Molecular and Behavioral Neuroscience, 197 University Avenue, Rutgers University-Newark, Newark, NJ 07102, USA.
[Ti] Título:Differential Recruitment of Competing Valence-Related Amygdala Networks during Anxiety.
[So] Source:Neuron;96(1):81-88.e5, 2017 Sep 27.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The basolateral amygdala (BL) is involved in fear and anxiety, but it is currently unclear how the same network supports these two states. To address this question, we trained rats on appetitive and aversive conditioning in different contexts. Distinct groups of BL neurons displayed increased activity during appetitive (CS-R) versus aversive (CS-S) conditioned stimuli (R cells and S cells, respectively), and they were typically inhibited by the other CS. When the CS-S was presented in the safe context, rats entered a long-lasting, anxiety-like state characterized by increased inter-CS freezing and impaired reward seeking. During this state, a subset of BL cells ("state cells") showed sustained shifts in baseline activity whose time course matched that of the behavioral changes. Many state cells with increased firing rates were S cells, whereas R cells only included state cells with reduced firing rates. Thus, anxiety involves persistent activity changes that are differentially expressed by subsets of valence-specific BL neurons.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Complexo Nuclear Basolateral da Amígdala/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Complexo Nuclear Basolateral da Amígdala/citologia
Condicionamento Clássico/fisiologia
Eletrochoque
Medo/fisiologia
Masculino
Inibição Neural/fisiologia
Neurônios/fisiologia
Ratos
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE


  4 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28859122
[Au] Autor:Luszczki JJ; Patrzylas P; Zagaja M; Andres-Mach M; Zaluska K; Kondrat-Wrobel MW; Szpringer M; Chmielewski J; Florek-Luszczki M
[Ad] Endereço:Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.
[Ti] Título:Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
[So] Source:PLoS One;12(8):e0183873, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in clinical settings. This study was aimed at characterizing the influence of arachidonyl-2'-chloroethylamide (ACEA-a selective cannabinoid CB1 receptor agonist) co-administered with phenylmethylsulfonyl fluoride (PMSF) on the anticonvulsant potency of various antiepileptic drugs (clobazam, lacosamide, levetiracetam, phenobarbital, tiagabine and valproate) in the 6-Hz corneal stimulation model. Psychomotor seizures in male albino Swiss mice were evoked by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via corneal electrodes. Potential adverse effects produced by the antiepileptic drugs in combination with ACEA+PMSF were assessed using the chimney test (motor performance), passive avoidance task (remembering and acquisition of learning), and grip-strength test (muscular strength). Brain concentrations of antiepileptic drugs were measured by HPLC to exclude any pharmacokinetic contribution to the observed effect. ACEA (5 mg/kg, i.p.) + PMSF (30 mg/kg, i.p.) significantly potentiated the anticonvulsant potency of levetiracetam (P<0.05), but not that of clobazam, lacosamide, phenobarbital, tiagabine or valproate in the 6-Hz corneal stimulation model. Moreover, ACEA+PMSF did not significantly affect total brain concentrations of levetiracetam in mice. No behavioral side effects were observed in animals receiving combinations of the studied antiepileptic drugs with ACEA+PMSF. In conclusion, the combined administration of ACEA+PMSF with levetiracetam is associated with beneficial anticonvulsant pharmacodynamic interaction in the 6-Hz corneal stimulation model. The selective activation of cannabinoid CB1 receptor-mediated neurotransmission in the brain may enhance levetiracetam-related suppression of seizures in epilepsy patients, contributing to the efficacious treatment of epilepsy in future.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Ácidos Araquidônicos/farmacologia
Epilepsia Parcial Complexa/tratamento farmacológico
Fluoreto de Fenilmetilsulfonil/farmacologia
Piracetam/análogos & derivados
Receptor CB1 de Canabinoide/agonistas
[Mh] Termos MeSH secundário: Acetamidas/farmacologia
Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Benzodiazepinas/farmacologia
Córnea
Modelos Animais de Doenças
Sinergismo Farmacológico
Quimioterapia Combinada
Eletrochoque/métodos
Epilepsia Parcial Complexa/metabolismo
Epilepsia Parcial Complexa/fisiopatologia
Masculino
Camundongos
Força Muscular/efeitos dos fármacos
Ácidos Nipecóticos/farmacologia
Fenobarbital/farmacologia
Piracetam/farmacologia
Desempenho Psicomotor/efeitos dos fármacos
Ácido Valproico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Anticonvulsants); 0 (Arachidonic Acids); 0 (Nipecotic Acids); 0 (Receptor, Cannabinoid, CB1); 0 (arachidonyl-2-chloroethylamide); 12794-10-4 (Benzodiazepines); 230447L0GL (etiracetam); 2MRO291B4U (clobazam); 563KS2PQY5 (lacosamide); 57KD15003I (Phenylmethylsulfonyl Fluoride); 614OI1Z5WI (Valproic Acid); YQE403BP4D (Phenobarbital); Z80I64HMNP (tiagabine); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183873


  5 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28806600
[Au] Autor:Sahu M; Siddiqui N; Iqbal R; Sharma V; Wakode S
[Ad] Endereço:Department of Pharmaceutical Chemistry, School of Pharmaceutical Education & Research (Formerly, Faculty of Pharmacy), Jamia Hamdard, New Delhi 110062, India.
[Ti] Título:Design, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential.
[So] Source:Bioorg Chem;74:166-178, 2017 Oct.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several new 5,6-dihydropyrimidine-2(1H)-thione derivatives have been prepared and investigated for their potencies for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) test in mice. The acute neurotoxicity was measured by rotarod test. Compounds 3c and 3l were found active in both of the animal models. Further, in vitro GABA-AT enzyme activity assay was carried out to investigate the possible mechanism of action through GABA-AT inhibition. The most potent compounds 3c and 3l showed inhibitory potency (IC ) of 18.42µM and 19.23µM, respectively. The molecular modeling was performed for all the synthesized compounds. The docking results were found in concordant with the observed animal studies.
[Mh] Termos MeSH primário: 4-Aminobutirato Transaminase/antagonistas & inibidores
Anticonvulsivantes/farmacologia
Desenho de Drogas
Inibidores Enzimáticos/farmacologia
Pirimidinas/farmacologia
Convulsões/tratamento farmacológico
Tionas/farmacologia
[Mh] Termos MeSH secundário: 4-Aminobutirato Transaminase/metabolismo
Animais
Anticonvulsivantes/síntese química
Anticonvulsivantes/química
Relação Dose-Resposta a Droga
Eletrochoque
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Camundongos
Modelos Moleculares
Estrutura Molecular
Pentilenotetrazol
Pirimidinas/síntese química
Pirimidinas/química
Relação Estrutura-Atividade
Tionas/síntese química
Tionas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5,6-dihydropyrimidine-2(1H)-thione); 0 (Anticonvulsants); 0 (Enzyme Inhibitors); 0 (Pyrimidines); 0 (Thiones); EC 2.6.1.19 (4-Aminobutyrate Transaminase); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  6 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28708877
[Au] Autor:Balázsfi DG; Zelena D; Farkas L; Demeter K; Barna I; Cserép C; Takács VT; Nyíri G; Gölöncsér F; Sperlágh B; Freund TF; Haller J
[Ad] Endereço:Department of Behavioral Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.
[Ti] Título:Median raphe region stimulation alone generates remote, but not recent fear memory traces.
[So] Source:PLoS One;12(7):e0181264, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The median raphe region (MRR) is believed to control the fear circuitry indirectly, by influencing the encoding and retrieval of fear memories by amygdala, hippocampus and prefrontal cortex. Here we show that in addition to this established role, MRR stimulation may alone elicit the emergence of remote but not recent fear memories. We substituted electric shocks with optic stimulation of MRR in C57BL/6N male mice in an optogenetic conditioning paradigm and found that stimulations produced agitation, but not fear, during the conditioning trial. Contextual fear, reflected by freezing was not present the next day, but appeared after a 7 days incubation. The optogenetic silencing of MRR during electric shocks ameliorated conditioned fear also seven, but not one day after conditioning. The optogenetic stimulation patterns (50Hz theta burst and 20Hz) used in our tests elicited serotonin release in vitro and lead to activation primarily in the periaqueductal gray examined by c-Fos immunohistochemistry. Earlier studies demonstrated that fear can be induced acutely by stimulation of several subcortical centers, which, however, do not generate persistent fear memories. Here we show that the MRR also elicits fear, but this develops slowly over time, likely by plastic changes induced by the area and its connections. These findings assign a specific role to the MRR in fear learning. Particularly, we suggest that this area is responsible for the durable sensitization of fear circuits towards aversive contexts, and by this, it contributes to the persistence of fear memories. This suggests the existence a bottom-up control of fear circuits by the MRR, which complements the top-down control exerted by the medial prefrontal cortex.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Eletrochoque
Medo/fisiologia
Halorrodopsinas/metabolismo
Imuno-Histoquímica
Masculino
Memória/fisiologia
Camundongos
Camundongos Endogâmicos C57BL
Substância Cinzenta Periaquedutal/metabolismo
Proteínas Proto-Oncogênicas c-fos/metabolismo
Serotonina/metabolismo
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Halorhodopsins); 0 (Proto-Oncogene Proteins c-fos); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181264


  7 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28685540
[Au] Autor:Zurawinski W; Sosada K; Muc-Wierzgon M; Kokot T
[Ad] Endereço:Department of Emergency Medicine, School of Medicine in Katowice, Silesian Medical University in Katowice, Katowice, Poland.
[Ti] Título:Impact of low-energy shock impulse on nitric oxide serum levels in healthy rabbits.
[So] Source:J Biol Regul Homeost Agents;31(2):377-382, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Nitric oxide (NO) has emerged as a potent effector molecule for a post-resuscitation disease as a result of the low-energy defibrillation. In this article, the authors anlysed the changes of endogenous nitric oxide levels in serum of 35 healthy rabbits after the transthoracic application of low-energy two-phase shock impulse. The animals were randomised into four groups according to the electrical energy dose to be applied during the experiment. Life parameters of the animals were monitored using the BeneViev T5 patient monitor. The nitric oxide concentration in the groups was measured before, 15 and 360 minutes after applying the low-energy two-phase linear electrical impulse. From 15 to 360 minutes the decrease in nitric oxide concentration was observed. The effect was dependent on single impulse and accumulated energy volumes. The highest decrease of NO concentration was observed in 15 minutes following the application of two electrical impulses of accumulated energy of 8 J/kg/bm. After 360 minutes following the application, a significant increase in nitric oxide levels was recorded. The changes in the nitric oxide levels in the blood serum 15 minutes after the defibrillation may initiate the vasomotor disorders as a result of the low-energy influence of the shock impulse.
[Mh] Termos MeSH primário: Eletrochoque
Óxido Nítrico/sangue
[Mh] Termos MeSH secundário: Animais
Coelhos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  8 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28539417
[Au] Autor:Park H; Rhee J; Park K; Han JS; Malinow R; Chung C
[Ad] Endereço:Department of Biological Sciences, Konkuk University, Seoul 05029, South Korea, and.
[Ti] Título:Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula.
[So] Source:J Neurosci;37(25):6021-6030, 2017 Jun 21.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lateral habenula (LHb) is a small part of the epithalamus that projects to monoamine centers in the brain. Previously, neurotransmission onto the LHb was shown to be abnormally potentiated in animal models of depression. However, synaptic plasticity in this brain area and the effect of stressor exposure on synaptic plasticity of the LHb have not been investigated. Thus, we explored whether the LHb undergoes dynamic changes in synaptic efficacy or not. First, we observed that a moderate LTP occurs in a fraction of LHb neurons obtained from naive Sprague Dawley rats. Interestingly, a single exposure to acute stressors, such as inescapable foot shock or restraint plus tail shock (RTS), significantly enhances the magnitude of LTP in the LHb. We also observed an increased number of LHb neurons expressing phosphorylated cAMP response element-binding protein (pCREB) after exposure to stressors, which may contribute to determine the threshold for LTP induction. LTP induction in the LHb resulted in an additional increase in the number of pCREB-expressing neurons in stress-exposed animals but not in naive control animals. Together, we showed that LHb neurons have heterogeneous propensity for synaptic potentiation at rest; however, a single exposure to stressors greatly facilitates LTP induction in the LHb, suggesting that fundamental alterations in synaptic plasticity in the LHb may occur in animal models of depression or post-traumatic stress disorder. Stress exposure is known to cause depression in human patients and animal models, although explanations at the cellular level remain to be elaborated. Here, we show that the lateral habenula (LHb) exhibits LTP after a pattern of brief strong stimulation. In addition, we show that stress exposure facilitates LTP in the LHb by lowering the threshold for LTP induction. We observed a selective increase in the number of neurons expressing pCREB in the LHb of animal models of depression. LTP induction results in a further increase in the density of pCREB-expressing neurons only after stress exposure. Our study provides the first evidence that animal models of depression exhibit altered synaptic plasticity of the LHb.
[Mh] Termos MeSH primário: Habênula/fisiopatologia
Potenciação de Longa Duração
Estresse Psicológico/fisiopatologia
Sinapses
[Mh] Termos MeSH secundário: Animais
Ansiedade/fisiopatologia
Ansiedade/psicologia
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Eletrochoque
Técnicas In Vitro
Masculino
Ratos
Ratos Sprague-Dawley
Restrição Física
Transtornos de Estresse Pós-Traumáticos/metabolismo
Transtornos de Estresse Pós-Traumáticos/fisiopatologia
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclic AMP Response Element-Binding Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.2281-16.2017


  9 / 11632 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28412310
[Au] Autor:Socala K; Nieoczym D; Kowalczuk-Vasilev E; Wyska E; Wlaz P
[Ad] Endereço:Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland. Electronic address: ksocala@op.pl.
[Ti] Título:Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice.
[So] Source:Toxicol Appl Pharmacol;326:43-53, 2017 Jul 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Activation of Nrf2 with sulforaphane has recently gained attention as a new therapeutic approach in the treatment of many diseases, including epilepsy. As a plant-derived compound, sulforaphane is considered to be safe and well-tolerated. It is widely consumed, also by patients suffering from seizure and taking antiepileptic drugs, but no toxicity profile of sulforaphane exists. Since many natural remedies and dietary supplements may increase seizure risk and potentially interact with antiepileptic drugs, the aim of our study was to investigate the acute effects of sulforaphane on seizure thresholds and activity of some first- and second-generation antiepileptic drugs in mice. In addition, some preliminary toxicity profile of sulforaphane in mice after intraperitoneal injection was evaluated. The LD value of sulforaphane in mice was estimated at 212.67mg/kg, while the TD value - at 191.58mg/kg. In seizure tests, sulforaphane at the highest dose tested (200mg/kg) significantly decreased the thresholds for the onset of the first myoclonic twitch and generalized clonic seizure in the iv PTZ test as well as the threshold for the 6Hz-induced psychomotor seizure. At doses of 10-200mg/kg, sulforaphane did not affect the threshold for the iv PTZ-induced forelimb tonus or the threshold for maximal electroshock-induced hindlimb tonus. Interestingly, sulforaphane (at 100mg/kg) potentiated the anticonvulsant efficacy of carbamazepine in the maximal electroshock seizure test. This interaction could have been pharmacokinetic in nature, as sulforaphane increased concentrations of carbamazepine in both serum and brain tissue. The toxicity study showed that high doses of sulforaphane produced marked sedation (at 150-300mg/kg), hypothermia (at 150-300mg/kg), impairment of motor coordination (at 200-300mg/kg), decrease in skeletal muscle strength (at 250-300mg/kg), and deaths (at 200-300mg/kg). Moreover, blood analysis showed leucopenia in mice injected with sulforaphane at 200mg/kg. In conclusion, since sulforaphane was proconvulsant at a toxic dose, the safety profile and the risk-to-benefit ratio of sulforaphane usage in epileptic patients should be further evaluated.
[Mh] Termos MeSH primário: Anticonvulsivantes/toxicidade
Encéfalo/efeitos dos fármacos
Isotiocianatos/toxicidade
Convulsões/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Regulação da Temperatura Corporal/efeitos dos fármacos
Encéfalo/fisiopatologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Interações Medicamentosas
Eletrochoque
Dose Letal Mediana
Masculino
Memória de Longo Prazo/efeitos dos fármacos
Camundongos
Atividade Motora/efeitos dos fármacos
Força Muscular/efeitos dos fármacos
Pentilenotetrazol
Desempenho Psicomotor/efeitos dos fármacos
Medição de Risco
Convulsões/sangue
Convulsões/fisiopatologia
Convulsões/prevenção & controle
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Isothiocyanates); GA49J4310U (sulforafan); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


  10 / 11632 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28399089
[Au] Autor:Kondratova IV; Kulinkovich KY
[Ad] Endereço:Federal state budgetary institution 'Russian Centre of Forensic Medical Expertise', Russian Ministry of Health, Moscow, Russia, 125284.
[Ti] Título:[The topical problems of the application of the TASER electroshock devices].
[Ti] Título:Aktual'nye voprosy primeneniia élektroshokovogo ustroistva TASER..
[So] Source:Sud Med Ekspert;60(2):57-64, 2017.
[Is] ISSN:0039-4521
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was the analysis of publications in the foreign medical literature concerning the problems of safety, clinical diagnostics, pathological morphology, and treatment of the patients subjected to the impact by various models of the TASER electroshock devices. The materials for this article were borrowed from the available Internet resources and libraries. The methods of scientific analysis were employed to follow up the dynamics of publication and to determine the number of publications on the issues of interest. The main attention was given to the overview of the subject matter of scientific research and experiments. The review covers 74 foreign articles presenting the discussion of various conditions and circumstances of the action of various types of the TASER electroshock devices (ESD) on the man with special reference to their effectiveness and safety as confirmed by numerous experimental impacts on the volunteers and animals. It is shown that the dynamics of relevant publications in the foreign scientific periodicals gives evidence of the strong interest shown by the specialists in various scientific disciplines to the problem of safety of various models of the TASER electroshock devices. The largest number of the articles (60 or 81.1%) published during the period covered by the present study were submitted by the American authors describing their experiments involving the volunteers, anthropometric dummies, and human corpses (n=38 or 51%). The subject matter of these publications included the forensic medical evaluation of the lethal outcomes of the application of the TASER electroshock devices with the related technical problems and characteristic of various ESD models. Despite the extensive studies on the volunteers and the experimental animals, the authors of the publications failed to present direct and conclusive evidence of the lethal consequences of the application of the TASER electroshock devices (ESD) on the man. Some of them recommend to prohibit (or restrict whenever possible) the targeted application of the electric shock weapons to the thoracic region. Experiments on the animals have demonstrated the possibility of development of cardiovascular and respiratory complications following the application of the TASER X2 electroshock devices operating at a frequency of 40 Hz during 30 minutes. The clinical and laboratory studies with the participation of the volunteers in an alcoholic intoxication condition have confirmed the long-term increase in the blood lactate levels under the influence of the electric shocking weapons. The analogous data suggesting the development of pronounced acidosis under effect of the TASER X2 electroshock devices due to the elevation of the lactate concentration in the venous blood have been obtained in the animal experiments. The studies of humans in a narcotic intoxication condition failed to provide direct evidence of induction of psychic disorders in the form of an acute confusional state (delirium) under the influence of the TASER electroshock devices. The evaluation of changes in the skin cover in the form of the punctured or contused wounds in the victims of the application of the electroshock gun projectiles did not revealed any specific signs of the local electrical action.
[Mh] Termos MeSH primário: Lesões por Armas de Eletrochoque
Medicina Legal/métodos
Armas
[Mh] Termos MeSH secundário: Lesões por Armas de Eletrochoque/diagnóstico
Lesões por Armas de Eletrochoque/patologia
Lesões por Armas de Eletrochoque/fisiopatologia
Eletrochoque/instrumentação
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.17116/sudmed201760257-64



página 1 de 1164 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde