Base de dados : MEDLINE
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[PMID]:29431945
[Au] Autor:Sinitskaya TA; Malinovskaya NN
[Ti] Título:[Toxicological-hygienic justification of the acceptable daily intake of acetamiprid].
[So] Source:Gig Sanit;95(11):1055-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Neonicotinoids are currently meaningful component of rotation schemes of insecticides of selective action in the system of integrated pest control, which have agricultural importance in many countries. The research results of the biological impact of acetamiprid (neonicotinoids) on the body of laboratory animals are given in the article. The study showed that the explored active substance is related to the moderately hazardous compounds (hazard category 3) in case of one-time per oral penetration. Acetamiprid has polytropic action in the case of chronic (12 months) oral entering the body of laboratory animals, it gives rise changes in functionality of the central nervous system, blood system, liver functioning. On the base of alterations of the studied indices there were established both the no-effect dose level (NOEL) and acceptable daily intake of acetamiprid for humans.
[Mh] Termos MeSH primário: Células Sanguíneas/efeitos dos fármacos
Sistema Nervoso Central/efeitos dos fármacos
Neonicotinoides
Envenenamento
[Mh] Termos MeSH secundário: Administração Oral
Animais
Comportamento Animal/efeitos dos fármacos
Modelos Animais de Doenças
Testes Hematológicos/métodos
Inseticidas/farmacologia
Inseticidas/toxicidade
Testes de Função Hepática/métodos
Concentração Máxima Permitida
Neonicotinoides/farmacologia
Neonicotinoides/toxicidade
Nível de Efeito Adverso não Observado
Órgãos em Risco
Envenenamento/sangue
Envenenamento/diagnóstico
Envenenamento/etiologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 5HL5N372P0 (acetamiprid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:28822260
[Au] Autor:Omouri Z; Hawari J; Fournier M; Robidoux PY
[Ad] Endereço:INRS-Institut Armand Frappier, 531 boulevard des Prairies, Laval, Québec, Canada H7V 1B7; National Research Council of Canada, 6100 Avenue Royalmount, Montréal, Québec, Canada H4P 2R2. Electronic address: Zohra.Omouri@iaf.inrs.ca.
[Ti] Título:Bioavailability and chronic toxicity of bismuth citrate to earthworm Eisenia andrei exposed to natural sandy soil.
[So] Source:Ecotoxicol Environ Saf;147:1-8, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study describes bioavailability and chronic effects of bismuth to earthworms Eisenia andrei using OECD reproduction test. Adult earthworms were exposed to natural sandy soil contaminated artificially by bismuth citrate. Average total concentrations of bismuth in soil recovered by HNO digestion ranged from 75 to 289mg/kg. Results indicate that bismuth decreased significantly all reproduction parameters of Eisenia andrei at concentrations ≥ 116mg/kg. However, number of hatched cocoons and number of juveniles seem to be more sensitive than total number of cocoons, as determined by IC ; i.e., 182, 123 and > 289mg/kg, respectively. Bismuth did not affect Eisenia andrei growth and survival, and had little effect on phagocytic efficiency of coelomocytes. The low immunotoxicity effect might be explained by the involvement of other mechanisms i.e. bismuth sequestered by metal-binding compounds. After 28 days of exposure bismuth concentrations in earthworms tissue increased with increasing bismuth concentrations in soil reaching a stationary state of 21.37mg/kg dry tissue for 243mg Bi/kg dry soil total content. Data indicate also that after 56 days of incubation the average fractions of bismuth available extracted by KNO aqueous solution in soil without earthworms varied from 0.0051 to 0.0229mg/kg, while in soil with earthworms bismuth concentration ranged between 0.310-1.347mg/kg dry soil. We presume that mucus and chelating agents produced by earthworms and by soil or/and earthworm gut microorganisms could explain this enhancement, as well as the role of dermal and ingestion routes of earthworms uptake to soil contaminant.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Oligoquetos/efeitos dos fármacos
Compostos Organometálicos/toxicidade
Poluentes do Solo/toxicidade
Solo/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Biomarcadores/análise
Relação Dose-Resposta a Droga
Nível de Efeito Adverso não Observado
Oligoquetos/metabolismo
Compostos Organometálicos/análise
Compostos Organometálicos/metabolismo
Fagocitose/efeitos dos fármacos
Reprodução/efeitos dos fármacos
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Organometallic Compounds); 0 (Soil); 0 (Soil Pollutants); HS813P8QPX (bismuth tripotassium dicitrate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE


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[PMID]:29311446
[Au] Autor:Sato Y; Yasumiishi C; Chiba T; Umegaki K
[Ad] Endereço:Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition.
[Ti] Título:[A Systematic Review to Identify Unacceptable Intake Levels of Vitamin B6 among Patients Taking Levodopa].
[So] Source:Shokuhin Eiseigaku Zasshi;58(6):268-274, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The interaction of levodopa and vitamin B6 is a well-known issue. This study investigated the incidence of unacceptable intake levels of vitamin B6 among levodopa users by means of a systematic review. We searched two databases (PubMed and "Igaku Chuo Zasshi") for articles about adverse events due to the interaction of levodopa and vitamin B6 published up to August 2017. Of 98 citations retrieved, 11 studies met the selection criteria. The results indicated that a vitamin B6 intake level of more than 50 mg/day could reduce the efficacy of levodopa. The recommended intake of vitamin B6 for Japanese adults is 1.4 mg/day for men and 1.2 mg/day for women. Therefore, the acceptable intake of vitamin B6 for levodopa patients would be within the range of the recommended intake level, which is also within the usual range in foods in Japan, except for dietary supplements or health foods. Levodopa users should be cautious about taking dietary supplements and over-the-counter drugs.
[Mh] Termos MeSH primário: Levodopa/administração & dosagem
Nível de Efeito Adverso não Observado
Vitamina B 6/administração & dosagem
[Mh] Termos MeSH secundário: Bases de Dados Bibliográficas
Suplementos Nutricionais
Interações Medicamentosas
Feminino
Seres Humanos
Masculino
Medicamentos sem Prescrição
Doença de Parkinson/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Nonprescription Drugs); 46627O600J (Levodopa); 8059-24-3 (Vitamin B 6)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.268


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[PMID]:28454766
[Au] Autor:Rieke S; Heise T; Schmidt F; Haider W; Bednarz H; Niehaus K; Mentz A; Kalinowski J; Hirsch-Ernst KI; Steinberg P; Niemann L; Marx-Stoelting P
[Ad] Endereço:Bundesinstitut für Risikobewertung (BfR), Department for Pesticides Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
[Ti] Título:Mixture effects of azole fungicides on the adrenal gland in a broad dose range.
[So] Source:Toxicology;385:28-37, 2017 06 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Consumers are exposed to low concentrations of a variety of pesticide residues in or on food. Some of them might interfere with the endocrine system. While each individual active substance has been extensively tested for toxicity and safety, potential combination effects possibly resulting from combined exposure to different pesticides have seldomly been tested so far, especially in vivo. Since the adrenal gland is a key endocrine organ, we investigated if and how substances of a group of fungicides presumed to interfere with the biosynthesis of steroid hormones affect this organ when applied individually and in combination in a broad dose range. A 28-day feeding study was conducted in Wistar rats by using three (tri)azole fungicides considered to potentially affect the endocrine system (cyproconazole, epoxiconazole and prochloraz) individually at five dose levels, ranging from 0.9ppm to 2400ppm, and in combination at three dose levels. The parameters analysed included classical toxicology (pathology, histopathology, clinical chemistry) and molecular toxicology endpoints (gene expression arrays and quantitative real time PCR e.g. of Star, HSD3ß, Cyp11a1, Cyp11b1, Cyp11b2, Cyp 21, ApoE), as well as hormone analysis. A dose-dependent decrease in the adrenal gland weight of rats treated with epoxiconazole alone, which was accompanied by an atrophy of the adrenal gland as well as by an increase in the serum cholesterol level and which only became statistically significant at the top dose levels, was observed. These effects were attenuated in the combination experiments, although the same epoxiconazole concentration was used.
[Mh] Termos MeSH primário: Glândulas Suprarrenais/efeitos dos fármacos
Azóis/toxicidade
Fungicidas Industriais/toxicidade
[Mh] Termos MeSH secundário: 3-Hidroxiesteroide Desidrogenases/genética
Glândulas Suprarrenais/metabolismo
Glândulas Suprarrenais/patologia
Aldosterona/sangue
Animais
Apolipoproteínas E/genética
Colesterol/sangue
Corticosterona/sangue
Sistema Enzimático do Citocromo P-450/genética
Interações Medicamentosas
Expressão Gênica/efeitos dos fármacos
Masculino
Nível de Efeito Adverso não Observado
Tamanho do Órgão/efeitos dos fármacos
Fosfoproteínas/genética
Progesterona/sangue
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Azoles); 0 (Fungicides, Industrial); 0 (Phosphoproteins); 0 (steroidogenic acute regulatory protein); 4964P6T9RB (Aldosterone); 4G7DS2Q64Y (Progesterone); 9035-51-2 (Cytochrome P-450 Enzyme System); 97C5T2UQ7J (Cholesterol); EC 1.1.- (3-Hydroxysteroid Dehydrogenases); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28966025
[Au] Autor:Honda M; Kannan K
[Ad] Endereço:Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509, USA.
[Ti] Título:Biomonitoring of chlorophenols in human urine from several Asian countries, Greece and the United States.
[So] Source:Environ Pollut;232:487-493, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chlorophenols (CPs) are used in the production of pesticides and preservatives. Although human exposure to CPs has been known for years, current exposure levels to these chemicals in Asian countries are not known. In this study, we analyzed concentrations of eight CPs in 300 human urine samples collected from nine countries. Of these CPs, 2,5-dichlorophenol and 2,4-dichlorophenol were found at the highest median concentrations (median for all nine countries: 1.78 and 0.34 ng/mL, respectively). Pentachlorophenol was found in 59% of the samples analyzed at a median concentration of 0.07 ng/mL. Urine samples from Japan had the highest concentration of total CPs (median: 16.7 ng/mL) with 2,5-dichlorophenol accounting for 93.1% of the total concentration. The estimated daily intake (DI) for precursors of dichlorophenols varied widely, but several samples showed values higher than the acceptable DI recommended by the United States Environmental Protection Agency (EPA). These results suggest that CP exposure, especially to dichlorophenols, is prevalent in several countries, particularly in Asia, suggesting a pressing need for further assessment of the global sources and potential health effects of these chemicals.
[Mh] Termos MeSH primário: Clorofenóis/urina
Exposição Ambiental/análise
Poluentes Ambientais/urina
[Mh] Termos MeSH secundário: Ásia
Meio Ambiente
Exposição Ambiental/estatística & dados numéricos
Monitoramento Ambiental
Grécia
Seres Humanos
Japão
Nível de Efeito Adverso não Observado
Pentaclorofenol
Praguicidas
Fenóis/urina
Estados Unidos
United States Environmental Protection Agency
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorophenols); 0 (Environmental Pollutants); 0 (Pesticides); 0 (Phenols); 3B11G9AKBA (2,5-dichlorophenol); D9BSU0SE4T (Pentachlorophenol); R669TG1950 (2,4-dichlorophenol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


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[PMID]:29030271
[Au] Autor:Hirano T; Yanai S; Takada T; Yoneda N; Omotehara T; Kubota N; Minami K; Yamamoto A; Mantani Y; Yokoyama T; Kitagawa H; Hoshi N
[Ad] Endereço:Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
[Ti] Título:NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment.
[So] Source:Toxicol Lett;282:57-63, 2018 Jan 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neonicotinoids are novel systemic pesticides acting as agonists on the nicotinic acetylcholine receptors (nAChRs) of insects. Experimental studies have revealed that neonicotinoids pose potential risks for the nervous systems of non-target species, but the brain regions responsible for their behavioral effects remain incompletely understood. This study aimed to assess the neurobehavioral effects of clothianidin (CTD), a later neonicotinoid developed in 2001 and widely used worldwide, and to explore the target regions of neonicotinoids in the mammalian brain. A single-administration of 5 or 50mg/kg CTD to male C57BL/6N mice at or below the no-observed-adverse-effect level (NOAEL) induced an acute increase in anxiety during the elevated plus-maze test. In addition, mice in the CTD-administered group spontaneously emitted human-audible vocalizations (4-16kHz), which are behavioral signs of aversive emotions, and showed increased numbers of c-fos immunoreactive cells in the paraventricular thalamic nucleus and dentate gyrus of the hippocampus. In conclusion, mice exposed to NOAEL-dose CTD would be rendered vulnerable to a novel environment via the activation of thalamic and hippocampal regions related to stress responses. These findings should provide critical insight into the neurobehavioral effects of neonicotinoids on mammals.
[Mh] Termos MeSH primário: Ansiedade/induzido quimicamente
Encéfalo/efeitos dos fármacos
Guanidinas/toxicidade
Inseticidas/toxicidade
Neonicotinoides/toxicidade
Estresse Fisiológico/efeitos dos fármacos
Tiazóis/toxicidade
Vocalização Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ansiedade/psicologia
Encéfalo/fisiopatologia
Relação Dose-Resposta a Droga
Seres Humanos
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Nível de Efeito Adverso não Observado
Espectrografia do Som
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Guanidines); 0 (Insecticides); 0 (Neonicotinoids); 0 (Thiazoles); 2V9906ABKQ (clothianidin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28777041
[Au] Autor:Hansen BH; Hallmann A; Altin D; Jenssen BM; Ciesielski TM
[Ad] Endereço:a SINTEF Ocean AS, Environmental Technology , Trondheim , Norway.
[Ti] Título:Acute hydrogen peroxide (H O ) exposure does not cause oxidative stress in late-copepodite stage of Calanus finmarchicus.
[So] Source:J Toxicol Environ Health A;80(16-18):820-829, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Use of hydrogen peroxide (H O ) for removal of salmon lice in the aquaculture industry has created concern that non-target organisms might be affected during treatment scenarios. The aim of the present study was to examine the potential for H O to produce oxidative stress and reduce survival in one of the most abundant zooplankton species in Norwegian coastal areas, the copepod Calanus finmarchicus. Copepods were subjected to two 96-hr tests: (1) acute toxicity test where mortality was determined and (2) treated copepods were exposed to concentrations below the No Observed Effect Concentration (0.75 mg/L) H O and analyzed for antioxidant enzyme activities, as well as levels of glutathione (GSH) and malondialdehyde (MDA). Compared to available and comparable LC values from the literature, our results suggest that C. finmarchicus is highly sensitive to H O . However, 96-hr exposure of C. finmarchicus to 0.75 mg H O /L did not significantly affect the antioxidant systems even though the concentration is just below the level where mortality is expected. Data suggest that aqueous H O exposure did not cause cellular accumulation with associated oxidative stress, but rather produced acute effects on copepod surface (carapace). Further investigation is required to ensure that aqueous exposure during H O treatment in salmon fish farms does not exert adverse effects on local non-target crustacean species and populations. In particular, studies on copepod developmental stages with a more permeable carapace are warranted.
[Mh] Termos MeSH primário: Copépodes/efeitos dos fármacos
Peróxido de Hidrogênio/toxicidade
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Resistência a Medicamentos
Contaminação de Alimentos/prevenção & controle
Glutationa/metabolismo
Dose Letal Mediana
Malondialdeído/metabolismo
Nível de Efeito Adverso não Observado
Noruega
Espécies Reativas de Oxigênio/metabolismo
Água do Mar/química
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 4Y8F71G49Q (Malondialdehyde); BBX060AN9V (Hydrogen Peroxide); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1352182


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[PMID]:28735337
[Au] Autor:Hartung T
[Ad] Endereço:Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
[Ti] Título:Thresholds of Toxicological Concern - Setting a threshold for testing below which there is little concern.
[So] Source:ALTEX;34(3):331-351, 2017.
[Is] ISSN:1868-596X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Low dose, low risk; very low dose, no real risk. Setting a pragmatic threshold below which concerns become negligible is the purpose of thresholds of toxicological concern (TTC). The idea is that such threshold values do not need to be established for each and every chemical based on experimental data, but that by analyzing the distribution of lowest or no-effect doses of many chemicals, a TTC can be defined - typically using the 5th percentile of this distribution and lowering it by an uncertainty factor of, e.g., 100. In doing so, TTC aims to compare exposure information (dose) with a threshold below which any hazard manifestation is very unlikely to occur. The history and current developments of this concept are reviewed and the application of TTC for different regulated products and their hazards is discussed. TTC lends itself as a pragmatic filter to deprioritize testing needs whenever real-life exposures are much lower than levels where hazard manifestation would be expected, a situation that is called "negligible exposure" in the REACH legislation, though the TTC concept has not been fully incorporated in its implementation (yet). Other areas and regulations - especially in the food sector and for pharmaceutical impurities - are more proactive. Large, curated databases on toxic effects of chemicals provide us with the opportunity to set TTC for many hazards and substance classes and thus offer a precautionary second tier for risk assessments if hazard cannot be excluded. This allows focusing testing efforts better on relevant exposures to chemicals.
[Mh] Termos MeSH primário: Testes de Toxicidade/normas
[Mh] Termos MeSH secundário: Animais
Cosméticos/normas
Poluentes Ambientais/normas
Alimentos/normas
Seres Humanos
Nível de Efeito Adverso não Observado
Preparações Farmacêuticas/normas
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cosmetics); 0 (Environmental Pollutants); 0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE
[do] DOI:10.14573/altex.1707011


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[PMID]:28679150
[Au] Autor:Hu H; Zhang Y; Shi Y; Feng L; Duan J; Sun Z
[Ad] Endereço:Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
[Ti] Título:Microarray-based bioinformatics analysis of the combined effects of SiNPs and PbAc on cardiovascular system in zebrafish.
[So] Source:Chemosphere;184:1298-1309, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:With rapid development of nanotechnology and growing environmental pollution, the combined toxic effects of SiNPs and pollutants of heavy metals like lead have received global attentions. The aim of this study was to explore the cardiovascular effects of the co-exposure of SiNPs and lead acetate (PbAc) in zebrafish using microarray and bioinformatics analysis. Although there was no other obvious cardiovascular malformation except bleeding phenotype, bradycardia, angiogenesis inhibition and declined cardiac output in zebrafish co-exposed of SiNPs and PbAc at NOAEL level, significant changes were observed in mRNA and microRNA (miRNA) expression patterns. STC-GO analysis indicated that the co-exposure might have more toxic effects on cardiovascular system than that exposure alone. Key differentially expressed genes were discerned out based on the Dynamic-gene-network, including stxbp1a, ndfip2, celf4 and gsk3b. Furthermore, several miRNAs obtained from the miRNA-Gene-Network might play crucial roles in cardiovascular disease, such as dre-miR-93, dre-miR-34a, dre-miR-181c, dre-miR-7145, dre-miR-730, dre-miR-129-5p, dre-miR-19d, dre-miR-218b, dre-miR-221. Besides, the analysis of miRNA-pathway-network indicated that the zebrafish were stimulated by the co-exposure of SiNPs and PbAc, which might cause the disturbance of calcium homeostasis and endoplasmic reticulum stress. As a result, cardiac muscle contraction might be deteriorated. In general, our data provide abundant fundamental research clues to the combined toxicity of environmental pollutants and further in-depth verifications are needed.
[Mh] Termos MeSH primário: Sistema Cardiovascular/efeitos dos fármacos
Nanopartículas/toxicidade
Compostos Organometálicos/toxicidade
Silício/toxicidade
Testes de Toxicidade/métodos
Poluentes Químicos da Água/toxicidade
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Sistema Cardiovascular/patologia
Biologia Computacional
Seres Humanos
MicroRNAs/genética
Nível de Efeito Adverso não Observado
Fenótipo
RNA Mensageiro/metabolismo
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Organometallic Compounds); 0 (RNA, Messenger); 0 (Water Pollutants, Chemical); RX077P88RY (lead acetate); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28655517
[Au] Autor:Dekant W; Fujii K; Shibata E; Morita O; Shimotoyodome A
[Ad] Endereço:Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany. Electronic address: dekant@toxi.uni-wuerzburg.de.
[Ti] Título:Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements.
[So] Source:Toxicol Lett;277:104-108, 2017 Aug 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The safety of green tea infusions and green tea extract (GTE)-based products is reviewed regarding catechins. Epigallocatechin 3-gallate (EGCG), the major catechin present in green tea, is suspected of being responsible for liver toxicity reported in humans consuming food supplements. Intake of EGCG with green tea infusions and GTE-based beverages is up to about 450mg EGCG/person/day in Europe and higher in Asia. Consumption of green tea is not associated with liver damage in humans, and green tea infusion and GTE-based beverages are considered safe in the range of historical uses. In animal studies, EGCG's potency for liver effects is highly dependent on conditions of administration. Use of NOAELs from bolus administration to derive a tolerable upper intake level applying the margin of safety concept results in acceptable EGCG-doses lower than those from one cup of green tea. NOAELs from toxicity studies applying EGCG with diet/split of the daily dose are a better point of departure for risk characterization. In clinical intervention studies, liver effects were not observed after intakes below 600mg EGCG/person/day. Thus, a tolerable upper intake level of 300mg EGCG/person/day is proposed for food supplements; this gives a twofold safety margin to clinical studies that did not report liver effects and a margin of safety of 100 to the NOAELs in animal studies with dietary administration of green tea catechins.
[Mh] Termos MeSH primário: Camellia sinensis/química
Catequina/análogos & derivados
Suplementos Nutricionais
Inocuidade dos Alimentos
Extratos Vegetais/análise
Chá/química
Chás de Ervas/análise
[Mh] Termos MeSH secundário: Animais
Camellia sinensis/efeitos adversos
Catequina/efeitos adversos
Catequina/análise
Segurança de Produtos ao Consumidor
Suplementos Nutricionais/efeitos adversos
Análise de Perigos e Pontos Críticos de Controle
Seres Humanos
Nível de Efeito Adverso não Observado
Extratos Vegetais/efeitos adversos
Recomendações Nutricionais
Medição de Risco
Chá/efeitos adversos
Chás de Ervas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Tea); 0 (Teas, Herbal); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE



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