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[PMID]:29298017
[Au] Autor:Zaitseva EL; Tokmakova AY; Shestakova MV; Galstyan GR; Doronina LP
[Ti] Título:The Study of Influence of Different Methods of Local Treatment on Wound Healing in Patients with Diabetic Foot Ulcers.
[So] Source:Vestn Ross Akad Med Nauk;71(6):466-71, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Aim: To evaluate the influence of different methods of local treatment on tissue repair in patients with diabetic foot ulcers. Materials and Methods: We evaluated such clinical characteristics as wound size and local perfusion after using negative pressure wound therapy (NPWT), local collagen, and standard care in patients with diabetic foot ulcers. We observed 63 patients with neuropathic and neuroischemic forms of diabetic foot (without critical ischemia) after surgical debridement. After that 21 patients received NPWT, 21 local collagen treatment and 21 ­ standard care. Results: After using NPWT wound area and depth decreased in 19,8% and 42,8% (p<0.05), in group of collagen dressings in 26,4 and 30,4% (p<0.05). In control group those parameters were 17,0 и 16.6% respectively (p<0.05). There was found the significant increase of local perfusion according to oxygen monitoring in group of NPWT (p<0.05). Conclusion: The received data showed that the intensity of lower limb tissue repair processes increases more significant after using NPWT and collagen dressings in comparison to standard care which is found according to wound size and tissue perfusion alterations.
[Mh] Termos MeSH primário: Colágeno/uso terapêutico
Desbridamento/métodos
Pé Diabético
Tratamento de Ferimentos com Pressão Negativa/métodos
[Mh] Termos MeSH secundário: Idoso
Curativos Biológicos
Pé Diabético/diagnóstico
Pé Diabético/fisiopatologia
Pé Diabético/terapia
Feminino
Seres Humanos
Masculino
Meia-Idade
Imagem de Perfusão/métodos
Fluxo Sanguíneo Regional
Resultado do Tratamento
Cicatrização/efeitos dos fármacos
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
9007-34-5 (Collagen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn735


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[PMID]:29245303
[Au] Autor:Johnson EL; Tassis EK; Michael GM; Whittinghill SG
[Ad] Endereço:aBozeman Deaconess Hospital, Wound and Hyperbaric Center, Bozeman, MontanabOsiris Therapeutics, Inc., Columbia, Maryland.
[Ti] Título:Viable placental allograft as a biological dressing in the clinical management of full-thickness thermal occupational burns: Two case reports.
[So] Source:Medicine (Baltimore);96(49):e9045, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years. As a biological covering with a broad scope of potential uses, human placental membranes represent a dressing that is particularly advantageous for burn therapy. Recent advances in tissue-preservation technology have allowed for the commercialization of placental amnion products. PATIENT CONCERNS: To address several complications associated with burn injuries-contractures, scar formation, and pain-a viable cryopreserved placental membrane (vCPM) (Grafix-PRIME, Osiris Therapeutics, Inc., MD) retaining the anti-inflammatory, anti-fibrotic, and antimicrobial properties of fresh placental tissues was chosen for clinical use in the 2 cases reported, where both patients had restricted access to the regional burn center. DIAGNOSES: Two cases of work-related extremity burns presented to a local rural hospital for immediate post-injury assessment. The 1 case was of a man who sustained a 55.4 cm full-thickness 3 degree thermal burn with exposed bone and tendon, to the left dorsal forefoot after having an industrial pressure washer caught on his work boot. The 2 case was of a female who sustained a 4.7 cm full-thickness 3 degree crush burn to the dorsum extensor surface of her dominant hand's index finger after applying 80-pounds per square inch of heated pressure from a hydraulic press. INTERVENTIONS: Both burn patients elected to continue their care at the outpatient-based wound and hyperbaric center, receiving a combination of weekly ad libitum debridement, applications of vCPM, and occupational therapy. OUTCOMES: Both burns reached timely wound closure, and patients regained full range of motion of the affected limb, allowing for early return to work. The average number of allograft applications was 7.5, allowing both patients to return to work in an average of 63.5 days without adverse events or post-treatment complications. LESSONS: The incorporation of this product in the treatment of these complex burns prevented amputation in one patient, and skin autografting and potential index finger contracture-formation in the second patient. The incorporation of vCPM in burn management may offer a new approach to outpatient burn management and may mitigate several of the complications seen post burn injury, leading to favorable patient outcomes.
[Mh] Termos MeSH primário: Curativos Biológicos
Queimaduras/cirurgia
Traumatismos Ocupacionais/cirurgia
Placenta/transplante
[Mh] Termos MeSH secundário: Adulto
Queimaduras/etiologia
Feminino
Seres Humanos
Masculino
Gravidez
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009045


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[PMID]:28763910
[Au] Autor:Lin JH; Chen J; Xue DJ; Huang WX; Su GL
[Ad] Endereço:Burns and Skin Repair Surgery, the Third Affiliated Hospital of Whenzhou Medical University, Ruian 325200, China.
[Ti] Título:[Influence of different inner dressings in negative-pressure wound therapy on escharectomy wound of full-thickness burn rabbits].
[So] Source:Zhonghua Shao Shang Za Zhi;33(7):431-436, 2017 Jul 20.
[Is] ISSN:1009-2587
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the influence of different inner dressings in negative-pressure wound therapy (NPWT) on escharectomy wound of full-thickness burn rabbits. Eighteen Japanese white rabbits were inflicted with full-thickness burn on unilateral back. They were divided into polymer dressing group (PD), biological dressing group (BD), and silver biological dressing group (SBD), according to the random number table, with 6 rabbits in each group. On 3 days post burn, the wounds were performed with escharectomy, and then wounds of rabbits in group PD were covered with polyurethane foam. Wounds of rabbits in group BD were covered with porcine acellular dermal matrix (ADM) and wounds of rabbits in group SBD were covered with silver porcine ADM. Then continuous NPWT was performed on rabbits of the three groups for 7 days. Immediately after surgery and on post surgery day (PSD) 7, general observation of wound was conducted and tissue around the wound was harvested for determination of dry to wet weight ratio. The content of bacteria was counted and the content of tumor necrosis factor α (TNF-α), interleukin-1ß (IL-1ß), and IL-6 in wound was determined by enzyme-linked immunosorbent assay. Fibroblasts in wound were counted after Masson staining and number of microvessels was counted after CD31 antibody immunohistochemical staining. Data were processed with analysis of variance for repeated measurement, LSD- test, paired samples test, and Bonferroni correction. (1) Immediately after surgery, there was no granulation tissue in basal wound of rabbits in the three groups, with rich blood supply and obvious edema. On PSD 7, much granulation tissue was found in basal wound of rabbits in the three groups, with no or mild edema and no obvious redness and swelling in wound edge. (2) There were no significant differences in dry to wet weight ratios of tissue around the wound among and within the three groups immediately after surgery and on PSD 7 (with values respectively 0.70 and 0.09, values from 0.17 to 0.52, values above 0.05). (3) Immediately after surgery, the content of bacteria in wounds of rabbits in groups PD, BD, and SBD was respectively (603.0±146.0) ×10(4,) (573.0±63.0) ×10(4,) and (590.0±100.0)×10(4) colony-forming unit (CFU)/g, with no significant difference among them ( =0.13, >0.05). On PSD 7, the content of bacteria in wounds of rabbits in groups PD, BD, and SBD were respectively (5.4±0.8) ×10(4,) (4.6±0.9) ×10(4,) and (3.5±0.9)×10(4) CFU/g. Among them, the content of bacteria in wounds of rabbits in group SBD was lower than that in groups PD and BD, respectively (with values respectively 3.78 and 2.29, <0.05 or <0.01). The content of bacteria in wounds of rabbits in the three groups on PSD 7 was decreased compared with that immediately after surgery (with values from 10.05 to 21.81, values below 0.01). (4) There was no significant difference in content of TNF-α, IL-1ß, and IL-6 in wounds of rabbits in the three groups immediately after surgery and on PSD 7 (with values from 0.10 to 1.89, values above 0.05). The content of TNF-α in wounds of rabbits in the three groups on PSD 7 was significantly higher than that immediately after surgery (with values from 2.93 to 5.01, <0.05 or <0.01). (5) There was no significant difference in amount of fibroblasts in wounds of rabbits in the three groups immediately after surgery and on PSD 7 (with values respectively 0.01 and 0.81, values above 0.05). The amount of fibroblasts in wounds of rabbits in the three groups on PSD 7 was larger than that immediately after surgery (with values from 4.78 to 11.58, values below 0.01). (6) There was no significant difference in number of microvessels in wounds of rabbits in the three groups immediately after surgery and on PSD 7 (with values respectively 2.42 and 2.49, values above 0.05). The number of microvessels in wounds of rabbits in the three groups on PSD 7 was larger than that immediately after surgery (with values from 7.17 to 11.14, values below 0.01). SBD is better at inhibiting the growth of bacteria. PD, BD, and SBD have almost the same effects on reducing tissue edema and inflammatory reaction, and on promoting the accumulation of collagen fibers and tissue vascularization.
[Mh] Termos MeSH primário: Derme Acelular
Bandagens
Queimaduras/terapia
Tratamento de Ferimentos com Pressão Negativa
Cicatrização
[Mh] Termos MeSH secundário: Animais
Curativos Biológicos
Ensaio de Imunoadsorção Enzimática
Tecido de Granulação
Inflamação
Interleucina-1beta
Interleucina-6
Coelhos
Lesões dos Tecidos Moles
Resultado do Tratamento
Fator de Necrose Tumoral alfa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1009-2587.2017.07.008


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[PMID]:28546687
[Au] Autor:Dakhil TAB; Stone DU; Gritz DC
[Ad] Endereço:Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
[Ti] Título:Adjunctive Therapies for Bacterial Keratitis.
[So] Source:Middle East Afr J Ophthalmol;24(1):11-17, 2017 Jan-Mar.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Bacterial keratitis is the most common type among all types of infectious keratitis. Currently, antibiotics are the main-stay of treatment. The objective of this systematic review is to review published clinical studies which discuss the adjunctive treatment of bacterial keratitis to guide clinical decision-making. We reviewed the role of a variety of medications and surgeries which can help in managing bacterial keratitis complications, which include as thinning, perforation, and impaired wound healing. We have included appropriate animal and laboratory studies, case reports and case series, and randomized clinical trials regarding each therapy.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Curativos Biológicos
Crioterapia/métodos
Infecções Oculares Bacterianas/terapia
Oxigenação Hiperbárica/métodos
Ceratite/terapia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_264_16


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[PMID]:28079549
[Au] Autor:Herndon DN; Branski LK
[Ad] Endereço:From the *Department of Surgery, The University of Texas Medical Branch, Galveston, TX; and †Shriners Hospitals for Children, Galveston, TX.
[Ti] Título:Contemporary Methods Allowing for Safe and Convenient Use of Amniotic Membrane as a Biologic Wound Dressing for Burns.
[So] Source:Ann Plast Surg;78(2 Suppl 1):S9-S10, 2017 Feb.
[Is] ISSN:1536-3708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Partial-thickness burns involve damage to the upper layer of skin, which leaves nerve endings exposed, and therefore represent the most painful of several categories of thermal injuries. Historically, partial-thickness burns were treated conservatively by debriding the blisters, by daily tubbing and washing, and the application of new bandages with topical medications. Human amniotic membrane has been used for centuries as a biological wound dressing. In the past 20 years, there has been an increasing body of literature addressing the use of amniotic tissue in chronic wounds and burns. In this review, we present an overview of the use of amniotic membrane in the treatment of burns including processing methods and early clinical use. We believe that amniotic membranes have great potential in improving burn wound care in the future. Standardized processing methods and terminal sterilization ensure safety and allow the material to be available for use by health care providers around the world in clinical trials and for patient care.
[Mh] Termos MeSH primário: Curativos Biológicos
Queimaduras/terapia
Cicatrização
[Mh] Termos MeSH secundário: Anti-Infecciosos Locais
Ensaios Clínicos como Assunto
Seres Humanos
Transplante de Pele
Deiscência da Ferida Operatória/cirurgia
Transplante Homólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1097/SAP.0000000000000979


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[PMID]:27888184
[Au] Autor:Dua HS; Miri A; Elalfy MS; Lencova A; Said DG
[Ad] Endereço:Section of Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.
[Ti] Título:Amnion-assisted conjunctival epithelial redirection in limbal stem cell grafting.
[So] Source:Br J Ophthalmol;101(7):913-919, 2017 Jul.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To develop a technique using amniotic membrane (AM) to prevent admixture of conjunctival epithelial cells and limbal explant-derived corneal epithelial cells in patients undergoing limbal stem cell transplantation. To compare this technique with the current method of 'sequential sector conjunctival epitheliectomy' (SSCE). METHODS: 26 patients with total limbal stem cell deficiency who underwent ocular surface reconstruction with limbal stem cells transplantation were retrospectively studied. Patients were categorised into group A (11) in which AM was used to direct the conjunctival epithelial cells away from the corneal surface so that the latter could be covered by the limbal explant-derived epithelial cells-the procedure was termed 'amnion-assisted conjunctival epithelial redirection' (ACER)-and group B (15) in which the conjunctival epithelium was prevented from migrating on to the corneal surface by SSCE. RESULTS: In nine eyes of group A, the conjunctival epithelium was successfully directed on to the AM, preventing admixture with limbal explant-derived corneal epithelial cells. The AM was removed or it came off spontaneously within 1-4 weeks. Patients treated with SSCE (group B) underwent two to four interventions until complete re-epithelialisation. 12 patients had pain or discomfort. 11 patients had conjunctival haemorrhage during SSCE. The cornea was epithelised from the limbal explant-derived epithelium in all patients. CONCLUSIONS: ACER is a viable option in limbal transplantation that reduces multiple patient visits, bleeding and pain that can be associated with SSCE.
[Mh] Termos MeSH primário: Âmnio/transplante
Curativos Biológicos
Túnica Conjuntiva/citologia
Doenças da Córnea/cirurgia
Epitélio Anterior/citologia
Limbo da Córnea/citologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Doenças da Córnea/diagnóstico
Doenças da Córnea/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transplante de Células-Tronco
Transplante Autólogo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2015-307935


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[PMID]:27852013
[Au] Autor:Guo X; Kaplunovsky A; Zaka R; Wang C; Rana H; Turner J; Ye Q; Djuretic I; Gleason J; Jankovic V; Smiell JM; Bhatia M; Hofgartner W; Hariri R
[Ad] Endereço:Celgene Cellular Therapeutics, Warren, NJ.
[Ti] Título:Modulation of Cell Attachment, Proliferation, and Angiogenesis by Decellularized, Dehydrated Human Amniotic Membrane in In Vitro Models.
[So] Source:Wounds;29(1):28-38, 2017 Jan.
[Is] ISSN:1943-2704
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Decellularized, dehydrated human amniotic membrane (DDHAM) is an extracellular matrix devoid of cells, cell debris, and growth factors. This study examines the effect of cell attachment to the DDHAM and the induced cellular responses. MATERIALS AND METHODS: The cell types employed in this study were human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK), and human dermal microvascular endothelial cells (HDMEC), all of which play critical roles in the wound healing process. Further, the DDHAM was compared to a dehydrated human amnion/chorion membrane (dHACM), which contains and releases biological entities including growth factors and cytokines. The HDF and HEK were cultured on the DDHAM and the dHACM, and cell imaging and proliferation assays were performed to evaluate cell attachment to and the ability to proliferate on the DDHAM relative to the dHACM. In addition, the effect of soluble factors released by the DDHAM and the dHACM on cell survival, attachment, and proliferation were examined. The authors also evaluated the effect of soluble factors produced by culturing cells on the DDHAM in in vitro functional assays, including cell survival and endothelial cell migration in a wound closure angiogenesis assay. RESULTS: The HDF and HEK cells readily attached to and proliferated on the DDHAM, while the dHACM did not support cell attachment and proliferation when cultured under the same conditions. Soluble factors secreted when HDF were cultured on the DDHAM enhanced both endothelial cell and keratinocyte survival and endothelial cell migration in a wound closure assay. CONCLUSIONS: Although DDHAM is only an extracellular matrix and serves primarily as a scaffold, it has sufficient cues to allow for cell attachment and proliferation. Further, the biological entities released as a consequence of cell attachment promote cell survival and migration.
[Mh] Termos MeSH primário: Âmnio/química
Curativos Biológicos
Adesão Celular
Proliferação Celular
Neovascularização Fisiológica
Ferimentos e Lesões/patologia
[Mh] Termos MeSH secundário: Aloenxertos
Junções Célula-Matriz
Matriz Extracelular/metabolismo
Matriz Extracelular/ultraestrutura
Fibroblastos/citologia
Fibroblastos/metabolismo
Seres Humanos
Técnicas In Vitro
Resultado do Tratamento
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


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[PMID]:27761704
[Au] Autor:Chen R; Huang G; Liu S; Ma W; Yin X; Zhou S
[Ad] Endereço:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
[Ti] Título:Limbal conjunctival versus amniotic membrane in the intraoperative application of mitomycin C for recurrent pterygium: a randomized controlled trial.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(2):375-385, 2017 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study compared the outcomes of a limbal conjunctival autograft (LCAG) with those of an amniotic membrane graft (AMG) followed by intraoperative 0.02 % mitomycin C (MMC) to treat recurrent pterygium. METHODS: In this randomized controlled trial, ninety-six eyes with recurrent pterygium were enrolled and randomly allocated into two groups using a computer-generated random number table. Pterygium removal was followed by intraoperative 0.02 % MMC for 3 min and then either LCAG or AMG transplantation. The major outcomes were recurrence rate, conjunctival inflammation grade, healing time of the corneal epithelial defect, eye-movement amplitude (EMA), uncorrected distance visual acuity (UDVA), and complications. RESULTS: A follow-up of 12 months was conducted for 93 eyes of 82 patients. Grade D (recurrence) presented in one eye of the LCAG group and five eyes of the AMG group, with no between-group difference (p = 0.196). However, Grades A, B, and C presented in 46, zero and zero eyes of the LCAG group respectively, and in 37, two and two eyes of the AMG group respectively, with the surgical bed generally showing a better appearance in the LCAG group than in the AMG group (p = 0.008). Compared with baseline values, the postoperative EMA improved significantly in both groups (p < 0.001 for the LCAG group; p = 0.001 for the AMG group), as did UDVA (p = 0.005 for the LCAG group; p = 0.012 for the AMG group). No between-group differences were found in terms of the healing time for epithelial defect, conjunctival inflammation grade, or the frequency of complications such as punctate epithelial keratitis, episcleral melting, corneal pannus, and delayed corneal epithelium healing. CONCLUSIONS: LCAG transplantation with intraoperative 0.02 % MMC is as efficacious in treating recurrent pterygium as AMG transplantation with MMC. The former procedure results in an attractive cosmetic appearance but might result in limbal damage in some eyes. The surgeon's familiarity with these procedures should determine the method of treatment.
[Mh] Termos MeSH primário: Curativos Biológicos
Túnica Conjuntiva/transplante
Mitomicina/administração & dosagem
Pterígio/cirurgia
[Mh] Termos MeSH secundário: Administração Tópica
Movimentos Oculares
Feminino
Seguimentos
Seres Humanos
Período Intraoperatório
Masculino
Meia-Idade
Inibidores da Síntese de Ácido Nucleico/administração & dosagem
Estudos Prospectivos
Pterígio/diagnóstico
Pterígio/fisiopatologia
Recidiva
Transplante Autólogo
Resultado do Tratamento
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Nucleic Acid Synthesis Inhibitors); 50SG953SK6 (Mitomycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-016-3509-5


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[PMID]:27759861
[Au] Autor:Grewal DS; Mahmoud TH
[Ti] Título:Dehydrated Allogenic Human Amniotic Membrane Graft for Conjunctival Surface Reconstruction Following Removal of Exposed Scleral Buckle.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;47(10):948-951, 2016 Oct 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 54-year-old male developed symptomatic scleral buckle exposure 16 years after placement and presented with large conjunctival defects with fibrosed edges. Following surgical removal of the buckle elements, primary conjunctival closure could not be achieved due to significant wound tension despite undermining the conjunctival edges to mobilize the conjunctiva. A dehydrated amniotic membrane graft (Ambio5; IOP Ophthalmics, Costa Mesa, CA) was placed on the scleral bed and secured in place with fibrin sealant (TISSEEL; Baxter International, Westlake Village, CA). The amniotic membrane allowed successful closure of the large conjunctival defect with a good cosmetic outcome and resolution of symptoms. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:948-951.].
[Mh] Termos MeSH primário: Âmnio/transplante
Curativos Biológicos
Túnica Conjuntiva/cirurgia
Complicações Pós-Operatórias/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Recurvamento da Esclera/efeitos adversos
[Mh] Termos MeSH secundário: Dessecação
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Descolamento Retiniano/cirurgia
Transplante Homólogo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20161004-08


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Fotocópia
[PMID]:27701127
[Au] Autor:Kushnir I; Kushnir A; Serena TE; Garfinkel D
[Ad] Endereço:RedDress Ltd, Pardes Hanna, Israel.
[Ti] Título:Efficacy and Safety of a Novel Autologous Wound Matrix in the Management of Complicated, Chronic Wounds: A Pilot Study.
[So] Source:Wounds;28(9):317-327, 2016 Sep.
[Is] ISSN:1943-2704
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The objective of this pilot study was to evaluate the efficacy and safety of a novel method using an autologous whole blood clot formed with the RedDress Wound Care System (RD1, RedDress Ltd, Israel), a provisional whole blood clot matrix used in the treatment of chronic wounds of various etiologies. METHODS AND MATERIALS: Patients were treated at the bedside with the whole blood clot matrix. Blood was withdrawn from each patient using citrate, mixed with a calcium gluconate/kaolin suspension, and injected into an RD1 clotting tray. Within 10 minutes, a clot was formed, placed upon the wound, and fixed with primary and secondary dressings. Wounds were redressed weekly with a whole blood clot matrix. Treatment was terminated when complete healing was achieved, or when the clinician determined that the wound could not further improve without additional invasive procedures. RESULTS: Seven patients with multiple and serious comorbidities and 9 chronic wounds were treated with 35 clot matrices. Complete healing was achieved in 7 of 9 wounds (78%). In 1 venous ulcer with a nonhealing fistula, 77% healing was achieved. Treatment was terminated in 1 pressure ulcer at 82% closure, because an unexpected mechanical trauma resulted in deterioration; this was the only adverse event reported, unrelated to the product. No systemic adverse events occurred. CONCLUSIONS: This pilot study demonstrates the in vitro autologous whole blood clot matrix is effective and safe for treating patients with chronic wounds of different etiologies. A larger clinical trial is needed to assess the relative success rate of the matrix in different types of wounds in a diverse population with comorbidities.
[Mh] Termos MeSH primário: Curativos Biológicos
Doença Crônica/terapia
Cicatrização/fisiologia
Ferimentos e Lesões/terapia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Coagulação Sanguínea/fisiologia
Feminino
Seres Humanos
Israel
Masculino
Meia-Idade
Projetos Piloto
Plasma Rico em Plaquetas/fisiologia
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE



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