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[PMID]:29377912
[Au] Autor:Robertson MJ; Soibam B; O'Leary JG; Sampaio LC; Taylor DA
[Ad] Endereço:Scientific Stem Cell, Texas Heart Institute, Houston, Texas, United States of America.
[Ti] Título:Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology.
[So] Source:PLoS One;13(1):e0191892, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Liver-like organoids that recapitulate the complex functions of the whole liver by combining cells, scaffolds, and mechanical or chemical cues are becoming important models for studying liver biology and drug metabolism. The advantages of growing cells in three-dimensional constructs include enhanced cell-cell and cell-extracellular matrix interactions and preserved cellular phenotype including, prevention of de-differentiation. In the current study, biomimetic liver constructs were made via perfusion decellularization of rat liver, with the goal of maintaining the native composition and structure of the extracellular matrix. We optimized our decellularization process to produce liver scaffolds in which immunogenic residual DNA was removed but glycosaminoglycans were maintained. When the constructs were recellularized with rat or human liver cells, the cells remained viable, capable of proliferation, and functional for 28 days. Specifically, the cells continued to express cytochrome P450 genes and maintained their ability to metabolize a model drug, midazolam. Microarray analysis showed an upregulation of genes involved in liver regeneration and fibrosis. In conclusion, these liver constructs have the potential to be used as test beds for studying liver biology and drug metabolism.
[Mh] Termos MeSH primário: Fígado/citologia
Modelos Animais
Farmacocinética
[Mh] Termos MeSH secundário: Animais
Reatores Biológicos
Adesão Celular
Proliferação Celular
Meios de Cultura
Matriz Extracelular
Hepatócitos/efeitos dos fármacos
Hepatócitos/metabolismo
Seres Humanos
Técnicas In Vitro
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191892


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[PMID]:28974426
[Au] Autor:Chatzikonstantinou AV; Chatziathanasiadou MV; Ravera E; Fragai M; Parigi G; Gerothanassis IP; Luchinat C; Stamatis H; Tzakos AG
[Ad] Endereço:Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; Department of Biological Applications and Technologies, University of Ioannina, 45110 Ioannina, Greece.
[Ti] Título:Enriching the biological space of natural products and charting drug metabolites, through real time biotransformation monitoring: The NMR tube bioreactor.
[So] Source:Biochim Biophys Acta;1862(1):1-8, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Natural products offer a wide range of biological activities, but they are not easily integrated in the drug discovery pipeline, because of their inherent scaffold intricacy and the associated complexity in their synthetic chemistry. Enzymes may be used to perform regioselective and stereoselective incorporation of functional groups in the natural product core, avoiding harsh reaction conditions, several protection/deprotection and purification steps. METHODS: Herein, we developed a three step protocol carried out inside an NMR-tube. 1st-step: STD-NMR was used to predict the: i) capacity of natural products as enzyme substrates and ii) possible regioselectivity of the biotransformations. 2nd-step: The real-time formation of multiple-biotransformation products in the NMR-tube bioreactor was monitored in-situ. 3rd-step: STD-NMR was applied in the mixture of the biotransformed products to screen ligands for protein targets. RESULTS: Herein, we developed a simple and time-effective process, the "NMR-tube bioreactor", that is able to: (i) predict which component of a mixture of natural products can be enzymatically transformed, (ii) monitor in situ the transformation efficacy and regioselectivity in crude extracts and multiple substrate biotransformations without fractionation and (iii) simultaneously screen for interactions of the biotransformation products with pharmaceutical protein targets. CONCLUSIONS: We have developed a green, time-, and cost-effective process that provide a simple route from natural products to lead compounds for drug discovery. GENERAL SIGNIFICANSE: This process can speed up the most crucial steps in the early drug discovery process, and reduce the chemical manipulations usually involved in the pipeline, improving the environmental compatibility.
[Mh] Termos MeSH primário: Reatores Biológicos
Lipase/metabolismo
Espectroscopia de Ressonância Magnética/métodos
Quercetina/farmacologia
Quercetina/farmacocinética
[Mh] Termos MeSH secundário: Biotransformação
Lipase/química
Quercetina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9IKM0I5T1E (Quercetin); EC 3.1.1.- (Novozyme 435); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE


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[PMID]:28863363
[Au] Autor:Turker G; Akyol Ç; Ince O; Aydin S; Ince B
[Ad] Endereço:Institute of Environmental Sciences, Bogaziçi University, Bebek, 34342 Istanbul, Turkey.
[Ti] Título:Operating conditions influence microbial community structures, elimination of the antibiotic resistance genes and metabolites during anaerobic digestion of cow manure in the presence of oxytetracycline.
[So] Source:Ecotoxicol Environ Saf;147:349-356, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The way that antibiotic residues in manure follow is one of the greatest concerns due to its potential negative impacts on microbial communities, the release of metabolites and antibiotic resistant genes (ARGs) into the nature and the loss of energy recovery in anaerobic digestion (AD) systems. This study evaluated the link between different operating conditions, the biodegradation of oxytetracycline (OTC) and the formation of its metabolites and ARGs in anaerobic digesters treating cow manure. Microbial communities and ARGs were determined through the use of quantitative real-time PCR. The biodegradation of OTC and occurrence of metabolites were determined using UV-HPLC and LC/MS/MS respectively. The maximum quantity of resistance genes was also examined at the beginning of AD tests and concentration was in the order of: tetM >tetO. The numbers of ARGs were always higher at high volatile solids (VS) content and high mixing rate. The results of the investigation revealed that relationship between mixing rate and VS content plays a crucial role for elimination of ARGs, OTC and metabolites. This can be attributed to high abundance of microorganisms due to high VS content and their increased contact with elevated mixing rate. An increased interaction between microorganisms triggers the promotion of ARGs.
[Mh] Termos MeSH primário: Antibacterianos/toxicidade
Reatores Biológicos/microbiologia
Resistência Microbiana a Medicamentos/genética
Esterco/microbiologia
Consórcios Microbianos/efeitos dos fármacos
Oxitetraciclina/toxicidade
[Mh] Termos MeSH secundário: Anaerobiose
Animais
Antibacterianos/metabolismo
Biodegradação Ambiental
Bovinos
Cromatografia Líquida de Alta Pressão
Feminino
Esterco/análise
Consórcios Microbianos/genética
Oxitetraciclina/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Manure); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


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[PMID]:29215959
[Au] Autor:Garcia-Peña EI; Niño-Navarro C; Chairez I; Torres-Bustillos L; Ramírez-Muñoz J; Salgado-Manjarrez E
[Ad] Endereço:a Department of Bioprocesses , Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional , Mexico City , Mexico.
[Ti] Título:Performance intensification of a stirred bioreactor for fermentative biohydrogen production.
[So] Source:Prep Biochem Biotechnol;48(1):64-74, 2018 Jan 02.
[Is] ISSN:1532-2297
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the biohydrogen (bioH ) production of a microbial consortium was optimized by adjusting the type and configuration of two impellers, the mixing regimen and the mass transfer process (K a coefficients). A continuous stirred-tank reactor (CSTR) system, with a nonstandard geometry, was characterized. Two different mixing configurations with either predominant axial (PB4 impeller) or radial pumping (Rushton impeller) were assessed and four different impeller configurations to produce bioH . The best configuration for an adequate mixing time was determined by an ANOVA analysis. A response surface methodology was also used to fully elucidate the optimal configuration. When the PB4 impellers were placed in best configuration, c/Dt = 0.5, s/Di = 1, the maximum bioH productivity obtained was 440 mL L hr , with a bioH molar yield of 1.8. The second best configuration obtained with the PB4 impellers presented a bioH productivity of 407.94 mL L hr . The configurations based on Rushton impellers showed a lower bioH productivity and bioH molar yield of 177.065 mL L hr and 0.71, respectively. The experiments with axial impellers (PB4) showed the lowest K a coefficient and the highest bioH production, suggesting that mixing is more important than K a for the enhanced production of bioH
[Mh] Termos MeSH primário: Reatores Biológicos
Hidrogênio/metabolismo
Microbiologia Industrial/instrumentação
[Mh] Termos MeSH secundário: Análise de Variância
Reatores Biológicos/microbiologia
Desenho de Equipamento
Fermentação
Hidrodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1080/10826068.2017.1405269


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[PMID]:28968945
[Au] Autor:Amorim CL; Alves M; Castro PML; Henriques I
[Ad] Endereço:Biology Department and CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital 172, 4200-374 Porto, Po
[Ti] Título:Bacterial community dynamics within an aerobic granular sludge reactor treating wastewater loaded with pharmaceuticals.
[So] Source:Ecotoxicol Environ Saf;147:905-912, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pharmaceuticals are micropollutants often present in wastewater treatment systems. In this study, the potential impact of such micropollutants on the bacterial population within aerobic granular sludge (AGS) bioreactor was investigated. The AGS bacterial community structure and composition were accessed combining DGGE fingerprinting and barcoded pyrosequencing analysis. Both revealed the existence of a dynamic bacterial community, independently of the pharmaceuticals presence. The AGS microbiome at both phylum and class levels varied over time and, after stopping pharmaceuticals feeding, the bacterial community did not return to its initial composition. Nevertheless, most of the assigned OTUs were present throughout the different operational phases. This core microbiome, represented by over 72% of the total sequences in each phase, probably played an important role in biological removal processes, avoiding their failure during the disturbance period. Quantitative-PCR revealed that pharmaceuticals load led to gradual changes on the abundance of ammonia-oxidizing bacteria (AOB), nitrite-oxidizing bacteria (NOB) and polyphosphate-accumulating organisms (PAO) but their persistence during that phase demonstrated the resilience of such bacterial groups. AGS microbiome changed over time but a core community was maintained, probably ensuring the accomplishment of the main biological removal processes.
[Mh] Termos MeSH primário: Reatores Biológicos/microbiologia
Microbiota/efeitos dos fármacos
Preparações Farmacêuticas/análise
Esgotos/microbiologia
Águas Residuais/microbiologia
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Aerobiose
Microbiota/genética
RNA Ribossômico 16S/genética
Esgotos/química
Águas Residuais/química
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (RNA, Ribosomal, 16S); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28278777
[Au] Autor:Lu YF; Ma LJ; Ma L; Shan B; Chang JJ
[Ad] Endereço:a School of Ecology and Environmental Science, Yunnan University , Kunming , People's Republic of China.
[Ti] Título:Improvement of start-up and nitrogen removal of the anammox process in reactors inoculated with conventional activated sludge using biofilm carrier materials.
[So] Source:Environ Technol;39(1):59-67, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The start-up of the anaerobic ammonium oxidation (anammox) process in three up-flow column reactors seeded with common mixed activated sludge and added with three materials, sponge (R1), sponge + volcanic rock (R2) and sponge + charcoal (R3), as carriers for biofilm formation were comparatively investigated in this study. The supplement of volcanic rock and charcoal could significantly shorten the start-up time of the anammox process, which primarily occurred in the activity-enhanced phase, with ammonium and nitrite removal efficiencies stabilized above 92.5% and 93.4% after an operation period of 145, 105 and 121 d for R1, R2 and R3, respectively. After the successful anammox start-up, R2 performed significantly better in TN removal (p < .05), achieving an average rate of 91.0% and 191.5 g N m d compared to R1 of 88.4% and 172.1 g N m d , and R3 of 89.9% and 180.1 g N m d in the steady running phase. The ratios of consumed [Formula: see text] and generated [Formula: see text]/consumed [Formula: see text] after anammox start-up were lower than the theoretical values, probably suggesting the simultaneous existences of anammox, denitrification as well as nitrification processes in the reactors. A reddish brown biofilm was wrapped on the carriers and morphological detection of biofilm displayed the presentations of thick and compact floc aggregates and some filamentous bacteria on the sponge, and spherical-, ovoid- and shortrod-shaped microorganisms on the volcanic rock and charcoal. Using porous material as carrier for biofilm development is an effective strategy for practical application of the anammox reactor.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Nitrogênio/metabolismo
Eliminação de Resíduos Líquidos/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Compostos de Amônio
Reatores Biológicos/microbiologia
Carvão Vegetal
Crescimento Quimioautotrófico
Desnitrificação
Nitrificação
Nitritos
Nitrogênio/análise
Oxirredução
Esgotos/microbiologia
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Nitrites); 0 (Sewage); 0 (Water Pollutants, Chemical); 16291-96-6 (Charcoal); N762921K75 (Nitrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1294624


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[PMID]:28278776
[Au] Autor:Sreeda P; Sathya AB; Sivasubramanian V
[Ad] Endereço:a Department of Chemical Engineering , National Institute of Technology Calicut, Kozhikode , Kerala , India.
[Ti] Título:Novel application of high-density polyethylene mesh as self-forming dynamic membrane integrated into a bioreactor for wastewater treatment.
[So] Source:Environ Technol;39(1):51-58, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present study, self-forming dynamic membrane (SFDM) on rigid high-density polyethylene (HDPE) mesh with a large pore size of 2 mm is reported for the first time. The system was investigated for utilisation in simulated wastewater treatment by integrating the mesh with an aerobic bioreactor. The SFDM was analysed using Fourier transform infra-red (FT-IR) spectroscopy and visualised by scanning electron microscopy (SEM). The effect of the operating parameter on the change in composition of SFDM was also investigated. The system was used as a single unit for treatment of wastewater and showed stability over long-term treatment. The system could achieve a chemical oxygen demand (COD) reduction of 82.16 ± 6.47% at an influent COD concentration of 613.93 ± 72.13 mg/l and ammonia removal efficiency of 97.21 ± 0.62% at an influent ammonia concentration of 55.54 ± 2.23 mg/l. The reactor generated high-quality effluent and the turbidity recorded was less than 2NTU. In addition, the operational parameters, namely hydraulic retention time and organic loading rate, were optimised.
[Mh] Termos MeSH primário: Reatores Biológicos
Filtração/instrumentação
Polietileno/química
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Espectroscopia de Infravermelho com Transformada de Fourier
Águas Residuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waste Water); 9002-88-4 (Polyethylene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1294623


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[PMID]:28278766
[Au] Autor:Wu C; Xu P; Xu B; Li W; Li S; Wang X
[Ad] Endereço:a Key Laboratory of Biomass Chemical Engineering of Ministry of Education , Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering, Zhejiang University (Yuquan Campus) , Hangzhou , People's Republic of China.
[Ti] Título:o-Xylene removal using one- and two-phase partitioning biotrickling filters: steady/transient-state performance and microbial community.
[So] Source:Environ Technol;39(1):109-119, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, one- and two-phase partitioning biotrickling filters (1P-BTF and 2P-BTF, respectively) inoculated with a pre-acclimated mixed culture were examined for the removal of hydrophobic and refractory o-xylene. A small fraction of silicone oil (5% v/v) was added as a non-aqueous phase. Due to the presence of silicone oil, the 2P-BTF exhibited superior performance and stability for o-xylene biodegradation at steady and transient operations. Higher macro-kinetic constants for o-xylene removal by the Michaelis-Menten model were obtained for the 2P-BTF with a saturation constant of 0.396 g m and a maximum elimination capacity of 105.7 g m h . The enhancement of removal performance for the 2P-BTF was supported by dominant specialized microorganisms with o-xylene biodegradability. The diversity of microbial community was influenced by the presence of silicone oil. This study demonstrated that a BTF with 5% of silicone oil could be applied for the treatment of hydrophobic and refractory volatile organic compounds. It also provided valuable information for better understanding the relationship between microbial community and removal performance using two-phase partitioning bioreactors.
[Mh] Termos MeSH primário: Reatores Biológicos/microbiologia
Filtração/métodos
Eliminação de Resíduos Líquidos/métodos
Xilenos/análise
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Xilenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xylenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1296892


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[PMID]:28463576
[Au] Autor:Li K; Zhang C; Qiu L; Gao L; Zhang X
[Ad] Endereço:Tianjin Key Laboratory of Design and Intelligent Control of the Advanced Mechatronical System, School of Mechanical Engineering, Tianjin University of Technology , Tianjin, China .
[Ti] Título:Advances in Application of Mechanical Stimuli in Bioreactors for Cartilage Tissue Engineering.
[So] Source:Tissue Eng Part B Rev;23(4):399-411, 2017 Aug.
[Is] ISSN:1937-3376
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Articular cartilage (AC) is the weight-bearing tissue in diarthroses. It lacks the capacity for self-healing once there are injuries or diseases due to its avascularity. With the development of tissue engineering, repairing cartilage defects through transplantation of engineered cartilage that closely matches properties of native cartilage has become a new option for curing cartilage diseases. The main hurdle for clinical application of engineered cartilage is how to develop functional cartilage constructs for mass production in a credible way. Recently, impressive hyaline cartilage that may have the potential to provide capabilities for treating large cartilage lesions in the future has been produced in laboratories. The key to functional cartilage construction in vitro is to identify appropriate mechanical stimuli. First, they should ensure the function of metabolism because mechanical stimuli play the role of blood vessels in the metabolism of AC, for example, acquiring nutrition and removing wastes. Second, they should mimic the movement of synovial joints and produce phenotypically correct tissues to achieve the adaptive development between the micro- and macrostructure and function. In this article, we divide mechanical stimuli into three types according to forces transmitted by different media in bioreactors, namely forces transmitted through the liquid medium, solid medium, or other media, then we review and summarize the research status of bioreactors for cartilage tissue engineering (CTE), mainly focusing on the effects of diverse mechanical stimuli on engineered cartilage. Based on current researches, there are several motion patterns in knee joints; but compression, tension, shear, fluid shear, or hydrostatic pressure each only partially reflects the mechanical condition in vivo. In this study, we propose that rolling-sliding-compression load consists of various stimuli that will represent better mechanical environment in CTE. In addition, engineers often ignore the importance of biochemical factors to the growth and development of engineered cartilage. In our point of view, only by fully considering synergistic effects of mechanical and biochemical factors can we find appropriate culture conditions for functional cartilage constructs. Once again, rolling-sliding-compression load under appropriate biochemical conditions may be conductive to realize the adaptive development between the structure and function of engineered cartilage in vitro.
[Mh] Termos MeSH primário: Reatores Biológicos
[Mh] Termos MeSH secundário: Cartilagem
Cartilagem Articular
Condrócitos
Estresse Mecânico
Engenharia Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1089/ten.TEB.2016.0427


  10 / 27946 MEDLINE  
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[PMID]:29478643
[Au] Autor:Wang T; Huang Z; Ruan W; Zhao M; Shao Y; Miao H
[Ad] Endereço:School of Environment and Civil Engineering, Jiangnan University, Wuxi 214122, China; Jiangsu Key Laboratory of Anaerobic Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: wangtao0532@163.com.
[Ti] Título:Insights into sludge granulation during anaerobic treatment of high-strength leachate via a full-scale IC reactor with external circulation system.
[So] Source:J Environ Sci (China);64:227-234, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a full-scale internal circulation (IC) reactor coupled with an external circulation system was developed to treat high-strength leachate from a municipal solid waste (MSW) incineration plant, in which anaerobic sludge granulation was intensively investigated. Results showed that the IC reactor achieved excellent treatment performance under high organic loading rates (OLR) of 21.06-25.16kg chemical oxygen demand (COD)/(m ∙day). The COD removal efficiency and biogas yield respectively reached 89.4%-93.4% and 0.42-0.50m /kgCOD. The formation of extracellular polymeric substances (EPS) was closely associated with sludge granulation. Protein was the dominant component in sludge EPS, and its content was remarkably increased from 21.6 to 99.7mg/g Volatile Suspended Solid (VSS) during the reactor operation. The sludge Zeta potential and hydrophobicity positively correlated with the protein/polysaccharide ratio in EPS, and they were respectively increased from -26.2mV and 30.35% to -10.6mV and 78.67%, which was beneficial to microbial aggregation. Three-dimensional fluorescence spectroscopy (3D-EEM) and Fourier transform infrared spectroscopy (FT-IR) analysis further indicated the importance of protein-like EPS substances in the sludge granulation. Moreover, it was also found that the secondary structures of EPS proteins varied during the reactor operation.
[Mh] Termos MeSH primário: Reatores Biológicos
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Anaerobiose
Análise da Demanda Biológica de Oxigênio
Metano/análise
Esgotos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sewage); OP0UW79H66 (Methane)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE



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