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Pesquisa : E07.161 [Categoria DeCS]
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[PMID]:28132949
[Au] Autor:Calmette L; Ibrahim F; Gouin I; Horellou MH; Mazoyer É; Fontenay M; Flaujac C
[Ad] Endereço:Service d'hématologie biologique, Hôpital Cochin, APHP, Paris, France.
[Ti] Título:Impact of a pneumatic tube system transport on hemostasis parameters measurement: the experiment of Cochin universitary hospital (AP-HP, Paris, France).
[Ti] Título:Évaluation de l'influence du transport par pneumatique des échantillons pour la réalisation des examens d'hémostase : qualification du réseau pneumatique de l'hôpital Cochin (AP-HP)..
[So] Source:Ann Biol Clin (Paris);75(1):93-100, 2017 Feb 01.
[Is] ISSN:1950-6112
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Samples transported by pneumatic tube system are submitted to forces of acceleration and deceleration which can affect laboratory parameters. At Cochin hospital, majority of samples of hemostasis, except for platelets tests, are transported by pneumatic tube system. The objective of this study was to evaluate the impact of a pneumatic tube system (PTS) transport compared to hand-delivered transport on samples and to qualify Cochin hospital PTS according to requirements of standard ISO 15189. A bibliographical study was made and showed that pneumatic tube system particularly influences platelets tests. Four citrate tubes were collected in 5 healthy volunteers in the maternity: 2 tubes were transported by PTS and 2 others were hand-delivered to the laboratory. Five coagulation tests were analyzed: prothrombine time (PT), activated partial thromboplastin time (aPTT), factor (F) V, FVIII and platelet closure time with PFA-100TM collagen/epinephrine. For each volunteer, the results obtained by PTS and by hand-delivered transport were compared with formula usually used for biological analysis retake: 2.8 x standard deviation of reproductibility variation coefficient (SH GTA 01, COFRAC). This study did not show an impact of PTS on PT, aPTT, FV and FVIII. For PFA-100TM collagen/epinephrine, we noted an impact on 2/5 volunteers. These results, in agreement with the literature, led to the conclusion that Cochin hospital PTS is in compliance to transport samples for usual coagulation tests except platelet tests. This study allowed to issue French recommendations for PTS transport of hemostasis tubes qualification available on "Groupe français d'hémostase et thrombose" Web site.
[Mh] Termos MeSH primário: Automação Laboratorial/instrumentação
Coleta de Amostras Sanguíneas
Ar Comprimido
Hemostasia/fisiologia
Transportes
[Mh] Termos MeSH secundário: Testes de Coagulação Sanguínea/métodos
Coleta de Amostras Sanguíneas/instrumentação
Coleta de Amostras Sanguíneas/métodos
Feminino
Hospitais Universitários
Seres Humanos
Fenômenos Mecânicos
Paris
Transportes/instrumentação
Transportes/métodos
Vibração
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1684/abc.2016.1215


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[PMID]:27966204
[Au] Autor:Mitov G; Draenert F; Schumann P; Stötzer M; von See C
[Ad] Endereço:Centre for Prosthetic Dentistry and Dental Biomaterials Danube Private University, Steiner Landstraße 124 A-3500 Krems-Stein, Austria. gergo.mitov@dp-uni.ac.at.
[Ti] Título:The influence of pressure changes on the retentive force and coronal microleakage of different types of posts in endodontically treated teeth during simulated dives.
[So] Source:Diving Hyperb Med;46(4):247-252, 2016 Dec.
[Is] ISSN:1833-3516
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We assessed the influence of a simulated diving environment on the interfacial microleakage and retentive forces of different post types in root-canal-filled teeth. MATERIALS AND METHODS: One-hundred-and-twenty extracted, single-rooted teeth were endodontically treated and were randomly divided into three groups according to the post and cement used: ER Post/Harvard cement (Titanium), CeraPost/DentinBuild Evo (Zirconia), DT Light Post/Calibra (FRC). Each group was randomly divided into two equal subgroups, a control group, and an experimental group, subjected to simulated dives to 456 kPa in a diving chamber. For 10 specimens of each subgroup the pull-out strength and the coronal microleakage were measured. RESULTS: Significant differences in the linear coronal penetration were observed between the Titanium and FRC groups (experimental group P ≤ 0.001; control group P = 0.02). Diving simulation had no significant impact on the microleakage for the three post types. The FRC groups showed significantly higher retentive strength values compared to the Titanium and Zirconia groups before and after simulated diving. The pull-out strength of the titanium experimental group was significantly less than the control group (P = 0.008). CONCLUSIONS: Following root canal treatment the combination of fibre-reinforced posts and resin cement should be preferred for patients requiring retention for tooth restorations using posts that are likely to be exposed to hyperbaric conditions.
[Mh] Termos MeSH primário: Pressão do Ar
Cimentos Dentários
Infiltração Dentária
Mergulho
Técnica para Retentor Intrarradicular
Obturação do Canal Radicular
[Mh] Termos MeSH secundário: Ar Comprimido
Seres Humanos
Distribuição Aleatória
Cimentos de Resina
Preparo de Canal Radicular/métodos
Titânio
Cimento de Fosfato de Zinco
Zircônio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calibra); 0 (Dental Cements); 0 (Resin Cements); 7779-90-0 (Zinc Phosphate Cement); 84030-99-9 (Harvard Cement); C6V6S92N3C (Zirconium); D1JT611TNE (Titanium); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE


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[PMID]:27634703
[Au] Autor:Houston S; Wilkinson E
[Ad] Endereço:British Airways Health Services, Waterside, Harmondsworth, Middlesex, UK.
[Ti] Título:Flying After Conducting an Aircraft Excessive Cabin Leakage Test.
[So] Source:Aerosp Med Hum Perform;87(9):816-20, 2016 Sep.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Aviation medical specialists should be aware that commercial airline aircraft engineers may undertake a 'dive equivalent' operation while conducting maintenance activities on the ground. We present a worked example of an occupational risk assessment to determine a minimum safe preflight surface interval (PFSI) for an engineer before flying home to base after conducting an Excessive Cabin Leakage Test (ECLT) on an unserviceable aircraft overseas. METHOD: We use published dive tables to determine the minimum safe PFSI. RESULTS: The estimated maximum depth acquired during the procedure varies between 10 and 20 fsw and the typical estimated bottom time varies between 26 and 53 min for the aircraft types operated by the airline. Published dive tables suggest that no minimum PFSI is required for such a dive profile. DISCUSSION: Diving tables suggest that no minimum PFSI is required for the typical ECLT dive profile within the airline; however, having conducted a risk assessment, which considered peak altitude exposure during commercial flight, the worst-case scenario test dive profile, the variability of interindividual inert gas retention, and our existing policy among other occupational groups within the airline, we advised that, in the absence of a bespoke assessment of the particular circumstances on the day, the minimum PFSI after conducting ECLT should be 24 h. Houston S, Wilkinson E. Flying after conducting an aircraft excessive cabin leakage test. Aerosp Med Hum Perform. 2016; 87(9):816-820.
[Mh] Termos MeSH primário: Doença da Descompressão
Descompressão
Exposição Ocupacional
Pilotos
[Mh] Termos MeSH secundário: Medicina Aeroespacial
Aeronaves
Aviação
Barotrauma
Ar Comprimido
Mergulho
Seres Humanos
Medição de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4613.2016


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[PMID]:27022895
[Au] Autor:Wu J; Tan Y; Huo J
[Ad] Endereço:Department of Gastroenterology, The Second Xiangya Hospital of Central South University, China.
[Ti] Título:Rupture of esophagus by compressed air.
[So] Source:Rev Esp Enferm Dig;108(11):762, 2016 Nov.
[Is] ISSN:1130-0108
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Currently, beverages containing compressed air such as cola and champagne are widely used in our daily life. Improper ways to unscrew the bottle, usually by teeth, could lead to an injury, even a rupture of the esophagus. This letter to editor describes a case of esophageal rupture caused by compressed air.
[Mh] Termos MeSH primário: Ar Comprimido
Esôfago/lesões
Ruptura/etiologia
[Mh] Termos MeSH secundário: Endoscopia do Sistema Digestório
Esôfago/diagnóstico por imagem
Esôfago/cirurgia
Feminino
Seres Humanos
Intubação Gastrointestinal
Meia-Idade
Ruptura/diagnóstico por imagem
Ruptura/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE


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[PMID]:27006348
[Au] Autor:Berlinski A; Cooper B
[Ad] Endereço:Pulmonology Section, Department of Pediatrics, University of Arkansas for Medical Sciences and the Pediatric Aerosol Research Laboratory, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas. BerlinskiAriel@uams.edu.
[Ti] Título:Oronasal and Tracheostomy Delivery of Soft Mist and Pressurized Metered-Dose Inhalers With Valved Holding Chamber.
[So] Source:Respir Care;61(7):913-9, 2016 Jul.
[Is] ISSN:1943-3654
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Some pediatric tracheostomized patients who receive inhaled drugs undergo decannulation, and it is unknown whether the dose has to be adjusted. Pressurized metered-dose inhalers (pMDIs) and soft mist inhalers (SMIs) used with valved holding chambers (VHCs) made of non-electrostatic material are available. We hypothesized that using an SMI and changing the delivery route from tracheostomy to oronasal would increase lung dose. METHODS: Four units of a metallic VHC were studied with albuterol hydrofluoroalkane (pMDI) and albuterol/ipratropium bromide with an SMI using an anatomically correct in vitro model of a 5-y-old spontaneously breathing tracheostomized child. The drug was captured in a filter and was termed lung dose. We tested breathing patterns with tidal volumes of 50, 155, and 300 mL. A mask and a special adapter were used as interfaces for oronasal and tracheostomy delivery, respectively. Spectrophotometry (276 nm) was used to determine albuterol concentration. RESULTS: The use of SMI resulted in a higher lung dose than the pMDI for all tested conditions except delivery through tracheostomy with tidal volume of 155 mL (P = .69). Switching from oronasal to tracheostomy delivery increased the lung dose for all tested conditions except for the pMDI with the 300-mL tidal volume (P = .83). The use of SMI resulted in higher deposition in the tracheostomy tube than the pMDI. CONCLUSIONS: In general, an SMI delivers a higher lung dose than a pMDI when using a metallic spacer during oronasal and tracheostomy route with the latter providing a higher lung dose.
[Mh] Termos MeSH primário: Aerossóis/administração & dosagem
Broncodilatadores/administração & dosagem
Sistemas de Liberação de Medicamentos/instrumentação
Inaladores Dosimetrados
Traqueostomia
[Mh] Termos MeSH secundário: Administração por Inalação
Albuterol/administração & dosagem
Pré-Escolar
Ar Comprimido
Sistemas de Liberação de Medicamentos/métodos
Desenho de Equipamento
Seres Humanos
Espaçadores de Inalação
Pulmão
Máscaras
Modelos Anatômicos
Nebulizadores e Vaporizadores
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Bronchodilator Agents); QF8SVZ843E (Albuterol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.4187/respcare.04575


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[PMID]:26973403
[Au] Autor:Yin WB; Hu JL; Gao Y; Zhang XX; Zhang MS; Liu GW; Zheng XF; Lu Y
[Ad] Endereço:Wan-Bin Yin, Ji-Lin Hu, Yuan Gao, Xian-Xiang Zhang, Mao-Shen Zhang, Guang-Wei Liu, Xue-Feng Zheng, Yun Lu, Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao 266500, Shandong Province, China.
[Ti] Título:Rupture of sigmoid colon caused by compressed air.
[So] Source:World J Gastroenterol;22(10):3062-5, 2016 Mar 14.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Compressed air has been generally used since the beginning of the 20(th) century for various applications. However, rupture of the colon caused by compressed air is uncommon. We report a case of pneumatic rupture of the sigmoid colon. The patient was admitted to the emergency room complaining of abdominal pain and distention. His colleague triggered a compressed air nozzle against his anus as a practical joke 2 h previously. On arrival, his pulse rate was 126 beats/min, respiratory rate was 42 breaths/min and blood pressure was 86/54 mmHg. Physical examination revealed peritoneal irritation and the abdomen was markedly distended. Computed tomography of the abdomen showed a large volume of air in the abdominal cavity. Peritoneocentesis was performed to relieve the tension pneumoperitoneum. Emergency laparotomy was done after controlling shock. Laparotomy revealed a 2-cm perforation in the sigmoid colon. The perforation was sutured and temporary ileostomy was performed as well as thorough drainage and irrigation of the abdominopelvic cavity. Reversal of ileostomy was performed successfully after 3 mo. Follow-up was uneventful. We also present a brief literature review.
[Mh] Termos MeSH primário: Acidentes
Colo Sigmoide/lesões
Ar Comprimido/efeitos adversos
Perfuração Intestinal/etiologia
[Mh] Termos MeSH secundário: Adulto
Colo Sigmoide/diagnóstico por imagem
Colo Sigmoide/cirurgia
Seres Humanos
Perfuração Intestinal/diagnóstico por imagem
Perfuração Intestinal/cirurgia
Masculino
Pneumoperitônio/etiologia
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v22.i10.3062


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[PMID]:26970864
[Au] Autor:Bakhsheshi MF; Keenliside L; Lee TY
[Ad] Endereço:Imaging Program, Lawson Health Research Institute, London, Ontario, Canada(1); Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada. Electronic address: mfazelb@uwo.ca.
[Ti] Título:Rapid and selective brain cooling method using vortex tube: A feasibility study.
[So] Source:Am J Emerg Med;34(5):887-94, 2016 May.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vortex tubes are simple mechanical devices to produce cold air from a stream of compressed air without any moving parts. The primary focus of the current study is to investigate the feasibility and efficiency of nasopharyngeal brain cooling method using a vortex tube. Experiments were conducted on 5 juvenile pigs. Nasopharygeal brain cooling was achieved by directing cooled air via a catheter in each nostril into the nasal cavities. A vortex tube was used to generate cold air using various sources of compressed air: (I) hospital medical air outlet (n = 1); (II) medical air cylinders (n = 3); and (III) scuba (diving) cylinders (n = 1). By using compressed air from a hospital medical air outlet at fixed inlet pressure of 50 PSI, maximum brain-rectal temperature gradient of -2°C was reached about 45-60 minutes by setting the flow rate of 25 L/min and temperature of -7°C at the cold air outlet. Similarly, by using medical air cylinders at fill-pressure of 2265 PSI and down regulate the inlet pressure to the vortex tube to 50 PSI, brain temperature could be reduced more rapidly by blowing -22°C ± 2°C air at a flow rate of 50 L/min; brain-body temperature gradient of -8°C was obtained about 30 minutes. Furthermore, we examined scuba cylinders as a portable source of compressed gas supply to the vortex tube. Likewise, by setting up the vortex tube to have an inlet pressure of 25 PSI and 50 L/min and -3°C at the cold air outlet, brain temperature decreased 4.5°C within 10-20 min.
[Mh] Termos MeSH primário: Encéfalo
Ar Comprimido
Hipotermia Induzida/métodos
Nasofaringe
[Mh] Termos MeSH secundário: Animais
Estudos de Viabilidade
Hipotermia Induzida/instrumentação
Intubação/instrumentação
Intubação/métodos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160418
[Lr] Data última revisão:
160418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160314
[St] Status:MEDLINE


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[PMID]:26970442
[Au] Autor:Panda BK; Datta AK
[Ad] Endereço:Agricultural and Food Engineering Dept, Indian Inst. of Technology Kharagpur, Kharagpur, 721 302, India.
[Ti] Título:Quantitative Analysis of Major Phytochemicals in Orthodox tea (Camellia sinensis), Oxidized under Compressed Air Environment.
[So] Source:J Food Sci;81(4):C858-66, 2016 Apr.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study describes major changes in phytochemical composition of orthodox tea (Camellia sinensis var. Assamica) oxidized under compressed air (CA). The experiments for oxidation were conducted under air pressure (101, 202, and 303 kPa) for 150 min. Relative change in the concentrations of caffeine, catechins, theaflavins (TF), and thearubigins (TR) were analyzed. Effect of CA pressure was found to be nonsignificant in regulating caffeine concentration during oxidation. But degradation in different catechins as well as formation of different TF was significantly affected by CA pressure. At high CA pressure, TF showed highest peak value. TR was found to have slower rate of formation during initial phase of oxidation than TF. Even though the rate of TR formation was significantly influenced by CA, a portion of catechins remained unoxidized at end of oxidation. Except caffeine, the percent change in rate of formation or degradation were more prominent at 202 kPa.
[Mh] Termos MeSH primário: Ar
Antioxidantes/análise
Camellia sinensis/química
Catequina/análise
Manipulação de Alimentos/métodos
Pressão
Chá/química
[Mh] Termos MeSH secundário: Biflavonoides/análise
Cafeína/análise
Catequina/análogos & derivados
Cromatografia Líquida de Alta Pressão
Ar Comprimido
Seres Humanos
Oxirredução
Oxigênio
Compostos Fitoquímicos/análise
Extratos Vegetais/química
Polifenóis/análise
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biflavonoids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tea); 12698-96-3 (thearubigin); 1IA46M0D13 (theaflavin); 3G6A5W338E (Caffeine); 8R1V1STN48 (Catechin); S88TT14065 (Oxygen)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13265


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[PMID]:26897452
[Au] Autor:Kurata S; Sanuki T; Okayasu I; Kawai M; Moromugi S; Ayuse T
[Ad] Endereço:Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan.
[Ti] Título:A pilot study of upper airway management using a remote-controlled artificial muscle device during propofol anesthesia.
[So] Source:J Clin Anesth;29:75-82, 2016 Mar.
[Is] ISSN:1873-4529
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVE: To test the hypothesis that the jaw closure using a pneumatic actuator device affect airway collapsibility and resistance during propofol anesthesia. DESIGN: Prospective, randomized study. SETTING: University-affiliated hospital. PATIENTS: Six male subjects were included in the present study. INTERVENTION: We used pressure-flow relationships to evaluate critical closing pressure (PCRIT) and upper airway resistance in different conditions of body and head position. Anesthesia was induced and maintained with a propofol infusion, targeting a constant blood concentration of 1.5 to 2.0µg/mL to establish an adequate depth of anesthesia, with patients breathing spontaneously through a nasal mask. An air-inflatable pneumatic actuator was used to achieve jaw closure. Nasal mask pressure was intermittently reduced to evaluate upper airway collapsibility (passive PCRIT) and upstream resistance under 4 different conditions: (1) neutral occlusion at 0-cm head elevation (baseline), (2) jaw closure at 0-cm head elevation, (3) neutral occlusion at 6-cm head elevation, and (4) jaw closure at 6-cm head elevation. PCRIT and upstream resistance under each condition were compared using 1-way analysis of variance. P<.05 was considered significant. MEASUREMENTS: The pressure and inspiratory flow at the subjects' nose mask were recorded. Polysomonographic parameters (electroencephalograms, electrooculograms, submental electromyograms, and plethysmogram) were also recorded. MAIN RESULTS: The combination of 6-cm head elevation with jaw closure using the pneumatic actuator decreased upper airway collapsibility (PCRIT≈-3.0 cm H2O) compared to the baseline position (PCRIT≈-1.2 cm H2O; P=.0003). CONCLUSION: We demonstrated that jaw closure using an air-inflatable pneumatic actuator device can produce substantial decreases in upper airway collapsibility and maintain upper airway patency during propofol anesthesia.
[Mh] Termos MeSH primário: Manuseio das Vias Aéreas/métodos
Obstrução das Vias Respiratórias/prevenção & controle
Anestésicos Intravenosos/administração & dosagem
Propofol/administração & dosagem
Robótica/instrumentação
[Mh] Termos MeSH secundário: Adulto
Resistência das Vias Respiratórias
Anestesia Intravenosa/métodos
Ar Comprimido
Movimentos da Cabeça/fisiologia
Seres Humanos
Arcada Osseodentária/fisiologia
Masculino
Projetos Piloto
Robótica/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); YI7VU623SF (Propofol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160222
[St] Status:MEDLINE


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[PMID]:26400556
[Au] Autor:Demtröder C; Solass W; Zieren J; Strumberg D; Giger-Pabst U; Reymond MA
[Ad] Endereço:Department of Surgery, Marien Hospital, Ruhr University Bochum, Herne, Germany.
[Ti] Título:Pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in colorectal peritoneal metastasis.
[So] Source:Colorectal Dis;18(4):364-71, 2016 Apr.
[Is] ISSN:1463-1318
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an experimental drug delivery method that applies chemotherapy into the abdominal cavity as an aerosol under pressure. We present the first results obtained with PIPAC in colorectal peritoneal metastasis (CPM). METHOD: This is a retrospective analysis. PIPAC was applied in 17 consecutive patients with pretreated CPM. All patients had previously undergone surgery, and 16 had undergone previous lines of systemic chemotherapy (median, two lines). The mean peritoneal metastasis index (peritoneal cancer index) was 16 ± 10. Forty-eight applications of PIPAC with oxaliplatin (92 mg/m2 ) were given every 6 weeks at 37 °C and 12 mmHg for 30 min. The outcome criteria were microscopic pathological response, survival and adverse events according to Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. RESULTS: Forty-eight PIPAC administrations were performed with no intra-operative complications. The mean number of PIPAC administrations per patient was 2.8 (minimum one, maximum six). Postoperative adverse events (CTCAE level 3) were observed in four patients (23%), no CTCAE level-4 adverse events were reported. The hospital mortality was zero. Objective tumour responses were observed in 12/17 patients (71%), and the overall responses were as follows: complete pathological response (seven patients), major response (four patients), partial response (one patient), no response (two patients) and not eligible (three patients). The mean survival after first PIPAC was 15.7 months. CONCLUSION: Repeated PIPAC with oxaliplatin can induce the regression of pretreated CPM. The toxicity appears to be low. These preliminary results are encouraging and justify prospective clinical studies.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Neoplasias Colorretais/tratamento farmacológico
Compostos Organoplatínicos/administração & dosagem
Neoplasias Peritoneais/tratamento farmacológico
[Mh] Termos MeSH secundário: Aerossóis
Idoso
Neoplasias Colorretais/patologia
Ar Comprimido
Feminino
Seres Humanos
Infusões Parenterais/métodos
Masculino
Meia-Idade
Neoplasias Peritoneais/secundário
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Antineoplastic Agents); 0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150925
[St] Status:MEDLINE
[do] DOI:10.1111/codi.13130



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