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[PMID]:28942276
[Au] Autor:Wang H; Cao X; Li L; Fang Z; Li X
[Ad] Endereço:School of Energy and Environment, Southeast University, Nanjing 210096, China. Electronic address: lwcq306@163.com.
[Ti] Título:Augmenting atrazine and hexachlorobenzene degradation under different soil redox conditions in a bioelectrochemistry system and an analysis of the relevant microorganisms.
[So] Source:Ecotoxicol Environ Saf;147:735-741, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Soil microbial fuel cells (MFCs) are a sustainable technology that degrades organic pollutants while generating electricity. However, there have been no detailed studies of the mechanisms of pollutant degradation in soil MFCs. In this study, the effects of external resistance and electrode effectiveness on atrazine and hexachlorobenzene (HCB) degradation were evaluated, the performance of soil MFCs in the degradation of these pollutants under different soil redox conditions was assessed, and the associated microorganisms in the anode were investigated. With an external resistance of 20Ω, the degradation efficiencies of atrazine and HCB were 95% and 78%, respectively. The degradation efficiency, degradation rate increased with decreasing external resistance, while the half-life decreased. There were different degradation trends for different pollutants under different soil redox conditions. The fastest degradation rate of atrazine was in the upper MFC section (aerobic), whereas that of HCB was in the lower MFC section (anaerobic). The results showed that electrode effectiveness played a significant role in pollution degradation. In addition, the microbial community analysis demonstrated that Proteobacteria, especially Deltaproteobacteria involved in current generation was extremely abundant (27.49%) on soil MFC anodes, although the percentage abundances of atrazine degrading Rhodocyclaceae (8.77%), Desulfitobacterium (0.64%), and HCB degrading Desulfuromonas (0.73%), were considerably lower. The results of the study suggested that soil MFCs can enhance the degradation of atrazine and HCB, and bioelectrochemical reduction was the main mechanism for the pollutants degradation.
[Mh] Termos MeSH primário: Atrazina/análise
Fontes de Energia Bioelétrica/microbiologia
Técnicas Eletroquímicas/métodos
Hexaclorobenzeno/análise
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Aerobiose
Anaerobiose
Biodegradação Ambiental
Eletrodos
Meia-Vida
Cinética
Oxirredução
Proteobactérias/crescimento & desenvolvimento
Bactérias Redutoras de Enxofre/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 4Z87H0LKUY (Hexachlorobenzene); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:29247929
[Au] Autor:Lee SL; Ho LN; Ong SA; Wong YS; Voon CH; Khalik WF; Yusoff NA; Nordin N
[Ad] Endereço:School of Materials Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia.
[Ti] Título:Role of dissolved oxygen on the degradation mechanism of Reactive Green 19 and electricity generation in photocatalytic fuel cell.
[So] Source:Chemosphere;194:675-681, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, a membraneless photocatalytic fuel cell with zinc oxide loaded carbon photoanode and platinum loaded carbon cathode was constructed to investigate the impact of dissolved oxygen on the mechanism of dye degradation and electricity generation of photocatalytic fuel cell. The photocatalytic fuel cell with high and low aeration rate, no aeration and nitrogen purged were investigated, respectively. The degradation rate of diazo dye Reactive Green 19 and the electricity generation was enhanced in photocatalytic fuel cell with higher dissolved oxygen concentration. However, the photocatalytic fuel cell was still able to perform 37% of decolorization in a slow rate (k = 0.033 h ) under extremely low dissolved oxygen concentration (approximately 0.2 mg L ) when nitrogen gas was introduced into the fuel cell throughout the 8 h. However, the change of the UV-Vis spectrum indicates that the intermediates of the dye could not be mineralized under insufficient dissolved oxygen level. In the aspect of electricity generation, the maximum short circuit current (0.0041 mA cm ) and power density (0.00028 mW cm ) of the air purged photocatalytic fuel cell was obviously higher than that with nitrogen purging (0.0015 mA cm and 0.00008 mW cm ).
[Mh] Termos MeSH primário: Compostos Azo/química
Eletricidade
Eletrólise/métodos
Oxigênio/química
[Mh] Termos MeSH secundário: Carbono
Catálise
Eletrodos
Processos Fotoquímicos
Platina
Óxido de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (reactive green 19); 49DFR088MY (Platinum); 7440-44-0 (Carbon); S88TT14065 (Oxygen); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29372919
[Au] Autor:Karaballi RA; Merchant S; Power SR; Brosseau CL
[Ad] Endereço:Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia B3H 3C3, Canada. christa.brosseau@smu.ca.
[Ti] Título:Electrochemical surface-enhanced Raman spectroscopy (EC-SERS) study of the interaction between protein aggregates and biomimetic membranes.
[So] Source:Phys Chem Chem Phys;20(6):4513-4526, 2018 Feb 07.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human diseases characterized by the uncontrolled deposition of insoluble extracellular protein aggregates are collectively referred to as amyloidoses. Such diseases include Alzheimer's, Parkinson's, Huntington's, and prion disease. In Alzheimer's disease, it is believed that amyloid-ß proteins may be responsible for pore and defect formation within cellular membranes, leading to a breakdown of cellular homeostasis causing eventual neuronal death. This theory is referred to as the amyloid pore hypothesis of Alzheimer's disease. In this work, the interaction between a model amyloid-forming protein (insulin) and a biomimetic membrane was studied at the molecular level. Protein at different stages of aggregation was allowed to interact with a biomimetic membrane formed on a nanostructured substrate using Langmuir-Blodgett/Langmuir-Schaefer deposition. Electrochemical surface-enhanced Raman spectroscopy (EC-SERS) was used to monitor the molecular level changes occurring as a result of this interaction. Based on the results it was observed that oligomers and protofibrils caused the most significant membrane deterioration whilst native protein appeared to play a protective role. To the best of our knowledge, this work represents the first EC-SERS investigation of protein aggregate-biomembrane interactions, and highlights the usefulness of this tool for studying complex biomolecular interactions.
[Mh] Termos MeSH primário: Amiloide/química
Biomimética
Insulina/química
Bicamadas Lipídicas/química
Agregados Proteicos
[Mh] Termos MeSH secundário: Amiloide/metabolismo
Técnicas Eletroquímicas
Eletrodos
Seres Humanos
Insulina/metabolismo
Bicamadas Lipídicas/metabolismo
Nanopartículas Metálicas/química
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Nefelometria e Turbidimetria
Prata/química
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 0 (Insulin); 0 (Lipid Bilayers); 0 (Protein Aggregates); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06838g


  4 / 39937 MEDLINE  
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[PMID]:28467380
[Au] Autor:Lin A; Truong B; Patel S; Kaushik N; Choi EH; Fridman G; Fridman A; Miller V
[Ad] Endereço:C. & J. Nyheim Plasma Institute, Drexel University, Philadelphia, PA 19104, USA. agl46@glink.drexel.edu.
[Ti] Título:Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress.
[So] Source:Int J Mol Sci;18(5), 2017 May 03.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A novel application for non-thermal plasma is the induction of immunogenic cancer cell death for cancer immunotherapy. Cells undergoing immunogenic death emit danger signals which facilitate anti-tumor immune responses. Although pathways leading to immunogenic cell death are not fully understood; oxidative stress is considered to be part of the underlying mechanism. Here; we studied the interaction between dielectric barrier discharge plasma and cancer cells for oxidative stress-mediated immunogenic cell death. We assessed changes to the intracellular oxidative environment after plasma treatment and correlated it to emission of two danger signals: surface-exposed calreticulin and secreted adenosine triphosphate. Plasma-generated reactive oxygen and charged species were recognized as the major effectors of immunogenic cell death. Chemical attenuators of intracellular reactive oxygen species successfully abrogated oxidative stress following plasma treatment and modulated the emission of surface-exposed calreticulin. Secreted danger signals from cells undergoing immunogenic death enhanced the anti-tumor activity of macrophages. This study demonstrated that plasma triggers immunogenic cell death through oxidative stress pathways and highlights its potential development for cancer immunotherapy.
[Mh] Termos MeSH primário: Apoptose/imunologia
Imunoterapia/métodos
Neoplasias/terapia
Estresse Oxidativo/imunologia
Gases em Plasma/uso terapêutico
Espécies Reativas de Oxigênio/imunologia
[Mh] Termos MeSH secundário: Células A549
Trifosfato de Adenosina/metabolismo
Análise de Variância
Células Apresentadoras de Antígenos/metabolismo
Calreticulina/metabolismo
Condutividade Elétrica
Eletrodos
Seres Humanos
Imunidade
Quartzo/química
Espécies Reativas de Oxigênio/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calreticulin); 0 (Plasma Gases); 0 (Reactive Oxygen Species); 0 (calreticulin, human); 14808-60-7 (Quartz); 8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  5 / 39937 MEDLINE  
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[PMID]:28462905
[Au] Autor:David M; Levy E; Feldman Y; Ben Ishai P; Zelig O; Yedgar S; Barshtein G
[Ad] Endereço:Applied Physics Department, The Hebrew University of Jerusalem, Jerusalem, Israel.
[Ti] Título:The dielectric spectroscopy of human red blood cells: the differentiation of old from fresh cells.
[So] Source:Physiol Meas;38(7):1335-1348, 2017 Jun 22.
[Is] ISSN:1361-6579
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the study was to gauge the effect of storage lesions on the dielectric response of red blood cells (RBC), in particular those processes linked to deformations of the cellular membrane known as the ß-dispersion. APPROACH: The dielectric response of RBC suspensions, exposed to blood-bank cold storage, was studied using time-domain dielectric spectroscopy (TDDS) in the frequency range of 500 kHz up to 1 GHz. The measured dielectric processes are characterized by their dielectric strength (Δε) and relaxation time (τ). Changes in the dielectric properties of the RBC suspensions due to storage-related lesions were evaluated. For a quantitative characterization of RBC lesions, we measured the deformability of fresh and stored RBC as expressed by their elongation ratio (ER), which was achieved under a shear stress of 3.0 Pa. MAIN RESULT: The results show that the storage of RBC induced a statistically significant decrease of dielectric relaxation times. In addition, a sound correlation between the mean values of ER and the relaxation times was observed (Spearman's correlation coefficient ρ = 0.847). We draw the conclusion that those alterations in the relaxation time are induced by changes in the shape of the RBC that happen during cold-storage. SIGNIFICANCE: The evolution of the ß-dispersion of RBC opens new possibilities in the blood bank inventory management.
[Mh] Termos MeSH primário: Diferenciação Celular
Espectroscopia Dielétrica
Eritrócitos/citologia
[Mh] Termos MeSH secundário: Criopreservação
Espectroscopia Dielétrica/instrumentação
Eletrodos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6579/aa707a


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[PMID]:28470533
[Au] Autor:Öz S; Breiling A; Maercker C
[Ad] Endereço:German Cancer Research Center (DKFZ), Epigenomics and Cancer Risk Factors, Heidelberg, Germany.
[Ti] Título:Measurement of Cellular Behavior by Electrochemical Impedance Sensing.
[So] Source:Methods Mol Biol;1601:267-273, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a great demand for label-free in vitro assays in a high-throughput context, in order to measure cell viability and analyze cellular functions like cell migration or cell differentiation under noninvasive conditions. Here, we describe impedance measurement to quantify dynamic changes on cell morphology in real time. In order to monitor physiological changes, cells are grown in tissue culture vessels where gold electrodes are incorporated at the bottom. An alternating current signal of several kHz is applied to the electrodes and the resulting voltage is measured to calculate the cellular impedance. Since impedance is closely related to the area of the electrodes covered by the growing cells, parameters such as cell number, size of the cells attached to the electrodes, and cell-cell and cell-substrate/extracellular matrix interactions contribute to the overall impedance values.
[Mh] Termos MeSH primário: Diferenciação Celular/fisiologia
Movimento Celular/fisiologia
Sobrevivência Celular/fisiologia
Impedância Elétrica
[Mh] Termos MeSH secundário: Adesão Celular/fisiologia
Comunicação Celular/fisiologia
Contagem de Células
Tamanho Celular
Eletrodos
Células-Tronco de Carcinoma Embrionário/química
Matriz Extracelular/química
Ouro/química
Ensaios de Triagem em Larga Escala
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7440-57-5 (Gold)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6960-9_21


  7 / 39937 MEDLINE  
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[PMID]:29406115
[Au] Autor:Jin Y; Yue Q; Yang K; Wu S; Li S; Gao B; Gao Y
[Ad] Endereço:Shandong University, Jinan 250100, China.
[Ti] Título:Pre-treatment of pyridine wastewater by new cathodic-anodic-electrolysis packing.
[So] Source:J Environ Sci (China);63:43-49, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel cathodic-anodic-electrolysis packing (CAEP) used in the treatment of pyridine wastewater was researched, which mainly consisted of 4,4'-diamino-2,2'-disulfonic acid (DSD acid) industrial iron sludge. The physical properties and morphology of the packing were studied. The CAEP was used in a column reactor during the pretreatment of pyridine wastewater. The influence of pH, hydraulic retention time (HRT), the air-liquid ratio (A/L) and the initial concentration of pyridine were investigated by measuring the removal of total organic carbon (TOC) and pyridine. The characterization results showed that the bulk density, grain density, water absorption percentage and specific surface area were 921kg/m , 1086kg/m , 25% and 29.89m /g, respectively; the removal of TOC and pyridine could reach 50% and 58% at the optimal experimental conditions (pH=3, HRT=8hr, A/L=2). Notably, the surface of the packing was renewed constantly during the running of the filter, and the handling capacity was stable after running for three months.
[Mh] Termos MeSH primário: Eletrólise
Piridinas/química
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Técnicas Eletroquímicas
Eletrodos
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyridines); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28741115
[Au] Autor:Woo J; Jung S; Gauvin M; Lachapelle P
[Ad] Endereço:Departments of Ophthalmology and Neurology and Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montreal, QC, Canada.
[Ti] Título:The DTL ERG electrode comes in different shapes and sizes: Are they all good?
[So] Source:Doc Ophthalmol;135(2):155-164, 2017 10.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Although the DTL fiber electrode has been in use in the ERG field for more than four decades, its composition was never clearly defined. We compared five different types of conductive (DTL type) yarn (differing in terms of mass, number of filaments, and crimping degree) in order to determine whether we could identify one that would be better suited for the recording of ERGs. METHODS: Photopic flash ERGs were recorded from five subjects using the following DTL electrodes: 27/7, 22/1, 11/1, 11/1*2, and 22/1*2. Data analysis included amplitude and peak time measurements of the a- and b-waves in the time domain (TD) as well as measurements of specific frequency descriptors of the ERG waveform in the time-frequency domain using the discrete wavelet transform (DWT) approach. The degree of comfortableness was also assessed in 12 subjects with two surveys (Likert 5-point and the ranking scale). RESULTS: Comparisons of TD and DWT parameters did not permit to identify the best DTL electrode, all yielding comparable measures. There was a slight trend for the largest electrode (22/1*2) to yield the largest response, but this was at the expense of comfort, the 22/1*2 electrode being rated as the least comfortable. CONCLUSIONS: Given the minimal impact the different electrodes had on the amplitude of the signal, we believe that comfort should dictate our choice. It would appear from our results that use of a multifilament electrode is the best choice since one can get an electrode whose size is optimized for the recording of large responses while minimizing the foreign-body sensation due to the small size of each of the filaments that compose this multifilament electrode.
[Mh] Termos MeSH primário: Eletrodos
Eletrorretinografia/instrumentação
Retina/fisiologia
[Mh] Termos MeSH secundário: Visão de Cores/fisiologia
Eletrorretinografia/métodos
Feminino
Seres Humanos
Masculino
Conforto do Paciente
Satisfação do Paciente
Estimulação Luminosa
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9600-3


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[PMID]:29238765
[Au] Autor:Varade V; Markus T; Vankayala K; Friedman N; Sheves M; Waldeck DH; Naaman R
[Ad] Endereço:Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel. ron.naaman@weizmann.ac.il.
[Ti] Título:Bacteriorhodopsin based non-magnetic spin filters for biomolecular spintronics.
[So] Source:Phys Chem Chem Phys;20(2):1091-1097, 2018 Jan 03.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We discuss spin injection and spin valves, which are based on organic and biomolecules, that offer the possibility to overcome some of the limitations of solid-state devices, which are based on ferromagnetic metal electrodes. In particular, we discuss spin filtering through bacteriorhodopsin in a solid state biomolecular spin valve that is based on the chirality induced spin selectivity (CISS) effect and shows a magnetoresistance of ∼2% at room temperature. The device is fabricated using a layer of bacteriorhodopsin (treated with n-octyl-thioglucoside detergent: OTG-bR) that is adsorbed on a cysteamine functionalized gold electrode and capped with a magnesium oxide layer as a tunneling barrier, upon which a Ni top electrode film is placed and used as a spin analyzer. The bR based spin valves show an antisymmetric magnetoresistance response when a magnetic field is applied along the direction of the current flow, whereas they display a positive symmetric magnetoresistance curve when a magnetic field is applied perpendicular to the current direction.
[Mh] Termos MeSH primário: Bacteriorodopsinas/química
Imãs
[Mh] Termos MeSH secundário: Eletrodos
Elétrons
Ouro
Campos Magnéticos
Tioglucosídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thioglucosides); 53026-44-1 (Bacteriorhodopsins); 7440-57-5 (Gold); 85618-21-9 (n-octyl-beta-D-thioglucopyranoside)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06771b


  10 / 39937 MEDLINE  
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[PMID]:28459436
[Au] Autor:Lam AD; Deck G; Goldman A; Eskandar EN; Noebels J; Cole AJ
[Ad] Endereço:MGH Epilepsy Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.
[So] Source:Nat Med;23(6):678-680, 2017 Jun.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/fisiopatologia
Hipocampo/fisiopatologia
Convulsões/fisiopatologia
Sono
[Mh] Termos MeSH secundário: Idoso
Doença de Alzheimer/complicações
Encéfalo/diagnóstico por imagem
Encéfalo/fisiopatologia
Eletrodos
Eletroencefalografia
Feminino
Forame Oval
Hipocampo/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Consolidação da Memória
Meia-Idade
Testes Neuropsicológicos
Tomografia por Emissão de Pósitrons
Convulsões/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4330



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