Base de dados : MEDLINE
Pesquisa : E07.440 [Categoria DeCS]
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[PMID]:27633214
[Au] Autor:Ko SM; Lee K; Kim D; Ji YG
[Ad] Endereço:Department of Information and Industrial Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
[Ti] Título:Vibrotactile perception assessment for a haptic interface on an antigravity suit.
[So] Source:Appl Ergon;58:198-207, 2017 Jan.
[Is] ISSN:1872-9126
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Haptic technology is used in various fields to transmit information to the user with or without visual and auditory cues. This study aimed to provide preliminary data for use in developing a haptic interface for an antigravity (anti-G) suit. With the structural characteristics of the anti-G suit in mind, we determined five areas on the body (lower back, outer thighs, inner thighs, outer calves, and inner calves) on which to install ten bar-type eccentric rotating mass (ERM) motors as vibration actuators. To determine the design factors of the haptic anti-G suit, we conducted three experiments to find the absolute threshold, moderate intensity, and subjective assessments of vibrotactile stimuli. Twenty-six fighter pilots participated in the experiments, which were conducted in a fixed-based flight simulator. From the results of our study, we recommend 1) absolute thresholds of ∼11.98-15.84 Hz and 102.01-104.06 dB, 2) moderate intensities of 74.36 Hz and 126.98 dB for the lower back and 58.65 Hz and 122.37 dB for either side of the thighs and calves, and 3) subjective assessments of vibrotactile stimuli (displeasure, easy to perceive, and level of comfort). The results of this study will be useful for the design of a haptic anti-G suit.
[Mh] Termos MeSH primário: Trajes Gravitacionais
Militares
Pilotos
Limiar Sensorial
Percepção do Tato
Vibração
[Mh] Termos MeSH secundário: Adulto
Dorso/fisiologia
Comportamento do Consumidor
Desenho de Equipamento
Seres Humanos
Perna (Membro)/fisiologia
Masculino
República da Coreia
Coxa da Perna/fisiologia
Percepção do Tato/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170910
[Lr] Data última revisão:
170910
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE


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[PMID]:27135470
[Au] Autor:Carvil PA; Attias J; Evetts SN; Waldie JM; Green DA
[Ad] Endereço:1Centre of Human & Aerospace Physiological Sciences, King's College London, London, United Kingdom; 2Wyle GmbH, Cologne, Germany; and 3RMIT University, Melbourne, Australia.
[Ti] Título:The Effect of the Gravity Loading Countermeasure Skinsuit Upon Movement and Strength.
[So] Source:J Strength Cond Res;31(1):154-161, 2017 Jan.
[Is] ISSN:1533-4287
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carvil, PA, Attias, J, Evetts, SN, Waldie, JM, and Green, DA. The effect of the gravity loading countermeasure skinsuit upon movement and strength. J Strength Cond Res 31(1): 154-161, 2017-Effective countermeasures against musculoskeletal deconditioning induced by microgravity and disuse are required. A simple alternative to provision of artificial gravity by centrifugation is compressive axial loading. The Russian "Pingvin" suit was the first wearable suit to apply this concept using bungee cords tethered around the shoulders and feet. However, poor loading characteristics and severe thermal and movement discomfort were reported. The gravity loading countermeasure skinsuit (GLCS) uses a bidirectional weave to generate staged axial loading from shoulders to feet, better mimicking how Earth's gravity induces progressive loading head to foot. The Mk III GLCS's loading was evaluated and tolerability assessed during maximal joint motion, ambulation, and selected strength exercises. Eight subjects (5 male and 3 female; 28 ± 3 years; 179 ± 0.1 cm and 74.8 ± 2.9 kg), having given written informed consent, had an Mk III GLCS individually tailored. Axial loading imparted, body height, joint range of motion (ROM), ambulation, and strength tests (12 repetition maximum) were performed in the GLCS and gym attire, with subjective (rating of perceived exertion, thermal comfort, movement discomfort and body control) ratings recorded throughout. Gravity loading countermeasure skinsuit provided significant axial loading when standing but significantly reduced knee (-13°), spinal (-28°) and shoulder flexion/extension ROM (-34°/-13°), in addition to Sit and Reach (-12.8 cm). No thermal issues were reported but there was an increase in subjective discomfort. Gravity loading countermeasure skinsuit did not significantly impede strength exercise, with the exception of shoulder press. The GLCS (Mk III) demonstrates potential as a countermeasure by providing tolerable, static axial loading. Furthermore, it may serve as an elasticlike strength exercise adjunct, which may have utility as a rehabilitation modality after further design refinement.
[Mh] Termos MeSH primário: Exercício/fisiologia
Trajes Gravitacionais
Amplitude de Movimento Articular/fisiologia
Contramedidas de Ausência de Peso
[Mh] Termos MeSH secundário: Adulto
Centrifugação
Feminino
Gravidade Alterada
Seres Humanos
Masculino
Federação Russa
Caminhada
Ausência de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE
[do] DOI:10.1519/JSC.0000000000001460


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[PMID]:27450867
[Au] Autor:Hofmeyr GJ; Qureshi Z
[Ad] Endereço:Effective Care Research Unit, Universities of the Witwatersrand and Fort Hare and Eastern Cape Department of Health, South Africa; Centre for Evidence-Based Health Care, University of Stellenbosch, South Africa; Frere Maternity Hospital, Amalinda Drive, East London, South Africa. Electronic address: justhof@gmail.com.
[Ti] Título:Preventing deaths due to haemorrhage.
[So] Source:Best Pract Res Clin Obstet Gynaecol;36:68-82, 2016 Oct.
[Is] ISSN:1532-1932
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prevention of deaths from obstetric haemorrhage requires effective health systems including family planning, commodities, personnel, infrastructure and ultimately universal access to comprehensive obstetric care for women giving birth. The main causes of death associated with antepartum haemorrhage are placental abruption, placenta praevia and uterine rupture. Preventive measures include preconceptual folate supplementation, management of hypertensive disorders, early diagnosis of placenta praevia and use of uterine stimulants cautiously, particularly misoprostol. Preventive measures for post-partum haemorrhage include routine active management of the third stage of labour. Treatment involves a cascade of increasingly invasive interventions in rapid sequence until the bleeding is stopped. These interventions include fluid resuscitation, removal of the placenta, bimanual uterine compression, uterotonics, tranexamic acid, suturing of lower genital tract injury, blood product replacement, balloon tamponade, laparotomy, stepwise uterine devascularization, uterine compression sutures and hysterectomy. Emergency temporizing measures include application of the non-pneumatic anti-shock garment, and at laparotomy, aortic compression and uterine tourniquet application. The effectiveness of treatment methods and the optimal dosage of misoprostol are research priorities. Interesting new approaches include transvaginal uterine artery clamping and suction uterine tamponade.
[Mh] Termos MeSH primário: Descolamento Prematuro da Placenta/terapia
Antifibrinolíticos/uso terapêutico
Morte Materna/prevenção & controle
Ocitócicos/uso terapêutico
Placenta Prévia/terapia
Hemorragia Pós-Parto/terapia
Hemorragia Uterina/terapia
Ruptura Uterina/terapia
[Mh] Termos MeSH secundário: Transfusão de Sangue
Cesárea
Ergonovina/uso terapêutico
Feminino
Hidratação
Trajes Gravitacionais
Instalações de Saúde
Parto Domiciliar
Seres Humanos
Histerectomia
Soluções Isotônicas/uso terapêutico
Trabalho de Parto Induzido
Massagem/métodos
Morte Materna/etiologia
Misoprostol/uso terapêutico
Ocitocina/uso terapêutico
Gravidez
Torniquetes
Ácido Tranexâmico/uso terapêutico
Embolização da Artéria Uterina/métodos
Tamponamento com Balão Uterino/métodos
Hemorragia Uterina/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifibrinolytic Agents); 0 (Isotonic Solutions); 0 (Oxytocics); 0 (crystalloid solutions); 0E43V0BB57 (Misoprostol); 50-56-6 (Oxytocin); 6T84R30KC1 (Tranexamic Acid); WH41D8433D (Ergonovine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27099085
[Au] Autor:Morgan TR; Balldin U; Fischer JR
[Ti] Título:G Protection When Adding Pressurized Sleeves and Gloves to a Representative G-Suit Ensemble.
[So] Source:Aerosp Med Hum Perform;87(5):464-9, 2016 May.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In a previous study, pressurized sleeves and gloves were found to substantially diminish or eliminate G-induced arm pain. Since this equipment presumably acts similarly to a G suit for the arms and hands, it was hypothesized that higher inflation pressures might provide an additional increment of G protection. METHODS: In a human-rated centrifuge, 15 well trained subjects using Combat Edge and ATAGS G-protective equipment were exposed to gradual and rapid onset relaxed G exposures as well as rapid onset straining and simulated aerial combat maneuver G exposures up to + 9 Gz with and without pressurized sleeves and gloves. RESULTS: The pressurized sleeves and gloves did not show any improvement in G tolerance or endurance compared to the control. However, significantly lower heart rates (6-12%) and subjective effort (11%), along with slightly less peripheral vision loss, suggest a decreased work load when wearing the pressurized sleeves and gloves. A trend to shorter time on target in a tracking task was found with the pressurized sleeves and gloves, likely due to decreased mobility of the hands, thus affecting control stick input. CONCLUSIONS: G tolerance and endurance were not improved by the pressurized sleeves and gloves. However, a lower heart rate and a decreased subjective effort level and peripheral vision loss indicated that the subjects did not have to work as hard with this equipment.
[Mh] Termos MeSH primário: Centrifugação
Trajes Gravitacionais
Roupa de Proteção
[Mh] Termos MeSH secundário: Adulto
Medicina Aeroespacial
Feminino
Frequência Cardíaca
Seres Humanos
Masculino
Resistência Física
Visão Ocular
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160421
[Lr] Data última revisão:
160421
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4292.2016


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[PMID]:25627322
[Au] Autor:Downing J; El Ayadi A; Miller S; Butrick E; Mkumba G; Magwali T; Kaseba-Sata C; Kahn JG
[Ad] Endereço:Health Services and Policy Analysis, University of California, Berkeley, CA, USA. jdowning@berkeley.edu.
[Ti] Título:Cost-effectiveness of the non-pneumatic anti-shock garment (NASG): evidence from a cluster randomized controlled trial in Zambia and Zimbabwe.
[So] Source:BMC Health Serv Res;15:37, 2015 Jan 28.
[Is] ISSN:1472-6963
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obstetric hemorrhage is the leading cause of maternal mortality, particularly in low resource settings where delays in obtaining definitive care contribute to high rates of death. The non-pneumatic anti-shock garment (NASG) first-aid device has been demonstrated to be highly cost-effective when applied at the referral hospital (RH) level. In this analysis we evaluate the incremental cost-effectiveness of early NASG application at the Primary Health Center (PHC) compared to later application at the RH in Zambia and Zimbabwe. METHODS: We obtained data on health outcomes and costs from a cluster-randomized clinical trial (CRCT) and participating study hospitals. We translated health outcomes into disability-adjusted life years (DALYs) using standard methods. Econometric regressions estimated the contribution of earlier PHC NASG application to DALYs and costs, varying geographic covariates (country, referral hospital) to yield regression models best fit to the data. We calculated cost-effectiveness as the ratio of added costs to averted DALYs for earlier PHC NASG application compared to later RH NASG application. RESULTS: Overall, the cost-effectiveness of early application of the NASG at the primary health care level compared to waiting until arrival at the referral hospital was $21.78 per DALY averted ($15.51 in added costs divided by 0.712 DALYs averted per woman, both statistically significant). By country, the results were very similar in Zambia, though not statistically significant in Zimbabwe. Sensitivity analysis suggests that results are robust to a per-protocol outcome analysis and are sensitive to the cost of blood transfusions. CONCLUSIONS: Early NASG application at the PHC for women in hypovolemic shock has the potential to be cost-effective across many clinical settings. The NASG is designed to reverse shock and decrease further bleeding for women with obstetric hemorrhage; therefore, women who have received the NASG earlier may be better able to survive delays in reaching definitive care at the RH and recover more quickly from shock, all at a cost that is highly acceptable.
[Mh] Termos MeSH primário: Vestuário/economia
Trajes Gravitacionais/economia
Hemorragia Pós-Parto/terapia
Choque/terapia
[Mh] Termos MeSH secundário: Adulto
Análise Custo-Benefício
Feminino
Seres Humanos
Meia-Idade
Gravidez
Zâmbia
Zimbábue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150129
[St] Status:MEDLINE
[do] DOI:10.1186/s12913-015-0694-6


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[PMID]:25565528
[Au] Autor:Liu X; Xiao H; Shi W; Wen D; Yu L; Chen J
[Ad] Endereço:Beihang University, Beijing, P. R. China; the Institute of Aviation Medicine, Air Force of P. R. China, Beijing, P. R. China;
[Ti] Título:Physiological effects of positive pressure breathing with pure oxygen and a low oxygen gas mixture.
[So] Source:Aerosp Med Hum Perform;86(1):15-20, 2015 Jan.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Positive pressure breathing (PPB) can cause circulatory dysfunction due to peripheral pooling of blood. This study explored a better way at ground level to simulate pure oxygen PPB at 59,055 ft (18,000 m) by comparing the physiological changes during PPB with pure oxygen and low oxygen at ground level. METHODS: Six subjects were exposed to 3 min of 69-mmHg PPB and 3 min of 59-mmHg PPB with pure oxygen and low oxygen while wearing the thoracic counterpressure jerkin inflated to 1× breathing pressure and G-suit inflated to 3 and 4× breathing pressure. Stroke volume (SV), cardiac output (CO), heart rate (HR), and peripheral oxygen saturation (Spo2) were measured. Subjects completed a simulating flying task (SFT) during 3-min PPB and scores were recorded. RESULTS: HR and SV responses differed significantly between breathing pure oxygen and low oxygen. CO response was not significantly different for pure oxygen and low oxygen, the two levels of PPB, and the two levels of G-suit pressure. Spo2 declined as a linear function of time during low-oxygen PPB and there was a significant difference in Spo2 response for the two levels of PPB. The average score of SFT during pure oxygen PPB was 3970.5 ± 1050.4, which was significantly higher than 2708.0 ± 702.7 with low oxygen PPB. CONCLUSIONS: Hypoxia and PPB have a synergistic negative effect on both the cardiovascular system and SFT performance. PPB with low oxygen was more appropriate at ground level to investigate physiological responses during PPB and evaluate the protective performance of garments. Liu X, Xiao H, Shi W, Wen D, Yu L, Chen J. Physiological effects of positive pressure breathing with pure oxygen and a low oxygen gas mixture.
[Mh] Termos MeSH primário: Frequência Cardíaca
Hipóxia/fisiopatologia
Oxigênio/administração & dosagem
Oxigênio/fisiologia
Respiração com Pressão Positiva
Volume Sistólico
[Mh] Termos MeSH secundário: Adolescente
Medicina Aeroespacial
Altitude
Trajes Gravitacionais
Seres Humanos
Masculino
Oxigênio/sangue
Respiração com Pressão Positiva/efeitos adversos
Trajes Espaciais
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:150108
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4096.2015


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[PMID]:25479976
[Au] Autor:Ding L; Li X; Hedge A; Hu H; Feathers D; Qin Z; Xiao H; Xue L; Zhou Q
[Ad] Endereço:Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China. Electronic address: ding1971316@buaa.edu.cn.
[Ti] Título:Optimizing the physical ergonomics indices for the use of partial pressure suits.
[So] Source:Appl Ergon;47:72-83, 2015 Mar.
[Is] ISSN:1872-9126
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study developed an ergonomic evaluation system for the design of high-altitude partial pressure suits (PPSs). A total of twenty-one Chinese males participated in the experiment which tested three types of ergonomics indices (manipulative mission, operational reach and operational strength) were studied using a three-dimensional video-based motion capture system, a target-pointing board, a hand dynamometer, and a step-tread apparatus. In total, 36 ergonomics indices were evaluated and optimized using regression and fitting analysis. Some indices that were found to be linearly related and redundant were removed from the study. An optimal ergonomics index system was established that can be used to conveniently and quickly evaluate the performance of different pressurized/non-pressurized suit designs. The resulting ergonomics index system will provide a theoretical basis and practical guidance for mission planners, suit designers and engineers to design equipment for human use, and to aid in assessing partial pressure suits.
[Mh] Termos MeSH primário: Ergonomia/métodos
Trajes Gravitacionais
Articulações/fisiologia
Roupa de Proteção
Análise e Desempenho de Tarefas
[Mh] Termos MeSH secundário: Aeronaves
China
Desenho de Equipamento
Força da Mão
Seres Humanos
Masculino
Movimento/fisiologia
Amplitude de Movimento Articular
Gravação em Vídeo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1508
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141207
[St] Status:MEDLINE


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[PMID]:25467912
[Au] Autor:Figo Safe Motherhood and Newborn Health Committee; International Federation of Gynecology and Obstetrics
[Ti] Título:Non-pneumatic anti-shock garment to stabilize women with hypovolemic shock secondary to obstetric hemorrhage.
[So] Source:Int J Gynaecol Obstet;128(3):194-5, 2015 Mar.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Trajes Gravitacionais
Hemorragia Pós-Parto/terapia
Choque/terapia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Gravidez
Choque/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161229
[Lr] Data última revisão:
161229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141204
[St] Status:MEDLINE


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[PMID]:25448247
[Au] Autor:Figueroa JJ; Singer W; Sandroni P; Sletten DM; Gehrking TL; Gehrking JA; Low P; Basford JR
[Ad] Endereço:Department of Neurology, Medical College of Wisconsin, Milwaukee, WI.
[Ti] Título:Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension.
[So] Source:Arch Phys Med Rehabil;96(3):505-10, 2015 Mar.
[Is] ISSN:1532-821X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the effects of patient-controlled abdominal compression on postural changes in systolic blood pressure (SBP) associated with orthostatic hypotension (OH). Secondary variables included subject assessments of their preferences and the ease-of-use. DESIGN: Randomized crossover trial. SETTING: Clinical research laboratory. PARTICIPANTS: Adults with neurogenic OH (N=13). INTERVENTIONS: Four maneuvers were performed: moving from supine to standing without abdominal compression; moving from supine to standing with either a conventional or an adjustable abdominal binder in place; application of subject-determined maximal tolerable abdominal compression while standing; and while still erect, subsequent reduction of abdominal compression to a level the subject believed would be tolerable for a prolonged period. MAIN OUTCOME MEASURES: The primary outcome variable included postural changes in SBP. Secondary outcome variables included subject assessments of their preferences and ease of use. RESULTS: Baseline median SBP in the supine position was not affected by mild (10mmHg) abdominal compression prior to rising (without abdominal compression: 146mmHg; interquartile range, 124-164mmHg; with the conventional binder: 145mmHg; interquartile range, 129-167mmHg; with the adjustable binder: 153mmHg, interquartile range, 129-160mmHg; P=.85). Standing without a binder was associated with an -57mmHg (interquartile range, -40 to -76mmHg) SBP decrease. Levels of compression of 10mmHg applied prior to rising with the conventional and adjustable binders blunted these drops to -50mmHg (interquartile range, -33 to -70mmHg; P=.03) and -46mmHg (interquartile range, -34 to -75mmHg; P=.01), respectively. Increasing compression to subject-selected maximal tolerance while standing did not provide additional benefit and was associated with drops of -53mmHg (interquartile range, -26 to -71mmHg; P=.64) and -59mmHg (interquartile range, -49 to -76mmHg; P=.52) for the conventional and adjustable binders, respectively. Subsequent reduction of compression to more tolerable levels tended to worsen OH with both the conventional (-61mmHg; interquartile range, -33 to -80mmHg; P=.64) and adjustable (-67mmHg; interquartile range, -61 to -84mmHg; P=.79) binders. Subjects reported no differences in preferences between the binders in terms of preference or ease of use. CONCLUSIONS: These results suggest that mild (10mmHg) abdominal compression prior to rising can ameliorate OH, but further compression once standing does not result in additional benefit.
[Mh] Termos MeSH primário: Abdome/fisiologia
Pressão Sanguínea/fisiologia
Trajes Gravitacionais
Hipotensão Ortostática/fisiopatologia
Hipotensão Ortostática/reabilitação
Postura/fisiologia
[Mh] Termos MeSH secundário: Idoso
Monitorização Ambulatorial da Pressão Arterial
Estudos Cross-Over
Desenho de Equipamento
Feminino
Seres Humanos
Masculino
Meia-Idade
Minnesota
Pressão
Índice de Gravidade de Doença
Sístole/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1504
[Cu] Atualização por classe:161203
[Lr] Data última revisão:
161203
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25323531
[Au] Autor:Borges JB; Hedenstierna G; Bergman JS; Amato MB; Avenel J; Montmerle-Borgdorff S
[Ad] Endereço:Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology & Critical Care, Uppsala University, Uppsala, Sweden, joao.batista_borges@surgsci.uu.se.
[Ti] Título:First-time imaging of effects of inspired oxygen concentration on regional lung volumes and breathing pattern during hypergravity.
[So] Source:Eur J Appl Physiol;115(2):353-63, 2015 Feb.
[Is] ISSN:1439-6327
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Aeroatelectasis can develop in aircrew flying the latest generation high-performance aircraft. Causes alleged are relative hyperoxia, increased gravity in the head-to-foot direction (+Gz), and compression of legs and stomach by anti-G trousers (AGT). We aimed to assess, in real time, the effects of hyperoxia, +Gz accelerations and AGT inflation on changes in regional lung volumes and breathing pattern evaluated in an axial plane by electrical impedance tomography (EIT). METHODS: The protocol mimicked a routine peacetime flight in combat aircraft. Eight subjects wearing AGT were studied in a human centrifuge during 1 h 15 min exposure of +1 to +3.5Gz. They performed this sequence three times, breathing AIR, 44.5 % O2 or 100 % O2. Continuous recording of functional EIT enabled uninterrupted assessment of regional lung volumes at the 5th intercostal level. Breathing pattern was also monitored. RESULTS: EIT data showed that +3.5Gz, compared with any moment without hypergravity, caused an abrupt decrease in regional tidal volume (VT) and regional end-expiratory lung volume (EELV) measured in the EIT slice, independently of inspired oxygen concentration. Breathing AIR or 44.5 % O2, sub-regional EELV measured in the EIT slice decreased similarly in dorsal and ventral regions, but sub-regional VT measured in the EIT slice decreased significantly more dorsally than ventrally. Breathing 100 % O2, EELV and VT decreased similarly in both regions. Inspired tidal volume increased in hyperoxia, whereas breathing frequency increased in hypergravity and hyperoxia. CONCLUSIONS: Our findings suggest that hypergravity and AGT inflation cause airway closure and air trapping in gravity-dependent lung regions, facilitating absorption atelectasis formation, in particular during hyperoxia.
[Mh] Termos MeSH primário: Hipergravidade/efeitos adversos
Hiperóxia/fisiopatologia
Inalação
Pulmão/fisiologia
Oxigênio/toxicidade
Respiração
[Mh] Termos MeSH secundário: Adulto
Trajes Gravitacionais
Seres Humanos
Pulmão/efeitos dos fármacos
Masculino
Volume de Ventilação Pulmonar
Tomografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141018
[St] Status:MEDLINE
[do] DOI:10.1007/s00421-014-3020-9



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