Base de dados : MEDLINE
Pesquisa : E07.612 [Categoria DeCS]
Referências encontradas : 12671 [refinar]
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[PMID]:29390374
[Au] Autor:Tang S; Wu X; Shen H; Wang Y; Li J; Zhang J
[Ad] Endereço:Plastic and Aesthetic Surgery Department of Hangzhou First People's Hospital.
[Ti] Título:Use of small needle knife in autologous fat grafting for the treatment of depressed scar: A case report.
[So] Source:Medicine (Baltimore);96(50):e9266, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Scars always related to functional limitations, cosmetic impairment, and social and emotional problems. Clinical improvements in scar characteristics after autologous fat grafting are well described. In this paper, we present an innovative approach to treat depressed scars. PATIENT CONCERNS: We presented a 29-year-old woman with multiple depressed scars in the left upper arm and near the elbow joint after trauma in childhood. DIAGNOSES: The patient was diagnosed as having multiple depressed scars accompanied with retraction and pain. INTERVENTIONS: We used small needle knife during fat grafting to treat the depressed scar. Vancouver Scar Scale was used to assess the effect. OUTCOMES: Aesthetic and functional improvements were observed. Resolution of pain and improvement in scar elasticity were objectively assessable. Improvement of both clinical evaluation and patient perception was obtained. LESSONS: Use of small needle knife during fat grafting is a good alternative for the treatment of depressed scars.
[Mh] Termos MeSH primário: Tecido Adiposo/transplante
Braço
Cicatriz/cirurgia
Agulhas
[Mh] Termos MeSH secundário: Adulto
Autoenxertos
Desenho de Equipamento
Feminino
Seres Humanos
Medição da Dor
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009266


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[PMID]:29172683
[Au] Autor:Shimamura Y; Sasaki S; Shimohira M; Ogino H; Yuki D; Nakamae K; Hara M; Shibamoto Y
[Ad] Endereço:1 Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan.
[Ti] Título:New technique of percutaneous CT fluoroscopy-guided marking before video-assisted thoracoscopic surgery for small lung lesions: feasibility of using a 25-gauge needle without local anaesthesia.
[So] Source:Br J Radiol;91(1083):20170692, 2018 Feb.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To retrospectively evaluate the feasibility of CT fluoroscopy-guided percutaneous marking using a 25-gauge needle and indigo carmine before video-assisted thoracoscopic surgery (VATS) for small lung lesions. METHODS: 21 patients, 14 males and 7 females, with a median age of 69 years (range, 40-79), underwent CT fluoroscopy-guided percutaneous VATS marking using a 25-gauge, 70-mm needle and 1.5-ml indigo carmine. The mean diameter of the lung lesions was 14 mm (range, 6-27). We evaluated the technical success rate, surgical success rate and complications related to this procedure by reviewing medical records and images. Technical success was defined as completion of this procedure. Surgical success was defined as resection of the target lesion with negative margins on pathological examination after VATS. Complications that required advanced levels of care were classified as major complications, and the remaining complications were considered minor. RESULTS: The technical success rate was 100%. In all cases, VATS was successfully performed as planned, and the target lesion was resected with negative margins on pathological examination after VATS. Thus, the surgical success rate was 100%. Mild pneumothorax was found in two cases, but further treatment was not required. The minor complication rate was 9.5% (2/21), and major complication rate was 0%. Only two patients (9.5%) complained of slight pain upon puncture, but local anaesthesia was not required. CONCLUSION: Percutaneous CT fluoroscopy-guided VATS marking using a 25-gauge needle without local anaesthesia appears feasible and safe. Advances in knowledge: This technique expands a possibility of the CT-guided marking.
[Mh] Termos MeSH primário: Adenocarcinoma/cirurgia
Neoplasias Pulmonares/cirurgia
Agulhas
Radiografia Intervencionista/métodos
Cirurgia Torácica Vídeoassistida
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Corantes
Estudos de Viabilidade
Feminino
Fluoroscopia
Seres Humanos
Índigo Carmim
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); D3741U8K7L (Indigo Carmine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170692


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[PMID]:27776379
[Au] Autor:Kadihasanoglu M; Kilciler M; Atahan O
[Ad] Endereço:Department of Urology, Istanbul Training and Research Hospital, Istanbul Turkey.
[Ti] Título:Endoscopic Treatment of Renal Hydatid Cyst with Percutaneous Access through an All Seeing Needle.
[So] Source:Aktuelle Urol;47(6):494-496, 2016 12.
[Is] ISSN:1438-8820
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A 44-year-old woman, who had had left flank pain for the previous 3 months, was treated successfully for renal hydatid cyst disease by using an endoscopic technique with percutaneous access through an all seeing needle. Abdominal ultrasonography showed a Gharbi type III cyst in the lower pole of the left kidney. Computerised tomography of the abdomen revealed a bulky solid-cystic mass with calcified and well-defined wall and daughter cyst without contrast enhancement. The patient, who refused any renal operation, underwent a percutaneous intervention with access through an all seeing needle access. There were no intraoperative or early postoperative complications. To our knowledge, this is the first published report of this minimally invasive percutaneous access technique through an all seeing needle.
[Mh] Termos MeSH primário: Equinococose/cirurgia
Nefropatias/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação
Agulhas
Nefrostomia Percutânea/instrumentação
[Mh] Termos MeSH secundário: Adulto
Albendazol/uso terapêutico
Terapia Combinada
Equinococose/diagnóstico por imagem
Desenho de Equipamento
Feminino
Fluoroscopia
Seres Humanos
Nefropatias/diagnóstico por imagem
Sucção/instrumentação
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
F4216019LN (Albendazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28468141
[Au] Autor:Wan Y; Fei X; Jiang D; Chen H; Shi L; Wang Z
[Ad] Endereço:*Department of Neurosurgery, Suzhou Kowloon Hospital Affiliated With Shanghai Jiao Tong University School of Medicine †Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, China.
[Ti] Título:Clinical Observation of Treatment of Chronic Subdural Hematoma With Novel Double Needle Minimally Invasive Aspiration Technology.
[So] Source:J Craniofac Surg;28(3):646-649, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of the present study was to explore the clinical effects, including the prevention of complications, of the treatment of chronic subdural hematoma with double needle aspiration. METHODS: The clinical data of 31 patients with chronic subdural hematoma treated by double YL-1 needle double skull drilling and 31 controls treated by traditional drilling and drainage were analyzed retrospectively. RESULTS: In the YL-1 needle group, only 1 patient was with hematoma recurrence, 1 patient was with intracranial pneumocephalus, and the remaining patients who were followed up for 3 months achieved a clinical cure. In the traditional drilling and drainage group, 13 patients were with hematoma recurrence within 3 months after the operation and 7 patients were with postoperative intracranial pneumocephalus. CONCLUSIONS: The method of double YL-1 needle is better than the traditional drilling and drainage method for the treatment of chronic subdural hematoma because it reduces the postoperative recurrence rate and complications.
[Mh] Termos MeSH primário: Hematoma Subdural Crônico/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação
Agulhas
Paracentese/normas
Trepanação/instrumentação
Trepanação/normas
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Drenagem/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Pneumocefalia/etiologia
Complicações Pós-Operatórias/etiologia
Recidiva
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003462


  5 / 12671 MEDLINE  
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[PMID]:29235821
[Au] Autor:Higgins K; Chambers CT
[Ti] Título:Needle fear and insulin self-injection.
[So] Source:Can Nurse;113(2):38, 2017 Mar-Apr.
[Is] ISSN:0008-4581
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Medo
Hipoglicemiantes/administração & dosagem
Insulina/administração & dosagem
Agulhas
[Mh] Termos MeSH secundário: Diabetes Mellitus/tratamento farmacológico
Seres Humanos
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Insulin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:28461268
[Au] Autor:Dillon C; Hughes H; O'Reilly NJ; McLoughlin P
[Ad] Endereço:Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Cork Road, Waterford, Ireland. Electronic address: cdillon@wit.ie.
[Ti] Título:Formulation and characterisation of dissolving microneedles for the transdermal delivery of therapeutic peptides.
[So] Source:Int J Pharm;526(1-2):125-136, 2017 Jun 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The highly effective barrier properties of the stratum corneum (SC) limit the application of transdermal delivery to relatively small, lipophilic molecules. Microneedles (MNs) however, offer a route to effectively deliver a wide range of pharmaceuticals through the skin, bypassing the SC in a non-invasive and pain-free manner. This study presents a dissolving MN system composed of polyvinylpyrrolidone (PVP) and trehalose to encapsulate active pharmaceutical peptides within the MN matrix. Rapid systemic delivery is then achieved once the needles have penetrated the SC and dissolved in the interstitial fluid of the skin. A variety of characterisation techniques were carried out to determine the optimum formulation. A model peptide, polymyxin B, was then incorporated into the MN system and delivered through porcine skin. In addition, the activity of the model drug was monitored during all stages of the formulation process.
[Mh] Termos MeSH primário: Administração Cutânea
Sistemas de Liberação de Medicamentos
Microinjeções
Peptídeos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Química Farmacêutica
Agulhas
Pele
Suínos
Tecnologia Farmacêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29208833
[Au] Autor:Kelkar AS; Fogla R; Kelkar J; Kothari AA; Mehta H; Amoaku W
[Ad] Endereço:Department of Ophthalmology, National Institute of Ophthalmology, Pune, Maharashtra, India.
[Ti] Título:Sutureless 27-gauge needle-assisted transconjunctival intrascleral intraocular lens fixation: Initial experience.
[So] Source:Indian J Ophthalmol;65(12):1450-1453, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of the study was to report our initial experience with the transconjunctival Intrascleral Intraocular Lens (SFIOL) fixation with modified Yamane's double-needle technique and flanged haptics. METHODS: This was a prospective interventional study that enrolled 31 consecutive patients undergoing SFIOL with the modified Yamane's technique. All patients underwent comprehensive evaluation including uncorrected and best-corrected vision, intraocular pressure, ultrasound biomicroscopy, endothelial cell density, and macular thickness using optical coherence tomography (OCT). We excluded patients with visually significant coexistent pathology such as corneal scars, macular pathology, and glaucoma. RESULTS: The mean age of subjects was 57 ± 16.9 years and 23 were men (74%). Surgery was performed for aphakia following complicated cataract surgery in 10 eyes (32%), with lensectomy for subluxated/dislocated cataract in 6 eyes (19%), and with IOL explantation for subluxated/dislocated IOL in 15 eyes (48%). There were no intraoperative complications. Uncorrected visual acuity improved from median of 1.48 logarithm of minimum angle of resolution (logMAR) units (interquartile range [IQR] = 1.3-2 logMAR) at baseline to 0.3 logMAR (IQR = 0.2-0.4 logMAR) at 6 weeks (P < 0.001) which was maintained at 6 months. There were no significant changes in endothelial cell density (P = 0.34) and OCT-based macular thickness (P = 0.31) at 6 months. Two eyes had slight IOL decentration. CONCLUSION: Our initial experience suggests that the Yamane's technique for SFIOL is a simple procedure with a short-learning curve and is independent of scleral flaps, tunnels, sutures, and fibrin glue. Using widely available 27-gauge needle instead of 30-gauge thin wall needle as originally described by Yamane makes it possible for the use of various three-piece IOLs available globally. Further studies are required for widespread acceptance of this technique.
[Mh] Termos MeSH primário: Afacia/cirurgia
Túnica Conjuntiva/cirurgia
Lentes Intraoculares
Agulhas
Esclera/cirurgia
Procedimentos Cirúrgicos sem Sutura/instrumentação
Acuidade Visual
[Mh] Termos MeSH secundário: Afacia/fisiopatologia
Desenho de Equipamento
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_659_17


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[PMID]:29187457
[Au] Autor:Chen MY; Chen YY; Tsai HT; Tzai TS; Chen MC; Tsai YS
[Ad] Endereço:Department of Urology, Madou Sin-Lau Hospital, Sin-Lau Medical Foundation, the Presbyterian Church in Taiwan, Tainan, Taiwan, R.O.C.
[Ti] Título:Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy.
[So] Source:Anticancer Res;37(12):6791-6797, 2017 12.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Long-term administration of luteinizing hormone-releasing hormone analogs (LHRHa) is the main type of androgen-deprivation therapy (ADT) for lethal prostate cancer. A fully insertable microneedle system, composed of embeddable chitosan microneedles and a dissolvable polyvinyl alcohol/polyvinyl pyrrolidone supporting array, was developed for sustained delivery of LHRHa to the skin. A porcine cadaver skin test showed that chitosan microneedles can be fully embedded within the skin and microneedle-created micropores reseal within 7 days. The measured LHRHa loading amount was 73.3±2.8 µg per microneedle patch. After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7. In contrast, serum testosterone levels increased to reach a peak at day 14 and then declined to a castration level at day 21. Additionally, such a castration level was maintained for 2 weeks. Therefore, transdermal delivery of goserelin with embeddable chitosan microneedles can produce a castrated state in mice. Such a system is a promising, feasible means of delivering ADT.
[Mh] Termos MeSH primário: Antagonistas de Androgênios/administração & dosagem
Quitosana/química
Sistemas de Liberação de Medicamentos/métodos
Hormônio Liberador de Gonadotropina/administração & dosagem
Agulhas
[Mh] Termos MeSH secundário: Administração Cutânea
Antagonistas de Androgênios/química
Antagonistas de Androgênios/farmacocinética
Animais
Antineoplásicos Hormonais/administração & dosagem
Antineoplásicos Hormonais/química
Antineoplásicos Hormonais/farmacocinética
Hormônio Liberador de Gonadotropina/química
Hormônio Liberador de Gonadotropina/farmacocinética
Gosserrelina/administração & dosagem
Gosserrelina/química
Gosserrelina/farmacocinética
Seres Humanos
Hormônio Luteinizante/sangue
Masculino
Camundongos Endogâmicos ICR
Pele/metabolismo
Suínos
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgen Antagonists); 0 (Antineoplastic Agents, Hormonal); 0F65R8P09N (Goserelin); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 9002-67-9 (Luteinizing Hormone); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:27778225
[Au] Autor:Khilwani R; Gilgunn PJ; Kozai TD; Ong XC; Korkmaz E; Gunalan PK; Cui XT; Fedder GK; Ozdoganlar OB
[Ad] Endereço:Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.
[Ti] Título:Ultra-miniature ultra-compliant neural probes with dissolvable delivery needles: design, fabrication and characterization.
[So] Source:Biomed Microdevices;18(6):97, 2016 12.
[Is] ISSN:1572-8781
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stable chronic functionality of intracortical probes is of utmost importance toward realizing clinical application of brain-machine interfaces. Sustained immune response from the brain tissue to the neural probes is one of the major challenges that hinder stable chronic functionality. There is a growing body of evidence in the literature that highly compliant neural probes with sub-cellular dimensions may significantly reduce the foreign-body response, thereby enhancing long term stability of intracortical recordings. Since the prevailing commercial probes are considerably larger than neurons and of high stiffness, new approaches are needed for developing miniature probes with high compliance. In this paper, we present design, fabrication, and in vitro evaluation of ultra-miniature (2.7 µm x 10 µm cross section), ultra-compliant (1.4 × 10 µN/µm in the axial direction, and 2.6 × 10 µN/µm and 1.8 × 10 µN/µm in the lateral directions) neural probes and associated probe-encasing biodissolvable delivery needles toward addressing the aforementioned challenges. The high compliance of the probes is obtained by micron-scale cross-section and meandered shape of the parylene-C insulated platinum wiring. Finite-element analysis is performed to compare the strains within the tissue during micromotion when using the ultra-compliant meandered probes with that when using stiff silicon probes. The standard batch microfabrication techniques are used for creating the probes. A dissolvable delivery needle that encases the probe facilitates failure-free insertion and precise placement of the ultra-compliant probes. Upon completion of implantation, the needle gradually dissolves, leaving behind the ultra-compliant neural probe. A spin-casting based micromolding approach is used for the fabrication of the needle. To demonstrate the versatility of the process, needles from different biodissolvable materials, as well as two-dimensional needle arrays with different geometries and dimensions, are fabricated. Further, needles incorporating anti-inflammatory drugs are created to show the co-delivery potential of the needles. An automated insertion device is developed for repeatable and precise implantation of needle-encased probes into brain tissue. Insertion of the needles without mechanical failure, and their subsequent dissolution are demonstrated. It is concluded that ultra-miniature, ultra-compliant probes and associated biodissolvable delivery needles can be successfully fabricated, and the use of the ultra-compliant meandered probes results in drastic reduction in strains imposed in the tissue as compared to stiff probes, thereby showing promise toward chronic applications.
[Mh] Termos MeSH primário: Eletrodos Implantados
Fenômenos Mecânicos
Microtecnologia/instrumentação
Agulhas
[Mh] Termos MeSH secundário: Interfaces Cérebro-Computador
Módulo de Elasticidade
Desenho de Equipamento
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  10 / 12671 MEDLINE  
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[PMID]:28465054
[Au] Autor:Manuyakorn W; Bamrungchaowkasem B; Ruangwattanapaisarn N; Kamchaisatian W; Benjaponpitak S
[Ad] Endereço:Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: wiparatm@gmail.com.
[Ti] Título:Optimal needle length for epinephrine prefilled syringe in children.
[So] Source:Ann Allergy Asthma Immunol;118(6):740-741.e1, 2017 06.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Broncodilatadores/administração & dosagem
Epinefrina/administração & dosagem
Injeções Intramusculares/instrumentação
Agulhas
[Mh] Termos MeSH secundário: Pesos e Medidas Corporais
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Seringas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bronchodilator Agents); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE



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