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[PMID]: 29444068 [Au] Autor: Applegate MB; Roblyer D [Ti] Título: Multi-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning. [So] Source: Opt Lett;43(4):747-750, 2018 Feb 15. [Is] ISSN: 1539-4794 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Frequency-domain diffuse optical spectroscopy (FD-DOS) is an established technique capable of determining optical properties and chromophore concentrations in biological tissue. Most FD-DOS systems use either manually positioned, handheld probes or complex arrays of source and detector fibers to acquire data from many tissue locations, allowing for the generation of 2D or 3D maps of tissue. Here, we present a new method to rapidly acquire a wide range of source-detector (SD) separations by mechanically scanning a single SD pair. The source and detector fibers are mounted on a scan head that traces a hypotrochoidal pattern over the sample that, when coupled with a high-speed FD-DOS system, enables the rapid collection of dozens of SD separations for depth-resolved imaging. We demonstrate that this system has an average error of 4±2.6% in absorption and 2±1.8% in scattering across all SD separations. Additionally, by linearly translating the device, the size and location of an absorbing inhomogeneity can be determined through the generation of B-scan images in a manner conceptually analogous to ultrasound imaging. This work demonstrates the potential of single optode diffuse optical scanning for depth resolved visualization of heterogeneous biological tissues at near real-time rates. [Mh] Termos MeSH primário: Dispositivos Ópticos Análise Espectral/instrumentação [Mh] Termos MeSH secundário: Imagens de Fantasmas [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1364/OL.43.000747

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[PMID]: 29443989 [Au] Autor: Kim SB; Park JH [Ti] Título: Optical see-through Maxwellian near-to-eye display with an enlarged eyebox. [So] Source: Opt Lett;43(4):767-770, 2018 Feb 15. [Is] ISSN: 1539-4794 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We propose a Maxwellian near-to-eye display implemented using a multiplexed holographic optical element. Maxwellian configuration removes the focal cue of the displayed virtual image completely, presenting an always-focused image to the observer regardless of the focal length of the eye. The transparent property of the holographic optical element enables the optical see-through feature, making the proposed near-to-eye display suitable for augmented reality applications. The multiplexing of multiple concave mirrors into a single holographic optical element enlarges the effective eyebox, relaxing the limitation of the conventional Maxwellian displays. Optical experiment confirms that the proposed display can present always-focused images on top of the real environment with 9.2°(H)×5.2°(V) field of view, and 9 mm (H)×3 mm (V) eyebox. [Mh] Termos MeSH primário: Dispositivos Ópticos Retina Realidade Virtual [Mh] Termos MeSH secundário: Imagem Tridimensional Razão Sinal-Ruído [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1364/OL.43.000767

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[PMID]: 29358689 [Au] Autor: Gueye M; Manathunga M; Agathangelou D; Orozco Y; Paolino M; Fusi S; Haacke S; Olivucci M; Léonard J [Ad] Endereço: Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504, F-67034, Strasbourg, France. [Ti] Título: Engineering the vibrational coherence of vision into a synthetic molecular device. [So] Source: Nat Commun;9(1):313, 2018 01 22. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The light-induced double-bond isomerization of the visual pigment rhodopsin operates a molecular-level optomechanical energy transduction, which triggers a crucial protein structure change. In fact, rhodopsin isomerization occurs according to a unique, ultrafast mechanism that preserves mode-specific vibrational coherence all the way from the reactant excited state to the primary photoproduct ground state. The engineering of such an energy-funnelling function in synthetic compounds would pave the way towards biomimetic molecular machines capable of achieving optimum light-to-mechanical energy conversion. Here we use resonance and off-resonance vibrational coherence spectroscopy to demonstrate that a rhodopsin-like isomerization operates in a biomimetic molecular switch in solution. Furthermore, by using quantum chemical simulations, we show why the observed coherent nuclear motion critically depends on minor chemical modifications capable to induce specific geometric and electronic effects. This finding provides a strategy for engineering vibrationally coherent motions in other synthetic systems. [Mh] Termos MeSH primário: Materiais Biomiméticos/química Indanos/química Dispositivos Ópticos Pirróis/química Retinaldeído/química Rodopsina/química [Mh] Termos MeSH secundário: Alquilação Animais Materiais Biomiméticos/síntese química Engenharia Química Seres Humanos Indanos/síntese química Luz Processos Fotoquímicos Pirróis/síntese química Teoria Quântica Análise Espectral/instrumentação Análise Espectral/métodos Vibração Visão Ocular/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 0 (Indans); 0 (Pyrroles); 9009-81-8 (Rhodopsin); RR725D715M (Retinaldehyde) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180124 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02668-w

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[PMID]: 29235309 [Au] Autor: Farah CS [Ti] Título: Focus On: Oral Cancer Screening Devices. [So] Source: Dent Today;36(4):16, 2017 Apr. [Is] ISSN: 8750-2186 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Programas de Rastreamento/métodos Neoplasias Bucais/diagnóstico Dispositivos Ópticos [Mh] Termos MeSH secundário: Diagnóstico Diferencial Detecção Precoce de Câncer Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180115 [Lr] Data última revisão: 180115 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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[PMID]: 28464464 [Au] Autor: Qi J; Elson DS [Ad] Endereço: Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation, Imperial College London, Exhibition Road, London, SW7 2AZ, UK. [Ti] Título: Mueller polarimetric imaging for surgical and diagnostic applications: a review. [So] Source: J Biophotonics;10(8):950-982, 2017 Aug. [Is] ISSN: 1864-0648 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities. This review introduces the basis of the Stokes-Mueller formulism, interpretation methods of Mueller matrices into fundamental polarization properties, polarization properties of biological tissues, and considerations in the construction of Mueller polarimetric imaging devices for surgical and diagnostic applications, including primary configurations, optimization procedures, calibration methods as well as the instrument polarization properties of several widely-used biomedical optical devices. The paper also reviews recent progress in Mueller polarimetric endoscopes and fibre Mueller polarimeters, followed by the future outlook in applying the technique to surgery and diagnostics. Tissue polarization properties convey morphological, micro-structural and compositional information of tissue with great potential for label free characterization of tissue pathological changes. Recent progress in tissue polarimetric imaging and polarization resolved endoscopy paved the way for translation of polarimetric imaging to surgery and tissue diagnosis. [Mh] Termos MeSH primário: Imagem Óptica Análise Espectral/métodos [Mh] Termos MeSH secundário: Endoscópios Seres Humanos Luz Dispositivos Ópticos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180111 [Lr] Data última revisão: 180111 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1002/jbio.201600152

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[PMID]: 28464210 [Au] Autor: Odeleye AOO; Castillo-Avila S; Boon M; Martin H; Coopman K [Ad] Endereço: Centre for Biological Engineering, Loughborough University, Loughborough LE11 3TU, United Kingdom. [Ti] Título: Development of an optical system for the non-invasive tracking of stem cell growth on microcarriers. [So] Source: Biotechnol Bioeng;114(9):2032-2042, 2017 09. [Is] ISSN: 1097-0290 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The emergence of medicinal indications for stem cell therapies has seen a need to develop the manufacturing capacity for adherent cells such as mesenchymal stem cells (MSCs). One such development is in the use of microcarriers, which facilitate enhanced cell densities for adherent stem cell cultures when compared with 2D culture platforms. Given the variety of stem cell expansion systems commercially available, novel methods of non-invasive and automated monitoring of cell number, confluence, and aggregation, within disparate environments, will become imperative to process control, ensuring reliable and consistent performance. The in situ epi-illumination of mouse embryonic fibroblasts and human mesenchymal stem cells attached to Cytodex 1 and 3 microcarriers was achieved using a bespoke microscope. Robust image processing techniques were developed to provide quantitative measurements of confluence, aggregate recognition, and cell number, without the need for fluorescent labeling or cell detachment. Large datasets of cells counted on individual microcarriers were statistically analyzed and compared with NucleoCounter measurements, with an average difference of less than 7% observed from days 0 to 6 of a 12-day culture noted, prior to the onset of aggregation. The developed image acquisition system and post-processing methodologies were successfully applied to dynamically moving colonized microcarriers. The proposed system offers a novel method of cell identification at the individual level, to consistently and accurately assess viable cell number, confluence, and cell distribution, while also minimizing the variability inherent in the current invasive means by which cells adhered to microcarriers are analyzed. Biotechnol. Bioeng. 2017;114: 2032-2042. © 2017 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc. [Mh] Termos MeSH primário: Rastreamento de Células/instrumentação Aumento da Imagem/instrumentação Transplante de Células-Tronco Mesenquimais/instrumentação Células Mesenquimais Estromais/citologia Células Mesenquimais Estromais/fisiologia Microscopia/instrumentação Dispositivos Ópticos [Mh] Termos MeSH secundário: Crescimento Celular Células Cultivadas Seres Humanos Aumento da Imagem/métodos Miniaturização Reconhecimento Automatizado de Padrão/métodos Reprodutibilidade dos Testes Sensibilidade e Especificidade [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1002/bit.26328

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[PMID]: 28465085 [Au] Autor: Narikiyo H; Kakuta T; Matsuyama H; Gon M; Tanaka K; Chujo Y [Ad] Endereço: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. [Ti] Título: Development of the optical sensor for discriminating isomers of fatty acids based on emissive network polymers composed of polyhedral oligomeric silsesquioxane. [So] Source: Bioorg Med Chem;25(13):3431-3436, 2017 07 01. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: It was shown that water-soluble network polymers composed of polyhedral oligomeric silsesquioxane (POSS) had hydrophobic spaces inside the network because of strong hydrophobicity of the cubic silica cage. In this study, the water-soluble POSS network polymers connected with triphenylamine derivatives (TPA-POSS) were synthesized, and their functions as a sensor for discriminating the geometric isomers of fatty acids were investigated. Accordingly, in the photoluminescence spectra, different time-courses of intensity and peak wavelengths of the emission bands were detected from the TPA-POSS-containing solution in the presence of cis- or trans-fatty acids during incubation. Furthermore, variable time-dependent changes were obtained by changing coexisting ratios between two geometric isomers. From the mechanistic investigation, it was implied that these changes could be originated from the difference in the degree of interaction between the POSS networks and each fatty acid. Our data could be applicable for constructing a sensing material for generation and proportion of trans-fatty acids in the oil. [Mh] Termos MeSH primário: Ácidos Graxos/química Compostos de Organossilício/química Polímeros/química [Mh] Termos MeSH secundário: Medições Luminescentes Estrutura Molecular Dispositivos Ópticos Solubilidade Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Fatty Acids); 0 (Organosilicon Compounds); 0 (Polymers) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171208 [Lr] Data última revisão: 171208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE

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[PMID]: 28869632 [Au] Autor: Slomka KJ; Sobota G; Skowronek T; Rzepko M; Czarny W; Juras G [Ad] Endereço: The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland. [Ti] Título: Evaluation of reliability and concurrent validity of two optoelectric systems used for recording maximum vertical jumping performance versus the gold standard. [So] Source: Acta Bioeng Biomech;19(2):141-147, 2017. [Is] ISSN: 1509-409X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: PURPOSE: The objective of this study was to evaluate the reliability and validity of two alternative systems used for jumping performance measurement. METHODS: Two groups of subjects were tested. The first group consisted of 15 male adults (21.3 ± 1.7 years) and the second group consisted of 16 female volleyball players (17.2 ± 0.9 years). We used three different systems of data collection in the study. Two of the used systems are based on optoelectric components. The Optojump Next system is referred to as the optoelectric system, and BTS Smart-E is refered to as the video system. Concurrent validity of these systems was verified with the use of "gold standard" which is force platform. All systems were used to estimate the height of vertical jumps. RESULTS: Both optoelectric systems turned out to be highly reliable with the ICCs = 0.98 for Optojump and 0.9 for BTS Smart. Their concurrent validity with the force platform data was also very high r = 0.99 and r = 0.97, respectively. CONCLUSIONS: Comparison of these two systems shows distinct differences between them. Out of the two systems, Optojump system is more suitable for quick and reliable sports testing while when BTS-Smart is better for research and clinical testing. [Mh] Termos MeSH primário: Manometria/instrumentação Monitorização Ambulatorial/instrumentação Movimento/fisiologia Dispositivos Ópticos Esforço Físico/fisiologia [Mh] Termos MeSH secundário: Adolescente Desenho de Equipamento Análise de Falha de Equipamento Feminino Seres Humanos Masculino Monitorização Ambulatorial/métodos Reprodutibilidade dos Testes Sensibilidade e Especificidade [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170905 [St] Status: MEDLINE

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[PMID]: 28727615 [Au] Autor: Peli E; Jung JH [Ad] Endereço: Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. [Ti] Título: Multiplexing Prisms for Field Expansion. [So] Source: Optom Vis Sci;94(8):817-829, 2017 Aug. [Is] ISSN: 1538-9235 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: Prisms used for field expansion are limited by the optical scotoma at a prism apex (apical scotoma). For a patient with two functioning eyes, fitting prisms unilaterally allows the other eye to compensate for the apical scotoma. A monocular patient's field loss cannot be expanded with a conventional or Fresnel prism because of the apical scotoma. A newly invented optical device, the multiplexing prism (MxP), was developed to overcome the apical scotoma limitation in monocular field expansion. METHODS: A Fresnel-prism-like device with alternating prism and flat elements superimposes shifted and see-through views, thus creating the (monocular) visual confusion required for field expansion and eliminating the apical scotoma. Several implementations are demonstrated and preliminarily evaluated for different monocular conditions with visual field loss. The field expansion of the MxP is compared with the effect of conventional prisms using calculated and measured perimetry. RESULTS: Field expansion without apical scotomas is shown to be effective for monocular patients with hemianopia or constricted peripheral field. The MxPs are shown to increase the nasal field for a patient with only one eye and for patients with bitemporal hemianopia. The MxPs placed at the far temporal field are shown to expand the normal visual field. The ability to control the contrast ratio between the two images is verified. CONCLUSIONS: A novel optical device is demonstrated to have the potential for field expansion technology in a variety of conditions. The devices may be inexpensive and can be constructed in a cosmetically acceptable format. [Mh] Termos MeSH primário: Hemianopsia/reabilitação Dispositivos Ópticos Visão Binocular/fisiologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adulto Feminino Hemianopsia/fisiopatologia Seres Humanos Masculino Meia-Idade Visão Monocular/fisiologia Testes de Campo Visual [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170913 [Lr] Data última revisão: 170913 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.1097/OPX.0000000000001102

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[PMID]: 28582472 [Au] Autor: Baratto L; Park SY; Hatami N; Davidzon G; Srinivas S; Gambhir SS; Iagaru A [Ad] Endereço: Division of Nuclear Medicine and Molecular Imaging, Stanford University Medical Center, Stanford, California, United States of America. [Ti] Título: 18F-FDG silicon photomultiplier PET/CT: A pilot study comparing semi-quantitative measurements with standard PET/CT. [So] Source: PLoS One;12(6):e0178936, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate if the new Discovery Molecular Insights (DMI) PET/CT scanner provides equivalent results compared to the standard of care PET/CT scanners (GE Discovery 600 or GE Discovery 690) used in our clinic and to explore any possible differences in semi-quantitative measurements. METHODS: The local Institutional Review Board approved the protocol and written informed consent was obtained from each patient. Between September and November 2016, 50 patients underwent a single 18F-FDG injection and two scans: the clinical standard PET/CT followed immediately by the DMI PET/CT scan. We measured SUVmax and SUVmean of different background organs and up to four lesions per patient from data acquired using both scanners. RESULTS: DMI PET/CT identified all the 107 lesions detected by standard PET/CT scanners, as well as additional 37 areas of focal increased 18F-FDG uptake. The SUVmax values for all 107 lesions ranged 1.2 to 14.6 (mean ± SD: 2.8 ± 2.8), higher on DMI PET/CT compared with standard of care PET/CT. The mean lesion:aortic arch SUVmax ratio and mean lesion:liver SUVmax ratio were 0.2-15.2 (mean ± SD: 3.2 ± 2.6) and 0.2-8.5 (mean ± SD: 1.9 ± 1.4) respectively, higher on DMI PET/CT than standard PET/CT. These differences were statistically significant (P value < 0.0001) and not correlated to the delay in acquisition of DMI PET data (P < 0.0001). CONCLUSIONS: Our study shows high performance of the new DMI PET/CT scanner. This may have a significant role in diagnosing and staging disease, as well as for assessing and monitoring responses to therapies. [Mh] Termos MeSH primário: Fluordesoxiglucose F18/farmacocinética Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/instrumentação Compostos Radiofarmacêuticos/farmacocinética [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Aorta/diagnóstico por imagem Aorta/patologia Feminino Seres Humanos Neoplasias Renais/diagnóstico por imagem Neoplasias Renais/patologia Masculino Meia-Idade Dispositivos Ópticos Projetos Piloto Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos Sarcoidose/diagnóstico por imagem Sarcoidose/patologia Silício Neoplasias Tonsilares/diagnóstico por imagem Neoplasias Tonsilares/patologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); Z4152N8IUI (Silicon) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170919 [Lr] Data última revisão: 170919 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170606 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0178936

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