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  1 / 3674 MEDLINE  
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[PMID]:28742054
[Au] Autor:Camattari R
[Ad] Endereço:Department of Physics and Earth Sciences, University of Ferrara, Via Saragat 1/c, 44122 Ferrara and INFN section of Ferrara, Italy.
[Ti] Título:Laue lens for radiotherapy applications through a focused hard x-ray beam: a feasibility study on requirements and tolerances.
[So] Source:Phys Med Biol;62(18):7249-7266, 2017 Aug 21.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Focusing a hard x-ray beam would represent an innovative technique for tumour treatment, since such a beam may deliver a dose to a tumour located at a given depth under the skin, sparing the surrounding healthy cells. A detailed study of a focusing system for hard x-ray aimed at radiotherapy is presented here. Such a focusing system, named Laue lens, exploits x-ray diffraction and consists of a series of crystals disposed as concentric rings capable of concentrating a flux of x-rays towards a focusing point. A feasibility study regarding the positioning tolerances of the crystalline optical elements has been carried out. It is shown that a Laue lens can effectively be used in the context of radiotherapy for tumour treatments provided that the mounting errors are below certain values, which are reachable in the modern micromechanics. An extended survey based on an analytical approach and on simulations is presented for precisely estimating all the contributions of each mounting error, analysing their effect on the focal spot of the Laue lens. Finally, a simulation for evaluating the released dose in a water phantom is shown.
[Mh] Termos MeSH primário: Lentes
Radioterapia/efeitos adversos
Radioterapia/instrumentação
[Mh] Termos MeSH secundário: Estudos de Viabilidade
Seres Humanos
Neoplasias/radioterapia
Imagens de Fantasmas
Dosagem Radioterapêutica
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa81fa


  2 / 3674 MEDLINE  
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[PMID]:29401957
[Au] Autor:Bo E; Ge X; Wang L; Wu X; Luo Y; Chen S; Chen S; Liang H; Ni G; Yu X; Liu L
[Ti] Título:Multiple aperture synthetic optical coherence tomography for biological tissue imaging.
[So] Source:Opt Express;26(2):772-780, 2018 Jan 22.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension.
[Mh] Termos MeSH primário: Adipócitos
Lentes
Iluminação/métodos
Tomografia de Coerência Óptica/métodos
Vitis
[Mh] Termos MeSH secundário: Adipócitos/ultraestrutura
Algoritmos
Animais
Estudos de Viabilidade
Ratos
Vitis/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1364/OE.26.000772


  3 / 3674 MEDLINE  
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[PMID]:29245882
[Au] Autor:Chang M; Oh J; Kim Y; Hohng S; Lee JB
[Ti] Título:Extended depth of field for single biomolecule optical imaging-force spectroscopy.
[So] Source:Opt Express;25(25):32189-32197, 2017 Dec 11.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Real-time optical imaging combined with single-molecule manipulation broadens the horizons for acquiring information about the spatiotemporal localization and the mechanical details of target molecules. To obtain an optical signal outside the focal plane without unintended interruption of the force signal in single-molecule optical imaging-force spectroscopy, we developed an optical method to extend the depth of field in a high numerical aperture objective (≥ 1.2), required to visualize a single fluorophore. By axial scanning, using an electrically tunable lens with a fixed sample, we were successfully able to visualize the epidermal growth factor receptor (EGFR) moving along the three-dimensionally elongated filamentous actin bundles connecting cells (intercellular nanotube), while another EGFR on the intercellular nanotube was trapped by optical tweezers in living cells. Our approach is simple, fast and inexpensive, but it is powerful for imaging target molecules axially in single-molecule optical imaging-force spectroscopy.
[Mh] Termos MeSH primário: Citoesqueleto de Actina/química
Lentes
Microscopia Confocal/métodos
Microscopia de Fluorescência/métodos
Imagem Óptica/métodos
Pinças Ópticas
Receptor do Fator de Crescimento Epidérmico/análise
Análise Espectral/métodos
[Mh] Termos MeSH secundário: Células HeLa
Seres Humanos
Microscopia de Fluorescência/instrumentação
Nanotubos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1364/OE.25.032189


  4 / 3674 MEDLINE  
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[PMID]:29245841
[Au] Autor:Fitzgerald NM; Dainty C; Goncharov AV
[Ti] Título:Extending the depth of field with chromatic aberration for dual-wavelength iris imaging.
[So] Source:Opt Express;25(25):31696-31707, 2017 Dec 11.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We propose a method of extending the depth of field to twice that achievable by conventional lenses for the purpose of a low cost iris recognition front-facing camera in mobile phones. By introducing intrinsic primary chromatic aberration in the lens, the depth of field is doubled by means of dual wavelength illumination. The lens parameters (radius of curvature, optical power) can be found analytically by using paraxial raytracing. The effective range of distances covered increases with dispersion of the glass chosen and with larger distance for the near object point.
[Mh] Termos MeSH primário: Identificação Biométrica/métodos
Telefone Celular
Iris
Lentes
[Mh] Termos MeSH secundário: Identificação Biométrica/instrumentação
Desenho de Equipamento
Seres Humanos
Imagem Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1364/OE.25.031696


  5 / 3674 MEDLINE  
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[PMID]:28463225
[Au] Autor:Shahini A; Jin H; Zhou Z; Zhao Y; Chen PY; Hua J; Cheng MM
[Ad] Endereço:Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, United States of America.
[Ti] Título:Toward individually tunable compound eyes with transparent graphene electrode.
[So] Source:Bioinspir Biomim;12(4):046002, 2017 06 08.
[Is] ISSN:1748-3190
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present tunable compound eyes made of ionic liquid lenses, of which both curvatures (R and R in the lensmaker's equation) can be individually changed using electrowetting on dielectric (EWOD) and applied pressure. Flexible graphene is used as a transparent electrode and is integrated on a flexible polydimethylsiloxane (PDMS)/parylene hybrid substrate. Graphene electrodes allow a large lens aperture diameter of between 2.4 mm and 2.74 mm. Spherical aberration analysis is performed using COMSOL to investigate the optical property of the lens under applied voltage and pressure. The final lens system shows a resolution of 645.1 line pair per millimeter. A prototype of a tunable lens array is proposed for the application of a compound eye.
[Mh] Termos MeSH primário: Materiais Biomiméticos
Olho Composto de Artrópodes
Eletrodos
Grafite
Lentes
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
7782-42-5 (Graphite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1088/1748-3190/aa7084


  6 / 3674 MEDLINE  
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[PMID]:28973013
[Au] Autor:Giannini JP; York AG; Shroff H
[Ad] Endereço:Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:Anticipating, measuring, and minimizing MEMS mirror scan error to improve laser scanning microscopy's speed and accuracy.
[So] Source:PLoS One;12(10):e0185849, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We describe a method to speed up microelectromechanical system (MEMS) mirror scanning by > 20x, while also improving scan accuracy. We use Landweber deconvolution to determine an input voltage which would produce a desired output, based on the measured MEMS impulse response. Since the MEMS is weakly nonlinear, the observed behavior deviates from expectations, and we iteratively improve our input to minimize this deviation. This allows customizable MEMS angle vs. time with <1% deviation from the desired scan pattern. We demonstrate our technique by optimizing a point scanning microscope's raster patterns to image mammal submandibular gland and pollen at ~10 frames/s.
[Mh] Termos MeSH primário: Desenho de Equipamento
Sistemas Microeletromecânicos/métodos
Microscopia Confocal/métodos
[Mh] Termos MeSH secundário: Lentes
Pólen
Glândula Submandibular/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185849


  7 / 3674 MEDLINE  
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[PMID]:28798115
[Au] Autor:Madl T
[Ad] Endereço:Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria. tobias.madl@medunigraz.at.
[Ti] Título:Patchy proteins form a perfect lens.
[So] Source:Science;357(6351):546-547, 2017 08 11.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cristalino
Lentes
[Mh] Termos MeSH secundário: Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
0 (Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao1456


  8 / 3674 MEDLINE  
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[PMID]:28650971
[Au] Autor:Fuh YK; Lai ZH; Kau LH; Huang HJ
[Ad] Endereço:Institute of Opto-mechatronics Engineering, National Central University, Jhongli City, Taoyuan County, Taiwan.
[Ti] Título:A lab-on-phone instrument with varifocal microscope via a liquid-actuated aspheric lens (LAL).
[So] Source:PLoS One;12(6):e0179389, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, we introduce a novel concept of liquid-actuated aspheric lens (LAL) with a built-in aspheric polydimethylsiloxane lens (APL) to enable the design of compact optical systems with varifocal microscopic imaging. The varifocal lens module consists of a sandwiched structures such as 3d printed syringe pump functionally serves as liquid controller. Other key components include two acrylic cylinders, a rigid separator, a APL/membrane composite (APLMC) embedded PDMS membrane. In functional operation, the fluidic controller was driven to control the pressure difference and ALPMC deformation. The focal length can be changed through the pressure difference. This is achieved by the adjustment of volume change of injected liquid such that a widely tunable focal length. The proposed LAL can transform to 3 modes: microscopic mode (APLMC only), convex-concave mode and biconcave mode. It is noticeable that LAL in the operation of microscopic mode is tunable in focus via the actuation of APLMC (focal length is from 4.3 to 2.3 mm and magnification 50X) and can rival the images quality of commercial microscopes. A new lab-on-phone device is economically feasible and functionally versatile to offer a great potential in the point of care applications.
[Mh] Termos MeSH primário: Desenho de Equipamento
Lentes
Microscopia/instrumentação
Sistemas Automatizados de Assistência Junto ao Leito
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179389


  9 / 3674 MEDLINE  
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[PMID]:28628128
[Au] Autor:Zheng W; Wu Y; Winter P; Fischer R; Nogare DD; Hong A; McCormick C; Christensen R; Dempsey WP; Arnold DB; Zimmerberg J; Chitnis A; Sellers J; Waterman C; Shroff H
[Ad] Endereço:Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
[Ti] Título:Adaptive optics improves multiphoton super-resolution imaging.
[So] Source:Nat Methods;14(9):869-872, 2017 Sep.
[Is] ISSN:1548-7105
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We improve multiphoton structured illumination microscopy using a nonlinear guide star to determine optical aberrations and a deformable mirror to correct them. We demonstrate our method on bead phantoms, cells in collagen gels, nematode larvae and embryos, Drosophila brain, and zebrafish embryos. Peak intensity is increased (up to 40-fold) and resolution recovered (up to 176 ± 10 nm laterally, 729 ± 39 nm axially) at depths ∼250 µm from the coverslip surface.
[Mh] Termos MeSH primário: Aumento da Imagem/instrumentação
Aumento da Imagem/métodos
Lentes
Microscopia de Fluorescência por Excitação Multifotônica/instrumentação
Microscopia de Fluorescência por Excitação Multifotônica/métodos
[Mh] Termos MeSH secundário: Desenho de Equipamento
Análise de Falha de Equipamento
Retroalimentação
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1038/nmeth.4337


  10 / 3674 MEDLINE  
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[PMID]:28510776
[Au] Autor:Kemp PS; Chang YH; Melvin P; Dagi LR
[Ti] Título:Patient Characteristics and Surgical Approach Impacting Simultaneous to Alternate Prism Cover Test Disparity After Exotropia Surgery: A Quantitative Look at the Difference in Motor Outcomes.
[So] Source:J Pediatr Ophthalmol Strabismus;54(4):222-230, 2017 Jul 01.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the relationship between simultaneous prism and cover test (SPCT) and alternate prism and cover test (APCT) outcomes after exotropia surgery, and to identify characteristics associated with significant disparity between them. METHODS: Review of sensorimotor outcomes 2 to 6 months after exotropia surgery identified patients with alignment documented by both SPCT and APCT at the same examination. Two hundred seventy-four and 319 patients had both measurements recorded at distance and near, respectively. Correlation between the SPCT and APCT and range of APCT when the SPCT measurement was zero were determined. Patient characteristics studied for association with a difference between the SPCT and APCT exceeding known APCT test-retest variability included age, visual acuity, fusion, intermittency, pattern, preoperative and postoperative angle, and treatment with or without medial rectus resection. RESULTS: SPCT and APCT outcomes were strongly correlated (P < .001), significantly different (P < .001), and linearly related. The percentage of patients who were orthotropic (SPCT = 0) was 76% at distance and 80% at near. Misalignment of 10 prism diopters (PD) or less by the APCT was present in 92% of orthotropic patients at distance and 84% at near. Surgery without medial rectus resection (P = .015), larger preoperative angle (P = .003), intermittent exotropia (P = .028), and postoperative exotropia rather than esotropia (P < .001) were associated with a significant SPCT-APCT difference. CONCLUSIONS: Although a greater postoperative SPCT-APCT disparity was confirmed for patients with intermittent exotropia, it also independently associated with a larger preoperative deviation and surgery without medial rectus resection. Performing medial rectus resection, a surgeon's prerogative, provides more apparently consistent postoperative alignment characterized by less SPCT-APCT disparity. [J Pediatr Ophthalmol Strabismus. 2017;54(4):222-230.].
[Mh] Termos MeSH primário: Exotropia/cirurgia
Movimentos Oculares/fisiologia
Lentes
Procedimentos Cirúrgicos Oftalmológicos/métodos
Testes Visuais/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Exotropia/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Lactente
Masculino
Meia-Idade
Período Pós-Operatório
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20170320-03



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