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[PMID]:28744551
[Au] Autor:Halupka KJ; Abbott CJ; Wong YT; Cloherty SL; Grayden DB; Burkitt AN; Sergeev EN; Luu CD; Brandli A; Allen PJ; Meffin H; Shivdasani MN
[Ad] Endereço:NeuroEngineering Laboratory, Department of Biomedical Engineering, The University of Melbourne, Victoria, Australia 2Data61, Commonwealth Scientific and Industrial Research Organisation (CSIRO), New South Wales, Australia 3Bionics Institute, East Melbourne, Victoria, Australia.
[Ti] Título:Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3770-3784, 2017 07 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolution of retinal prostheses. However, the effects of simultaneous stimulation on degenerate retinae remain unknown. Therefore, we investigated the characteristics of cortical responses to multielectrode stimulation of the degenerate retina. Methods: Four adult cats were bilaterally implanted with retinal electrode arrays in the suprachoroidal space after unilateral adenosine triphosphate (ATP)-induced retinal photoreceptor degeneration. Functional and structural changes were characterized by using electroretinogram a-wave amplitude and optical coherence tomography. Multiunit activity was recorded from both hemispheres of the visual cortex. Responses to single- and multielectrode stimulation of the ATP-injected and fellow control eyes were characterized and compared. Results: The retinae of ATP-injected eyes displayed structural and functional changes consistent with mid- to late-stage photoreceptor degeneration and remodeling. Responses to multielectrode stimulation of the ATP-injected eyes exhibited shortened latencies, lower saturated spike counts, and higher thresholds, compared to stimulation of the fellow control eyes. Electrical receptive field sizes were significantly larger in the ATP-injected eye than in the control eye, and positively correlated with the extent of degeneration. Conclusions: Significant differences exist between cortical responses to stimulation of healthy and degenerate retinae. Our results highlight the importance of using a retinal degeneration model when evaluating the efficacy of novel stimulation paradigms.
[Mh] Termos MeSH primário: Estimulação Elétrica/métodos
Potenciais Evocados Visuais/fisiologia
Células Fotorreceptoras de Vertebrados/fisiologia
Degeneração Retiniana/fisiopatologia
Córtex Visual/fisiologia
Próteses Visuais
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/toxicidade
Animais
Gatos
Modelos Animais de Doenças
Eletrodos Implantados
Eletrorretinografia
Estimulação Luminosa
Degeneração Retiniana/induzido quimicamente
Degeneração Retiniana/diagnóstico
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21290


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[PMID]:28793152
[Au] Autor:Shivdasani MN; Sinclair NC; Gillespie LN; Petoe MA; Titchener SA; Fallon JB; Perera T; Pardinas-Diaz D; Barnes NM; Blamey PJ; Bionic Vision Australia Consortium
[Ad] Endereço:Bionics Institute, East Melbourne, Victoria, Australia.
[Ti] Título:Identification of Characters and Localization of Images Using Direct Multiple-Electrode Stimulation With a Suprachoroidal Retinal Prosthesis.
[So] Source:Invest Ophthalmol Vis Sci;58(10):3962-3974, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Retinal prostheses provide vision to blind patients by eliciting phosphenes through electrical stimulation. This study explored whether character identification and image localization could be achieved through direct multiple-electrode stimulation with a suprachoroidal retinal prosthesis. Methods: Two of three retinitis pigmentosa patients implanted with a suprachoroidal electrode array were tested on three psychophysical tasks. Electrode patterns were stimulated to elicit perception of simple characters, following which percept localization was tested using either static or dynamic images. Eye tracking was used to assess the association between accuracy and eye movements. Results: In the character identification task, accuracy ranged from 2.7% to 93.3%, depending on the patient and character. In the static image localization task, accuracy decreased from near perfect to <20% with decreasing contrast (patient 1). Patient 2 scored up to 70% at 100% contrast. In the dynamic image localization task, patient 1 recognized the trajectory of the image up to speeds of 64 deg/s, whereas patient 2 scored just above chance. The degree of eye movement in both patients was related to accuracy and, to some extent, stimulus direction. Conclusions: The ability to identify characters and localize percepts demonstrates the capacity of the suprachoroidal device to provide meaningful information to blind patients. The variation in scores across all tasks highlights the importance of using spatial cues from phosphenes, which becomes more difficult at low contrast. The use of spatial information from multiple electrodes and eye-movement compensation is expected to improve performance outcomes during real-world prosthesis use in a camera-based system. (ClinicalTrials.gov number, NCT01603576.).
[Mh] Termos MeSH primário: Estimulação Elétrica/métodos
Eletrodos Implantados
Reconhecimento Visual de Modelos/fisiologia
Retina/fisiopatologia
Retinite Pigmentosa/cirurgia
Próteses Visuais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Psicofísica
Retinite Pigmentosa/fisiopatologia
Movimentos Sacádicos/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21311


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[PMID]:28660276
[Au] Autor:Petoe MA; McCarthy CD; Shivdasani MN; Sinclair NC; Scott AF; Ayton LN; Barnes NM; Guymer RH; Allen PJ; Blamey PJ; Bionic Vision Australia Consortium
[Ad] Endereço:Bionics Institute of Australia, East Melbourne, Victoria, Australia 2Department of Medical Bionics, University of Melbourne, Parkville, Victoria, Australia.
[Ti] Título:Determining the Contribution of Retinotopic Discrimination to Localization Performance With a Suprachoroidal Retinal Prosthesis.
[So] Source:Invest Ophthalmol Vis Sci;58(7):3231-3239, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: With a retinal prosthesis connected to a head-mounted camera, subjects can perform low vision tasks using a combination of electrode discrimination and head-directed localization. The objective of the present study was to investigate the contribution of retinotopic electrode discrimination (perception corresponding to the arrangement of the implanted electrodes with respect to their position beneath the retina) to visual performance for three recipients of a 24-channel suprachoroidal retinal implant. Proficiency in retinotopic discrimination may allow good performance with smaller head movements, and identification of this ability would be useful for targeted rehabilitation. Methods: Three participants with retinitis pigmentosa performed localization and grating acuity assessments using a suprachoroidal retinal prosthesis. We compared retinotopic and nonretinotopic electrode mapping and hypothesized that participants with measurable acuity in a normal retinotopic condition would be negatively impacted by the nonretinotopic condition. We also expected that participants without measurable acuity would preferentially use head movement over retinotopic information. Results: Only one participant was able to complete the grating acuity task. In the localization task, this participant exhibited significantly greater head movements and significantly lower localization scores when using the nonretinotopic electrode mapping. There was no significant difference in localization performance or head movement for the remaining two subjects when comparing retinotopic to nonretinotopic electrode mapping. Conclusions: Successful discrimination of retinotopic information is possible with a suprachoroidal retinal prosthesis. Head movement behavior during a localization task can be modified using a nonretinotopic mapping. Behavioral comparisons using retinotopic and nonretinotopic electrode mapping may be able to highlight deficiencies in retinotopic discrimination, with a view to address these deficiencies in a rehabilitation environment. (ClinicalTrials.gov number, NCT01603576).
[Mh] Termos MeSH primário: Cegueira/reabilitação
Eletrodos Implantados
Retinite Pigmentosa/complicações
Próteses Visuais
[Mh] Termos MeSH secundário: Cegueira/fisiopatologia
Potenciais Evocados Visuais/fisiologia
Feminino
Movimentos da Cabeça
Seres Humanos
Masculino
Meia-Idade
Retinite Pigmentosa/fisiopatologia
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21041


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[PMID]:28320674
[Au] Autor:Gao M; Yu Y; Zhao H; Li G; Jiang H; Wang C; Cai F; Chan LL; Chiu B; Qian W; Qiu W; Zheng H
[Ti] Título:Simulation Study of an Ultrasound Retinal Prosthesis With a Novel Contact-Lens Array for Noninvasive Retinal Stimulation.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(9):1605-1611, 2017 Sep.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Millions of people around the world suffer from varying degrees of vision loss (including complete blindness) because of retinal degenerative diseases. Artificial retinal prosthesis, which is usually based on electrical neurostimulation, is the most advanced technology for different types of retinal degeneration. However, this technology involves placing a device into the eyeball, and such a highly invasive procedure is inevitably highly risk and expensive. Ultrasound has been demonstrated to be a promising technology for noninvasive neurostimulation, making it possible to stimulate the retina and induce action potentials similar to those elicited by light stimulation. However, the technology of ultrasound retinal stimulation still requires considerable developments before it could be applied clinically. This paper proposes a novel contact-lens array transducer for use in an ultrasound retinal prosthesis (USRP). The transducer was designed in the shape of a contact lens so as to facilitate acoustic coupling with the eye liquid. The key parameters of the ultrasound transducer were simulated, and results are presented that indicate the achievement of 2-D pattern generation and that the proposed contact-lens array is suitable for multiple-focus neurostimulation, and can be used in a USRP.
[Mh] Termos MeSH primário: Lentes de Contato
Terapia por Estimulação Elétrica/instrumentação
Neuroestimuladores Implantáveis
Retina/fisiologia
Transdutores
Terapia por Ultrassom/instrumentação
Próteses Visuais
[Mh] Termos MeSH secundário: Simulação por Computador
Projeto Auxiliado por Computador
Terapia por Estimulação Elétrica/métodos
Desenho de Equipamento
Análise de Falha de Equipamento
Seres Humanos
Modelos Teóricos
Dose de Radiação
Reprodutibilidade dos Testes
Retina/efeitos da radiação
Espalhamento de Radiação
Sensibilidade e Especificidade
Terapia por Ultrassom/métodos
Ondas Ultrassônicas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2017.2682923


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[PMID]:28135031
[Au] Autor:FitzGibbon T
[Ad] Endereço:Physiology Department, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
[Ti] Título:Retinal prosthesis that incorporates the organization of the nerve fibre layer.
[So] Source:Clin Exp Ophthalmol;45(4):401-408, 2017 May.
[Is] ISSN:1442-9071
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Recent efforts to restore partial vision in blind patients have made significant progress. Currently, prosthetic design concentrates on stimulating as many foveal retinal ganglion cells as possible but is hampered by stimulation of the nerve fibre layer. This results in a nonvisuotopic arrangement of phosphenes (stimulation percepts). This article suggests that by extending the stimulation area well beyond the fovea and stimulating the nerve fibre layer, axons from any remaining ganglion cells in more peripheral regions of the retina (low acuity) can be used to generate a visuotopic map. Stimulation of the fibre layer will generate a large number of stimulation percepts; however, it is unlikely that these will have sufficient topographic order to be immediately useful to the patient. Thus, it will be necessary to recreate an ordered visuotopic map by using appropriate computer algorithms and interactions between the patient and the clinician.
[Mh] Termos MeSH primário: Cegueira/reabilitação
Simulação por Computador
Fibras Nervosas/fisiologia
Células Ganglionares da Retina/fisiologia
Próteses Visuais
[Mh] Termos MeSH secundário: Cegueira/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1111/ceo.12899


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[PMID]:28124761
[Au] Autor:Daschner R; Greppmaier U; Kokelmann M; Rudorf S; Rudorf R; Schleehauf S; Wrobel WG
[Ad] Endereço:Retina Implant AG, Gerhard-Kindler-Strasse 8, 72770, Reutlingen, Germany. renate.daschner@retina-implant.de.
[Ti] Título:Laboratory and clinical reliability of conformally coated subretinal implants.
[So] Source:Biomed Microdevices;19(1):7, 2017 Mar.
[Is] ISSN:1572-8781
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite recent developments and new treatments in ophthalmology there is nothing available to cure retinal degenerations like Retinitis Pigmentosa (RP) yet. One of the most advanced approaches to treat people that have gone blind due to RP is to replace the function of the degenerated photoreceptors by a microelectronic neuroprosthetic device. Basically, this subretinal active implant transforms the incoming light into electric pulses to stimulate the remaining cells of the retina. The functional time of such devices is a crucial aspect. In this paper the laboratory and clinical reliability of the two active subretinal implants Alpha IMS and Alpha AMS is presented. Based on clinical data the median operating life of the Alpha AMS is estimated to be 3.3 years with a one-sided lower 75 % confidence level of 2.0 years. This data shows a significant improvement of the device lifetime compared to the previous device Alpha IMS which shows a median lifetime of 0.6 years with a lower confidence bound (75 %) of 0.5 years. The results are in good agreement with laboratory data from accelerated aging tests of the implant components, showing an estimated median lifetime for Alpha IMS components of 0.7 years compared to the improved lifetime of Alpha AMS of 4.7 years.
[Mh] Termos MeSH primário: Laboratórios
Retina
Próteses Visuais
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Seres Humanos
Estimativa de Kaplan-Meier
Desenho de Prótese
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1007/s10544-017-0147-6


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[PMID]:28114567
[Au] Autor:Caspi A; Roy A; Dorn JD; Greenberg RJ
[Ad] Endereço:Department of Applied Physics, Jerusalem College of Technology, Jerusalem, Israel 2Second Sight Medical Products, Inc., Sylmar, California, United States.
[Ti] Título:Retinotopic to Spatiotopic Mapping in Blind Patients Implanted With the Argus II Retinal Prosthesis.
[So] Source:Invest Ophthalmol Vis Sci;58(1):119-127, 2017 Jan 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To quantify the precision of mapping from retinotopic (retina-centered) to spatiotopic (world-centered) coordinates in blind humans implanted with a retinal prosthesis device. Additionally, to demonstrate that an eye tracker can be calibrated on sightless patients based on the percept from a visual implant. Methods: We directly activated epiretinal electrodes to create retinotopic stimuli and recorded the location of the percept at world-based coordinates. In contrast to normal Argus II use where stimulation is a function of the captured scene's image, in this research we directly controlled the waveform in each electrode and measured the percept's location using a trackable handheld marker. For eye tracking, pupil images were recorded with a timestamp synchronized to the stimulation and marker positions. Results: Remapping of the measured world locations to the position of the electrodes on the retina is feasible by accounting for eye orientation at the onset of stimulation. Transformation of pupil images to the eye's orientation (i.e., eye tracker calibration) can be done by solving for the variables that minimize the spread of the remapped retinal electrode locations. After mapping to retinal coordinates based on eye positions, the measured precision of pointing was 2° to 3°, which is comparable to open-loop pointing in sighted individuals. Conclusions: The brain accurately maps the artificial vision induced by a retinal prosthesis based on instantaneous gaze position. Remapping based on eye position is feasible and will increase visual stability in prosthetic vision.
[Mh] Termos MeSH primário: Cegueira/reabilitação
Fixação Ocular/fisiologia
Retina/fisiopatologia
Movimentos Sacádicos/fisiologia
Córtex Visual/fisiopatologia
Percepção Visual/fisiologia
Próteses Visuais
[Mh] Termos MeSH secundário: Atenção/fisiologia
Cegueira/fisiopatologia
Feminino
Seres Humanos
Masculino
Orientação/fisiologia
Estimulação Luminosa
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20398


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[PMID]:28085534
[Au] Autor:Liu S; Matsuo T; Hosoya O; Uchida T
[Ad] Endereço:1 Department of Ophthalmology, Okayama University Medical School and Graduate School of Medicine , Dentistry, and Pharmaceutical Sciences, Okayama City, Japan .
[Ti] Título:Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells.
[So] Source:J Ocul Pharmacol Ther;33(3):149-160, 2017 Apr.
[Is] ISSN:1557-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Our previous study demonstrated that photoelectric dye-coupled polyethylene film (Okayama University-type retinal prosthesis), which was implanted in subretinal space of the eyes of Royal College of Surgeons (RCS) rats, prevented retinal neurons from apoptotic death. In this study, we aimed to examine whether photoelectric dye itself would protect retinal neurons from apoptosis in RCS rats. METHODS: RCS rats received intravitreous injection of different concentrations of the dye in the left eye and housed under a 12-h light-dark cycle. Saline injection in the right eye served as control. In addition, RCS rats with dye injection were kept in 24-h daily dark condition. Sections were processed for terminal deoxynucleotidyl transferase-mediated fluorescein-conjugated-dUTP nick-end-labeling (TUNEL) assay and immunohistochemical staining of glial fibrillary acidic protein (GFAP) and protein kinase Cα (PKCα). RESULTS: The number of TUNEL-positive cells significantly decreased in the retina of dye-injected eyes compared with those in saline-injected eyes (P = 0.0001, 2-factor analysis of variance [ANOVA]), under 12-h light-dark cycle. Significant decrease of TUNEL-positive cells was noted in the retina of rats with dye injection compared with those with saline injection, kept under 24-h dark condition (P = 0.0001, 2-factor ANOVA). Immunoreactive area for GFAP decreased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.0001, 2-factor ANOVA), whereas immunoreactive area for PKCα increased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.01, 2-factor ANOVA). CONCLUSIONS: Photoelectric dye inhibits apoptotic death of photoreceptor cells in RCS rats and downregulates GFAP expression in retinal Müller cells. Photoelectric dye may be a candidate agent for neuroprotection in retinitis pigmentosa and other retinal diseases.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Corantes/farmacologia
Células Fotorreceptoras/efeitos dos fármacos
Polietileno/farmacologia
Retina/efeitos dos fármacos
Próteses Visuais
[Mh] Termos MeSH secundário: Animais
Corantes/química
Polietileno/química
Ratos
Ratos Mutantes
Retina/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 9002-88-4 (Polyethylene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1089/jop.2016.0093


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[PMID]:28060358
[Au] Autor:MacLaren RE
[Ad] Endereço:Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford and Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust and NIHR Biomedical Research Centre, Oxford, UK.
[Ti] Título:Electronic retinal implant surgery.
[So] Source:Eye (Lond);31(2):191-195, 2017 Feb.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Blindness due to outer retinal degeneration still remains largely untreatable. Photoreceptor loss removes light sensitivity, but the remaining inner retinal layers, the optic nerve, and indeed the physical structure of the eye itself may be unaffected by the degenerative processes. This provides the opportunity to restore some degree of vision with an electronic device in the subretinal space. In this lecture I will provide an overview of our experiences with the first-generation retinal implant Alpha IMS, developed by Retina Implant AG and based on the technology developed by Eberhart Zrenner as part of a multicentre clinical trial (NCT01024803). We are currently in the process of running a second NIHR-funded clinical trial to assess the next-generation device. The positive results from both studies to date indicate that the retinal implant should be included as a potential treatment for patients who are completely blind from retinitis pigmentosa. Evolution of the technology in future may provide further opportunities for earlier intervention or for other diseases.
[Mh] Termos MeSH primário: Cegueira/reabilitação
Eletrodos Implantados
Degeneração Retiniana/complicações
Percepção Visual/fisiologia
Próteses Visuais
[Mh] Termos MeSH secundário: Atividades Cotidianas
Cegueira/etiologia
Cegueira/fisiopatologia
Seres Humanos
Retina/cirurgia
Degeneração Retiniana/fisiopatologia
Degeneração Retiniana/cirurgia
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2016.280


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[PMID]:28009400
[Au] Autor:Parmeggiani F; De Nadai K; Piovan A; Binotto A; Zamengo S; Chizzolini M
[Ad] Endereço:Eye Clinic, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara - Italy.
[Ti] Título:Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system.
[So] Source:Eur J Ophthalmol;27(1):e16-e21, 2017 Jan 19.
[Is] ISSN:1724-6016
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region. RESULTS: Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode-retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks. CONCLUSIONS: The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design.
[Mh] Termos MeSH primário: Cegueira/reabilitação
Coroideremia/diagnóstico por imagem
Implante de Prótese
Retinite Pigmentosa/diagnóstico por imagem
Tomografia de Coerência Óptica
Próteses Visuais
[Mh] Termos MeSH secundário: Adulto
Cegueira/diagnóstico por imagem
Coroideremia/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Cuidados Pós-Operatórios
Cuidados Pré-Operatórios
Retinite Pigmentosa/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE



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