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Pesquisa : E07.858.082 [Categoria DeCS]
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[PMID]:29236205
[Au] Autor:Chiti MC; Dolmans MM; Mortiaux L; Zhuge F; Ouni E; Shahri PAK; Van Ruymbeke E; Champagne SD; Donnez J; Amorim CA
[Ad] Endereço:Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium.
[Ti] Título:A novel fibrin-based artificial ovary prototype resembling human ovarian tissue in terms of architecture and rigidity.
[So] Source:J Assist Reprod Genet;35(1):41-48, 2018 Jan.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study is to optimize fibrin matrix composition in order to mimic human ovarian tissue architecture for human ovarian follicle encapsulation and grafting. METHODS: Ultrastructure of fresh human ovarian cortex in age-related women (n = 3) and different fibrin formulations (F12.5/T1, F30/T50, F50/T50, F75/T75), rheology of fibrin matrices and histology of isolated and encapsulated human ovarian follicles in these matrices. RESULTS: Fresh human ovarian cortex showed a highly fibrous and structurally inhomogeneous architecture in three age-related patients, but the mean ± SD of fiber thickness (61.3 to 72.4 nm) was comparable between patients. When the fiber thickness of four different fibrin formulations was compared with human ovarian cortex, F50/T50 and F75/T75 showed similar fiber diameters to native tissue, while F12.5/T1 was significantly different (p value < 0.01). In addition, increased concentrations of fibrin exhibited enhanced storage modulus with F50/T50, resembling physiological ovarian rigidity. Excluding F12.5/T1 from further analysis, only three remaining fibrin matrices (F30/T50, F50/T50, F75/T75) were histologically investigated. For this, frozen-thawed fragments of human ovarian tissue collected from 22 patients were used to isolate ovarian follicles and encapsulate them in the three fibrin formulations. All three yielded similar follicle recovery and loss rates soon after encapsulation. Therefore, based on fiber thickness, porosity, and rigidity, we selected F50/T50 as the fibrin formulation that best mimics native tissue. CONCLUSIONS: Of all the different fibrin matrix concentrations tested, F50/T50 emerged as the combination of choice in terms of ultrastructure and rigidity, most closely resembling human ovarian cortex.
[Mh] Termos MeSH primário: Órgãos Artificiais
Fibrina/química
Ovário
[Mh] Termos MeSH secundário: Materiais Biomiméticos/química
Composição de Medicamentos
Elasticidade
Feminino
Dureza
Seres Humanos
Fenômenos Mecânicos
Folículo Ovariano/transplante
Folículo Ovariano/ultraestrutura
Ovário/química
Ovário/citologia
Ovário/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9001-31-4 (Fibrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-1091-3


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[PMID]:29326255
[Au] Autor:Shultz D
[Ti] Título:Creating a modern monster.
[So] Source:Science;359(6372):151, 2018 Jan 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Órgãos Artificiais
Biônica
Clonagem de Organismos
Técnicas de Cultura de Órgãos
Transplantes
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.359.6372.151


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[PMID]:29245217
[Au] Autor:Lu H; Peng L
[Ad] Endereço:aDepartment of Orthopaedics, Jiangjin Central Hospital of ChongqingbDepartment of Orthopaedics, The People's Hospital of Bishan District, Chongqing, P.R. China.
[Ti] Título:Efficacy and safety of Mobi-C cervical artificial disc versus anterior discectomy and fusion in patients with symptomatic degenerative disc disease: A meta-analysis.
[So] Source:Medicine (Baltimore);96(49):e8504, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Total disc replacement (TDR) using Mobi-C cervical artificial disc might be promising to treat symptomatic degenerative disc disease. However, the results remained controversial. We conducted a systematic review and meta-analysis to compare the efficacy and safety of Mobi-C cervical artificial disc and anterior cervical discectomy and fusion (ACDF) in patients with symptomatic degenerative disc disease. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of Mobi-C versus ACDF on the treatment of symptomatic degenerative disc disease were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcomes were neck disability index (NDI) score, patient satisfaction, and subsequent surgical intervention. Meta-analysis was performed using the random-effect model. RESULTS: Four RCTs were included in the meta-analysis. Overall, compared with ACDF surgery for symptomatic degenerative disc disease, TDR using Mobi-C was associated with a significantly increased NDI score (Std. mean difference = 0.32; 95% CI = 0.10-0.53; P = .004), patient satisfaction (odds risk [OR] = 2.75; 95% confidence interval [CI] = 1.43-5.27; P = .002), and reduced subsequent surgical intervention (OR = 0.20; 95% CI = 0.11-0.37; P < .001). Mobi-C was found to produce comparable neurological deterioration (OR = 0.77; 95% CI = 0.35-1.72; P = .53), radiographic success (OR = 1.18; 95% CI = 0.39-3.59; P = .77), and overall success (OR = 2.13; 95% CI = 0.80-5.70; P = .13) compared with ACDF treatment. CONCLUSION: Among the 4 included RCTs, 3 articles were studying patients with 1 surgical level, and 1 article reported 2 surgical levels. When compared with ACDF surgery in symptomatic degenerative disc disease, TDR using Mobi-C cervical artificial disc resulted in a significantly improved NDI score, patient satisfaction, and reduced subsequent surgical intervention. There was no significant difference of neurological deterioration, radiographic success, and overall success between TDR using Mobi-C cervical artificial disc versus ACDF surgery. TDR using Mobi-C cervical artificial disc should be recommended for the treatment of symptomatic degenerative disc disease.
[Mh] Termos MeSH primário: Órgãos Artificiais
Discotomia/métodos
Degeneração do Disco Intervertebral/cirurgia
Fusão Vertebral/métodos
Substituição Total de Disco/métodos
[Mh] Termos MeSH secundário: Adulto
Vértebras Cervicais/fisiopatologia
Vértebras Cervicais/cirurgia
Avaliação da Deficiência
Feminino
Seguimentos
Seres Humanos
Degeneração do Disco Intervertebral/fisiopatologia
Masculino
Meia-Idade
Pescoço/fisiopatologia
Pescoço/cirurgia
Satisfação do Paciente
Ensaios Clínicos Controlados Aleatórios como Assunto
Amplitude de Movimento Articular
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008504


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[PMID]:28662941
[Au] Autor:Muzychuk AK; Durr GM; Shine JJ; Robert MC; Harissi-Dagher M
[Ad] Endereço:Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montreal, Quebec, Canada. Electronic address: muzychuk@gmail.com.
[Ti] Título:No Light Perception Outcomes Following Boston Keratoprosthesis Type 1 Surgery.
[So] Source:Am J Ophthalmol;181:46-54, 2017 Sep.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the incidence rate, principal causes, and clinical course of eyes developing no light perception (NLP) visual acuity (VA) following Boston Keratoprosthesis (B-KPro) type 1 surgery. Secondary objectives include determining the incidence rate, relative risk (RR), and survival probability with respect to NLP outcomes among eyes with congenital aniridia. DESIGN: Retrospective, interventional case series. SUBJECTS: All patients undergoing B-KPro type 1 surgery between October 2008 and June 2016 by a single surgeon at CHUM - Hôpital Notre-Dame. METHODS: Records of patients having undergone B-KPro implantation were reviewed. Eyes with a final outcome of NLP were further reviewed to determine best recorded postoperative VA, time to NLP onset, clinical course, and principal cause. Descriptive statistics, incidence rates, Kaplan-Meier survival curves, and the RR of NLP outcomes among eyes with aniridia were determined. Statistical significance was defined as P < .05. RESULTS: Records of 119 patients were included, with an average follow-up of 49.1 ± 26.8 months postoperatively. Nineteen eyes had a final outcome of NLP, representing 16.0%. The incidence rate of NLP was 0.04 cases per eye-year of follow-up. The most common principal causes were inoperable retinal detachment (n = 7, 36.8%), terminal glaucoma (n = 6, 31.6%), and carrier graft melt-related complications (n = 5, 26.3%). The RR of developing NLP among eyes with aniridia was 3.04 (P = .01). CONCLUSIONS: No light perception is a devastating but uncommon outcome of B-KPro surgery. Patients with aniridia seem to be at increased risk. In spite of all available medical and surgical interventions, some eyes may still suffer this outcome.
[Mh] Termos MeSH primário: Órgãos Artificiais/efeitos adversos
Cegueira/epidemiologia
Córnea
Próteses e Implantes/efeitos adversos
Implante de Prótese/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Aniridia/complicações
Cegueira/etiologia
Feminino
Seguimentos
Glaucoma/complicações
Seres Humanos
Incidência
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Descolamento Retiniano/complicações
Estudos Retrospectivos
Fatores de Risco
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


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[PMID]:28646647
[Au] Autor:Usuda H; Watanabe S; Miura Y; Saito M; Musk GC; Rittenschober-Böhm J; Ikeda H; Sato S; Hanita T; Matsuda T; Jobe AH; Newnham JP; Stock SJ; Kemp MW
[Ad] Endereço:Division of Obstetrics and Gynecology, University of Western Australia, Crawley, Australia; Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan. Electronic address: haruo.usuda@uwa.edu.au.
[Ti] Título:Successful maintenance of key physiological parameters in preterm lambs treated with ex vivo uterine environment therapy for a period of 1 week.
[So] Source:Am J Obstet Gynecol;217(4):457.e1-457.e13, 2017 Oct.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Extremely preterm infants born at the border of viability (22-24 weeks' gestation) have high rates of death and lasting disability. Ex vivo uterine environment therapy is an experimental neonatal intensive care strategy that provides gas exchange using parallel membranous oxygenators connected to the umbilical vessels, sparing the extremely preterm cardiopulmonary system from ventilation-derived injury. OBJECTIVE: In this study, we aimed to refine our ex vivo uterine environment therapy platform to eliminate fetal infection and inflammation, while simultaneously extending the duration of hemodynamically stable ex vivo uterine environment therapy to 1 week. STUDY DESIGN: Merino-cross ewes with timed, singleton pregnancies were surgically delivered at 112-115 days of gestation (term is ∼150 days) and adapted to ex vivo uterine environment therapy (treatment group; n = 6). Physiological variables were continuously monitored; humerus and femur length, ductus arteriosus directional flow, and patency were estimated with ultrasound; serial blood samples were collected for hematology and microbiology studies; weight was recorded at the end of the experiment. Control group animals (n = 7) were euthanized at 122 days of gestation and analyzed accordingly. Bacteremia was defined by positive blood culture. Infection and fetal inflammation was assessed with white blood cell counts (including differential leukocyte counts), plasma and lung proinflammatory cytokine measurements, and lung histopathology. RESULTS: Five of 6 fetuses in the treatment group completed the 1-week study period with key physiological parameters, blood counts remaining within normal ranges, and no bacteremia detected. There were no significant differences (P > .05) in arterial blood oxygen content or lactate levels between ex vivo uterine environment therapy and control groups at delivery. There was no significant difference (P > .05) in birthweight between control and ex vivo uterine environment groups. In the ex vivo uterine environment group, we observed growth of fetal humerus (P < .05) and femur (P < .001) over the course of the 7-day experimental period. There was no difference in airway or airspace morphology or consolidation between control and ex vivo uterine environment animals, and there was no increase in the number of lung cells staining positive for T-cell marker CD3 . CONCLUSION: Five preterm lambs were maintained in a physiologically stable condition for 1 week with significant growth and without clinically significant bacteremia or systemic inflammation. Although substantial further refinement is required, a life support platform based around ex vivo uterine environment therapy may provide an avenue to improve outcomes for extremely preterm infants.
[Mh] Termos MeSH primário: Órgãos Artificiais
Placenta
Nascimento Prematuro/terapia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Complexo CD3/metabolismo
Cuidados Críticos/métodos
Citocinas/genética
Citocinas/metabolismo
Feminino
Fêmur/diagnóstico por imagem
Fêmur/crescimento & desenvolvimento
Úmero/diagnóstico por imagem
Úmero/crescimento & desenvolvimento
Ácido Láctico/sangue
Pulmão/metabolismo
Modelos Animais
Oxigênio/sangue
Gravidez
RNA Mensageiro/metabolismo
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD3 Complex); 0 (Cytokines); 0 (RNA, Messenger); 33X04XA5AT (Lactic Acid); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE


  6 / 2790 MEDLINE  
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[PMID]:28594815
[Au] Autor:Deng J; Xu Y; He S; Chen P; Bao L; Hu Y; Wang B; Sun X; Peng H
[Ad] Endereço:Department of Macromolecular Science and Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.
[Ti] Título:Preparation of biomimetic hierarchically helical fiber actuators from carbon nanotubes.
[So] Source:Nat Protoc;12(7):1349-1358, 2017 Jul.
[Is] ISSN:1750-2799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mechanically responsive materials that are able to sense and respond to external stimuli have important applications in soft robotics and the formation of artificial muscles, such as intelligent electronics, prosthetic limbs, comfort-adjusting textiles and miniature actuators for microfluidics. However, previous artificial muscles based on polymer materials are insufficient in generating large actuations, fast responses, diverse deformation modes and high cycle performances. To this end, carbon nanotubes (CNTs) are proposed as promising candidates to be assembled into artificial muscles, as they are lightweight, robust and have high surface-to-volume ratios. This protocol describes a reproducible biomimetic method for preparing a family of hierarchically arranged helical fiber (HHF) actuators that are responsive to solvents and vapors. These HHFs are produced through helical assembly of CNTs into primary fibers and further twisting of the multi-ply primary fibers into a helical structure. A large number of nanoscale gaps between the CNTs and micron-scale gaps between the primary fibers ensure large volume changes and fast responses upon the infiltration of solvents and vapors (e.g., water, ethanol, acetone and dichloromethane) by capillarity. The modes of shape transformations can be modulated precisely by controlling how the CNTs are assembled into primary fibers, multi-ply primary fibers, HHFs and hierarchical springs. This protocol provides a prototype for preparing actuators with different fiber components. The overall time required for the preparation of HHF actuators is 17 h.
[Mh] Termos MeSH primário: Órgãos Artificiais
Biomimética
Músculos
Nanotecnologia/métodos
Nanotubos de Carbono
[Mh] Termos MeSH secundário: Solventes
Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 0 (Solvents); 0 (Steam)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1038/nprot.2017.038


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[PMID]:28528012
[Au] Autor:Perez VL; Leung EH; Berrocal AM; Albini TA; Parel JM; Amescua G; Alfonso EC; Ali TK; Gibbons A
[Ad] Endereço:Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Ocular Surface Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: vperez4@med.miami.edu.
[Ti] Título:Impact of Total Pars Plana Vitrectomy on Postoperative Complications in Aphakic, Snap-On, Type 1 Boston Keratoprosthesis.
[So] Source:Ophthalmology;124(10):1504-1509, 2017 Oct.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the impact of total pars plana vitrectomies (PPVs) with peripheral shaving of the vitreous base on the rates of postoperative complications in patients with aphakic, snap-on type I Boston keratoprostheses (KPros). DESIGN: Retrospective, consecutive case series. PARTICIPANTS: A total of 48 eyes in 46 patients with implantation of aphakic, snap-on type 1 Boston KPros performed at a tertiary care facility between January 1, 2007, and December 31, 2013, were included. METHODS: The cumulative incidences of postoperative complications were compared between patients who underwent total PPVs with shaving of the vitreous base (n = 22) and those who had partial PPVs or anterior vitrectomies (AVs) at the time of KPro implantation (n = 26). MAIN OUTCOME MEASURES: Rates of complications between patients who underwent total PPVs and partial PPVs or AVs. RESULTS: The rate of total postoperative complications was lower in the total PPV group (P = 0.018, log-rank test). In particular, eyes that underwent total PPVs had lower rates of retroprosthetic membranes (RPMs) requiring intervention (P = 0.049) and less vision loss due to glaucoma progression (P = 0.046). There was also a trend for fewer corneal melts (P = 0.060) and less sight-threatening complications (P = 0.051) in the total vitrectomy group. There was no difference in the rates of KPro extrusion (P = 0.41), endophthalmitis or vitritis (P = 0.15), retinal detachments (P = 0.76), cystoid macular edema (P = 0.83), or timing of complications between the 2 groups. The mean preoperative and postoperative visual acuities were similar between the 2 groups (P = 0.97). The mean follow-up was 49±22 months. CONCLUSIONS: Eyes that underwent total PPVs during implantation of aphakic, snap-on, type I Boston KPros had less postoperative complications than eyes with partial PPVs or AVs during the average 4 years of follow-up.
[Mh] Termos MeSH primário: Órgãos Artificiais
Córnea
Complicações Pós-Operatórias
Implante de Prótese
Vitrectomia
Corpo Vítreo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Afacia Pós-Catarata
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Próteses e Implantes
Estudos Retrospectivos
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


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[PMID]:28422937
[Au] Autor:Holmes D
[Ti] Título:Let there be sight.
[So] Source:Nature;544(7650):S2-S3, 2017 04 19.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Transplante de Células
Córnea/citologia
Córnea/patologia
Doenças da Córnea/patologia
Doenças da Córnea/cirurgia
Células-Tronco/citologia
[Mh] Termos MeSH secundário: Órgãos Artificiais
Técnicas de Cultura de Células
Transplante de Córnea
Rejeição de Enxerto/prevenção & controle
Seres Humanos
Imunossupressão
Mucosa Bucal/citologia
Células-Tronco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1038/544S2a


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[PMID]:28383302
[Au] Autor:Saeed HN; Shanbhag S; Chodosh J
[Ad] Endereço:Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:The Boston keratoprosthesis.
[So] Source:Curr Opin Ophthalmol;28(4):390-396, 2017 Jul.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The Boston keratoprosthesis (BKPro) is often the only hope for visual rehabilitation in severe corneal disease. Since Food and Drug Administration approval of the device in 1992, there have been a series of advances in its design, surgical techniques, and postoperative care, which have widened its applicability and decreased associated complications. The purpose of this review is to highlight the indications, management, outcomes, and advances in the BKPro literature. RECENT FINDINGS: With more surgeons reporting long-term data, it is evident that modifications to the device and perioperative care have led to higher rates of device retention and improved visual outcomes. Recent data also suggest that BKPro may be superior to traditional corneal transplant in the setting of a previously failed graft. There may be advantages to implantation of the device earlier in the course of some diseases without an increased risk of postoperative complications. Devices to reliably measure intraocular pressure and imaging modalities to provide improved visualization of intraocular structures have the potential to further improve outcomes. SUMMARY: The current indications for implantation of the BKPro have broadened. Initially considered a surgery of last resort, the clinical indications for use of the BKPro continue to grow. Early detection and management of postoperative complications can mitigate vision loss and improve outcomes.
[Mh] Termos MeSH primário: Órgãos Artificiais
Córnea
Doenças da Córnea/cirurgia
Próteses e Implantes
[Mh] Termos MeSH secundário: Cegueira/reabilitação
Seres Humanos
Pressão Intraocular
Procedimentos Cirúrgicos Oftalmológicos/métodos
Desenho de Prótese
Implante de Prótese/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000373


  10 / 2790 MEDLINE  
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[PMID]:28369043
[Au] Autor:Seet CS; He C; Bethune MT; Li S; Chick B; Gschweng EH; Zhu Y; Kim K; Kohn DB; Baltimore D; Crooks GM; Montel-Hagen A
[Ad] Endereço:Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, California, USA.
[Ti] Título:Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids.
[So] Source:Nat Methods;14(5):521-530, 2017 May.
[Is] ISSN:1548-7105
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies of human T cell development require robust model systems that recapitulate the full span of thymopoiesis, from hematopoietic stem and progenitor cells (HSPCs) through to mature T cells. Existing in vitro models induce T cell commitment from human HSPCs; however, differentiation into mature CD3 TCR-αß single-positive CD8 or CD4 cells is limited. We describe here a serum-free, artificial thymic organoid (ATO) system that supports efficient and reproducible in vitro differentiation and positive selection of conventional human T cells from all sources of HSPCs. ATO-derived T cells exhibited mature naive phenotypes, a diverse T cell receptor (TCR) repertoire and TCR-dependent function. ATOs initiated with TCR-engineered HSPCs produced T cells with antigen-specific cytotoxicity and near-complete lack of endogenous TCR Vß expression, consistent with allelic exclusion of Vß-encoding loci. ATOs provide a robust tool for studying human T cell differentiation and for the future development of stem-cell-based engineered T cell therapies.
[Mh] Termos MeSH primário: Órgãos Artificiais
Diferenciação Celular
Células-Tronco Hematopoéticas/citologia
Organoides/citologia
Linfócitos T/citologia
Timo/citologia
[Mh] Termos MeSH secundário: Biotecnologia/métodos
Células-Tronco Hematopoéticas/imunologia
Seres Humanos
Organoides/imunologia
Células-Tronco/citologia
Células-Tronco/imunologia
Linfócitos T/imunologia
Timo/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1038/nmeth.4237



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