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[PMID]:29169598
[Au] Autor:Bashir MM; Sohail M; Shami HB
[Ad] Endereço:Department of Plastic, Reconstructive Surgery and Burn Unit, King Edward Medical University, Mayo Hospital, House No 327-block-H DHA, Phase 5, Lahore, Pakistan.
[Ti] Título:Traumatic Wounds of the Upper Extremity: Coverage Strategies.
[So] Source:Hand Clin;34(1):61-74, 2018 02.
[Is] ISSN:1558-1969
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soft tissue coverage of traumatic wounds of the upper extremity is often required to restore adequate function and form. An optimal coverage should be stable, durable, and able to withstand heavy demands of work, should allow free joint mobility, and should have an aesthetically acceptable appearance. Reconstructive options for coverage include autologous tissue and dermal skin substitutes. Multiple factors, including wound characteristics and complexity, general condition of the patient, and surgeon comfort and expertise, help in selection of the reconstructive technique. This article summarizes commonly used soft tissue reconstructive options for traumatic wounds of the upper extremity.
[Mh] Termos MeSH primário: Lesões dos Tecidos Moles/cirurgia
Extremidade Superior/lesões
Extremidade Superior/cirurgia
[Mh] Termos MeSH secundário: Algoritmos
Desbridamento
Seres Humanos
Tratamento de Ferimentos com Pressão Negativa
Pele Artificial
Retalhos Cirúrgicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171125
[St] Status:MEDLINE


  2 / 2287 MEDLINE  
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[PMID]:29025671
[Au] Autor:Stumpf TR; Yang X; Zhang J; Cao X
[Ad] Endereço:Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
[Ti] Título:In situ and ex situ modifications of bacterial cellulose for applications in tissue engineering.
[So] Source:Mater Sci Eng C Mater Biol Appl;82:372-383, 2018 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bacterial cellulose (BC) is secreted by a few strains of bacteria and consists of a cellulose nanofiber network with unique characteristics. Because of its excellent mechanical properties, outstanding biocompatibilities, and abilities to form porous structures, BC has been studied for a variety of applications in different fields, including the use as a biomaterial for scaffolds in tissue engineering. To extend its applications in tissue engineering, native BC is normally modified to enhance its properties. Generally, BC modifications can be made by either in situ modification during cell culture or ex situ modification of existing BC microfibers. In this review we will first provide a brief introduction of BC and its attributes; this will set the stage for in-depth and up-to-date discussions on modified BC. Finally, the review will focus on in situ and ex situ modifications of BC and its applications in tissue engineering, particularly in bone regeneration and wound dressing.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Celulose/química
Engenharia Tecidual
[Mh] Termos MeSH secundário: Bandagens
Materiais Biocompatíveis/química
Seres Humanos
Pele Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biocompatible Materials); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  3 / 2287 MEDLINE  
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[PMID]:28697174
[Au] Autor:Wäster P; Orfanidis K; Eriksson I; Rosdahl I; Seifert O; Öllinger K
[Ad] Endereço:Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden.
[Ti] Título:UV radiation promotes melanoma dissemination mediated by the sequential reaction axis of cathepsins-TGF-ß1-FAP-α.
[So] Source:Br J Cancer;117(4):535-544, 2017 Aug 08.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ultraviolet radiation (UVR) is the major risk factor for development of malignant melanoma. Fibroblast activation protein (FAP)-α is a serine protease expressed on the surface of activated fibroblasts, promoting tumour invasion through extracellular matrix (ECM) degradation. The signalling mechanism behind the upregulation of FAP-α is not yet completely revealed. METHODS: Expression of FAP-α was analysed after UVR exposure in in vitro co-culture systems, gene expression arrays and artificial skin constructs. Cell migration and invasion was studied in relation to cathepsin activity and secretion of transforming growth factor (TGF)-ß1. RESULTS: Fibroblast activation protein-α expression was induced by UVR in melanocytes of human skin. The FAP-α expression was regulated by UVR-induced release of TGF-ß1 and cathepsin inhibitors prevented such secretion. In melanoma cell culture models and in a xenograft tumour model of zebrafish embryos, FAP-α mediated ECM degradation and facilitated tumour cell dissemination. CONCLUSIONS: Our results provide evidence for a sequential reaction axis from UVR via cathepsins, TGF-ß1 and FAP-α expression, promoting cancer cell dissemination and melanoma metastatic spread.
[Mh] Termos MeSH primário: Catepsinas/metabolismo
Gelatinases/genética
Gelatinases/metabolismo
Melanoma/genética
Melanoma/metabolismo
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Nevo/genética
Serina Endopeptidases/genética
Serina Endopeptidases/metabolismo
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/metabolismo
Fator de Crescimento Transformador beta/secreção
Raios Ultravioleta
[Mh] Termos MeSH secundário: Animais
Catepsinas/genética
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Senescência Celular/genética
Técnicas de Cocultura
Meios de Cultivo Condicionados/farmacologia
Regulação para Baixo
Fibroblastos/efeitos dos fármacos
Gelatinases/efeitos da radiação
Expressão Gênica/efeitos da radiação
Inativação Gênica
Seres Humanos
Queratinócitos
Melanócitos
Proteínas de Membrana/efeitos da radiação
Transplante de Neoplasias
Cultura Primária de Células
Serina Endopeptidases/efeitos da radiação
Transdução de Sinais/efeitos da radiação
Pele/efeitos da radiação
Pele Artificial
Transcriptoma
Fator de Crescimento Transformador beta/antagonistas & inibidores
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/efeitos da radiação
Regulação para Cima
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media, Conditioned); 0 (Membrane Proteins); 0 (Transforming Growth Factor beta); EC 3.4.- (Cathepsins); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.- (fibroblast activation protein alpha); EC 3.4.24.- (Gelatinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.182


  4 / 2287 MEDLINE  
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[PMID]:28560888
[Au] Autor:Greenwood JE
[Ad] Endereço:Royal Adelaide Hospital , Australia.
[Ti] Título:The evolution of acute burn care - retiring the split skin graft.
[So] Source:Ann R Coll Surg Engl;99(6):432-438, 2017 Jul.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The skin graft was born in 1869 and since then, surgeons have been using split skin grafts for wound repair. Nevertheless, this asset fails the big burn patient, who deserves an elastic, mobile and robust outcome but who receives the poorest possible outcome based on donor site paucity. Negating the need for the skin graft requires an autologous composite cultured skin and a material capable of temporising the burn wound for four weeks until the composite is produced. A novel, biodegradable polyurethane chemistry has been used to create two such products. This paper describes the design, production, optimisation and evaluation of several iterations of these products. The evaluation has occurred in a variety of models, both in vitro and in vivo, employing Hunterian scientific principles, and embracing Hunter's love and appreciation of comparative anatomy. The process has culminated in significant human experience in complex wounds and extensive burn injury. Used serially, the products offer robust and elastic healing in deep burns of any size within 6 weeks of injury.
[Mh] Termos MeSH primário: Queimaduras/cirurgia
Transplante de Pele
Pele Artificial
Engenharia Tecidual
Tecidos Suporte
Transplante Autólogo
[Mh] Termos MeSH secundário: Implantes Absorvíveis
Idoso
Animais
Autoenxertos
Materiais Biocompatíveis
Pesquisa Biomédica
Modelos Animais de Doenças
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Poliuretanos
Ovinos
Transplante de Pele/história
Transplante de Pele/instrumentação
Transplante de Pele/métodos
Suínos
Técnicas de Cultura de Tecidos
Transplante Autólogo/história
Transplante Autólogo/instrumentação
Transplante Autólogo/métodos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (NovoSorb); 0 (Polyurethanes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0110


  5 / 2287 MEDLINE  
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[PMID]:28520509
[Au] Autor:Chen S; Liu B; Carlson MA; Gombart AF; Reilly DA; Xie J
[Ad] Endereço:Department of Surgery-Transplant & Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
[Ti] Título:Recent advances in electrospun nanofibers for wound healing.
[So] Source:Nanomedicine (Lond);12(11):1335-1352, 2017 Jun.
[Is] ISSN:1748-6963
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos
Nanofibras/química
Nanofibras/uso terapêutico
Regeneração/efeitos dos fármacos
Fenômenos Fisiológicos da Pele/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bandagens
Técnicas Eletroquímicas/instrumentação
Técnicas Eletroquímicas/métodos
Desenho de Equipamento
Seres Humanos
Nanotecnologia/instrumentação
Nanotecnologia/métodos
Medicina Regenerativa/instrumentação
Medicina Regenerativa/métodos
Pele/efeitos dos fármacos
Pele Artificial
Suturas
Tecidos Suporte/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.2217/nnm-2017-0017


  6 / 2287 MEDLINE  
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[PMID]:28514414
[Au] Autor:Drew L; Scott A; Morgan B; Gruber K
[Ti] Título:Clinical devices and services: Repair shops.
[So] Source:Nature;545(7654):S21-S24, 2017 05 17.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Contrato de Risco
Equipamentos e Provisões/economia
Técnicas de Diagnóstico Molecular/economia
Pele Artificial/economia
Tropoelastina/economia
Cicatrização
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Infecção/diagnóstico
Infecção/microbiologia
Infecção/virologia
Articulação do Joelho/patologia
Menisco/patologia
Modelos Animais
Análise de Sequência de DNA/economia
Tropoelastina/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tropoelastin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1038/545S21a


  7 / 2287 MEDLINE  
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[PMID]:28504393
[Au] Autor:Jimenez F
[Ad] Endereço:Mediteknia Dermatology Clinic, and Research Associate of the Medical Pathology Group, Instituto de Investigación Biosanitaria, Universidad de Las Palmas de Gran Canaria, Gran Canaria, Canary Islands, Spain.
[Ti] Título:Incorporating hair follicle cells in artificial skin.
[So] Source:Br J Dermatol;176(5):1124-1125, 2017 05.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Folículo Piloso
Pele Artificial
[Mh] Termos MeSH secundário: Cabelo
Seres Humanos
Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15475


  8 / 2287 MEDLINE  
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[PMID]:28444764
[Au] Autor:Chang EI; Liu J
[Ad] Endereço:Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
[Ti] Título:Prospective unbiased experience with three acellular dermal matrices in breast reconstruction.
[So] Source:J Surg Oncol;116(3):365-370, 2017 Sep.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of acellular dermal matrix (ADM) has become the standard of care in breast reconstruction. However, the majority of current studies are biased or combine large databases introducing inherent flaws. Here, we present a prospective single surgeon experience comparing three ADM. METHODS: All expander based breast reconstructions between 2014 and 2015 using ADM were included. RESULTS: Eighteen patients (32 breasts) underwent reconstruction using Flex Pliable, 15 patients (22 breasts) used Alloderm, and 14 patients (20 breasts) had Dermacell. There were no significant differences in patient demographics or comorbidities. All expanders were placed into a subpectoral position, and there were no direct to implant cases. Average intraoperative fill was comparable, (Flex: 225 cc, Alloderm: 180 cc, Dermacell: 130 cc). There were no differences in seroma, infection, or mastectomy skin flap necrosis rates. There were no cases of red breast, expander explanation or failed reconstruction in any cohort. Time to drain removal was significantly shorter in Flex and Dermacell patients compared to Alloderm (20 days vs 15 days vs 26 days, respectively; P = 0.01). CONCLUSIONS: While there are differences between available ADM, successful outcomes can be achieved with proper patient selection, sound surgical technique, and diligent post-operative management.
[Mh] Termos MeSH primário: Derme Acelular
Implantes de Mama
Neoplasias da Mama/cirurgia
Colágeno
Mamoplastia
Pele Artificial
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Mastectomia
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alloderm); 9007-34-5 (Collagen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24656


  9 / 2287 MEDLINE  
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[PMID]:28415483
[Au] Autor:Yousefi I; Pakravan M; Rahimi H; Bahador A; Farshadzadeh Z; Haririan I
[Ad] Endereço:School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran. Electronic address: iman_yousefi@ut.ac.ir.
[Ti] Título:An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:433-444, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Wound healing characteristics of some plant extracts have been well known for many years, and they have been utilized for such applications in traditional way. Recently electrospun nanofibrous mats showed promising properties for tissue engineering and especially for skin repair. It is expected that incorporation of plant extracts into such structures could provide higher performance and synergistic effect for biomedical and wound healing applications. The final purpose of this study is to fabricate chitosan based nanofiber mats loaded with a traditional plant extract of Lawsonia inermis (Henna) leaves to enhance the antibacterial efficacy and wound healing of the precursor nanofibers. The morphology, structure, mechanical properties and swelling and weight loss degree of the electrospun nanofibers have been investigated in this study. Antibacterial activity, cell biocompatibility evaluations and in vivo wound healing activity of the abovementioned mats were also studied. The FESEM images of Henna leaves extract-loaded nanofibers proved that homogeneous, smooth and defect free nanofibers of 64-87nm in diameter have been prepared. Presence of Henna extract in the electrospun fibers was approved by Fourier Transform Infrared spectroscopy. Incorporation of Henna extract into the nanofiber mats exhibited significant synergistic antibacterial activity against bacterial cells. It was well supported by the results of cell viability and proliferation of human foreskin fibroblast cells on the prepared scaffolds. Therefore, the results of this work showed that Henna leaves extract incorporated chitosan nonwoven mats have a great potential to be used as the biodegradable, biobased and antibacterial wound healing dressings.
[Mh] Termos MeSH primário: Quitosana
Lawsonia (Planta)/química
Nanofibras/química
Extratos Vegetais
Folhas de Planta/química
Pele Artificial
[Mh] Termos MeSH secundário: Animais
Quitosana/química
Quitosana/farmacologia
Seres Humanos
Masculino
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  10 / 2287 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28403359
[Au] Autor:Guzmán-Uribe D; Alvarado-Estrada KN; Pierdant-Pérez M; Torres-Álvarez B; Sánchez-Aguilar JM; Rosales-Ibáñez R
[Ad] Endereço:Universidad Autónoma de San Luis Potosí, Facultad de Estomatología, Grupo de Investigación en Ingeniería Tisular, San Luis Potosí, México.
[Ti] Título:Oral mucosa: an alternative epidermic cell source to develop autologous dermal-epidermal substitutes from diabetic subjects.
[So] Source:J Appl Oral Sci;25(2):186-195, 2017 Mar-Apr.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. Material and Methods: Oral mucosa was obtained from diabetic and healthy subjects (n=20 per group). Epidermal cells were isolated and cultured using autologous fibrin to develop dermal-epidermal in vitro substitutes by the air-liquid technique with autologous human serum as a supplement media. Substitutes were immunocharacterized with collagen IV and cytokeratin 5-14 as specific markers. A Student´s t- test was performed to assess the differences between both groups. Results: It was possible to isolate epidermal cells from the oral mucosa of diabetic and healthy subjects and develop autologous dermal-epidermal skin substitutes using autologous serum as a supplement. Differences in the expression of specific markers were observed and the cytokeratin 5-14 expression was lower in the diabetic substitutes, and the collagen IV expression was higher in the diabetic substitutes when compared with the healthy group, showing a significant difference. Conclusion: Cells from oral mucosa could be an alternative and less invasive source for skin substitutes and wound healing. A difference in collagen production of diabetic cells suggests diabetic substitutes could improve diabetic wound healing. More research is needed to determine the crosstalk between components of these skin substitutes and damaged tissues.
[Mh] Termos MeSH primário: Transplante de Células/métodos
Diabetes Mellitus Tipo 2
Epiderme/citologia
Células Epiteliais/transplante
Mucosa Bucal/citologia
Pele Artificial
[Mh] Termos MeSH secundário: Adulto
Idoso
Materiais Biocompatíveis
Estudos de Casos e Controles
Técnicas de Cultura de Células
Proliferação Celular
Células Cultivadas
Colágeno/análise
Diabetes Mellitus Tipo 2/terapia
Feminino
Fibroblastos
Seres Humanos
Queratinócitos/citologia
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Úlcera Cutânea/terapia
Fatores de Tempo
Transplante Autólogo
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 9007-34-5 (Collagen)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE



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