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[PMID]:29273953
[Au] Autor:Coutinho MCL; Teixeira VL; Santos CSG
[Ad] Endereço:Department of Marine Biology, Institute of Biology, Federal Fluminense University, Outeiro São João Batista, s/no, P.O. Box 100.644, Niterói, RJ, 24020-150, Brazil. marinacoutinho88@gmail.com.
[Ti] Título:A Review of "Polychaeta" Chemicals and their Possible Ecological Role.
[So] Source:J Chem Ecol;44(1):72-94, 2018 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the many publications concerning the isolation of substances and the many reviews of marine natural products, some groups of organisms remain poorly studied, including "Polychaeta". In response, this review covers articles published through December 2016 that address marine natural products produced from polychaetes, with a focus on antipredatory strategies, competitors, fouling, and pathogens. A total of 121 compounds were isolated from 1934 to 2016, which includes halogenated aromatics, proteins, amino acids and Lumazine derivatives most notably-with a defensive function were found in the literature, most frequently in the families Sabellidae, Terebellidae, Glyceridae, and Nereididae. The period of highest discovery of natural products in defensive actions for the group was the 2000s. Polychaetes were addressed in 26 revisions of the total 51 articles analyzed and are less reported than other marine invertebrates such as sponges, cnidarians, mollusks, and tunicates. In sum, the present review provides a basis for future research on the marine chemical ecology of polychaetes.
[Mh] Termos MeSH primário: Organismos Aquáticos/química
Produtos Biológicos/química
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/metabolismo
Produtos Biológicos/isolamento & purificação
Cnidários/química
Cnidários/metabolismo
Comportamento Consumatório/fisiologia
Equinodermos/química
Equinodermos/metabolismo
Fenômenos Ecológicos e Ambientais
Moluscos/química
Moluscos/metabolismo
Urocordados/química
Urocordados/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0915-z


  2 / 441 MEDLINE  
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[PMID]:28460280
[Au] Autor:Da Silva S; Saperia S; Siddiqui I; Fervaha G; Agid O; Daskalakis ZJ; Ravindran A; Voineskos AN; Zakzanis KK; Remington G; Foussias G
[Ad] Endereço:Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: susana.dasilva@camh.ca.
[Ti] Título:Investigating consummatory and anticipatory pleasure across motivation deficits in schizophrenia and healthy controls.
[So] Source:Psychiatry Res;254:112-117, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Anhedonia has traditionally been considered a characteristic feature of schizophrenia, but the true nature of this deficit remains elusive. This study sought to investigate consummatory and anticipatory pleasure as it relates to motivation deficits. Eighty-four outpatients with schizophrenia and 81 healthy controls were administered the Temporal Experience of Pleasure Scale (TEPS), as well as a battery of clinical and cognitive assessments. Multivariate analyses of variance were used to examine the experience of pleasure as a function of diagnosis, and across levels of motivation deficits (i.e. low vs. moderate. vs. high) in schizophrenia. Hierarchical regression analyses were also conducted to evaluate the predictive value of amotivation in relation to the TEPS. There were no significant differences between schizophrenia and healthy control groups for either consummatory or anticipatory pleasure. Within the schizophrenia patients, only those with high levels of amotivation were significantly impaired in consummatory and anticipatory pleasure compared to low and moderate groups, and compared to healthy controls. Further, our results revealed that amotivation significantly predicts both consummatory and anticipatory pleasure, with no independent contribution of group. Utilizing study samples with a wide range of motivation deficits and incorporating objective paradigms may provide a more comprehensive understanding of hedonic deficits.
[Mh] Termos MeSH primário: Antecipação Psicológica/fisiologia
Comportamento Consumatório/fisiologia
Motivação/fisiologia
Prazer/fisiologia
Esquizofrenia/fisiopatologia
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Adulto
Anedonia/fisiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Esquizofrenia/diagnóstico
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:27889434
[Au] Autor:Frenk H; Martin J; Vitouchanskaia C; Dar R; Shalev U
[Ad] Endereço:The School of Psychological Sciences, Tel Aviv University, Ramat Aviv, Israel. Electronic address: frenk@mta.ac.il.
[Ti] Título:Effects of contingent and noncontingent nicotine on lever pressing for liquids and consumption in water-deprived rats.
[So] Source:Eur J Pharmacol;794:224-233, 2017 Jan 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nicotine has been proposed to be a primary reinforcer and a reinforcement enhancer. To date, no studies have examined whether nicotine enhances consummatory behaviors or only operant responding (appetitive behaviors). Experiments were designed to test whether contingent and noncontingent nicotine enhance lever pressing for and consumption of fluids in water-deprived rats. Animals were water-deprived throughout all experiments. They were trained to press two levers under a variable interval (VI-20, 1-35s). Their lever pressing and water consumption were measured after noncontingent subcutaneous (s.c.) injection of nicotine (1mg/kg), and in 3 choice conditions (water and quinine solution (18µg/ml); water and nicotine (32µg/ml) solution; quinine (18µg/ml) and nicotine (32µg/ml) solutions) where nicotine was thus delivered contingently upon lever pressing. The effects of nicotine (1mg/kg; s.c.) on the consumption of water in a time-limited free access (1h) paradigm were assessed. Nicotine significantly increased lever pressing and the number of earned reinforcements on both levers in the two choice conditions and when administered s.c. compared to all groups that did not receive nicotine. However, under no condition did animals consume more fluids than baseline. Under the time-limited free access condition nicotine reduced water consumption. Although our findings do not support a reinforcing effect for nicotine, they are consistent with the incentive-amplification hypothesis. Its relevance for human smoking is yet unclear.
[Mh] Termos MeSH primário: Ingestão de Líquidos/efeitos dos fármacos
Nicotina/farmacologia
Privação de Água
Água/metabolismo
[Mh] Termos MeSH secundário: Animais
Comportamento de Escolha/efeitos dos fármacos
Condicionamento Operante/efeitos dos fármacos
Comportamento Consumatório/efeitos dos fármacos
Masculino
Ratos
Reforço (Psicologia)
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


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[PMID]:27251581
[Au] Autor:Suárez AB; Pautassi RM; Kamenetzky GV
[Ad] Endereço:Instituto de Investigaciones Médicas A Lanari, IDIM-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Consummatory succesive positive contrast produced by the downshift of an aversive solution in infant rats.
[So] Source:Dev Psychobiol;59(1):118-122, 2017 01.
[Is] ISSN:1098-2302
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Subjects trained in successive positive contrast are usually given an appetitive stimulus of relatively low quality during a pre-shift, followed by exposure to a significantly greater quality of the same stimulus. Enhanced responsiveness to the high-quality stimulus during the post-shift phase, compared to a control group that receives the superior reward in both phases, is taken as an index of successive positive contrast. Successive positive contrast reports are rare, probably due to performance limitations inherent to the experimental protocols available. We exposed infant rats (14 days old at the start of training) to .1% or .01% quinine during 4, 10 min, trials (pre-shift phase). All animals were then given two trials of exposure to .01% quinine (post-shift phase). During the pre-shift the level of intake was greater in pups stimulated with the relatively less aversive .01% quinine solution. These animals also exhibited, compared to those stimulated with .1% quinine, lower emission of the aversive response paw treading. During the post-shift phase, the group that had been exposed to .1% quinine exhibited significantly greater intake of .01% quinine, along with a reduction in the emission of paw treading and an enhancement in paw licking, an ingestive, appetitive response. Altogether, the evidence is suggestive of the emergence of consummatory successive positive contrast during the second week of life of the rat. To our knowledge, this is the first evidence of positive contrast using an aversive solution.
[Mh] Termos MeSH primário: Comportamento Apetitivo/fisiologia
Comportamento Consumatório/fisiologia
Aprendizagem/fisiologia
Quinina/farmacologia
Paladar/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Feminino
Aprendizagem/efeitos dos fármacos
Masculino
Quinina/administração & dosagem
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
A7V27PHC7A (Quinine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1002/dev.21430


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[PMID]:27764142
[Au] Autor:Jiménez-García AM; Ruíz-Leyva L; Cendán CM; Torres C; Papini MR; Morón I
[Ad] Endereço:Department of Pharmacology, Biomedical Research Center (CIBM) and Institute of Neuroscience, Faculty of Medicine, University of Granada, Campus Ciencias de la Salud, 18016, Granada, Spain.
[Ti] Título:Hypoalgesia Induced by Reward Devaluation in Rats.
[So] Source:PLoS One;11(10):e0164331, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reduced sensitivity to physical pain (hypoalgesia) has been reported after events involving reward devaluation. Reward devaluation was implemented in a consummatory successive negative contrast (cSNC) task. Food-deprived Wistar rats had access to 32% sucrose during 16 sessions followed by access to 4% sucrose during 3 additional sessions. An unshifted control group had access to 4% sucrose throughout the 19 sessions. Pain sensitivity was measured using von Frey filaments (Experiment 1) and Hargreaves thermal stimuli (Experiment 2) in pretraining baseline, 5 min, and 300 min after either the first (session 17) or second (session 18) devaluation session in the cSNC situation. Sucrose consumption was lower in downshifted groups relative to unshifted groups during postshift sessions-the cSNC effect. Hypoalgesia was observed in downshifted groups relative to unshifted controls when pain sensitivity was assessed 5 min after either the first or second devaluation session, regardless of the pain sensitivity test used. Both pain sensitivity tests yielded evidence of hypoalgesia 300 min after the second downshift session, but not 300 min after the first devaluation session. Whereas hypoalgesia was previously shown only after the second devaluation session, here we report evidence of hypoalgesia after both the first and second devaluation sessions using mechanical and thermal nociceptive stimuli. Moreover, the hypoalgesia observed 300 min after the second devaluation session in both experiments provides unique evidence of the effects of reward loss on sensitivity to physical pain 5 hours after the loss episode. The underlying neurobehavioral mechanisms remain to be identified.
[Mh] Termos MeSH primário: Dor/patologia
Recompensa
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante
Comportamento Consumatório/fisiologia
Masculino
Ratos
Ratos Wistar
Sacarose/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
57-50-1 (Sucrose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164331


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[PMID]:27421228
[Au] Autor:Mikhailova MA; Bass CE; Grinevich VP; Chappell AM; Deal AL; Bonin KD; Weiner JL; Gainetdinov RR; Budygin EA
[Ad] Endereço:Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
[Ti] Título:Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors.
[So] Source:Neuroscience;333:54-64, 2016 Oct 01.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent optogenetic studies demonstrated that phasic dopamine release in the nucleus accumbens may play a causal role in multiple aspects of natural and drug reward-related behaviors. The role of tonic dopamine release in reward consummatory behavior remains unclear. The current study used a combinatorial viral-mediated gene delivery approach to express ChR2 on mesolimbic dopamine neurons in rats. We used optical activation of this dopamine circuit to mimic tonic dopamine release in the nucleus accumbens and to explore the causal relationship between this form of dopamine signaling within the ventral tegmental area (VTA)-nucleus accumbens projection and consumption of a natural reward. Using a two bottle choice paradigm (sucrose vs. water), the experiments revealed that tonic optogenetic stimulation of mesolimbic dopamine transmission significantly decreased reward consummatory behaviors. Specifically, there was a significant decrease in the number of bouts, licks and amount of sucrose obtained during the drinking session. Notably, activation of VTA dopamine cell bodies or dopamine terminals in the nucleus accumbens resulted in identical behavioral consequences. No changes in water intake were evident under the same experimental conditions. Collectively, these data demonstrate that tonic optogenetic stimulation of VTA-nucleus accumbens dopamine release is sufficient to inhibit reward consummatory behavior, possibly by preventing this circuit from engaging in phasic activity that is thought to be essential for reward-based behaviors.
[Mh] Termos MeSH primário: Dopamina/metabolismo
Comportamento Alimentar/fisiologia
Núcleo Accumbens/metabolismo
Optogenética
Recompensa
Área Tegmentar Ventral/metabolismo
[Mh] Termos MeSH secundário: Animais
Comportamento de Escolha/fisiologia
Comportamento Consumatório/fisiologia
Sacarose na Dieta
Neurônios Dopaminérgicos/citologia
Neurônios Dopaminérgicos/metabolismo
Água Potável
Estimulação Elétrica
Comportamento Alimentar/psicologia
Masculino
Núcleo Accumbens/citologia
Periodicidade
Ratos Long-Evans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Sucrose); 0 (Drinking Water); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE


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[PMID]:27298234
[Au] Autor:Annicchiarico I; Glueck AC; Cuenya L; Kawasaki K; Conrad SE; Papini MR
[Ad] Endereço:Department of Psychology, Texas Christian University, USA.
[Ti] Título:Complex effects of reward upshift on consummatory behavior.
[So] Source:Behav Processes;129:54-67, 2016 Aug.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Exposing rats to an upshift from a small reward to a larger reward sometimes yields evidence of consummatory successive positive contrast (cSPC), an effect that could be a suitable animal model of positive emotion. However, cSPC is an unreliable effect. Ten experiments explored the effects of an upshift in sucrose or saccharin concentration on consummatory behavior under several conditions. There was occasional evidence of cSPC, but mostly a combination of increased consummatory behavior relative to preshift reward concentrations and a reduced behavioral level relative to unshifted controls. Such a pattern is consistent with processes causing opposite changes on behavior. Reward upshift may induce processes that suppress behavior, such as taste neophobia (induced by an intense sucrose taste) and generalization decrement (induced by novelty in reward conditions after the upshift). An experiment tested the role of such novelty-related effects by preexposing animals to either the upshift concentration (12% sucrose) or water during three days before the start of the experiment. Sucrose-preexposed animals drank significantly more than water-preexposed animals during the upshift, but just as much as unshifted controls (i.e., no evidence of cSPC). These results suggest that cSPC may be difficult to obtain reliably because reward upshift induces opposing processes. However, they also seriously question the ontological status of cSPC.
[Mh] Termos MeSH primário: Comportamento Consumatório/efeitos dos fármacos
Recompensa
Sacarina/farmacologia
Sacarose/farmacologia
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante/efeitos dos fármacos
Relação Dose-Resposta a Droga
Feminino
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
57-50-1 (Sucrose); FST467XS7D (Saccharin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


  8 / 441 MEDLINE  
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[PMID]:27002387
[Au] Autor:Chang GQ; Karatayev O; Lukatskaya O; Leibowitz SF
[Ad] Endereço:Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, NY, USA.
[Ti] Título:Prenatal fat exposure and hypothalamic PPAR ß/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons.
[So] Source:Peptides;79:16-26, 2016 05.
[Is] ISSN:1873-5169
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gestational exposure to a fat-rich diet, while elevating maternal circulating fatty acids, increases in the offspring's hypothalamus and amygdala the proliferation and density of neurons that express neuropeptides known to stimulate consummatory behavior. To understand the relationship between these phenomena, this study examined in the brain of postnatal offspring (day 15) the effect of prenatal fat exposure on the transcription factor, peroxisome proliferator-activated receptor (PPAR) ß/δ, which is sensitive to fatty acids, and the relationship of PPAR ß/δ to the orexigenic neuropeptides, orexin, melanin-concentrating hormone, and enkephalin. Prenatal exposure to a fat-rich diet compared to low-fat chow increased the density of cells immunoreactive for PPAR ß/δ in the hypothalamic paraventricular nucleus (PVN), perifornical lateral hypothalamus (PFLH), and central nucleus of the amygdala (CeA), but not the hypothalamic arcuate nucleus or basolateral amygdaloid nucleus. It also increased co-labeling of PPAR ß/δ with the cell proliferation marker, BrdU, or neuronal marker, NeuN, and the triple labeling of PPAR ß/δ with BrdU plus NeuN, indicating an increase in proliferation and density of new PPAR ß/δ neurons. Prenatal fat exposure stimulated the double-labeling of PPAR ß/δ with orexin or melanin-concentrating hormone in the PFLH and enkephalin in the PVN and CeA and also triple-labeling of PPAR ß/δ with BrdU and these neuropeptides, indicating that dietary fat increases the genesis of PPAR ß/δ neurons that produce these peptides. These findings demonstrate a close anatomical relationship between PPAR ß/δ and the increased proliferation and density of peptide-expressing neurons in the hypothalamus and amygdala of fat-exposed offspring.
[Mh] Termos MeSH primário: Gorduras na Dieta/farmacologia
Neurônios/fisiologia
PPAR delta/metabolismo
PPAR beta/metabolismo
Efeitos Tardios da Exposição Pré-Natal/metabolismo
[Mh] Termos MeSH secundário: Tonsila do Cerebelo
Animais
Comportamento Consumatório
Dieta Hiperlipídica
Suscetibilidade a Doenças/metabolismo
Encefalinas/metabolismo
Feminino
Hormônios Hipotalâmicos/metabolismo
Hipotálamo/citologia
Melaninas/metabolismo
Neurogênese
Hormônios Hipofisários/metabolismo
Gravidez
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Enkephalins); 0 (Hypothalamic Hormones); 0 (Melanins); 0 (PPAR delta); 0 (PPAR-beta); 0 (Pituitary Hormones); 67382-96-1 (melanin-concentrating hormone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE


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[PMID]:26561646
[Au] Autor:Thomas MA; Ryu V; Bartness TJ
[Ad] Endereço:Department of Biology, Center for Obesity Reversal, Georgia State University, Atlanta, Georgia.
[Ti] Título:Central ghrelin increases food foraging/hoarding that is blocked by GHSR antagonism and attenuates hypothalamic paraventricular nucleus neuronal activation.
[So] Source:Am J Physiol Regul Integr Comp Physiol;310(3):R275-85, 2016 Feb 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The stomach-derived "hunger hormone" ghrelin increases in the circulation in direct response to time since the last meal, increasing preprandially and falling immediately following food consumption. We found previously that peripheral injection of ghrelin potently stimulates food foraging (FF), food hoarding (FH), and food intake (FI) in Siberian hamsters. It remains, however, largely unknown if central ghrelin stimulation is necessary/sufficient to increase these behaviors regardless of peripheral stimulation of the ghrelin receptor [growth hormone secretagogue receptor (GHSR)]. We injected three doses (0.01, 0.1, and 1.0 µg) of ghrelin into the third ventricle (3V) of Siberian hamsters and measured changes in FF, FH, and FI. To test the effects of 3V ghrelin receptor blockade, we used the potent GHSR antagonist JMV2959 to block these behaviors in response to food deprivation or a peripheral ghrelin challenge. Finally, we examined neuronal activation in the arcuate nucleus and paraventricular hypothalamic nucleus in response to peripheral ghrelin administration and 3V GHSR antagonism. Third ventricular ghrelin injection significantly increased FI through 24 h and FH through day 4. Pretreatment with 3V JMV2959 successfully blocked peripheral ghrelin-induced increases in FF, FH, and FI at all time points and food deprivation-induced increases in FF, FH, and FI up to 4 h. c-Fos immunoreactivity was significantly reduced in the paraventricular hypothalamic nucleus, but not in the arcuate nucleus, following pretreatment with intraperitoneal JMV2959 and ghrelin. Collectively, these data suggest that central GHSR activation is both necessary and sufficient to increase appetitive and consummatory behaviors in Siberian hamsters.
[Mh] Termos MeSH primário: Comportamento Apetitivo/efeitos dos fármacos
Comportamento Consumatório/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Comportamento Alimentar/efeitos dos fármacos
Grelina/administração & dosagem
Glicina/análogos & derivados
Núcleo Hipotalâmico Paraventricular/efeitos dos fármacos
Receptores de Grelina/agonistas
Receptores de Grelina/antagonistas & inibidores
Triazóis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Privação de Alimentos
Glicina/administração & dosagem
Injeções Intraperitoneais
Injeções Intraventriculares
Masculino
Núcleo Hipotalâmico Paraventricular/metabolismo
Phodopus
Proteínas Proto-Oncogênicas c-fos/metabolismo
Receptores de Grelina/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Ghrelin); 0 (N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide); 0 (Proto-Oncogene Proteins c-fos); 0 (Receptors, Ghrelin); 0 (Triazoles); TE7660XO1C (Glycine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00216.2015


  10 / 441 MEDLINE  
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[PMID]:26449720
[Au] Autor:Barker JM; Lench DH; Chandler LJ
[Ad] Endereço:Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA.
[Ti] Título:Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice.
[So] Source:Psychopharmacology (Berl);233(2):235-42, 2016 Jan.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alcohol exposure leads to these impairments will enable further investigation of the neurobiological mechanisms by which it acts to dysregulate adaptive behavior. OBJECTIVES: In the present study, we examined the effects of chronic intermittent ethanol exposure (CIE) on the use of reward-paired cues to guide consummatory behaviors in a mouse model, and further, how manipulations of mGluR2/3 signaling-known to be dysregulated after chronic alcohol exposure-may alter the expression of this behavior. METHODS: Adult male C57B/6J mice were trained to self-administer 10 % ethanol and exposed to CIE via vapor inhalation. After CIE exposure, mice were trained in a Pavlovian task wherein a cue (tone) was paired with the delivery of a 10 % sucrose unconditioned stimulus. The use of the reward-paired cue to guide licking behavior was determined across training. The effect of systemic mGluR2/3 manipulation on discrimination between cue-on and cue-off intervals was assessed by administration of the mGluR2/3 agonist LY379268 or the antagonist LY341495 prior to a testing session. RESULTS: Exposure to CIE resulted in reductions in discrimination between cue-on and cue-off intervals, with CIE-exposed mice exhibiting significantly lower consummatory behavior during reward-paired cues than air controls. In addition, systemic administration of an mGluR2/3 agonist restored the use of reward-paired cues in CIE-exposed animals without impacting behavior in air controls. Conversely, administration of an mGluR2/3 antagonist mimicked the effects of CIE on cue-guided licking behavior, indicating that mGluR2/3 signaling can bidirectionally regulate the ability to use reward-paired cues to guide behavior. CONCLUSIONS: Together, these data suggest that chronic ethanol exposure drives impairments in the ability to use reward-paired cues to adaptively regulate behavior and that mGluR2/3 receptors represent a therapeutic target for restoration of these deficits in behavioral control in the alcoholic.
[Mh] Termos MeSH primário: Alcoolismo/psicologia
Sinais (Psicologia)
Receptores de AMPA/agonistas
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adaptação Psicológica/efeitos dos fármacos
Aminoácidos/farmacologia
Animais
Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia
Condicionamento Operante/efeitos dos fármacos
Comportamento Consumatório/efeitos dos fármacos
Agonistas de Aminoácidos Excitatórios/farmacologia
Antagonistas de Aminoácidos Excitatórios/farmacologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Desempenho Psicomotor/efeitos dos fármacos
Receptores de AMPA/antagonistas & inibidores
Receptores de AMPA/biossíntese
Recompensa
Autoadministração
Xantenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Amino Acids); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Excitatory Amino Acid Agonists); 0 (Excitatory Amino Acid Antagonists); 0 (LY 341495); 0 (LY 379268); 0 (Receptors, AMPA); 0 (Xanthenes); 0 (glutamate receptor ionotropic, AMPA 2); 0 (glutamate receptor ionotropic, AMPA 3)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151010
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-015-4101-0



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