Base de dados : MEDLINE
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[PMID]:28456768
[Au] Autor:Skorzewska A; Wislowska-Stanek A; Lehner M; Turzynska D; Sobolewska A; Krzascik P; Plaznik A
[Ad] Endereço:Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland. skorzews@ipin.edu.pl.
[Ti] Título:Corticotropin releasing factor receptor 1 antagonist differentially inhibits freezing behavior and changes gamma-aminobutyric acidergic activity in the amygdala in low- and high-anxiety rats.
[So] Source:J Physiol Pharmacol;68(1):35-46, 2017 Feb.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to examine the effects of non-peptide corticotropin-releasing factor receptor 1 (CRF ) antagonist (antalarmin) administration on rat conditioned fear responses and gamma-aminobutyric acid (GABA)-ergic brain activity (GAD67 expression and GABA concentration) in low-anxiety (LR) and high-anxiety (HR) rats. The animals were divided into the LR and HR groups based on the duration of their conditioned freezing response in the first contextual fear test. After 28 days, the animals were re-subjected to the contextual fear training and test. The rats received an antalarmin injection (10 mg/kg or 20 mg/kg) 80 min before the second exposure to the aversive context. Antalarmin significantly attenuated the conditioned fear response only in the HR rats. The behavioral effect of a lower dose (10 mg/kg) of antalarmin was accompanied by increased GAD67 expression in the prelimbic cortex (PL) and central nucleus of the amygdala (CeA) and an increased GABA concentration in the amygdala. These studies showed that HR rats were more susceptible to the anxiolytic effects of CRF antagonist administration, which were associated with increased GABAergic activity in the medial prefrontal cortex and amygdala. The current data may provide insights into the neurobiological mechanism operating within the mesolimbic CRF-GABA neurotransmitter systems, which may be responsible for individual differences in stress-related diseases. This knowledge can be applied to further elucidate the pathophysiology of anxiety and trauma/stress-related disorders.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/efeitos dos fármacos
Ansiedade/metabolismo
Reação de Congelamento Cataléptica/efeitos dos fármacos
Córtex Pré-Frontal/efeitos dos fármacos
Pirimidinas/farmacologia
Pirróis/farmacologia
Receptores de Hormônio Liberador da Corticotropina/antagonistas & inibidores
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/metabolismo
Animais
Comportamento Animal/efeitos dos fármacos
Condicionamento Clássico
Medo
Glutamato Descarboxilase/metabolismo
Masculino
Córtex Pré-Frontal/metabolismo
Ratos Wistar
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CRF receptor type 1); 0 (Pyrimidines); 0 (Pyrroles); 0 (Receptors, Corticotropin-Releasing Hormone); 0 (antalarmin); 56-12-2 (gamma-Aminobutyric Acid); EC 4.1.1.15 (Glutamate Decarboxylase); EC 4.1.1.15 (glutamate decarboxylase 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29045469
[Au] Autor:Ly V; Roijendijk L; Hazebroek H; Tonnaer C; Hagenaars MA
[Ad] Endereço:Department of Clinical Psychology, Leiden University, Leiden, The Netherlands.
[Ti] Título:Incident experience predicts freezing-like responses in firefighters.
[So] Source:PLoS One;12(10):e0186648, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Freezing is a defensive response to acute stress that is associated with coping and alterations in attentional processing. However, it remains unclear whether individuals in high risk professions, who are skilled at making rapid decisions in emergency situations, show altered threat-induced freezing. Here we investigated the effect of incident experience in a high risk profession on freezing. Additionally, we explored whether any effect of incident experience on freezing would be different for profession-related and -unrelated threat. Forty experienced and inexperienced firefighters were presented neutral, pleasant, related-unpleasant, and unrelated-unpleasant pictures in a passive viewing task. Postural sway and heart rate were assessed to determine freezing. Both postural and heart rate data evidenced reduced freezing upon unpleasant pictures in the experienced versus the inexperienced group. Relatedness of the unpleasant pictures did not modulate these effects. These findings indicate that higher incident experience relates to decreased threat-induced freezing, at least in a passive task context. This might suggest that primary defense responses are malleable through experience. Finally, these findings demonstrate the potential of using animal to human translational approaches to investigate defensive behaviors in relation to incident experience in high risk professions and stimulate future research on the role of freezing in resilience and coping.
[Mh] Termos MeSH primário: Bombeiros
Reação de Congelamento Cataléptica/fisiologia
[Mh] Termos MeSH secundário: Adulto
Nível de Alerta/fisiologia
Demografia
Frequência Cardíaca/fisiologia
Seres Humanos
Resposta de Imobilidade Tônica/fisiologia
Masculino
Equilíbrio Postural/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186648


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[PMID]:28416629
[Au] Autor:King G; Scott E; Graham BM; Richardson R
[Ad] Endereço:School of Psychology, The University of New South Wales, UNSW, Sydney, 2052, Australia.
[Ti] Título:Individual differences in fear extinction and anxiety-like behavior.
[So] Source:Learn Mem;24(5):182-190, 2017 May.
[Is] ISSN:1549-5485
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is growing appreciation for the substantial individual differences in the acquisition and inhibition of aversive associations, and the insights this might give into identifying individuals particularly vulnerable to stress and psychopathology. We examined whether animals that differed in rate of extinction (i.e., Fast versus Slow) were different in their response to an acute stress in adulthood or following a chronic stress that occurred either early or later in life. We found that Slow Extinguishers had significantly poorer extinction retention than Fast Extinguishers, but an acute stressor did not differentially affect anxiety-like behavior in the two groups. Further, while exposure to chronic stress in adulthood did not impact on the extinction phenotypes or anxiety-like behavior, exposure to chronic stress early in life affected both extinction retention and anxiety-like behavior. These findings have implications for the development of a more nuanced approach to identifying those most at risk of anxiety disorders.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Condicionamento Clássico/fisiologia
Extinção Psicológica/fisiologia
Medo/fisiologia
Individualidade
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/metabolismo
Glândulas Suprarrenais/patologia
Animais
Animais Recém-Nascidos
Ansiedade/etiologia
Aprendizagem por Associação/fisiologia
Peso Corporal/efeitos dos fármacos
Condicionamento Clássico/efeitos dos fármacos
Corticosterona/farmacologia
Extinção Psicológica/efeitos dos fármacos
Medo/efeitos dos fármacos
Reação de Congelamento Cataléptica/efeitos dos fármacos
Reação de Congelamento Cataléptica/fisiologia
Masculino
Privação Materna
Aprendizagem em Labirinto
Ratos
Ratos Sprague-Dawley
Retenção (Psicologia)/efeitos dos fármacos
Retenção (Psicologia)/fisiologia
Estresse Psicológico/complicações
Natação/psicologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
W980KJ009P (Corticosterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1101/lm.045021.117


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[PMID]:28388632
[Au] Autor:Glover LR; Schoenfeld TJ; Karlsson RM; Bannerman DM; Cameron HA
[Ad] Endereço:National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cues.
[So] Source:PLoS Biol;15(4):e2001154, 2017 Apr.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fear learning is highly adaptive if utilized in appropriate situations but can lead to generalized anxiety if applied too widely. A role of predictive cues in inhibiting fear generalization has been suggested by stress and fear learning studies, but the effects of partially predictive cues (ambiguous cues) and the neuronal populations responsible for linking the predictive ability of cues and generalization of fear responses are unknown. Here, we show that inhibition of adult neurogenesis in the mouse dentate gyrus decreases hippocampal network activation and reduces defensive behavior to ambiguous threat cues but has neither of these effects if the same negative experience is reliably predicted. Additionally, we find that this ambiguity related to negative events determines their effect on fear generalization, that is, how the events affect future behavior under novel conditions. Both new neurons and glucocorticoid hormones are required for the enhancement of fear generalization following an unpredictably cued threat. Thus, adult neurogenesis plays a central role in the adaptive changes resulting from experience involving unpredictable or ambiguous threat cues, optimizing behavior in novel and uncertain situations.
[Mh] Termos MeSH primário: Giro Denteado/citologia
Reação de Congelamento Cataléptica
Generalização da Resposta
Hipocampo/fisiologia
Neurogênese
Neurônios/citologia
Células Piramidais/citologia
[Mh] Termos MeSH secundário: Animais
Ansiedade/etiologia
Ansiedade/patologia
Ansiedade/fisiopatologia
Condicionamento (Psicologia)
Cruzamentos Genéticos
Sinais (Psicologia)
Giro Denteado/patologia
Giro Denteado/fisiologia
Giro Denteado/fisiopatologia
Depressão/etiologia
Depressão/patologia
Depressão/fisiopatologia
Comportamento Exploratório
Glucocorticoides/metabolismo
Hipocampo/patologia
Hipocampo/fisiopatologia
Seres Humanos
Masculino
Camundongos
Camundongos Transgênicos
Neurônios/patologia
Neurônios/fisiologia
Células Piramidais/patologia
Células Piramidais/fisiologia
Distribuição Aleatória
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001154


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[PMID]:28362231
[Au] Autor:Alban MW; Pocknell V
[Ad] Endereço:a Northern Arizona University.
[Ti] Título:Cognitive Factors Affecting Freeze-like Behavior in Humans.
[So] Source:J Gen Psychol;144(2):140-156, 2017 Apr-Jun.
[Is] ISSN:1940-0888
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contemporary research on survival-related defensive behaviors has identified physiological markers of freeze/flight/fight. Our research focused on cognitive factors associated with freeze-like behavior in humans. Study 1 tested if an explicit decision to freeze is associated with the psychophysiological state of freezing. Heart rate deceleration occurred when participants chose to freeze. Study 2 varied the efficacy of freezing relative to other defense options and found "freeze" was responsive to variations in the perceived effectiveness of alternative actions. Study 3 tested if individual differences in motivational orientation affect preference for a "freeze" option when the efficacy of options is held constant. A trend in the predicted direction suggested that naturally occurring cognitions led loss-avoiders to select "freeze" more often than reward-seekers. In combination, our attention to the cognitive factors affecting freeze-like behavior in humans represents a preliminary step in addressing an important but neglected research area.
[Mh] Termos MeSH primário: Cognição/fisiologia
Medo/psicologia
Reação de Congelamento Cataléptica/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Atenção/fisiologia
Feminino
Seres Humanos
Individualidade
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1080/00221309.2016.1276046


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[PMID]:28160752
[Au] Autor:Butler JS; Fearon C; Killane I; Waechter SM; Reilly RB; Lynch T
[Ad] Endereço:Trinity Centre for Bioengineering, Trinity College, The University of Dublin, Dublin 2, Ireland; School of Engineering, Trinity College, The University of Dublin, Dublin 2, Ireland; School of Mathematical Sciences, Dublin Institute of Technology, Kevin Street, Dublin, Ireland.
[Ti] Título:Motor preparation rather than decision-making differentiates Parkinson's disease patients with and without freezing of gait.
[So] Source:Clin Neurophysiol;128(3):463-471, 2017 Mar.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson's disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in cognitive function and motor preparation. METHOD: We studied 20 people with PD (10 with FOG, 10 without FOG) and performed a timed response target detection task while electroencephalographic data were acquired. We analysed the data to detect and examine cortical markers of cognitive decision making (P3b or centroparietal positivity, CPP) and motor readiness potential. We analysed current source density (CSD) to increase spatial resolution and allow identification of distinct signals. RESULTS: There was no difference in the P3b/CPP response between people with PD with and without FOG, suggesting equivalent cognitive processing with respect to decision-making. However, the FOG group had significant difference with an earlier onset and larger amplitude of the lateralized readiness potential. Furthermore, the amplitude of the lateralised readiness potential correlated strongly with total Frontal Assessment Battery score. CONCLUSIONS: The difference in lateralized readiness potentials may reflect excessive recruitment of lateral premotor areas to compensate for dysfunction of the supplementary motor area and resultant loss of automatic motor control. This early, excessive recruitment of frontal networks occurs in spite of equivalent motor scores and reaction times between groups. SIGNIFICANCE: The saturation of frontal processing mechanisms could help explain deficits in attentional set-shifting, dual-tasking and response inhibition which are frequently reported in FOG.
[Mh] Termos MeSH primário: Tomada de Decisões
Potencial Evocado Motor
Reação de Congelamento Cataléptica
Marcha
Doença de Parkinson/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Potenciais Evocados
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28126819
[Au] Autor:Yokose J; Okubo-Suzuki R; Nomoto M; Ohkawa N; Nishizono H; Suzuki A; Matsuo M; Tsujimura S; Takahashi Y; Nagase M; Watabe AM; Sasahara M; Kato F; Inokuchi K
[Ad] Endereço:Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
[Ti] Título:Overlapping memory trace indispensable for linking, but not recalling, individual memories.
[So] Source:Science;355(6323):398-403, 2017 01 27.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiologia
Condicionamento Clássico/fisiologia
Rememoração Mental/fisiologia
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/citologia
Animais
Condicionamento Clássico/efeitos dos fármacos
Sinais (Psicologia)
Medo
Reação de Congelamento Cataléptica
Camundongos
Neurônios/fisiologia
Sacarina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
FST467XS7D (Saccharin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1126/science.aal2690


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[PMID]:28120762
[Au] Autor:Bockaert J; Bécamel C
[Ad] Endereço:Institut de génomique fonctionnelle, CNRS-UMR5203, Inserm U1191, université de Montpellier, F-34094 Montpellier Cedex 5, France.
[Ti] Título:[The anxiogenic effects of SSRI are mediated by 5-HT2c receptors of the stria terminalis].
[Ti] Título:Contrôle de l'anxiété par les récepteurs de la sérotonine 5-HT2c de la strie terminale - Une explication des effets anxiogènes des inhibiteurs sélectifs de la recapture de la sérotonine (ISRS) ?.
[So] Source:Med Sci (Paris);33(1):87-89, 2017 Jan.
[Is] ISSN:1958-5381
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Ansiedade/prevenção & controle
Receptor 5-HT2C de Serotonina/fisiologia
Núcleos Septais/metabolismo
Inibidores da Captação de Serotonina/farmacologia
[Mh] Termos MeSH secundário: Animais
Ansiedade/metabolismo
Reação de Congelamento Cataléptica
Receptor 5-HT2C de Serotonina/metabolismo
Núcleos Septais/efeitos dos fármacos
Núcleos Septais/fisiologia
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Receptor, Serotonin, 5-HT2C); 0 (Serotonin Uptake Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1051/medsci/20173301015


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[PMID]:28117439
[Au] Autor:Fadok JP; Krabbe S; Markovic M; Courtin J; Xu C; Massi L; Botta P; Bylund K; Müller C; Kovacevic A; Tovote P; Lüthi A
[Ad] Endereço:Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
[Ti] Título:A competitive inhibitory circuit for selection of active and passive fear responses.
[So] Source:Nature;542(7639):96-100, 2017 02 02.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:When faced with threat, the survival of an organism is contingent upon the selection of appropriate active or passive behavioural responses. Freezing is an evolutionarily conserved passive fear response that has been used extensively to study the neuronal mechanisms of fear and fear conditioning in rodents. However, rodents also exhibit active responses such as flight under natural conditions. The central amygdala (CEA) is a forebrain structure vital for the acquisition and expression of conditioned fear responses, and the role of specific neuronal sub-populations of the CEA in freezing behaviour is well-established. Whether the CEA is also involved in flight behaviour, and how neuronal circuits for active and passive fear behaviour interact within the CEA, are not yet understood. Here, using in vivo optogenetics and extracellular recordings of identified cell types in a behavioural model in which mice switch between conditioned freezing and flight, we show that active and passive fear responses are mediated by distinct and mutually inhibitory CEA neurons. Cells expressing corticotropin-releasing factor (CRF ) mediate conditioned flight, and activation of somatostatin-positive (SOM ) neurons initiates passive freezing behaviour. Moreover, we find that the balance between conditioned flight and freezing behaviour is regulated by means of local inhibitory connections between CRF and SOM neurons, indicating that the selection of appropriate behavioural responses to threat is based on competitive interactions between two defined populations of inhibitory neurons, a circuit motif allowing for rapid and flexible action selection.
[Mh] Termos MeSH primário: Reação de Fuga/fisiologia
Medo/fisiologia
Medo/psicologia
Reação de Congelamento Cataléptica/fisiologia
Inibição Neural
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Animais
Núcleo Central da Amígdala/citologia
Núcleo Central da Amígdala/fisiologia
Hormônio Liberador da Corticotropina/metabolismo
Locomoção/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Modelos Neurológicos
Vias Neurais
Optogenética
Somatostatina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
51110-01-1 (Somatostatin); 9015-71-8 (Corticotropin-Releasing Hormone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1038/nature21047


  10 / 974 MEDLINE  
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Quillfeldt, Jorge A
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[PMID]:28100032
[Au] Autor:Pedraza LK; Sierra RO; Crestani AP; Quillfeldt JA; de Oliveira Alvares L
[Ad] Endereço:Laboratório de Neurobiologia da Memória, Biophysics Department, Biosciences Institute, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Título:Sequential learning during contextual fear conditioning guides the rate of systems consolidation: Implications for consolidation of multiple memory traces.
[So] Source:Hippocampus;27(5):518-528, 2017 May.
[Is] ISSN:1098-1063
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Systems consolidation has been described as a time-dependent reorganization process involving the neocortical and hippocampal networks underlying memory storage and retrieval. Previous studies of our lab were able to demonstrate that systems consolidation is a dynamic process, rather than a merely passive, time-dependent phenomenon. Here, we studied the influence of sequential learning in contextual fear conditioning (CFC) with different training intensities in the time-course of hippocampal dependency and contextual specificity. We found that sequential learning with high-intensity shocks during CFC induces generalization of the first learning (context A) and maintains contextual specificity of the second learning (context B) 15 days after acquisition. Moreover, subsequent experiences reorganize brain structures involved in retrieval, accelerating the involvement of cortical structures and diminishing the hippocampal participation. Exposure to original context before novelty seems to only induce context specificity in hippocampal-dependent memories. We propose that systems consolidation could be considered a potential biological mechanism for reducing possible interferences between similar memory traces. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Condicionamento (Psicologia)/fisiologia
Medo/fisiologia
Consolidação da Memória/fisiologia
[Mh] Termos MeSH secundário: Animais
Cateteres de Demora
Condicionamento (Psicologia)/efeitos dos fármacos
Eletrochoque
Medo/efeitos dos fármacos
Reação de Congelamento Cataléptica/efeitos dos fármacos
Reação de Congelamento Cataléptica/fisiologia
Agonistas de Receptores de GABA-A/farmacologia
Giro do Cíngulo/efeitos dos fármacos
Giro do Cíngulo/fisiologia
Hipocampo/efeitos dos fármacos
Hipocampo/fisiologia
Masculino
Consolidação da Memória/efeitos dos fármacos
Muscimol/farmacologia
Testes Neuropsicológicos
Distribuição Aleatória
Ratos Wistar
Receptores de GABA-A/metabolismo
Fatores de Tempo
Transferência de Experiência (Psicologia)/efeitos dos fármacos
Transferência de Experiência (Psicologia)/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 0 (Receptors, GABA-A); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1002/hipo.22708



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