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[PMID]:29045469
[Au] Autor:Ly V; Roijendijk L; Hazebroek H; Tonnaer C; Hagenaars MA
[Ad] Endereço:Department of Clinical Psychology, Leiden University, Leiden, The Netherlands.
[Ti] Título:Incident experience predicts freezing-like responses in firefighters.
[So] Source:PLoS One;12(10):e0186648, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Freezing is a defensive response to acute stress that is associated with coping and alterations in attentional processing. However, it remains unclear whether individuals in high risk professions, who are skilled at making rapid decisions in emergency situations, show altered threat-induced freezing. Here we investigated the effect of incident experience in a high risk profession on freezing. Additionally, we explored whether any effect of incident experience on freezing would be different for profession-related and -unrelated threat. Forty experienced and inexperienced firefighters were presented neutral, pleasant, related-unpleasant, and unrelated-unpleasant pictures in a passive viewing task. Postural sway and heart rate were assessed to determine freezing. Both postural and heart rate data evidenced reduced freezing upon unpleasant pictures in the experienced versus the inexperienced group. Relatedness of the unpleasant pictures did not modulate these effects. These findings indicate that higher incident experience relates to decreased threat-induced freezing, at least in a passive task context. This might suggest that primary defense responses are malleable through experience. Finally, these findings demonstrate the potential of using animal to human translational approaches to investigate defensive behaviors in relation to incident experience in high risk professions and stimulate future research on the role of freezing in resilience and coping.
[Mh] Termos MeSH primário: Bombeiros
Reação de Congelamento Cataléptica/fisiologia
[Mh] Termos MeSH secundário: Adulto
Nível de Alerta/fisiologia
Demografia
Frequência Cardíaca/fisiologia
Seres Humanos
Resposta de Imobilidade Tônica/fisiologia
Masculino
Equilíbrio Postural/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186648


  2 / 550 MEDLINE  
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[PMID]:28842312
[Au] Autor:Xie X; Chen Y; Wang Q; Shen Q; Ma L; Huang L; Wu T; Fu Z
[Ad] Endereço:College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
[Ti] Título:Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.
[So] Source:Life Sci;188:96-100, 2017 Nov 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Our previous finding demonstrates that major depressive disorder can mediate accelerated aging in rats. Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors. However, whether desipramine can rescue age-related phenotypes in depressed individuals is not understood. In the present study, we investigated the physiological function of desipramine on rescuing the age-related phenotypes in these animals. MAIN METHODS: The rats were induced by chronic mild stress paradigm, and the depression-like behaviors of rats were detected by sucrose intake test, open field test (OFT) and forced swimming test (FST). Then the depressed rats were treated by desipramine. KEY FINDINGS: Desipramine administration was effective in counteracting depression-like behaviors by increasing the sucrose solution intake, reducing the immobility time in the FST, and increasing total distance travelled and numbers of grid line crossed in the OFT. Moreover, desipramine treatment was able to reduce the oxidative damage to rat liver, and to increase the expression of telomerase reverse transcriptase (TERT), leading to correspondingly restored telomerase activity. SIGNIFICANCE: Our findings identify that one function of desipramine may partly be to rescue age-related phenotypes in depressed individuals induced by chronic stress.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Comportamento Animal/efeitos dos fármacos
Depressão/complicações
Depressão/tratamento farmacológico
Desipramina/farmacologia
Estresse Fisiológico/efeitos dos fármacos
Estresse Psicológico/tratamento farmacológico
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Animais
Antidepressivos Tricíclicos/farmacologia
Ingestão de Alimentos/efeitos dos fármacos
Resposta de Imobilidade Tônica/efeitos dos fármacos
Fígado/metabolismo
Masculino
Atividade Motora/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Fenótipo
Ratos
Estresse Psicológico/metabolismo
Estresse Psicológico/psicologia
Telomerase/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents, Tricyclic); EC 2.7.7.49 (Telomerase); TG537D343B (Desipramine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


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[PMID]:28732029
[Au] Autor:Passos LF; Garcia G; Young RJ
[Ad] Endereço:School of Environment and Life Sciences, Peel Building, University of Salford Manchester, Salford, United Kingdom.
[Ti] Título:The tonic immobility test: Do wild and captive golden mantella frogs (Mantella aurantiaca) have the same response?
[So] Source:PLoS One;12(7):e0181972, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adaptations to captivity that reduce fitness are one of many reasons, which explain the low success rate of reintroductions. One way of testing this hypothesis is to compare an important behavioural response in captive and wild members of the same species. Thanatosis, is an anti-predator strategy that reduces the risk of death from predation, which is a common behavioral response in frogs. The study subjects for this investigation were captive and wild populations of Mantella aurantiaca. Thanatosis reaction was measured using the Tonic Immobility (TI) test, a method that consists of placing a frog on its back, restraining it in this position for a short period of time and then releasing it and measuring how much time was spent feigning death. To understand the pattern of reaction time, morphometric data were also collected as body condition can affect the duration of thanatosis. The significantly different TI times found in this study, one captive population with shorter responses, were principally an effect of body condition rather than being a result of rearing environment. However, this does not mean that we can always dismiss the importance of rearing environment in terms of behavioural skills expressed.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Anuros/fisiologia
Resposta de Imobilidade Tônica/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Predatório/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181972


  4 / 550 MEDLINE  
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[PMID]:28589545
[Au] Autor:Möller A; Söndergaard HP; Helström L
[Ad] Endereço:Department of Clinical Science and Education, Karolinska Institute, Stockholm, Sweden.
[Ti] Título:Tonic immobility during sexual assault - a common reaction predicting post-traumatic stress disorder and severe depression.
[So] Source:Acta Obstet Gynecol Scand;96(8):932-938, 2017 Aug.
[Is] ISSN:1600-0412
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Active resistance is considered to be the 'normal' reaction during rape. However, studies have indicated that similar to animals, humans exposed to extreme threat may react with a state of involuntary, temporary motor inhibition known as tonic immobility. The aim of the present study was to assess the occurrence of tonic immobility during rape and subsequent post-traumatic stress disorder and severe depression. MATERIAL AND METHODS: Tonic immobility at the time of the assault was assessed using the Tonic Immobility Scale in 298 women who had visited the Emergency clinic for raped women within 1 month of a sexual assault. Information about the assault and the victim characteristics were taken from the structured clinical data files. After 6 months, 189 women were assessed regarding the development of post-traumatic stress disorder and depression. RESULTS: Of the 298 women, 70% reported significant tonic immobility and 48% reported extreme tonic immobility during the assault. Tonic immobility was associated with the development of post-traumatic stress disorder (OR 2.75; 95% CI 1.50-5.03, p = 0.001) and severe depression (OR 3.42; 95% CI 1.51-7.72, p = 0.003) at 6 months. Further, previous trauma history (OR 2.36; 95% CI 1.48-3.77, p < 0.001) and psychiatric treatment history (OR 2.00; 95% CI 1.26-3.19, p = 0.003) were associated with the tonic immobility response. CONCLUSIONS: Tonic immobility during rape is a common reaction associated with subsequent post-traumatic stress disorder and severe depression. Knowledge of this reaction in sexual assault victims is important in legal matters and for healthcare follow up.
[Mh] Termos MeSH primário: Transtorno Depressivo/psicologia
Resposta de Imobilidade Tônica
Estupro
Transtornos de Estresse Pós-Traumáticos/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Meia-Idade
Valor Preditivo dos Testes
Escalas de Graduação Psiquiátrica
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1111/aogs.13174


  5 / 550 MEDLINE  
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[PMID]:28587054
[Au] Autor:Ganapathi R; Manda K
[Ad] Endereço:NeuroBehavior Laboratory, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
[Ti] Título:Later Life Changes in Hippocampal Neurogenesis and Behavioral Functions After Low-Dose Prenatal Irradiation at Early Organogenesis Stage.
[So] Source:Int J Radiat Oncol Biol Phys;98(1):63-74, 2017 May 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate long-term changes in behavioral functions of mice after exposure to low-dose prenatal radiation at an early organogenesis stage. METHODS AND MATERIALS: Pregnant C57BL/6J mice were irradiated (20 cGy) at postcoitus day 5.5. The male and female offspring were subjected to different behavioral assays for affective, motor, and cognitive functions at 3, 6, and 12 months of age. Behavioral functions were further correlated with the population of CA1 and CA3 pyramidal neurons and immature neurons in hippocampal dentate gyrus. RESULTS: Prenatally exposed mice of different age groups showed a sex-specific pattern of sustained changes in behavioral functions. Male mice showed significant changes in anxiety-like phenotypes, learning, and long-term memory at age 3 months. At 6 months of age such behavioral functions were recovered to a normal level but could not be sustained at age 12 months. Female mice showed an appreciable recovery in almost all behavioral functions at 12 months. Patterns of change in learning and long-term memory were comparable to the population of CA1 and CA3 pyramidal neurons and doublecortin-positive neurons in hippocampus. CONCLUSION: Our finding suggests that prenatal (early organogenesis stage) irradiation even at a lower dose level (20 cGy) is sufficient to cause potential changes in neurobehavioral function at later stages of life. Male mice showed relatively higher vulnerability to radiation-induced neurobehavioral changes as compared with female.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos da radiação
Hipocampo/efeitos da radiação
Neurogênese/efeitos da radiação
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Afeto/fisiologia
Afeto/efeitos da radiação
Fatores Etários
Animais
Comportamento Animal/fisiologia
Peso Corporal/efeitos da radiação
Cognição/fisiologia
Cognição/efeitos da radiação
Comportamento Exploratório/fisiologia
Comportamento Exploratório/efeitos da radiação
Feminino
Hipocampo/embriologia
Hipocampo/patologia
Resposta de Imobilidade Tônica/fisiologia
Resposta de Imobilidade Tônica/efeitos da radiação
Locomoção/fisiologia
Locomoção/efeitos da radiação
Masculino
Aprendizagem em Labirinto/efeitos da radiação
Memória de Longo Prazo/fisiologia
Memória de Longo Prazo/efeitos da radiação
Camundongos
Camundongos Endogâmicos C57BL
Destreza Motora/fisiologia
Destreza Motora/efeitos da radiação
Neurogênese/fisiologia
Gravidez
Dose de Radiação
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


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[PMID]:28436980
[Au] Autor:Burgos-Robles A; Kimchi EY; Izadmehr EM; Porzenheim MJ; Ramos-Guasp WA; Nieh EH; Felix-Ortiz AC; Namburi P; Leppla CA; Presbrey KN; Anandalingam KK; Pagan-Rivera PA; Anahtar M; Beyeler A; Tye KM
[Ad] Endereço:Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
[Ti] Título:Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
[So] Source:Nat Neurosci;20(6):824-835, 2017 Jun.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiologia
Córtex Pré-Frontal/fisiologia
Punição
Recompensa
[Mh] Termos MeSH secundário: 2-Amino-5-fosfonovalerato/administração & dosagem
2-Amino-5-fosfonovalerato/farmacologia
Potenciais de Ação/fisiologia
Animais
Condicionamento Clássico/efeitos dos fármacos
Condicionamento Clássico/fisiologia
Sinais (Psicologia)
Discriminação (Psicologia)/efeitos dos fármacos
Discriminação (Psicologia)/fisiologia
Estimulação Elétrica
Resposta de Imobilidade Tônica/fisiologia
Masculino
Microinjeções
Inibição Neural/fisiologia
Vias Neurais/fisiologia
Córtex Pré-Frontal/efeitos dos fármacos
Quinoxalinas/administração & dosagem
Quinoxalinas/farmacologia
Ratos
Ratos Transgênicos
Sacarose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Quinoxalines); 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline); 57-50-1 (Sucrose); 76726-92-6 (2-Amino-5-phosphonovalerate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4553


  7 / 550 MEDLINE  
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Volchan, Eliane
Andreoli, Sérgio Baxter
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[PMID]:28319694
[Au] Autor:Kalaf J; Coutinho ESF; Vilete LMP; Luz MP; Berger W; Mendlowicz M; Volchan E; Andreoli SB; Quintana MI; de Jesus Mari J; Figueira I
[Ad] Endereço:Institute of Psychiatry, Universidade Federal do Rio de Janeiro (IPUB-UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: jukalaf@gmail.com.
[Ti] Título:Sexual trauma is more strongly associated with tonic immobility than other types of trauma - A population based study.
[So] Source:J Affect Disord;215:71-76, 2017 Jun.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tonic immobility is an involuntary motor and vocal inhibition reaction, considered the last-ditch response of the defensive cascade model. It is elicited in context of inescapable threat and perception of entrapment. Our aim was to investigate the association between different traumatic events and peritraumatic tonic immobility (PTI) in a representative sample of the general population. METHODS: This is a cross-sectional study of general population from Rio de Janeiro and São Paulo with 3231 victims of traumatic events aged 15-75 years who completed the Tonic Immobility Scale (TIS). We calculated the frequency of the different traumatic events and estimated the mean scores with 95% confidence intervals for each traumatic event, controlling for the potential confounders using multiple linear regression models. Finally, we calculated the proportion of individual scoring zero in TIS for the 16 traumatic events. RESULTS: PTI scores in child sexual abuse and adult sexual violence were almost twice as high as in other types of traumatic events, even when controlled for gender and educational level. Torture and war also showed high PTI scores, but these were based on very small number of cases and need to be interpreted with caution. Furthermore, victims of sexual trauma had the lowest proportion of individuals with total absence of PTI symptoms. LIMITATIONS: This is a cross-sectional study and causal inferences must be drawn with caution. CONCLUSIONS: Peritraumatic tonic immobility is more strongly associated with sexual trauma, particularly in childhood, than to other types of trauma in the general population.
[Mh] Termos MeSH primário: Abuso Sexual na Infância/psicologia
Resposta de Imobilidade Tônica
Delitos Sexuais/psicologia
Transtornos de Estresse Pós-Traumáticos/etiologia
Violência/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Exposição à Guerra
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28288814
[Au] Autor:Flores-Burgess A; Millón C; Gago B; Narváez M; Borroto-Escuela DO; Mengod G; Narváez JA; Fuxe K; Santín L; Díaz-Cabiale Z
[Ad] Endereço:Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, Spain.
[Ti] Título:Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.
[So] Source:Neuropharmacology;118:233-241, 2017 May 15.
[Is] ISSN:1873-7064
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-HT) activity. Specifically, selective 5-HT reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its effect of elevating 5-HT is limited. The interaction between serotoninergic system and neuropeptides signaling could be a key aspect. We examined the ability of the neuropeptide Galanin(1-15) [GAL(1-15)] to modulate the behavioral effects of FLX in the forced swimming test (FST) and studied feasible molecular mechanisms. The data show that GAL(1-15) enhances the antidepressant-like effects induced by FLX in the FST, and we demonstrate the involvement of GALR1/GALR2 heteroreceptor complex in the GAL(1-15)-mediated effect using in vivo rat models for siRNA GALR1 or GALR2 knockdown. Importantly, 5-HT1A receptors (5HT1A-R) also participate in the GAL(1-15)/FLX interactions since the 5HT1AR antagonist WAY100635 blocked the behavioral effects in the FST induced by the coadministration of GAL(1-15) and FLX. The mechanism underlying GAL(1-15)/FLX interactions affected the binding characteristics as well as the mRNA levels of 5-HT1A-R specifically in the dorsal hippocampus while leaving unaffected mRNA levels and affinity and binding sites of this receptor in the dorsal raphe. The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Depressão/tratamento farmacológico
Depressão/fisiopatologia
Fluoxetina/uso terapêutico
Galanina/uso terapêutico
Fragmentos de Peptídeos/uso terapêutico
Natação/psicologia
[Mh] Termos MeSH secundário: Animais
Autorradiografia
Cicloexanos/uso terapêutico
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Sistemas de Liberação de Medicamentos
Quimioterapia Combinada
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Resposta de Imobilidade Tônica/efeitos dos fármacos
Masculino
Piperazinas/uso terapêutico
RNA Interferente Pequeno/metabolismo
Ratos
Ratos Sprague-Dawley
Receptor Tipo 1 de Galanina/genética
Receptor Tipo 1 de Galanina/metabolismo
Receptor Tipo 2 de Galanina/genética
Receptor Tipo 2 de Galanina/metabolismo
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Cyclohexanes); 0 (Peptide Fragments); 0 (Piperazines); 0 (RNA, Small Interfering); 0 (Receptor, Galanin, Type 1); 0 (Receptor, Galanin, Type 2); 0 (WAY 101363); 01K63SUP8D (Fluoxetine); 112747-70-3 (galanin (1-15)); 88813-36-9 (Galanin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28247204
[Au] Autor:Smaga I; Jastrzebska J; Zaniewska M; Bystrowska B; Gawlinski D; Faron-Górecka A; Broniowska Z; Miszkiel J; Filip M
[Ad] Endereço:Department of Toxicology, Faculty of Pharmacy, College of Medicum, Jagiellonian University, Medyczna 9, PL 30-688, Kraków, Poland.
[Ti] Título:Changes in the Brain Endocannabinoid System in Rat Models of Depression.
[So] Source:Neurotox Res;31(3):421-435, 2017 Apr.
[Is] ISSN:1476-3524
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A growing body of evidence implicates the endocannabinoid (eCB) system in the pathophysiology of depression. The aim of this study was to investigate the influence of changes in the eCB system, such as levels of neuromodulators, eCB synthesizing and degrading enzymes, and cannabinoid (CB) receptors, in different brain structures in animal models of depression using behavioral and biochemical analyses. Both models used, i.e., bulbectomized (OBX) and Wistar Kyoto (WKY) rats, were characterized at the behavioral level by increased immobility time. In the OBX rats, anandamide (AEA) levels were decreased in the prefrontal cortex, hippocampus, and striatum and increased in the nucleus accumbens, while 2-arachidonoylglycerol (2-AG) levels were increased in the prefrontal cortex and decreased in the nucleus accumbens with parallel changes in the expression of eCB metabolizing enzymes in several structures. It was also observed that CB receptor expression decreased in the hippocampus, dorsal striatum, and nucleus accumbens, and CB receptor expression decreased in the prefrontal cortex and hippocampus. In WKY rats, the levels of eCBs were reduced in the prefrontal cortex (2-AG) and dorsal striatum (AEA) and increased in the prefrontal cortex (AEA) with different changes in the expression of eCB metabolizing enzymes, while the CB receptor density was increased in several brain regions. These findings suggest that dysregulation in the eCB system is implicated in the pathogenesis of depression, although neurochemical changes were linked to the particular brain structure and the factor inducing depression (surgical removal of the olfactory bulbs vs. genetic modulation).
[Mh] Termos MeSH primário: Ácidos Araquidônicos/metabolismo
Encéfalo/metabolismo
Depressão/metabolismo
Endocanabinoides/metabolismo
Glicerídeos/metabolismo
Alcamidas Poli-Insaturadas/metabolismo
Receptor CB1 de Canabinoide/biossíntese
Receptor CB2 de Canabinoide/biossíntese
[Mh] Termos MeSH secundário: Amidoidrolases/biossíntese
Animais
Modelos Animais de Doenças
Resposta de Imobilidade Tônica
Lipase Lipoproteica/biossíntese
Masculino
Monoacilglicerol Lipases/biossíntese
Bulbo Olfatório/cirurgia
Fosfolipase D/biossíntese
Ratos
Ratos Endogâmicos WKY
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (Glycerides); 0 (Polyunsaturated Alkamides); 0 (Receptor, Cannabinoid, CB1); 0 (Receptor, Cannabinoid, CB2); 8D239QDW64 (glyceryl 2-arachidonate); EC 3.1.1.23 (Monoacylglycerol Lipases); EC 3.1.1.34 (Lipoprotein Lipase); EC 3.1.4.4 (NAPE-PLD protein, rat); EC 3.1.4.4 (Phospholipase D); EC 3.5.- (Amidohydrolases); EC 3.5.1.- (fatty-acid amide hydrolase); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s12640-017-9708-y


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[PMID]:28174136
[Au] Autor:Oliveira CE; Sari MH; Zborowski VA; Araujo PC; Nogueira CW; Zeni G
[Ad] Endereço:Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.
[Ti] Título:p,p'-Methoxyl-diphenyl diselenide elicits an antidepressant-like effect in mice without discontinuation anxiety phenotype.
[So] Source:Pharmacol Biochem Behav;154:31-38, 2017 Mar.
[Is] ISSN:1873-5177
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Major depressive disorder is the most severe and debilitating disease among psychiatric illnesses. The abrupt interruption of antidepressant treatment may lead to a complex physiological and neuropsychiatric syndrome. The organoselenium compound (MeOPhSe) has been reported to have neuroprotective properties in animal models. The study aimed to investigate the effects of single or repeated administration of (MeOPhSe) on depressive-like behavior and if the compound administration, and its discontinuation, may affect the anxiolytic-like phenotype in Swiss mice. The results showed that repeated intragastric administration of (MeOPhSe) (dose range: 0.1-5mg/kg), different from a single administration, reduced the immobility time in the mouse tail suspension test. A single administration of (MeOPhSe) at a dose of 5mg/kg decreased the immobility time, increased the swimming time and did not alter the climbing behavior in the modified forced swimming test (mFST). Repeated administration of (MeOPhSe) decreased the immobility time, did not alter the swimming time and increased the climbing behavior in the mouse mFST. Repeated administration of (MeOPhSe) at a dose of 5mg/kg elicited a mouse anxiolytic-like phenotype in the elevated plus maze and light-dark tests. Markers of hepatic and renal function tests were not altered by repeated administration of (MeOPhSe) to mice. The findings indicate that a single or repeated administration of (MeOPhSe) elicited an antidepressant-like action in mice. Moreover, repeated treatment with (MeOPhSe) produced an anxiolytic-like action in mice and its profile remained stable after discontinuation.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Antidepressivos/farmacologia
Resposta de Imobilidade Tônica/efeitos dos fármacos
Compostos Organosselênicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Relação Dose-Resposta a Droga
Testes de Função Renal
Testes de Função Hepática
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Antidepressive Agents); 0 (Organoselenium Compounds); 0 (p,p'-methoxyl-diphenyl diselenide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE



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