Base de dados : MEDLINE
Pesquisa : F01.145.113.700 [Categoria DeCS]
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[PMID]:28272358
[Au] Autor:Vullo D; Del Prete S; Di Fonzo P; Carginale V; Donald WA; Supuran CT; Capasso C
[Ad] Endereço:Laboratorio di Chimica Bioinorganica, Dipartimento Di Chimica, Università degli Studi di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy. daniela.vullo@unifi.it.
[Ti] Título:Comparison of the Sulfonamide Inhibition Profiles of the ß- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei.
[So] Source:Molecules;22(3), 2017 Mar 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We have cloned, purified, and characterized a ß-carbonic anhydrase (CA, EC 4.2.1.1), BpsCAß, from the pathogenic bacterium , responsible for the tropical disease melioidosis. The enzyme showed high catalytic activity for the physiologic CO2 hydration reaction to bicarbonate and protons, with the following kinetic parameters: k of 1.6 × 105 s and k /K of 3.4 × 107 M s . An inhibition study with a panel of 38 sulfonamides and one sulfamate-including 15 compounds that are used clinically-revealed an interesting structure-activity relationship for the interaction of this enzyme with these inhibitors. Many simple sulfonamides and clinically used agents such as topiramate, sulpiride, celecoxib, valdecoxib, and sulthiame were ineffective BpsCAß inhibitors (K > 50 µM). Other drugs, such as ethoxzolamide, dorzolamide, brinzolamide, zonisamide, indisulam, and hydrochlorothiazide were moderately potent micromolar inhibitors. The best inhibition was observed with benzene-1,3-disulfonamides-benzolamide and its analogs acetazolamide and methazolamide-which showed K in the range of 185-745 nM. The inhibition profile of BpsCAß is very different from that of the γ-class enzyme from the same pathogen, BpsCAγ. Thus, identifying compounds that would effectively interact with both enzymes is relatively challenging. However, benzolamide was one of the best inhibitors of both of these CAs with K of 653 and 185 nM, respectively, making it an interesting lead compound for the design of more effective agents, which may be useful tools for understanding the pathogenicity of this bacterium.
[Mh] Termos MeSH primário: Burkholderia pseudomallei/efeitos dos fármacos
Burkholderia pseudomallei/enzimologia
Inibidores da Anidrase Carbônica/farmacologia
Sulfanilamidas/farmacologia
[Mh] Termos MeSH secundário: Burkholderia pseudomallei/genética
Ativação Enzimática/efeitos dos fármacos
Cinese
Estrutura Molecular
Proteínas Recombinantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonic Anhydrase Inhibitors); 0 (Recombinant Proteins); 0 (Sulfanilamides); 21240MF57M (sulfanilamide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:27921292
[Au] Autor:Bailleul AM; Witmer LM; Holliday CM
[Ad] Endereço:Department of Pathology and Anatomical Sciences, University of Missouri-School of Medicine, Columbia, MO, USA.
[Ti] Título:Cranial joint histology in the mallard duck (Anas platyrhynchos): new insights on avian cranial kinesis.
[So] Source:J Anat;230(3):444-460, 2017 Mar.
[Is] ISSN:1469-7580
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The evolution of avian cranial kinesis is a phenomenon in part responsible for the remarkable diversity of avian feeding adaptations observable today. Although osteological, developmental and behavioral features of the feeding system are frequently studied, comparatively little is known about cranial joint skeletal tissue composition and morphology from a microscopic perspective. These data are key to understanding the developmental, biomechanical and evolutionary underpinnings of kinesis. Therefore, here we investigated joint microstructure in juvenile and adult mallard ducks (Anas platyrhynchos; Anseriformes). Ducks belong to a diverse clade of galloanseriform birds, have derived adaptations for herbivory and kinesis, and are model organisms in developmental biology. Thus, new insights into their cranial functional morphology will refine our understanding of avian cranial evolution. A total of five specimens (two ducklings and three adults) were histologically sampled, and two additional specimens (a duckling and an adult) were subjected to micro-computed tomographic scanning. Five intracranial joints were sampled: the jaw joint (quadrate-articular); otic joint (quadrate-squamosal); palatobasal joint (parasphenoid-pterygoid); the mandibular symphysis (dentary-dentary); and the craniofacial hinge (a complex flexion zone involving four different pairs of skeletal elements). In both the ducklings and adults, the jaw, otic and palatobasal joints are all synovial, with a synovial cavity and articular cartilage on each surface (i.e. bichondral joints) ensheathed in a fibrous capsule. The craniofacial hinge begins as an ensemble of patent sutures in the duckling, but in the adult it becomes more complex: laterally it is synovial; whereas medially, it is synostosed by a bridge of chondroid bone. We hypothesize that it is chondroid bone that provides some of the flexible properties of this joint. The heavily innervated mandibular symphysis is already fused in the ducklings and remains as such in the adult. The results of this study will serve as reference for documenting avian cranial kinesis from a microanatomical perspective. The formation of: (i) secondary articular cartilage on the membrane bones of extant birds; and (ii) their unique ability to form movable synovial joints within two or more membrane bones (i.e. within their dermatocranium) might have played a role in the origin and evolution of modern avian cranial kinesis during dinosaur evolution.
[Mh] Termos MeSH primário: Patos/anatomia & histologia
Articulações/anatomia & histologia
Cinese
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1111/joa.12562


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[PMID]:27507819
[Au] Autor:Imoto T
[Ad] Endereço:Professor Emeritus, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan imoto1825@beach.ocn.ne.jp.
[Ti] Título:Derivation of a valid momentary first-order rate constant for kinetic and energetic analyses of enzymatic reactions.
[So] Source:J Biochem;160(6):381-389, 2016 Dec.
[Is] ISSN:1756-2651
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To analyze enzymatic reactions energetically for comparison with non-enzymatic reactions (first order) under the same dimension, a method to derive valid momentary first-order rate constants for enzymatic reactions was developed. The momentary first-order rate constant, k = k [E'S'] /[S] , was derived for an enzymatic reaction under a certain condition. It was shown that this rate constant is applicable for a wide range of enzymatic reactions. Utilizing this constant, one can conduct reliable kinetic and energetic analyses of enzymatic reactions.
[Mh] Termos MeSH primário: Enzimas/química
Modelos Químicos
[Mh] Termos MeSH secundário: Cinese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzymes)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


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[PMID]:26284366
[Au] Autor:McDonald LM; Griffin HJ; Angeli A; Torkamani M; Georgiev D; Jahanshahi M
[Ad] Endereço:Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom.
[Ti] Título:Motivational Modulation of Self-Initiated and Externally Triggered Movement Speed Induced by Threat of Shock: Experimental Evidence for Paradoxical Kinesis in Parkinson's Disease.
[So] Source:PLoS One;10(8):e0135149, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Paradoxical kinesis has been observed in bradykinetic people with Parkinson's disease. Paradoxical kinesis occurs in situations where an individual is strongly motivated or influenced by relevant external cues. Our aim was to induce paradoxical kinesis in the laboratory. We tested whether the motivation of avoiding a mild electric shock was sufficient to induce paradoxical kinesis in externally-triggered and self-initiated conditions in people with Parkinson's disease tested on medication and in age-matched controls. METHODS: Participants completed a shock avoidance behavioural paradigm in which half of the trials could result in a mild electric shock if the participant did not move fast enough. Half of the trials of each type were self-initiated and half were externally-triggered. The criterion for avoiding shock was a maximum movement time, adjusted according to each participant's performance on previous trials using a staircase tracking procedure. RESULTS: On trials with threat of shock, both patients with Parkinson's disease and controls had faster movement times compared to no potential shock trials, in both self-initiated and externally-triggered conditions. The magnitude of improvement of movement time from no potential shock to potential shock trials was positively correlated with anxiety ratings. CONCLUSIONS: When motivated to avoid mild electric shock, patients with Parkinson's disease, similar to healthy controls, showed significant speeding of movement execution. This was observed in both self-initiated and externally-triggered versions of the task. Nevertheless, in the ET condition the improvement of reaction times induced by motivation to avoid shocks was greater for the PD patients than controls, highlighting the value of external cues for movement initiation in PD patients. The magnitude of improvement from the no potential shock to the potential shock trials was associated with the threat-induced anxiety. This demonstration of paradoxical kinesis in the laboratory under both self-initiated and externally-triggered conditions has implications for motivational and attentional enhancement of movement speed in Parkinson's disease.
[Mh] Termos MeSH primário: Cinese
Motivação
Movimento
Doença de Parkinson/fisiopatologia
Doença de Parkinson/psicologia
[Mh] Termos MeSH secundário: Idoso
Sinais (Psicologia)
Estimulação Elétrica
Retroalimentação
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150819
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0135149


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[PMID]:25975215
[Au] Autor:Xu H; Wang Y; Greenland K; Bloswick D; Merryweather A
[Ad] Endereço:School of Medical Imaging, XuZhou Medical College, Xuzhou, China; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: h_xu@xzmc.edu.cn.
[Ti] Título:The influence of deformation height on estimating the center of pressure during level and cross-slope walking on sand.
[So] Source:Gait Posture;42(2):110-5, 2015 Jul.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Force plates are frequently used to collect the ground reaction forces (GRF) and center of pressure (COP) during gait. The calculated COP is affected by the material type and thickness covering the top surface. If the surface is deformable, these effects can be significant. The purpose of this study is to simulate and evaluate the effects of deformation height when calculating the COP in a deformable surface during gait. The GRF and COP data during normal gait were collected from 20 healthy adult males on sand in two conditions (level and cross-slope of 10°). The COP differences in the anteroposterior (AP) and mediolateral (ML) directions were modeled for constant deformation heights (10-50 mm, 10 mm increments). The results showed the magnitude of COP changes in the AP and ML directions were different in both level and cross-slope conditions. A significantly larger COPML difference was shown for the cross-slope condition than level condition for the same deformation height. The COP was more sensitive to the deformation height for the downhill limb than uphill limb in the cross-slope condition. The results of this study suggest that the maximum allowable deformation height before a correction for surface deformation is needed is 20mm for level condition and 10mm for cross-slope condition, where 3mm difference in COP is considered as the tolerance limit. Surface deformations beyond these thresholds may lead to an inaccurate interpretation and evaluation of joint kinetics during gait on deformable surfaces.
[Mh] Termos MeSH primário: Fenômenos Biomecânicos
Marcha
Cinese
Equilíbrio Postural
Dióxido de Silício
Caminhada
Suporte de Carga
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Propriedades de Superfície
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150727
[Lr] Data última revisão:
150727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE


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[PMID]:25798914
[Au] Autor:Machová I; Snásel J; Dostál J; Brynda J; Fanfrlík J; Singh M; Tarábek J; Vanek O; Bednárová L; Pichová I
[Ad] Endereço:Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
[Ti] Título:Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis.
[So] Source:PLoS One;10(3):e0120682, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms metabolism in response to the host niche. Phosphoenolpyruvate carboxykinase (Pck) is the enzyme at the center of the phosphoenolpyruvate-pyruvate-oxaloacetate node, which is involved in regulating the carbon flow distribution to catabolism, anabolism, or respiration in different states of Mtb infection. Under standard growth conditions, Mtb Pck is associated with gluconeogenesis and catalyzes the metal-dependent formation of phosphoenolpyruvate. In non-replicating Mtb, Pck can catalyze anaplerotic biosynthesis of oxaloacetate. Here, we present insights into the regulation of Mtb Pck activity by divalent cations. Through analysis of the X-ray structure of Pck-GDP and Pck-GDP-Mn2+ complexes, mutational analysis of the GDP binding site, and quantum mechanical (QM)-based analysis, we explored the structural determinants of efficient Mtb Pck catalysis. We demonstrate that Mtb Pck requires presence of Mn2+ and Mg2+ cations for efficient catalysis of gluconeogenic and anaplerotic reactions. The anaplerotic reaction, which preferably functions in reducing conditions that are characteristic for slowed or stopped Mtb replication, is also effectively activated by Fe2+ in the presence of Mn2+ or Mg2+ cations. In contrast, simultaneous presence of Fe2+ and Mn2+ or Mg2+ inhibits the gluconeogenic reaction. These results suggest that inorganic ions can contribute to regulation of central carbon metabolism by influencing the activity of Pck. Furthermore, the X-ray structure determination, biochemical characterization, and QM analysis of Pck mutants confirmed the important role of the Phe triad for proper binding of the GDP-Mn2+ complex in the nucleotide binding site and efficient catalysis of the anaplerotic reaction.
[Mh] Termos MeSH primário: Mycobacterium tuberculosis/enzimologia
Fosfoenolpiruvato Carboxiquinase (ATP)/química
Fosfoenolpiruvato Carboxiquinase (ATP)/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sítios de Ligação
Catálise
Cátions Bivalentes
Ativação Enzimática
Gluconeogênese
Seres Humanos
Ligações de Hidrogênio
Cinese
Modelos Moleculares
Dados de Sequência Molecular
Mutação
Mycobacterium tuberculosis/genética
Nucleotídeos/metabolismo
Fosfoenolpiruvato Carboxiquinase (ATP)/genética
Conformação Proteica
Multimerização Proteica
Alinhamento de Sequência
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cations, Divalent); 0 (Nucleotides); EC 4.1.1.49 (Phosphoenolpyruvate Carboxykinase (ATP))
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150324
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0120682


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[PMID]:25690901
[Au] Autor:Dubiez E; Aleksandrov A; Lazennec-Schurdevin C; Mechulam Y; Schmitt E
[Ad] Endereço:Laboratoire de Biochimie, Unité Mixte de Recherche 7654, Ecole Polytechnique, Centre National de la Recherche Scientifique, F-91128 Palaiseau cedex, France.
[Ti] Título:Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2.
[So] Source:Nucleic Acids Res;43(5):2946-57, 2015 Mar 11.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eukaryotic and archaeal translation initiation processes involve a heterotrimeric GTPase e/aIF2 crucial for accuracy of start codon selection. In eukaryotes, the GTPase activity of eIF2 is assisted by a GTPase-activating protein (GAP), eIF5. In archaea, orthologs of eIF5 are not found and aIF2 GTPase activity is thought to be non-assisted. However, no in vitro GTPase activity of the archaeal factor has been reported to date. Here, we show that aIF2 significantly hydrolyses GTP in vitro. Within aIF2γ, H97, corresponding to the catalytic histidine found in other translational GTPases, and D19, from the GKT loop, both participate in this activity. Several high-resolution crystal structures were determined to get insight into GTP hydrolysis by aIF2γ. In particular, a crystal structure of the H97A mutant was obtained in the presence of non-hydrolyzed GTP. This structure reveals the presence of a second magnesium ion bound to GTP and D19. Quantum chemical/molecular mechanical simulations support the idea that the second magnesium ion may assist GTP hydrolysis by helping to neutralize the developing negative charge in the transition state. These results are discussed in light of the absence of an identified GAP in archaea to assist GTP hydrolysis on aIF2.
[Mh] Termos MeSH primário: Proteínas Arqueais/metabolismo
Guanosina Trifosfato/metabolismo
Magnésio/metabolismo
Fatores de Iniciação de Peptídeos/metabolismo
[Mh] Termos MeSH secundário: Proteínas Arqueais/química
Proteínas Arqueais/genética
Cristalografia por Raios X
GTP Fosfo-Hidrolases/genética
GTP Fosfo-Hidrolases/metabolismo
Guanosina Trifosfato/química
Hidrólise
Cinese
Magnésio/química
Modelos Moleculares
Mutação
Fatores de Iniciação de Peptídeos/química
Fatores de Iniciação de Peptídeos/genética
Estrutura Terciária de Proteína
Sulfolobus solfataricus/genética
Sulfolobus solfataricus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Archaeal Proteins); 0 (Peptide Initiation Factors); 0 (initiation factor 2, archaeal); 86-01-1 (Guanosine Triphosphate); EC 3.6.1.- (GTP Phosphohydrolases); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150219
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkv053


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[PMID]:25661136
[Au] Autor:Chen M; Hill GM; Patrianakos TD; Ku ES; Chen ML
[Ad] Endereço:From the University of Hawaii (M. Chen), Honolulu, Hawaii, John H. Stroger, Jr. Hospital of Cook County (Hill, Patrianakos) and University of Illinois Chicago (Ku), Chicago, Illinois, and A.T. Still University (M.L. Chen), Mesa, Arizona, USA.
[Ti] Título:Oral diazepam versus intravenous midazolam for conscious sedation during cataract surgery performed using topical anesthesia.
[So] Source:J Cataract Refract Surg;41(2):415-21, 2015 Feb.
[Is] ISSN:1873-4502
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the intraoperative pain, anxiety, undesired movement, and cooperation between patients receiving oral diazepam or intravenous (IV) midazolam for conscious sedation during cataract surgery under topical anesthesia. SETTING: Ambulatory surgical center, Honolulu, Hawaii, USA. DESIGN: Prospective randomized controlled trial. METHODS: Patients having first-time cataract extraction with topical anesthesia were randomized to receive sedation with oral diazepam 30 minutes before surgery or IV midazolam immediately preceding surgery. The outcomes of intraoperative pain, anxiety, undesired movement, and poor cooperation were observed by the surgeon and recorded during surgery. RESULTS: One hundred fifty-six cataract surgeries were included, 83 in the IV midazolam group and 73 in the oral diazepam group. Twenty-four patients (29%) in the IV group and 7 patients (10%) in the oral group showed undesired movement (P < .02). Seven patients (8%) in the IV group and 2 patients (3%) in the oral group showed poor cooperation (P > .05). Fifteen patients (18%) in the IV group and 9 patients (12%) in the oral group had anxiety (P > .05). Three patients (4%) in the IV group and 3 patients (4%) in the oral group experienced pain (P > .05). CONCLUSIONS: Fewer patients receiving oral diazepam 30 minutes before cataract surgery than patients receiving IV midazolam immediately preceding surgery showed undesired movement during surgery. There was no statistically significant difference in the number of patients showing poor cooperation or experiencing pain or anxiety between the 2 groups. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
[Mh] Termos MeSH primário: Sedação Consciente/métodos
Diazepam/administração & dosagem
Hipnóticos e Sedativos/administração & dosagem
Implante de Lente Intraocular
Midazolam/administração & dosagem
Facoemulsificação/métodos
[Mh] Termos MeSH secundário: Administração Oral
Idoso
Anestésicos Intravenosos
Anestésicos Locais/administração & dosagem
Dor Ocular/diagnóstico
Dor Ocular/fisiopatologia
Feminino
Seres Humanos
Cinese
Masculino
Medição da Dor
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Anesthetics, Local); 0 (Hypnotics and Sedatives); Q3JTX2Q7TU (Diazepam); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150209
[Lr] Data última revisão:
150209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150210
[St] Status:MEDLINE


  9 / 271 MEDLINE  
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[PMID]:25465982
[Au] Autor:Mandic R; Jakovljevic S; Jaric S
[Ad] Endereço:University of Belgrade, Faculty of Sport and Physical Education, The Research Center, Blagoja Parovica 156, Belgrade, Serbia.
[Ti] Título:Effects of countermovement depth on kinematic and kinetic patterns of maximum vertical jumps.
[So] Source:J Electromyogr Kinesiol;25(2):265-72, 2015 Apr.
[Is] ISSN:1873-5711
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although maximum height (H(max)), muscle force (F), and power output (P), have been routinely obtained from maximum vertical jumps for various purposes, a possible role of the countermovement depth (H(cmd)) on the same variables remains largely unexplored. Here we hypothesized that (1) the optimum H(cmd) for maximizing H(max) exists, while (2) an increase in H(cmd) would be associated with a decrease in both F and P. Professional male basketball players (N=11) preformed maximum countermovement jumps with and without arm swing while varying H(cmd)±25 cm from its preferred value. Although regression models revealed a presence of optimum H(cmd) for maximizing H(max), H(max) revealed only small changes within a wide range of H(cmd). The preferred H(cmd) was markedly below its optimum value (p < .05). However, both F and P sharply decreased with H(cmd), while F also revealed a minimum for H(cmd) close to its highest values. Therefore, we conclude that although the optimum H(cmd) should exists, the magnitude of its effect on H(max) should be only minimal within a typical H(cmd) range. Conversely, F and P of leg muscles assessed through maximum vertical jumps should be taken with caution since both of them could be markedly confounded by H(cmd).
[Mh] Termos MeSH primário: Basquetebol/fisiologia
Teste de Esforço/métodos
Cinese/fisiologia
Perna (Membro)/fisiologia
Movimento/fisiologia
Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos/fisiologia
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1509
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141204
[St] Status:MEDLINE


  10 / 271 MEDLINE  
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[PMID]:24903694
[Au] Autor:Væver M; Beebe B; Kirk O; Snidmann N; Harder S; Tronick E
[Ad] Endereço:Department of Psychology, University of Copenhagen, Copenhagen, Denmark, mette.vaever@psy.ku.dk.
[Ti] Título:An automated approach for measuring infant head orientation in a face-to-face interaction.
[So] Source:Behav Res Methods;47(2):328-39, 2015 Jun.
[Is] ISSN:1554-3528
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Head orientation in face-to-face interactions between mothers and infants is an important component of their communicative processes. Manual coding, however, is laborious. Obtaining inter-observer reliability is difficult, with disagreements mostly being related to the on- and offsets of a limited number of orientation categories. We used a motion capture system and developed an automated method for the quantitative measurement of infant head orientation in mother--infant face-to-face-interactions. Automated motion capture systems have the potential to objectively document not only the on- and offset of behaviors, but also continuous changes. Infants wore a cap with three reflecting markers, and eight infrared cameras captured the positions of the markers. Analytic algorithms generated continuous three-dimensional descriptions of the infants' head movements. We report here on an initial feasibility study of four infants. To evaluate the effectiveness of the automated approach, we compared it to standard manual categorical coding of six infant head orientations. We found that the central reliability issue was disagreement at the boundaries of the coding categories identified by continuous automated coding versus manual coding. The automated method was both more feasible and more precise in capturing continuous small changes. The study provides evidence for the usefulness of automated measurement of infant head orientation when infants interact in relational space.
[Mh] Termos MeSH primário: Cabeça
Comportamento do Lactente
Cinese
Relações Mãe-Filho/psicologia
Orientação
[Mh] Termos MeSH secundário: Pesquisa Comportamental/métodos
Feminino
Seres Humanos
Imagem Tridimensional/métodos
Lactente
Masculino
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150512
[Lr] Data última revisão:
150512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140607
[St] Status:MEDLINE
[do] DOI:10.3758/s13428-014-0487-6



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